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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Environmental Contributors to Oxidative Stress: Mechanisms and Effects

edited by Halina Tkaczenko and

Natalia Kurhaluk

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2647 | Submission Open

Keywords: oxidative stress; environmental pollution; climate change; antioxidants; biological effects; toxicology; health risks; reactive oxygen species (ROS); public health; mitigation strategies; cellular damage in human and animal disorders; environmental stressors in human and animal health

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Phytochemicals in Antioxidation, Antimicrobial, and Cytoprotective Properties

edited by

Mihaela Niculae

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2593 | Submission Open

Keywords: phytochemicals; antioxidant; antimicrobial; cytoprotective; in vitro screening; in vivo evaluation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms and Functions of Extracellular Vesicles

edited by

Sigrun Lange

and Jameel M. Inal

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2575 | Submission Open

Keywords: extracellular vesicles; molecular mechanisms; biomarkers; liquid biopsy; cell-communication; cellular function; pathobiology; clinical

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into the Role of Exercise in Disease and Health, 2nd Edition

edited by

Brisamar Estébanez

, María José Cuevas-González and Chun-Jung Huang

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2553 | Submission Open

Keywords: physical activity; molecular mechanisms; disease prevention; metabolic health; cardiovascular diseases; neurodegenerative diseases; sarcopenia; immune function; healthy aging; epigenetics

(This special issue belongs to the Section Molecular Biology)

Molecular Diagnosis and Treatment of Migraine

edited by

Fabiola Dach

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2528 | Submission Open

Keywords: migraine; pathophysiology; diagnostics; therapy; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

Exploring the Genetics in Rare Diseases: A Genomic Odyssey

edited by

Klaus Brusgaard

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2500 | Submission Open

Keywords: novel discoveries in rare disorders; polygenic risk scores; mosaicism; protein interaction; tools utilized to engineer DNA; somatic variants; patient advocacy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Heart Failure: From Bench to Bedside

edited by

Nadia Aspromonte

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2481 | Submission Open

Keywords: heart failure; cardiac biomarkers; medical therapy; molecular pathways; prognosis; target therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Targets in Cardiometabolic Disorders

edited by Massimiliano M. Corsi Romanelli and

Pietro Formisano

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2458 | Submission Open

Keywords: atherosclerosis; angiotensin; endothelial cell; inflammation; biomarkers; gLP-1; sT-2

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Impact of Biomolecules on the Pathogenesis of Oral and Periodontal Diseases

edited by

Ujjal Kumar Bhawal

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2450 | Submission Open

Keywords: biomolecules; inflammatory mediators; enzymes; cytokines; dysbiosis; microbiome; genetic and epigenetic factors; oral and periodontal diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancing Liver Health: State of the Art and Recent Research Advances

edited by

Chase Wehrle

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2436 | Submission Open

Keywords: liver; liver cancer and malignancy; liver transplantation; inflammation and immunity; liver health and ageing; molecular genomics; cellular senescence; metabolic dysfunction-associated liver disease; cirrhosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biology of Lung Cancer: From Intrinsic to Acquired Resistance Mechanisms

edited by

Federico Pio Fabrizio

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2414 | Submission Open

Keywords: lung cancer; NSCLC; cancer therapy; resistance; DNA methylation

(This special issue belongs to the Section Molecular Oncology)

Protein Kinase in Disease, 2nd Edition

edited by

Manae Suzuki Kurokawa

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2412 | Submission Open

Keywords: protein kinases; phosphorylation; cancers; inflammatory diseases; protein kinase inhibitors; anticancer drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Metabolic Phenotypes of Pediatric Obesity

edited by Simona Georgiana Popa

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2406 | Submission Open

Keywords: cardiometabolic phenotypes of pediatric obesity; metabolomic profiles; microbiota; entero-insular axis; adipocytokines; precision therapy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Toxicological Impacts of Emerging Contaminants on Aquatic Organisms

edited by

Mohamed Hamed

submission deadline 20 Feb 2026 | 3 articles | Viewed by 2309 | Submission Open

Keywords: aquatic toxicology; emerging contaminants; physiology and behavior; oxidative stress; antioxidant biomarkers; immunotoxicity; neuroendocrine toxicity; bioremediation; molecular mechanisms

