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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of Age-Related Cognitive Decline

edited by

Cristovam Wanderley Picanço Diniz

submission deadline 20 Dec 2025 | Viewed by 678 | Submission Open

Keywords: cognitive decline; molecular mechanisms; aging individuals; therapeutic targets; neuroinflammation; oxidative stress; protein aggregation; vascular changes

(This special issue belongs to the Section Molecular Neurobiology)

Signaling in GPCR Research

edited by

Zvi Naor

submission deadline 20 Dec 2025 | Viewed by 658 | Submission Open

Keywords: GPCR; G protein; signaling; drug design; cell surface receptors

(This special issue belongs to the Section Biochemistry)

Rethinking Fat: A Deeper Dive into the Diversity and Dynamic Roles of Adipose Tissue

edited by

Ahmed Bettaieb

submission deadline 20 Dec 2025 | Viewed by 652 | Submission Open

Keywords: adipose tissue biology; stem cell commitment and differentiation; thermogenic adipocytes; genetic regulation; metabolic homeostasis; selective targeting

(This special issue belongs to the Section Molecular Biology)

Molecular Studies of Skin Diseases: From Mechanisms to Therapy

edited by

Soon Hyo Kwon

submission deadline 20 Dec 2025 | 1 articles | Viewed by 631 | Submission Open

Keywords: multiomics; genomics; transcriptomics; proteomics; metabolomics; skin diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomolecular Condensates and Their Role in Cellular Organization and Disease

edited by Anna Bratek-Skicki

submission deadline 20 Dec 2025 | Viewed by 593 | Submission Open

Keywords: biocondensates; membrane-less organelles; liquid-liquid phase separation; protein aggregation; neurogenerative diseases

(This special issue belongs to the Section Molecular Biology)

Red Blood Cells in Health and Disease

edited by Annamaria Russo and Ester Tellone

submission deadline 20 Dec 2025 | Viewed by 588 | Submission Open

Keywords: oxidative stress; metabolism; hemoglobin; erythrocytes

(This special issue belongs to the Section Biochemistry)

Exploring Natural Products for Antimicrobial Innovation: New Paths and Promising Leads

edited by

Shagufta Perveen

submission deadline 20 Dec 2025 | Viewed by 563 | Submission Open

Keywords: antimicrobial agents; drug resistance; plant-derived compounds; bioactive molecules; phytochemicals; marine natural products; fungal metabolites; novel drug discovery; microbial pathogens; natural product isolation; drug development; biotechnology in antimicrobial research

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Fibrinolytic Factors in Disease

edited by

Yosuke Kanno

submission deadline 20 Dec 2025 | Viewed by 520 | Submission Open

Keywords: fibrinolysis; plasminogen; plasmin; α 2-antiplasmin; uPA; uPAR; tPA; PAI-1

(This special issue belongs to the Section Molecular Biology)

Design, Synthesis and Biological Activity of Heterocyclic Compounds

edited by

Monika Kadela-Tomanek

submission deadline 20 Dec 2025 | Viewed by 479 | Submission Open

Keywords: synthesis of new bioactive compounds; biological activity of heterocyclic compounds; structural analysis; pharmacokinetic analysis of potential drugs; molecular docking study of new heterocyclic compounds

(This special issue belongs to the Section Biochemistry)

Histological and Molecular Perspectives on Immune Mechanisms of the Nasal and Bronchial Mucosa Diseases

edited by

Emanuela Chiarella

submission deadline 20 Dec 2025 | Viewed by 467 | Submission Open

Keywords: nasal and bronchial mucosa; nasal polyposis; bronchial inflammation; immunotherapy; mucosal immunity; inflammatory biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Collagen-Based Biomaterials in Tissue Engineering and Regenerative Medicine

edited by Martin Braun,

Selestina Gorgieva

and

Eva Filova

submission deadline 20 Dec 2025 | Viewed by 465 | Submission Open

Keywords: collagen; tissue engineering; advanced biomaterials; biodegradable composites; scaffolds; protein structure; biochemical analysis; material characterization; medical application; gelatine

(This special issue belongs to the Section Macromolecules)

Role of EGFR in Colorectal Cancer

edited by

Verónica Moreno-Viedma

submission deadline 20 Dec 2025 | Viewed by 464 | Submission Open

Keywords: EGFR; RAS; biomarkers/prognosis; resistance mechanisms; tumor microenvironment; EGFR signaling pathways; EGFR inhibitors; onco-immunology

(This special issue belongs to the Section Biochemistry)

