ijms-logo

Journal Browser

Journal Browser

Molecular Research Progress of Cereal Crop Disease Resistance

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Plant Sciences".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 3294

Special Issue Editors


E-Mail Website
Guest Editor
1. The National Engineering Laboratory of Crop Molecular Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China
2. Xianghu Laboratory, Institute of Biotechnology, Hangzhou 311231, China
Interests: wheat genetics and breeding; wheat germplasm enhancement; molecular characterization and map-based cloning of wheat; disease resistance genes; resistance to wheat diseases caused by fungi and nematodes
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China
Interests: wheat genetics and breeding; wheat fusarium head blight resistance; resistance to wheat diseases

Special Issue Information

Dear Colleagues,

Cereal crops, such as wheat and barley, are fundamental to global food security, serving as staple foods that underpin human nutrition and economic stability worldwide. The importance of these cereal crops necessitates their productivity and resilience to be safeguarded against a multitude of challenges caused by various pathogens such as fungi, bacteria, nematodes, and viruses. The combined effects of these pathogens pose a significant threat to cereal crop yields and, by extension, the global food supply.

Addressing these challenges through molecular research into disease resistance is a critical focus within cereal crop breeding programs. Deciphering the genetic underpinnings of disease resistance allows for the more effective development of disease-resistant cultivars. This Special Issue is dedicated to exploring the state-of-the-art progress being made and current trends in the discovery of novel resistance sources, the molecular characterization of resistance genes, their regulatory networks, and the application of molecular markers in the breeding process.

The scope of this Special Issue includes several critical areas:

  1. Discovery of novel resistance (gene) sources: Exploring new sources of resistance genes from diverse genetic backgrounds provides further avenues for developing resilient crops. This exploration extends to research on wild relatives and landraces of cereal crops.
  2. Molecular dissection of resistance genes: Elucidating the structure, function, and mechanisms of resistance genes offers insights into their role in defending against various diseases. A comprehensive understanding of these genes is essential for the advancement of resistant crop cultivars.
  3. Molecular regulatory networks: Unraveling the complex regulatory networks governing the expression of resistance genes helps in understanding their activation and interaction with other molecular pathways during responses to pathogens. These insights can identify additional targets for breeding efforts.
  4. Molecular marker-assisted selection in breeding: Incorporating molecular markers into breeding programs accelerates the creation of disease-resistant cultivars by enabling precise targeting of desirable traits, thereby enhancing the efficiency and success of breeding programs.

This Special Issue aims to collate pioneering research and review articles that highlight significant progress made in these areas. It aims to provide a comprehensive view of the molecular mechanisms underlying disease resistance in cereal crops and to offer visionary perspectives on future research avenues and practical applications for breeding initiatives. By advancing the understanding and application of molecular research in cereal crop disease resistance, this Special Issue will directly contribute to the objectives of enhancing global food security and the sustainability of agriculture.

Prof. Dr. Hongjie Li
Prof. Dr. Zhenqi Su
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cereal crops
  • disease resistance
  • resistance genes
  • breeding
  • molecular marker-assisted selection
  • molecular regulatory network

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 2522 KiB  
Article
Identification of Leaf Stripe Resistance Genes in Hulless Barley Landrace Teliteqingke from Qinghai-Tibet Plateau
by Zemin Tan, Sai Zhang, Yunfeng Qu, Shenghua Kang, Shiyu Fang and Lu Hou
Int. J. Mol. Sci. 2025, 26(3), 1133; https://doi.org/10.3390/ijms26031133 - 28 Jan 2025
Viewed by 633
Abstract
Leaf stripe disease, caused by Pyrenophora graminea, is a seed-borne fungal disease that significantly impacts hulless barley (Hordeum vulgare var. nudum) production on the Qinghai-Tibet Plateau. This study aimed to identify genetic factors conferring resistance to the leaf stripe by [...] Read more.
Leaf stripe disease, caused by Pyrenophora graminea, is a seed-borne fungal disease that significantly impacts hulless barley (Hordeum vulgare var. nudum) production on the Qinghai-Tibet Plateau. This study aimed to identify genetic factors conferring resistance to the leaf stripe by analyzing an F3 population derived from a cross between the resistant landrace Teliteqingke and the susceptible landrace Dulihuang. Genetic analysis revealed that resistance in Teliteqingke was governed by two dominant genes. Using bulked segregant analysis combined with an SNP array (BSA-SNP) and RNA-seq, we identified two candidate regions on chromosomes 3H and 7H. Further analysis focused on chromosome 3H, which revealed a candidate genomic region containing seven potential disease-resistance genes. Among these, RT-qPCR experiments demonstrated significant expression induction of HORVU.MOREX.r3.3HG0232110.1 (encoding a RING/U-box superfamily protein) and HORVU.MOREX.r3.3HG0232410.1 (encoding a bZIP transcription factor) showed significant expression induction following inoculation with P. graminea. These genes are strong candidates for the resistance mechanism against leaf stripes in Teliteqingke. These results provide a foundation for functional validation of these genes and offer valuable insights for breeding disease-resistant hulless barley. Full article
(This article belongs to the Special Issue Molecular Research Progress of Cereal Crop Disease Resistance)
Show Figures

