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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Structures, Syntheses of Natural Products, and Their Biological Effects

edited by

Ran Jia

submission deadline 20 Sep 2026 | 4 articles | Viewed by 10950 | Submission Open

Keywords: structures of natural products; syntheses; biological effects; biomedical applications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms, Pathogenesis, and Novel Therapeutic Strategies in Cardiovascular Disease, 2nd Edition

edited by

Dai Yamanouchi

submission deadline 20 Sep 2026 | 3 articles | Viewed by 10587 | Submission Open

Keywords: aneurysm pathobiology; vascular remodeling; extracellular matrix degradation; inflammatory signaling pathways; molecular targets for therapy; autophagy; macrophage; inflammation; immune cell regulation; age-related diseases; therapeutic implications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of the Aging Process: 2nd Edition

edited by

Giuseppe Coppotelli

and

Jaime M. Ross

submission deadline 20 Sep 2026 | 2 articles | Viewed by 10471 | Submission Open

Keywords: aging process; molecular mechanisms; epigenetic clock; cancer; metabolic disease

(This special issue belongs to the Section Molecular Biology)

Thyroid Function in Human Diseases: From Physiopathology to Clinical Impact on Human Health

edited by

Rosa Maria Paragliola

and Andrea Corsello

submission deadline 20 Sep 2026 | 5 articles | Viewed by 10332 | Submission Open

Keywords: thyroid physiology; hypothyroidism; hyperthyroidism; central hypothyroidism; inappropriate TSH secretion syndrome; drugs interfering with thyroid function; sick euthyroid syndrome; consumptive hypothyroidism syndrome

(This special issue belongs to the Section Molecular Biology)

The Role of Bioactive Compounds in Human Health and Disease: 3rd Edition

edited by

Guan-Jhong Huang

submission deadline 20 Sep 2026 | 6 articles | Viewed by 10272 | Submission Open

Keywords: cancer; inflammation; cardiovascular diseases; plants; bioactive compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Melanin and Other Pigments: Function, Synthesis and Characterization

edited by Koen P. Vercruysse

submission deadline 20 Sep 2026 | 4 articles | Viewed by 10129 | Submission Open

Keywords: melanin; eumelanin; pheomelanin; allomelanin; catechol; indole; phenol

(This special issue belongs to the Section Biochemistry)

Gluten/Wheat-Related Disorders: The Role of Nutrition, Gut Barrier, Microbiota, and New Therapeutic Strategies

edited by Lisa Lungaro

submission deadline 20 Sep 2026 | 2 articles | Viewed by 9945 | Submission Open

Keywords: gluten-related disorders; celiac disease; non celiac gluten wheat sensitivity; gluten free diet; microbiota; gut barrier; probiotics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biosynthesis of Phytochemicals and Their Applications in Novel Drug Lead Development

edited by

Piotr Szymczyk

submission deadline 20 Sep 2026 | 5 articles | Viewed by 9833 | Submission Open

Keywords: biosynthesis of phytochemicals in plants; phytochemical isolation; phytochemical structure; animal and human protein targets of phytochemicals; chemical derivatives of phytochemicals

(This special issue belongs to the Section Molecular Pharmacology)

Bioactive Molecules from Food or Other Natural Sources Against Cancer: 2nd Edition

edited by

Alessandro Maugeri

and

Michele Navarra

submission deadline 20 Sep 2026 | 3 articles | Viewed by 9670 | Submission Open

Keywords: cancer; natural bioactive molecules; natural products; tumor

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Medicinal Plant Resources—from Molecular Studies to Sustainable Use

edited by Ekaterina Kozuharova

submission deadline 20 Sep 2026 | 3 articles | Viewed by 9647 | Submission Open

Keywords: genetic improvement of medicinal plants; sustainable use; bioactive compounds