Physiopathology and Therapeutics of HIV Infection

edited by

Inês Bártolo

submission deadline 20 Dec 2025 | Viewed by 445 | Submission Open

Keywords: HIV; physiopathology; ART; HAART; NRTIs; NNRTIs; PIs; INSTIs; fusion inhibitors; CCR5 antagonists; post-attachment inhibitors; capsid inhibitors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanotransduction and Tissue Regeneration in Skeletal Muscle

edited by

Mahtab Nourbakhsh

submission deadline 20 Dec 2025 | Viewed by 431 | Submission Open

Keywords: skeletal muscle tissue regeneration; mechanotransduction; skeletal muscle spindles; tissue-resident macrophages

(This special issue belongs to the Section Molecular Biology)

Adipose Tissue and Adipose Tissue-Derived Stem Cells in Multidisciplinary Research

edited by Oliver Felthaus

submission deadline 20 Dec 2025 | Viewed by 428 | Submission Open

Keywords: adipose tissue; adipose-derived stem cells; regenerative medicine; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Molecular and Immunological Biomarkers in Cervical Cancer

edited by Janaina Cristiana de Oliveira Crispim and

Ricardo Ney Oliveira Cobucci

submission deadline 20 Dec 2025 | Viewed by 409 | Submission Open

Keywords: cervical cancer; molecular biomarkers; immunological biomarkers; human papillomavirus (HPV); tumor microenvironment; immune responses; immunotherapy; diagnostic biomarkers; prognostic biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Effects of Xenobiotic Exposure on Human Health: A Molecular Perspective

edited by

Maria Lisa Garavaglia

submission deadline 20 Dec 2025 | Viewed by 406 | Submission Open

Keywords: xenobiotic exposure; human health; toxic effects; environmental chemicals; molecular research

(This special issue belongs to the Section Molecular Toxicology)

Roles and Mechanisms of Non-Coding RNAs in Breast Cancer

edited by

Oliver Treeck

submission deadline 20 Dec 2025 | Viewed by 405 | Submission Open

Keywords: breast cancer; NcRNA; MmiRNA; LncRNA; CircRNA; PiRNA; exosome-packed ncRNA; role and mechanisms of ncRNA in breast cancer tissue or cell lines; modulation of ncRNA levels by knock-out or knock-down approaches; effects on breast cancer cell proliferation; invasion; or apoptosis; identification of BC-relevant ncRNA– mRNA networks; targeting ncRNAs with potential clinical implications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Quantum Chemistry, Vibrational Spectroscopy and Biophysics on Biomolecules

edited by

Mauricio Alcolea Palafox

submission deadline 20 Dec 2025 | Viewed by 397 | Submission Open

Keywords: molecular simulations; computer calculations; structure predictions; molecular structure; DNA structure; nucleobases pairs; inter-molecular interactions; spectroscopic predictions; scaling; Raman simulations; macromolecular crystallography; molecular modeling; electronic properties

(This special issue belongs to the Section Molecular Biophysics)

Pediatric Autoimmune Diseases: Molecular Basis, Diagnostic and Therapy

edited by

Marija Jelusic

submission deadline 20 Dec 2025 | Viewed by 397 | Submission Open

Keywords: autoimmunity; immune regulation; biomarker analysis; molecular pathways; precision medicine; genetics

(This special issue belongs to the Section Molecular Immunology)

Circumventing Resistance to Channel-Targeting Insecticides: A Challenge for Global Health and Food Security

edited by

Bruno Lapied

and David Barry Sattelle

submission deadline 20 Dec 2025 | Viewed by 397 | Submission Open

Keywords: pest insects and resistance; resistance in insect vectors of human and livestock diseases; mechanisms of resistance; circumventing resistance; ion channels and resistance; integrated approaches to resistance management; alternating insecticide classes; minimizing risk to beneficial insects; novel control strategies

(This special issue belongs to the Section Molecular Biology)

Protein Modification: New Insights

edited by

Yeou-Guang Tsay

submission deadline 20 Dec 2025 | Viewed by 396 | Submission Open

Keywords: post-translational modifications (PTMs); side chain modifications; backbone modifications; analytical protein chemistry; mass spectrometry

(This special issue belongs to the Section Biochemistry)

Bacteria-Mediated Cancer Therapy: New Molecular Insights

edited by

Che-Hsin Lee

submission deadline 20 Dec 2025 | Viewed by 389 | Submission Open

Keywords: bacteria-mediated cancer therapy; tumor microenvironment (TME); tumour immunotherapy; anticancer bacteria

(This special issue belongs to the Section Molecular Oncology)

Metabolomics of Medicinal Plants

edited by

L. Gerardo Zepeda Vallejo

and

Elvia Becerra-Martínez

submission deadline 20 Dec 2025 | 1 articles | Viewed by 384 | Submission Open

Keywords: metabolomics; medicinal plants; nuclear magnetic resonance; mass spectrometry; bioinformatic; phenotyping; metabolic pathways; bioactive metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Chronic Pain: Mechanisms and Therapeutic Innovations

edited by

Roberto Tedeschi

submission deadline 20 Dec 2025 | Viewed by 379 | Submission Open

Keywords: chronic pain; pain mechanisms; pain management; therapeutic innovation; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Apoptosis and Autophagy in Cancer Research

edited by

Ioana Berindan-Neagoe

and

Radu Pirlog

submission deadline 20 Dec 2025 | Viewed by 371 | Submission Open

Keywords: apoptosis; autophagy; cancer biology; coding and noncoding genomes; cell homeostasis; therapeutic strategies; cell death and survival