(This special issue belongs to the Section Molecular Toxicology)

New Insights into the Antibacterial Effect of Nano- and Micro-Materials

edited by

Krasimir Vasilev

and

Vi Khanh Truong

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2276 | Submission Open

Keywords: antibacterial coatings; biomaterials; medical devices; antimicrobial resistance; nanomedicine

(This special issue belongs to the Section Materials Science)

Advances in Pathogenesis and Treatment of Skin Cancer (2nd Edition)

edited by

Enrica Flori

Giorgia Cardinali

and

Vittoria Maresca

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2183 | Submission Open

Keywords: melanoma; squamous cell carcinoma; basal cell carcinoma; tumor microenvironment; epithelial– mesenchymal transition (EMT) process; ultraviolet radiation; oxidative stress; bioactive modulators; signal transduction pathways

(This special issue belongs to the Section Molecular Oncology)

Molecular Research on Dyslipidemia

edited by

Aleksandra Zeljkovic

and

Jelena Vekić

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2111 | Submission Open

Keywords: dyslipidemia; chronic non-communicable diseases; dysregulation of lipid homeostasis; genetic and epigenetic regulation; lipidomics in personalized medicine; lipid biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research on Alloy Materials Microstructure and Their Functionalization

edited by

Ozkan Gokcekaya

and Celaletdin Ergun

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2084 | Submission Open

Keywords: alloy design; microstructure; production methods; additive manufacturing; sol– gel process; biofunctional materials; magnetic properties; nanoparticles; ceramics; composites

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms and Therapeutic Strategies of Colorectal Cancer

edited by

Daniel Gabriel Pons

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2041 | Submission Open

Keywords: colorectal cancer; tumor microenvironment; biomarkers; intercellular communication; therapeutic strategies

(This special issue belongs to the Section Molecular Oncology)

Plant Metabolism and Natural Product Biosynthesis

edited by

Andrej Frolov

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2006 | Submission Open

Keywords: plant metabolism; natural product; biosynthesis; metabolomics; bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Ruminant Physiology: Digestion, Metabolism, and Endocrine System

edited by Rui Hu

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2003 | Submission Open

Keywords: ruminant physiology; digestive health; metabolic regulation; endocrine signaling; rumen microbiome; nutrient partitioning; methane mitigation; epigenetic modulation; nutritional stress adaptation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Study on the Microenvironment in Lymphoma

edited by

Jonathan P. Butchar

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1967 | Submission Open

Keywords: tumor microenvironment; lymphoma; hodgkin lymphoma; non-hodgkin lymphoma; burkitt lymphoma; follicular lymphoma; waldenströ m’ s macroglobulinemia; NK/T-cell lymphoma; diffuse large B-cell lymphoma; mantle cell lymphoma; marginal zone lymphoma; lymphoproliferative disorder; anaplastic large cell lymphoma; mediastinal B cell lymphoma; T-cell lymphomas

(This special issue belongs to the Section Molecular Oncology)

Harnessing Bioinformatics for miRNA Research: Methods, Insights and Applications

edited by Maria Rosaria Tumolo and Saverio Sabina

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1954 | Submission Open

Keywords: microRNA; bioinformatics; hub genes; miRNA target prediction; miRNA regulatory networks; miRNA-based biomarkers; artificial intelligence in miRNA research; multi-omics approaches

(This special issue belongs to the Section Molecular Informatics)

New Advances in Cystinosis from Basic to Clinical Research

edited by

Francesco Bellomo

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1932 | Submission Open

Keywords: cystinosis; kidney; Fanconi syndrome; muscles; eyes; autophagy; bioenergetics; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Developing Chiral Products: New Progression in Separation, Synthesis, and Application

edited by István Ilisz

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1923 | Submission Open

Keywords: chirality; enantioselective separations; chiral selector molecules; chiral stationary phases; chiral sensors; enantiorecognition; chiral separation mechanisms