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Pharmacology and Interventions in Cardiovascular Disease: 2nd Edition

edited by

Magdalena Zabielska-Kaczorowska

submission deadline 20 Sep 2026 | 5 articles | Viewed by 9384 | Submission Open

Keywords: cardiovascular pharmacology; cardiovascular interventions; cardioprotection; myocardial ischemia and infarction; heart failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Immunosuppressive Therapy

edited by

Marta Grabowska

submission deadline 20 Sep 2026 | 2 articles | Viewed by 9219 | Submission Open

Keywords: immunosuppressive drugs; calcineurin inhibitors; corticosteroids; inhibitors of purine synthesis; mammalian target of rapamycin inhibitors; biological treatment; cell-based therapies; biomarkers; genetic profiling

(This special issue belongs to the Section Molecular Immunology)

New Challenges of Parkinson’s Disease, 2nd Edition

edited by

Franca Rosa Guerini

and

Cristina Agliardi

submission deadline 20 Sep 2026 | 5 articles | Viewed by 9139 | Submission Open

Keywords: Parkinson’s disease; neurodegeneration; synuclein; diagnosis; genetics; epigenetics; extracellular vesicles; biomarkers; treatments; rehabilitation

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Nutrition, Genetics, and Biochemistry: From Mechanisms to Therapeutics

edited by

Anna Cieslinska

and

Edyta Sienkiewicz-Szłapka

submission deadline 20 Sep 2026 | 2 articles | Viewed by 9041 | Submission Open

Keywords: nutrigenomics and nutrigenetics; molecular nutrition; oxidative stress and redox biology; epigenetics and diet; lipid and glucose metabolism; inflammatory pathways; transcriptomics, metabolomics, proteomics; mitochondrial dysfunction and nutrition; biomarkers of diet-related disease; precision nutrition and molecular therapeutics

(This special issue belongs to the Section Molecular Biology)

From Macrophage Biology to Cell and EV-Based Immunotherapies

edited by

Katarzyna Nazimek

and

Krzysztof Bryniarski

submission deadline 20 Sep 2026 | 2 articles | Viewed by 8956 | Submission Open

Keywords: macrophage-based; macrophage-targeting; cancer immunotherapies; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Cellular and Molecular Study of Neurodevelopmental and Neurological Disorders

edited by

Kazuhito Toyooka

submission deadline 20 Sep 2026 | 2 articles | Viewed by 8918 | Submission Open

Keywords: autism spectrum disorder; ADHD; schizophrenia; intellectual disability; Alzheimer’s disease; Parkinson’s disorder; traumatic brain injury; epilepsy; neurodevelopmental disorders; neurological diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the Complex Interplay Between Metabolic Diseases, MASLD, and Liver Cancer

edited by

Daniela Gabbia

and

Sara De Martin

submission deadline 20 Sep 2026 | 4 articles | Viewed by 8681 | Submission Open

Keywords: hepatocellular carcinoma; MASLD; MASH; obesity; insulin resistance; dyslipidemia; liver cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Regenerative Medicine and Therapeutics

edited by

Diana Torge

submission deadline 20 Sep 2026 | 3 articles | Viewed by 8613 | Submission Open

Keywords: regenerative medicine; morphology; regenerative dentistry; biomaterials; scaffolds; organoids; tissue regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Dialogue Between Inflammation and Immunity: From Mechanism to Therapy

edited by

Nikolina Mihaylova

submission deadline 20 Sep 2026 | 4 articles | Viewed by 8497 | Submission Open

Keywords: inflammation; immune activation; immunomodulation; tolerance; immunotherapy; autoimmune diseases; cancer

(This special issue belongs to the Section Molecular Immunology)

Advanced Molecular Research in Brain Tumors

edited by

Shiv K. Gupta

submission deadline 20 Sep 2026 | 7 articles | Viewed by 8397 | Submission Open

Keywords: targeted therapy; blood–brain barrier; GBM; glioma; immune checkpoint blockers; TME

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Therapeutic Strategies of Colorectal Cancer

edited by

Daniel Gabriel Pons

submission deadline 20 Sep 2026 | 5 articles | Viewed by 8301 | Submission Open

Keywords: colorectal cancer; tumor microenvironment; biomarkers; intercellular communication; therapeutic strategies

(This special issue belongs to the Section Molecular Oncology)

