Neurodegenerative Diseases: Molecular Mechanisms, Drug Targets and Therapeutic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 33
Special Issue Editor
Interests: neurotrasmitters; estrogens; neurotrophins; neurodegenerative disorders; drug discovery and development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue of IJMS provides a forum for the dissemination of the most recent findings on molecular mechanisms, therapeutic targets and strategies for neurodegenerative diseases.
A major challenge for researchers and our society is the lack of effective disease-modifying or curative treatments for neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and multiple sclerosis. There is a critical need for therapies to prevent and/or slow the progression of these disorders. Several factors contribute to the neurodegenerative process, such as oxidative stress, excitotoxicity, protein aggregation, vascular dysfunction, and neuroinflammation, but gaining a better understanding of their contribution to disease pathology is key for identifying new potential therapeutic targets. To design effective therapies, it is fundamental to conduct studies that aim to increase understanding of the molecular mechanisms of disease pathology and identify the most promising drug targets.
We welcome the submission of original research and review articles on the advances in every aspect of research on molecular mechanisms and therapeutics relevant to neurodegenerative diseases.
Dr. Andrea Kwakowsky
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- beta amyloid peptide
- tau protein
- alpha-synuclein protein
- huntingtin protein
- autophagy
- neuromodulators
- neurotrophins
- natural compounds
- neuroinflammation
- vascular dysfunction
- neuronal death
- drug development
- therapeutic biomarkers
- blood–brain barrier
- small-molecule therapeutics
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