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

The Diversity of Life: Light to Heavy Metal Coordination Compounds of Biological Relevance

edited by

Ivayla Pantcheva

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1913 | Submission Open

Keywords: coordination compounds; metal-based drugs; antimicrobial; anti-inflammatory; antiviral agents; cancer therapy; drug delivery systems

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms of Tumorigenesis of Human and Animal Stem Cells

edited by

Daniela Salvatori

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1830 | Submission Open

Keywords: malignancy; stem cells; safety; chromosal aberrations; animal; human; teratoma assay; in vitro assays

(This special issue belongs to the Section Molecular Oncology)

Gynecological Oncology: From Molecular Basis to Therapy

edited by

Martin Götte

and Lars Hanker

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1763 | Submission Open

Keywords: gynecological oncology; molecular basis; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Neural Circuits in Behavioral Neuroscience

edited by Matteo Di Segni and Rossella Ventura

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1702 | Submission Open

Keywords: behavioral neuroscience; neural circuits; psychopathology; neuroscience; drug addiction; depression; mental illness

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Parasitic Infection

edited by Marcin Wiśniewski and

Piotr Bąska

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1682 | Submission Open

Keywords: parasitic infections; host– parasite interactions; parasite genomics; drug-resistance mechanisms; transcriptomics; proteomics; diagnostic tools; immune evasion; therapeutic strategies

(This special issue belongs to the Section Molecular Microbiology)

Bioactive Natural Compounds in Neuroscience

edited by

Sarmistha Mitra

submission deadline 20 Feb 2026 | Viewed by 1640 | Submission Open

Keywords: natural products; bioactive metabolites; secondary metabolites; neuronal development; neurotrophins; neuromedicine; neurodegeneration; memory disorders

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Vitiligo: From Mechanisms to Treatment Innovations

edited by Hyun Jeong Ju

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1637 | Submission Open

Keywords: autoimmune disease; cytokine signaling; depigmentation; immunotherapy; melanocyte regeneration; microbiome; oxidative stress; vitiligo

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research and Insight in Neurotransmission and Neuromodulation

edited by Miklos Jaszberenyi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1624 | Submission Open

Keywords: histology; microanatomy; morphology; molecular biology; neurotransmitter; neuromodulator; neuropeptide; neurohormone; nervous system

(This special issue belongs to the Section Molecular Neurobiology)

Biomechanics and Molecular Research on Glioblastoma: 2nd Edition

edited by

Lorenzo Corsi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1616 | Submission Open

Keywords: GBM; molecular pathways; biomechanics; oncogene; cancer; microenvironment; drug targeting; diagnostic; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Interactions and Advanced Computational Methods for Biomolecular Systems

edited by

Amar Singh

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1597 | Submission Open

Keywords: molecular interactions; biological systems; computational biology; protein– protein interactions; protein docking; bioinformatics; structural modeling; multiscale modeling techniques

(This special issue belongs to the Section Molecular Biophysics)

The Plant Cell Wall: Structural Dynamics, Functions, and Future Innovations

edited by

Ioannis-Dimosthenis Adamakis

and

Kosmas Haralampidis

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1547 | Submission Open

Keywords: plant cell wall; biosynthesis; biomass; abiotic stress; biotic stress; renewable resources; biotechnology; climate change

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Research on Plant-Derived Products in the Service of Immune Regulation

edited by

Lyuba Dineva Miteva

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1517 | Submission Open

Keywords: plant bioactive compound; inflammation; immunity; cytokine; chronic disease

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Toxicity of Bisphenol A and Its Analogs

edited by

Krystyna Makowska

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1404 | Submission Open

Keywords: bisphenols; endocrine disruptors; bisphenol A and analogs; toxicology

(This special issue belongs to the Section Molecular Toxicology)

