ijms-logo

Journal Browser

Journal Browser

New Progression of Developing Novel Chiral Separation Materials, Chiral Selectors and Chiral Products

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Physical Chemistry and Chemical Physics".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 430

Special Issue Editor


E-Mail Website
Guest Editor
Institute of Pharmaceutical Analysis, University of Szeged, H-6720 Szeged, Hungary
Interests: enantioselective separations; chiral stationary phases; recognition mechanism; liquid chromatography; bioanalytics

Special Issue Information

Dear Colleagues,

We already know that chirality, the most important form of molecular asymmetry, is universal and that chirality on the molecular level plays an essential role in biological systems. Amino acids (except for glycine), proteins, sugars, and enzymes are all chiral compounds; depending on the number of stereogenic centers, they may possess numerous stereoisomers. The enantiomers (the “mirror-image” compounds) can only be differentiated in a chiral environment, where they may behave differently. Thus, it is understandable that if a mixture of enantiomers enters a living organism, there might be a difference in their utilization, distribution, and metabolism, thus affecting the type and scale of the biological effect. It is important to realize that apart from pharmaceutical drugs, chiral products can be found in vast quantities of food additives, agricultural chemicals, or fragrance materials of perfumes. To gain information about each enantiomer’s exact role and possible transformations, efficient analytical techniques such as applying chiral selectors are required.

This Special Issue aims to bring together the development of chiral separation materials and selectors to qualify and quantify chiral products. Both original research papers and reviews in these fields are welcome.

Prof. Dr. István Ilisz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chirality
  • enantioselective separations
  • chiral selector molecules
  • chiral stationary phases
  • chiral sensors
  • enantiorecognition
  • chiral separation mechanisms

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

18 pages, 4984 KiB  
Article
High-Performance Liquid Chromatographic Separation of Stereoisomers of ß-Methyl-Substituted Unusual Amino Acids Utilizing Ion Exchangers Based on Cinchona Alkaloids
by Gábor Németi, Róbert Berkecz, Dániel Ozsvár, Zsolt Szakonyi, Wolfgang Lindner, Aleksandra Misicka, Dagmara Tymecka, Géza Tóth, Antal Péter and István Ilisz
Int. J. Mol. Sci. 2025, 26(9), 4004; https://doi.org/10.3390/ijms26094004 - 23 Apr 2025
Viewed by 217
Abstract
Novel peptides based on common amino acid building blocks may serve as possible drug candidates; however, their flexible structures may require stabilization via the incorporation of conformational constraints. The insertion of unusual amino acids is a feasible option that may provide improved pharmacokinetic [...] Read more.
Novel peptides based on common amino acid building blocks may serve as possible drug candidates; however, their flexible structures may require stabilization via the incorporation of conformational constraints. The insertion of unusual amino acids is a feasible option that may provide improved pharmacokinetic and pharmacodynamic properties of such peptide-type drugs. The stereochemical purity of these kinds of building blocks must be verified by an efficient separation technique, such as high-performance liquid chromatography. Here, we present and discuss the results of the stereoselective separation mechanism of ß-methylated phenylalanine (ß-MePhe), tyrosine (ß-MeTyr), 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (ß-MeTic), and cyclohexylalanine (ß-MeCha) together with non-methylated Phe, Tyr, Tic, and Cha applying Cinchona alkaloid-based chiral stationary phases (CSPs). The studied zwitterionic CSPs acting as ion exchangers provided optimal performance in the polar ionic mode when methanol or a mixture of methanol and acetonitrile was utilized as the mobile phase together with organic acid and base additives. It was found that the basicity of small amines applied as mobile phase additives did not directly influence the chromatographic ion exchange concept. However, the size of the amines and their concentration led to a reduced retention time following the principles of ion exchange chromatography. On the basis of a systematic study of the effects of the eluent composition on the chromatographic behavior, important structure–retention and enantioselectivity relationships could be revealed. Through a temperature study, it has become evident that the composition of the eluent and the structure of analytes markedly affect the thermodynamic properties. Full article
Show Figures

Figure 1

Back to TopTop