Bee Products and Their Flavonoids: Recent Advances in Molecular Mechanisms, Therapeutic Applications, and Innovative Delivery Systems

edited by

Nada Orsolic

and

Maja Jazvinšćak Jembrek

submission deadline 20 Sep 2026 | 2 articles | Viewed by 8073 | Submission Open

Keywords: honeybee products; flavonoids; bioactive compounds; biological activity; pharmacological activity; health benefits; side effects; disease prevention; antioxidant activity; apitherapy; nutritional properties; innovative technical approaches

(This special issue belongs to the Section Molecular Biology)

New Advances in Metabolic Engineering and Synthetic Biology of Yeasts

edited by

Justyna Ruchała

submission deadline 20 Sep 2026 | 1 articles | Viewed by 8071 | Submission Open

Keywords: yeast metabolic engineering; synthetic biology; CRISPR-Cas9; metabolic pathways; bio-based chemicals; bioprocess engineering; yeast strain optimization; industrial biotechnology

(This special issue belongs to the Section Molecular Microbiology)

Neutrophil Extracellular Traps (NETs) in Immunity and Diseases, 3rd Edition

edited by

Jasmin Knopf

submission deadline 20 Sep 2026 | 3 articles | Viewed by 8026 | Submission Open

Keywords: neutrophils; neutrophil functions; neutrophil extracellular traps (NETs); NET biology; NETs in autoimmune diseases; NETs in immune response; NETs in the development and progression of cancer diseases; NETs in immunothrombosis; degradation of NETs

(This special issue belongs to the Section Molecular Immunology)

Aging: From Molecular Mechanisms and Pathophysiology to Novel Therapeutic Approaches (3rd Edition)

edited by

Darío Acuña-Castroviejo

submission deadline 20 Sep 2026 | 6 articles | Viewed by 7658 | Submission Open

Keywords: human aging; molecular clock; aging genes; epigenetics; nutrigenomics; inflammaging; stem cells; telomeres; mitochondria; brain-gut axis; brain-muscle axis; gut microbiota; chronodisruption

(This special issue belongs to the Section Molecular Biology)

Pathophysiological Insights, Biomarkers and New Therapeutic Strategies in Immune-Mediated Disorders and Neurodegenerative Diseases

edited by

Eleonora Virgilio

submission deadline 20 Sep 2026 | 3 articles | Viewed by 7223 | Submission Open

Keywords: neurodegeneration; neuroimmunology; inflammation; biomarkers; treatment; pathophysiology; multiple sclerosis; myasthenia gravis; neurodegenerative disease

(This special issue belongs to the Section Molecular Immunology)

Molecular Aspects of Forensic Toxicology

edited by

Angelo Montana

submission deadline 20 Sep 2026 | 1 articles | Viewed by 7105 | Submission Open

Keywords: forensic toxicology; molecular mechanism; toxicological biomarkers; post-mortem interval; in vitro, in vivo, and in silico models; new psychoactive substances (NPSs); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-tandem mass spectrometry (GC-MS/MS)

(This special issue belongs to the Section Molecular Toxicology)

Recent Advances in New Biomarkers for Cancers

edited by

Maria Panagopoulou

submission deadline 20 Sep 2026 | 6 articles | Viewed by 7087 | Submission Open

Keywords: biomarkers; cancer research; liquid biopsy; epigenetic and genetic biomarkers; precision oncology; diagnosis; prognosis; prediction

(This special issue belongs to the Section Molecular Oncology)

Molecular Forensics and the Genetic Foundations of Forensic Biology

edited by

Laura Caine

submission deadline 20 Sep 2026 | 3 articles | Viewed by 6970 | Submission Open

Keywords: molecular forensics; forensic genetics; epigenetics; biological fluid identification; forensic microbiology; sexual assault

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Heart Failure: From Bench to Bedside

edited by

Nadia Aspromonte

submission deadline 20 Sep 2026 | 4 articles | Viewed by 6839 | Submission Open

Keywords: heart failure; cardiac biomarkers; medical therapy; molecular pathways; prognosis; target therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Th2-Mediated Inflammation in Dermatology: Mechanistic and Therapeutic Perspectives

edited by

Luca Mastorino

submission deadline 20 Sep 2026 | 1 articles | Viewed by 6751 | Submission Open

Keywords: Th2 inflammation; inflammatory skin disease; immunology of the skin; type 2 inflammatory diseases; immunophenotype