The Environment, Human Stress, and Gut Microbiome: A Triad in Disease Development

edited by

Natalia Kurhaluk

and Halina Tkaczenko

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1355 | Submission Open

Keywords: gut microbiome stress interactions; environmental microbiome disease linkages; stress-driven microbiome dysbiosis; microbiome environment disease pathways; human microbiome stress responses; environmental stress disease mechanisms; gut microbiome oxidative stress interactions; environmental oxidative stress impacts; stress-driven microbiome oxidative imbalance; oxidative stress microbiome diseases; human oxidative stress pathways; oxidative stress disease mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Novel Insights into Buckwheat Reproductive Biology

edited by

Agnieszka Płażek

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1346 | Submission Open

Keywords: antioxidant properties; biotechnological methods; embryology; seed chemical composition; yield

(This special issue belongs to the Section Molecular Plant Sciences)

Cancer Progression and Therapeutic Resistance Mechanisms

edited by

Fabrizio Fontana

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1318 | Submission Open

Keywords: cancer drug resistance; growth factors; DNA repair; miRNAs; ABC transporters; cancer stem cells; extracellular vesicles; circulating cancer cells; circulating cancer DNA; liquid biopsies; natural anticancer compounds

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms Underlying Skin Diseases

edited by Maria Lucia Dell'Anna

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1297 | Submission Open

Keywords: pigmentation; lipid signaling; immune cells; inflammation; skin barrier; oxidative damage; mitochondria

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolic Dynamics and Immune Surveillance in the Tumor Microenvironment

edited by

Jyoti Kaushal

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1273 | Submission Open

Keywords: cancer; TME; metabolism; immune cells; signaling pathway; therapy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Health Targeting Cardiovascular and Cerebrovascular Diseases: Molecular Aspects

edited by

Byeong-Wook Song

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1239 | Submission Open

Keywords: cardiovascular disease; cerebrovascular disease; cell therapy; gene therapy; extracellular vesicles; regenerative medicine; brain– heart axis; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuromodulatory Effects of Serotonin, 2nd Edition

edited by

Yasemin M. Akay

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1218 | Submission Open

Keywords: neuromodulation; Serotonin; pain research; cognition; emotions; depression; anxiety; GBM

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms Linking Obesity to Atherosclerosis Pathogenesis

edited by

Weibin Shi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1144 | Submission Open

Keywords: obesity; overweight; atherosclerosis; coronary artery disease; obesity paradox; body mass index; visceral fat

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cardiovascular Research: From Molecular Mechanisms to Novel Therapies

edited by Piotr Musiałek, Monika M. Gladká and Lukasz Tekieli

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1023 | Submission Open

Keywords: cardiovascular diseases; cardiovascular repair and regeneration; molecular cardiology; gene and stem cell therapy; drug and gene delivery; advanced imaging; biomarkers; tissue engineering; thrombosis and clotting abnormalities; animal models of human disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights in Biomodelling

edited by

Jacques Demongeot

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1010 | Submission Open

Keywords: biomodelling; biomathematics; bioinformatics; biostatistics; biophysics; theoretical biology; theoretical ecology; mathematical biology; theoretical physics; physical chemistry

(This special issue belongs to the Section Molecular Informatics)

Algae-Derived Bioactives: Key Molecular Interactions Govern High-Value Applications

edited by Evan Stephens and Kirsten Heimann

submission deadline 20 Feb 2026 | 2 articles | Viewed by 991 | Submission Open

Keywords: microalgae; macroalgae; cyanobacteria; bioactive compounds; health and nutrition; algal food products; market analysis

(This special issue belongs to the Section Molecular Microbiology)

Advances in Heparin, Heparan Sulfate and Heparanase, 2nd Edition

edited by

Nobuaki Higashi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 989 | Submission Open

Keywords: allergy; angiogenesis; cancer metastasis; cellular trafficking; exosome; fibrosis; glycocalyx; glycosaminoglycans; heparan sulfate; heparanase; heparin; immune responses; inflammation; inbibitor development; sepsis/SIRS (systemic inflammatory response syndrome); sulfatase; viral infections

(This special issue belongs to the Section Macromolecules)

Displaying special issue 901-950 on page 19 of 67.

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