Figure 1

12 pages, 1754 KiB  
Article
A Unique Expression Profile Responding to Powdery Mildew in Wild Emmer Wheat D430
by Yintao Dai, Ningning Yu, Hongxing Xu, Shaoqing Liu, Jiadong Zhang, Ruishan Liu, Jiatong Li, Yaoxue Li, Bei Xiao, Guantong Pan, Dongming Li, Cheng Liu, Yuli Jin and Pengtao Ma
Int. J. Mol. Sci. 2025, 26(1), 242; https://doi.org/10.3390/ijms26010242 - 30 Dec 2024
Cited by 1 | Viewed by 757
Abstract
Powdery mildew, caused by Blumeria graminis f. sp. tritici (Bgt), is a disease that seriously harms wheat production and occurs in all wheat-producing areas around the world. Exploring Pm gene(s) and developing resistant cultivars are preferred to control the disease. Wild [...] Read more.
Powdery mildew, caused by Blumeria graminis f. sp. tritici (Bgt), is a disease that seriously harms wheat production and occurs in all wheat-producing areas around the world. Exploring Pm gene(s) and developing resistant cultivars are preferred to control the disease. Wild emmer wheat (Triticum dicoccoides, 2n = 4x = 28, AABB) has accumulated abundant gene resources for resistance to powdery mildew during the long process of natural evolution. In the current study, the WEW accession D430 was highly resistant to powdery mildew at the whole-growth stage. Genetic analysis showed that the powdery mildew resistance in D430 was conferred by a single dominant locus or gene by the cross of D430 and susceptible durum wheat 647, tentatively named PmD430. Combining BSR-Seq analysis, molecular mapping, and sequence alignment, PmD430 was finally mapped to Pm4 locus, and the sequence was identical to Pm4b. Subsequently, 1871 DEGs between resistant and susceptible bulks were annotated and analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. Eight disease-related genes were evaluated by qRT-PCR and exhibited a unique expression pattern when invaded by Bgt isolate E09 and was, therefore, presented as latent targets for regulating powdery mildew resistance in D430. Full article
(This article belongs to the Special Issue Molecular Research Progress of Cereal Crop Disease Resistance)
Show Figures

Figure 1

21 pages, 7230 KiB  
Article
Novel SNPs Linked to Blast Resistance Genes Identified in Pearl Millet Through Genome-Wide Association Models
by Swati Singh, Ganesan Prakash, Sandeep Nanjundappa, Renuka Malipatil, Prerana Kalita, Tara C. Satyavathi and Nepolean Thirunavukkarasu
Int. J. Mol. Sci. 2024, 25(22), 12048; https://doi.org/10.3390/ijms252212048 - 9 Nov 2024
Cited by 1 | Viewed by 1536
Abstract
Foliar blast, caused by Pyricularia grisea, poses a major challenge to pearl millet (Pennisetum glaucum (L.) R. Br) production, leading to severe yield losses, particularly in rainfed ecologies. This study aimed to elucidate the genetic basis of blast resistance through a [...] Read more.
Foliar blast, caused by Pyricularia grisea, poses a major challenge to pearl millet (Pennisetum glaucum (L.) R. Br) production, leading to severe yield losses, particularly in rainfed ecologies. This study aimed to elucidate the genetic basis of blast resistance through a genome-wide association study (GWAS) involving 281 diverse pearl millet inbreds. GWAS panel was phenotyped for blast resistance against three distinct isolates of P. grisea collected from Delhi, Gujarat, and Rajasthan locations, revealing a significant variability with 16.7% of the inbreds showing high resistance. Bayesian information and linkage disequilibrium iteratively nested keyway (BLINK) and Multi-Locus Mixed Model (MLMM) models using transformed means identified 68 significant SNPs linked to resistance, with hotspots for resistance-related genes on chromosomes 1, 2, and 6. These regions harbor genes involved in defense mechanisms, including immune response, stress tolerance, signal transduction, transcription regulation, and pathogen defense. Genes, namely 14-3-3-like proteins RGA2, RGA4, hypersensitive-induced response proteins, NHL3, NBS-LRR, LRR-RLK, LRRNT_2, and various transcription factors such as AP2/ERF and WRKY, played a crucial role in the stress-responsive pathways. Analyses of transporter proteins, redox processes, and structural proteins revealed additional mechanisms contributing to blast resistance. This study offers valuable insights into the complex genetic architecture of blast resistance in pearl millet, offering a solid foundation for marker-assisted breeding programs and gene-editing experiments. Full article
(This article belongs to the Special Issue Molecular Research Progress of Cereal Crop Disease Resistance)
Show Figures

Figure 1

Back to TopTop