Neurodegenerative Diseases: Molecular Mechanisms, Drug Targets and Therapeutic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 517
Special Issue Editor
Interests: neurotrasmitters; estrogens; neurotrophins; neurodegenerative disorders; drug discovery and development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue of IJMS provides a forum for the dissemination of the most recent findings on molecular mechanisms, therapeutic targets and strategies for neurodegenerative diseases.
A major challenge for researchers and our society is the lack of effective disease-modifying or curative treatments for neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and multiple sclerosis. There is a critical need for therapies to prevent and/or slow the progression of these disorders. Several factors contribute to the neurodegenerative process, such as oxidative stress, excitotoxicity, protein aggregation, vascular dysfunction, and neuroinflammation, but gaining a better understanding of their contribution to disease pathology is key for identifying new potential therapeutic targets. To design effective therapies, it is fundamental to conduct studies that aim to increase understanding of the molecular mechanisms of disease pathology and identify the most promising drug targets.
We welcome the submission of original research and review articles on the advances in every aspect of research on molecular mechanisms and therapeutics relevant to neurodegenerative diseases.
Dr. Andrea Kwakowsky
Guest Editor
Manuscript Submission Information
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Keywords
- beta amyloid peptide
- tau protein
- alpha-synuclein protein
- huntingtin protein
- autophagy
- neuromodulators
- neurotrophins
- natural compounds
- neuroinflammation
- vascular dysfunction
- neuronal death
- drug development
- therapeutic biomarkers
- blood–brain barrier
- small-molecule therapeutics
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