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Tumor Angiogenesis and Metastasis: From Molecular Signalling to Therapeutic Approaches

edited by

Federica Finetti

and

Lorenza Trabalzini

submission deadline 20 Dec 2025 | Viewed by 367 | Submission Open

Keywords: tumour angiogenesis; tumour invasion; tumour metastasis; molecular mechanisms; metabolic patterns; signalling pathways

(This special issue belongs to the Section Molecular Oncology)

Anticancer Antibiotics: Progresses, Opportunities and Challenges

edited by Jose Kaneti

submission deadline 20 Dec 2025 | Viewed by 367 | Submission Open

Keywords: tetracycline antibiotics; antitumor activity; molecular mechanism; G-quadruplex complexes; computational modeling; pharmacological evaluation

(This special issue belongs to the Section Molecular Pharmacology)

Thrombo-Inflammatory Signaling and Complications in Autoimmune Disorders

edited by

Alexandros Tsoupras

submission deadline 20 Dec 2025 | Viewed by 364 | Submission Open

Keywords: inflammation; thrombosis; platelets; coagulation; autoimmune disorders; rheumatoid arthritis; systematic erythematosus lupus; antiphospholipid syndrome; thrombo-inflammation; antithrombotic; antiplatelet

(This special issue belongs to the Section Molecular Immunology)

Growth Factor Signaling in Cancer Progression

edited by

Hyeong-Reh Choi Kim

and Abdo J. Najy

submission deadline 20 Dec 2025 | Viewed by 357 | Submission Open

Keywords: growth factor signaling; proteolysis; cancer progression; tumor dormancy; metastasis; tumor microenvironment; therapeutic strategies

(This special issue belongs to the Section Molecular Biology)

Developmental Origins of Kidney Disease: Renal Programming

edited by Hyung-Eun Yim

submission deadline 20 Dec 2025 | 1 articles | Viewed by 354 | Submission Open

Keywords: air pollution; chronic kidney disease; congenital anomalies of the kidneys and urinary tract; high-risk pregnancy; nephrogenesis; renal programming; renin angiotensin system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Roles of AI in Disease Diagnosis and Treatment

edited by

Miguel Souto-Bayarri

submission deadline 20 Dec 2025 | Viewed by 340 | Submission Open

Keywords: artificial intelligence; radiomics; machine learning; deep learning; diagnosis; treatment; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pharmacology of Cation-Permeable Ion Channels

edited by

Jian Shi

submission deadline 20 Dec 2025 | Viewed by 331 | Submission Open

Keywords: cation-permeable ion channel structure; cation-permeable ion channel functions; cation-permeable ion channel pharmacology; cation-permeable ion channel and diseases; innovative techniques for cation-permeable ion channel research

(This special issue belongs to the Section Molecular Pharmacology)

Antiviral Mechanisms of Natural/Synthetic Compounds

edited by Cybele Carina García

submission deadline 20 Dec 2025 | Viewed by 325 | Submission Open

Keywords: antiviral mechanisms; natural compound; synthetic compound; druggable viral/host target; emerging virus; host– virus interaction; innate antiviral response; cell-intrinsic restriction factor

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research on Aging: How Can We Live Beyond 100 Years?

edited by

Shin Murakami

submission deadline 20 Dec 2025 | Viewed by 323 | Submission Open

Keywords: aging; biomarkers; centenarians; longevity interventions; stress resistance and metabolism; age-related diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Targets and Mechanisms of Innovative Therapies and Natural Adjuvants in Glioblastoma Management

edited by

Maria Grazia Bottone

and Fabrizio De Luca

submission deadline 20 Dec 2025 | Viewed by 322 | Submission Open

Keywords: glioblastoma; targeted therapy; traditional and emerging therapies; signaling pathways; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Mechanistic and Data-Driven Modelling Approaches for Regulatory Networks and Diseases

edited by

Tianhai Tian

submission deadline 20 Dec 2025 | Viewed by 319 | Submission Open

Keywords: mathematical modelling; data-driven approach; mechanistic and data dual-driven approach; hybrid modelling; machine learning; modelling of regulatory network; inference of molecular regulation; cancer; infection disease; disease intervention

(This special issue belongs to the Section Molecular Informatics)

