ijms-logo

Journal Browser

Journal Browser

Molecular Insights into the Environmental Toxicity of Contaminants and Risk Mitigation Strategies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 249

Special Issue Editors


E-Mail Website
Guest Editor
Department of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy
Interests: the effect of microplastics, alone or in combination with environmental pollutants, on human health and the potential use of drugs and/or natural substances to prevent or treat it

E-Mail Website
Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy
Interests: ecocytotoxicology to elucidate the impact of traditional and emerging toxicants on the health status of aquatic organisms and humans at the cellular level
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce the “Molecular Insights into the Environmental Toxicity of Contaminants and Risk Mitigation Strategies” Special Issue for the International Journal of Molecular Sciences. Environmental toxicants, ranging from heavy metals and pesticides to emerging pollutants such as microplastics and pharmaceuticals, represent a significant and growing concern for ecosystems and human health. Despite extensive research, the molecular and cellular mechanisms underlying the toxicity of these substances remain incompletely understood, particularly in the context of real-world exposure scenarios involving complex mixtures of pollutants.

This Special Issue aims to deepen our understanding of the biological effects of environmental toxicants by encouraging research employing in vivo, in vitro, and in silico models. Studies exploring the interactions between different toxicants, including microplastics, and their synergistic or antagonistic effects on biological systems are particularly welcome. We also invite investigations into innovative methodologies, including -omics, for assessing toxicity and strategies for mitigating the harmful effects of environmental pollutants. By providing molecular insights into the toxicity of diverse environmental exposures, this Special Issue seeks to contribute to the development of effective approaches with which to safeguard environmental and public health.

Dr. Barbara Mognetti
Dr. Tiziana Cappello
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microplastic toxicity
  • environmental pollutants
  • molecular mechanisms
  • cell metabolic pathways
  • in vivo, in vitro, and in silico models
  • pollutant interactions
  • risk mitigation strategies

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

16 pages, 2151 KiB  
Article
Mitigation of PFOA-Induced Developmental Toxicity in Danio rerio by Bacillus subtilis var. natto: Focus on Growth and Ossification
by Christian Giommi, Marta Lombó, Francesca Francioni, Fiorenza Sella, Hamid R. Habibi, Francesca Maradonna and Oliana Carnevali
Int. J. Mol. Sci. 2025, 26(9), 4261; https://doi.org/10.3390/ijms26094261 - 30 Apr 2025
Viewed by 144
Abstract
Perfluorooctanoic acid (PFOA) is a persistent environmental contaminant that resists biological degradation and accumulates in organisms. It disrupts zebrafish embryo development, affecting their heartbeat rate and locomotion. Meanwhile, probiotics are known to enhance the development and ossification of zebrafish embryos. In this study, [...] Read more.
Perfluorooctanoic acid (PFOA) is a persistent environmental contaminant that resists biological degradation and accumulates in organisms. It disrupts zebrafish embryo development, affecting their heartbeat rate and locomotion. Meanwhile, probiotics are known to enhance the development and ossification of zebrafish embryos. In this study, we examined the toxic effects of PFOA on growth and bone formation in zebrafish and the potential of the probiotic Bacillus subtilis var. natto to counteract its toxicity. Larvae were exposed to 0, 50, or 100 mg/L PFOA from hatching to 21 days post-fertilization (dpf), with or without dietary probiotic supplementation (107 CFU/larva/day), and they were sampled at 7, 14, and 21 dpf. PFOA exposure reduced standard length at 21 dpf, while the co-administration of probiotics mitigated these effects. Craniofacial cartilage defects appeared in larvae exposed to 50 mg/L PFOA at 7 and 14 dpf, while 100 mg/L PFOA impaired bone development at 7 dpf. Probiotics counteracted these abnormalities. PFOA also delayed ossification, correlating with the downregulation of col10a1a, runx2b, and cyp26b1, while the probiotic treatment restored normal ossification. These findings improve our understanding of PFOA’s detrimental effects on zebrafish growth and bone formation while demonstrating the protective role of probiotics against PFOA-induced developmental toxicity. Full article
Show Figures

Figure 1

Back to TopTop