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights into the Environmental Toxicity of Contaminants and Risk Mitigation Strategies

edited by

Barbara Mognetti

and

Tiziana Cappello

submission deadline 20 Sep 2026 | 4 articles | Viewed by 6741 | Submission Open

Keywords: microplastic toxicity; environmental pollutants; molecular mechanisms; cell metabolic pathways; in vivo, in vitro, and in silico models; pollutant interactions; risk mitigation strategies

(This special issue belongs to the Section Molecular Toxicology)

The Food Processing Industry’s 200th Anniversary: Bioactive Compounds, Antioxidants, and Potential Health Benefits (2nd Edition)

edited by

Vassilis Athanasiadis

submission deadline 20 Sep 2026 | 4 articles | Viewed by 6738 | Submission Open

Keywords: antioxidants; bioactive compounds; food processing; functional foods; green processes; health potentials; molecular mechanisms; polyphenols; shelf life; vitamins

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Studies of Bone Biology and Bone Tissue: 2nd Edition

edited by

Giovanna Iezzi

submission deadline 20 Sep 2026 | 5 articles | Viewed by 6698 | Submission Open

Keywords: bone; stem cells; immunomodulation; biomaterials; bone regeneration; bone repair; bone diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Melanoma: Molecular Mechanism and New Agents for Prevention and Therapy

edited by

M. Letizia Motti

submission deadline 20 Sep 2026 | 3 articles | Viewed by 6681 | Submission Open

Keywords: melanoma; therapy resistance; melanoma microenvironment (MME); melanoma plasticity; epigenetic mechanism; predictive markers; prognostic markers; extracellular vesicles; molecular therapy; natural molecules

(This special issue belongs to the Section Molecular Oncology)

New Insights into Network Pharmacology

edited by

Mi Hye Kim

submission deadline 20 Sep 2026 | 4 articles | Viewed by 6631 | Submission Open

Keywords: network pharmacology; traditional medicine; drug discovery; computational biology; molecular mechanisms; protein–protein interaction; enrichment analysis; herb–compound–gene network

(This special issue belongs to the Section Molecular Pharmacology)

Modulating the Niche: Targeting the Tumor Microenvironment for Enhanced Therapy

edited by

Dong Min Lee

submission deadline 20 Sep 2026 | 2 articles | Viewed by 6510 | Submission Open

Keywords: microenvironment dynamics; immune modulation; biomarker discovery; tumor microenvironment; extracellular matrix; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Abiotic Stress in Plants: Physiological and Molecular Responses

edited by Edyta Zdunek-Zastocka

submission deadline 20 Sep 2026 | 8 articles | Viewed by 6377 | Submission Open

Keywords: cold; drought; gene expression; heat; heavy metals; oxidative stress; salinity; stress tolerance; stress perception; stress signaling

(This special issue belongs to the Section Molecular Plant Sciences)

Advancements and Trends in Plant Genomics

edited by Rongbin Hu

submission deadline 20 Sep 2026 | 5 articles | Viewed by 6325 | Submission Open

Keywords: plant; genomics; next-generation sequencing; third-generation sequencing; CRISPR-Cas

(This special issue belongs to the Section Molecular Plant Sciences)

Neurodegenerative Diseases: Molecular Mechanisms, Drug Targets and Therapeutic Strategies

edited by

Andrea Kwakowsky

submission deadline 20 Sep 2026 | 2 articles | Viewed by 5826 | Submission Open

Keywords: beta amyloid peptide; tau protein; alpha-synuclein protein; huntingtin protein; autophagy; neuromodulators; neurotrophins; natural compounds; neuroinflammation; vascular dysfunction; neuronal death; drug development; therapeutic biomarkers; blood–brain barrier; small-molecule therapeutics