Abscisic Acid, a New Old Friend to Regulate Abiotic Stress Tolerance in Plants

edited by Marta Marina Pérez-Alonso and

Miguel González-Guzmán

submission deadline 20 Dec 2025 | Viewed by 314 | Submission Open

Keywords: abscisic acid (ABA); ABA perception; ABA signaling network; abiotic stress; hormonal crosstalk; crop species; stress tolerance; plant productivity; agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

DNA Methylation in Cancer: Progress and Challenges

edited by

Michael Eccles

submission deadline 20 Dec 2025 | Viewed by 308 | Submission Open

Keywords: DNA methylation; cancer; hypomethylation; hypermethylation; epigenetics; tumor onset; tumor progression; technologies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Stem Cell or Exosome-Based Therapy for Kidney and Urinary Tract Diseases: Mechanisms, Applications, and Future Perspectives

edited by

Yuanyuan Zhang

submission deadline 20 Dec 2025 | Viewed by 307 | Submission Open

Keywords: stem cell therapy; exosome therapy; kidney disease; regenerative medicine; cell differentiation; tissue engineering; drug discovery; in vitro 3D models; anti-inflammation; antioxidant stress; antifibrosis; extracellular vesicles; precision medicine; bioengineering; artificial intelligence; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Coenzyme Q Redox State and Cellular Homeostasis: Implications for Clinical Practice

edited by

Iain P. Hargreaves

submission deadline 20 Dec 2025 | Viewed by 305 | Submission Open

Keywords: coenzyme Q; cellular homeostasis; cellular energy production; antioxidant defense

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Chronic Liver Disease and Liver Failure

edited by Paolo Gallo

submission deadline 20 Dec 2025 | Viewed by 301 | Submission Open

Keywords: cirrhosis; portal hypertension; liver failure; advanced chronic liver disease; sarcopenia and malnutrition; ascites; medical treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chronic Kidney Disease: Novel Advances in Pathophysiology and Therapeutics

edited by

Shihping Hsu

submission deadline 20 Dec 2025 | Viewed by 295 | Submission Open

Keywords: anti-fibrosis; anti-inflammation; biomarker; chronic kidney disease; complement; glucagon-like peptide-1 receptor agonist; immuno modulaton; sodium– glucose cotransporter-2 inhibitor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Physiology and Pathophysiology of Neurodegeneration: New Insights and Advances from Molecular to Cellular Level

edited by

Alessandro Romano

and

Amilcare Barca

submission deadline 20 Dec 2025 | Viewed by 293 | Submission Open

Keywords: central and peripheral nervous systems; neuron homeostasis; neurodegeneration; neurodegenerative disease; neurophysiology; -omic technologies; induced pluripotent stem cell (iPSC); three-dimensional cell culture; organ-on-a-chip (OoC)

(This special issue belongs to the Section Molecular Neurobiology)

Cell–Cell Communication Through Extracellular Vesicles

edited by Federica Fratini

submission deadline 20 Dec 2025 | Viewed by 284 | Submission Open

Keywords: EV biomarkers; EV biogenesis; EV drug delivery; EV trafficking; EV immuno escape

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Action and Cytotoxicity of Platinum-Based Therapeutics

edited by

Antonella Muscella

submission deadline 20 Dec 2025 | Viewed by 277 | Submission Open

Keywords: platinum-based drugs; cancer therapy; cisplatin; drug resistance; nanodrugs; targeted delivery systems; molecular mechanisms; systemic toxicity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Immunology of Infectious Diseases

edited by

Salvatore Giovanni De Simone

submission deadline 20 Dec 2025 | Viewed by 270 | Submission Open

Keywords: molecular immunology; infectious diseases; innate immunity; adaptive immunity; immunomodulation-based therapies

(This special issue belongs to the Section Molecular Immunology)

Epigenetic and RNA-Based Regulation in Cancer: Mechanism, Therapeutic Targets, and Translational Perspectives

edited by

Moon Nyeo Park

submission deadline 20 Dec 2025 | Viewed by 263 | Submission Open

Keywords: molecular underpinnings of DNA; histone; RNA-based epigenetic regulation; small molecules and epigenetic inhibitors; epigenetic signatures; oncology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advanced Cell Based Biomaterials for Musculoskeletal Tissue Engineering

edited by

Isabel Calejo

submission deadline 20 Dec 2025 | Viewed by 259 | Submission Open

Keywords: cell-based materials; bioprinting; microfluidics; hydrogels; vascularization; innervation; hierarchical; fiber technologies; microtissues

(This special issue belongs to the Section Materials Science)

Molecular Applications of Nanoparticles in Cancer Therapy

edited by Carlos Caro and Iñigo Martínez-Zubiaurre

submission deadline 20 Dec 2025 | Viewed by 246 | Submission Open

Keywords: nanomedicine; molecular biology of cancer; advanced therapies; tumor microenvironment; cellular crosstalk

(This special issue belongs to the Section Materials Science)

Displaying special issue 701-750 on page 15 of 69.

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