(This special issue belongs to the Section Molecular Neurobiology)

From Genes to Medicine: Exploring the Genetic and Biological Bases of Medicinal Plants

edited by Wajid Zaman

submission deadline 20 Sep 2026 | 5 articles | Viewed by 5740 | Submission Open

Keywords: medicinal plants; genetic diversity; biosynthesis pathways; bioactive compounds; genomic technologies; plant breeding; biotechnology; CRISPR; phytochemistry; pharmacology; drug discovery; plant-based therapies

(This special issue belongs to the Section Molecular Biology)

Neuroimaging Studies in Exploring the Molecular Mechanisms of Neurological Diseases

edited by

Ming-Chang Chiang

submission deadline 20 Sep 2026 | 2 articles | Viewed by 5655 | Submission Open

Keywords: neuroimaging; neurological diseases; brain imaging; biomarkers; functional connectivity; AI in neuroimaging

(This special issue belongs to the Section Molecular Neurobiology)

Ongoing Anticancer Agents

edited by

Mauro Coluccia

submission deadline 20 Sep 2026 | 4 articles | Viewed by 5593 | Submission Open

Keywords: tumorigenesis; anticancer drugs; therapeutic innovation; platinum-based drugs; anticancer therapies

(This special issue belongs to the Section Molecular Oncology)

New Horizons in Structure and AI-Based Drug Design

edited by

Huiyong Sun

submission deadline 20 Sep 2026 | 2 articles | Viewed by 5578 | Submission Open

Keywords: artificial intelligence; machine learning; MD simulation; free energy calculation; drug design

(This special issue belongs to the Section Molecular Informatics)

Plant Cell/Organ Structure and Function Research

edited by

Bartosz Płachno

submission deadline 20 Sep 2026 | 4 articles | Viewed by 5473 | Submission Open

Keywords: leaf development; root development; plant cell ultrastructure; plant morphogenesis; plant organs and bacteria, fungi and animal interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Application of Mass Spectrometry and Chromatography in Biomedicine: 2nd Edition

edited by

Giovanni Ventura

submission deadline 20 Sep 2026 | 5 articles | Viewed by 5205 | Submission Open

Keywords: mass spectrometry; chromatography; LC-MS; GC-MS; biomarker discovery; pharmaceuticals; metabolomics; proteomics; lipidomics

(This special issue belongs to the Section Molecular Biophysics)

Advances in Natural Antioxidants in Human Health and Diseases

edited by

Eman M. Othman

submission deadline 20 Sep 2026 | 3 articles | Viewed by 5016 | Submission Open

Keywords: oxidative stress and diseases; antioxidants; natural products

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Diagnostics and Therapeutic Targets in Bladder Cancer (Second Edition)

edited by

Hideki Furuya

submission deadline 20 Sep 2026 | 4 articles | Viewed by 4984 | Submission Open

Keywords: non-muscle invasive bladder cancer; muscle-invasive bladder cancer; metastatic bladder cancer; diagnostic biomarkers; therapeutic targets; early detection; progression biomarkers; liquid biopsy; genomic profiling; proteomics; metabolomics; imaging biomarkers; multi-omics; targeted therapy; immunotherapy; antibody–drug conjugates; DNA damage response; tumor microenvironment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Latest Development of Molecular Research in Animal Nutrition

edited by

Mohammad Moniruzzaman

submission deadline 20 Sep 2026 | 3 articles | Viewed by 4894 | Submission Open

Keywords: animal nutrition; molecular biology; microbiome; feed efficiency; sustainable aquaculture; proteomics; metabolomics; molecular mechanisms; metabolic regulation; disease resistance

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Viral Infections: Physiology, Pathophysiology, Pathogenesis, Diagnosis and Treatment, 2nd Edition

edited by

Barbara Bażanów

and Dominika Marta Stygar

submission deadline 20 Sep 2026 | 3 articles | Viewed by 4775 | Submission Open

Keywords: viral infections; virus mutations; molecular diagnostic methods; antiviral drugs/preparations; viral diseases; physiological mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Displaying special issue 401-450 on page 9 of 64.

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