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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Fish Genomics and Developmental Biology, 2nd Edition

edited by

Elena Sarropoulou

and

Jorge Fernandes

submission deadline 20 Feb 2026 | 6 articles | Viewed by 8143 | Submission Open

Keywords: development; teleost; gene regulation; comparative genomics; genomics; aquaculture; transcriptomics; gene expression; environment; genomes; population genomics; selective breeding; biomarker

(This special issue belongs to the Section Molecular Biology)

Role of Diet and Nutrition in Metabolic Diseases

edited by

Fernando Guerrero-Romero

submission deadline 20 Feb 2026 | 3 articles | Viewed by 8067 | Submission Open

Keywords: nutrients; biomarkers; molecular targets; pahodiagnosis; treatment

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Computer-Aided Drug Design Strategies

edited by

Alexandre G. De Brevern

submission deadline 20 Feb 2026 | 3 articles | Viewed by 8046 | Submission Open

Keywords: computer-aided drug design; artificial intelligence in drug discovery; molecular docking; molecular dynamics simulations; macromolecular systems; quantum mechanics/molecular mechanics (QM/MM); big data analytics in drug development; pharmacokinetics optimization; structure-based drug design (SBDD); ligand-based drug design; virtual screening techniques

(This special issue belongs to the Section Molecular Informatics)

Advances in Tea Tree Metabolism and Genetics

edited by Xiaoling Sun

submission deadline 20 Feb 2026 | 5 articles | Viewed by 7912 | Submission Open

Keywords: tea tree; secondary metabolite; genetic transformation; genetic breeding; tea germplasm improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms, Pathophysiology and Therapeutic Strategies of Chronic Obstructive Pulmonary Disease (COPD)

edited by

Shih-feng Liu

submission deadline 20 Feb 2026 | 3 articles | Viewed by 7812 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); pathophysiology; novel therapeutic approaches; biomarkers; pulmonary rehabilitation; inflammation; oxidative stress; genetic factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Transcription Factors in Plant Gene Expression Regulation, 2nd Edition

edited by

Piotr Szymczyk

submission deadline 20 Feb 2026 | 6 articles | Viewed by 7780 | Submission Open

Keywords: plant trans-factor; cis-active sequence; post-translational modification; dimerization and oligomerization; DNA modules

(This special issue belongs to the Section Molecular Plant Sciences)

Identification of Novel Biomarkers Towards Improved Diagnosis and Management of Peripheral Vascular Diseases

edited by

Daniel P. Zalewski

submission deadline 20 Feb 2026 | 5 articles | Viewed by 7625 | Submission Open

Keywords: vascular pathophysiology; peripheral atherosclerosis; aneurysm; venous disorders; congenital vascular malformations; molecular biomarkers; diagnostic biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research of Gut Microbiota in Human Health and Diseases

edited by

Juan Francisco Martínez-Blanch

submission deadline 20 Feb 2026 | 3 articles | Viewed by 7553 | Submission Open

Keywords: gut microbiota; gut metabolites; gastroenterology; microbiology; inflammation; human diseases

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Neuromuscular Mechanisms in Skeletal Muscle Aging, 2nd Edition

edited by

Rosa Mancinelli

submission deadline 20 Feb 2026 | 5 articles | Viewed by 7418 | Submission Open

Keywords: aging; sarcopenia; neuromuscular junction; molecular muscle modifications; myokines

(This special issue belongs to the Section Molecular Biology)

Embryonic Development and Differentiation: 2nd Edition

edited by

László Márk

submission deadline 20 Feb 2026 | 3 articles | Viewed by 7379 | Submission Open

Keywords: blastocyte; embryogenesis; endometrium; implantation; in vitro fertilization (IFV); ICSI; oocyte; pregnancy; seminal plasma; sperm

(This special issue belongs to the Section Molecular Biology)

Advancements in Hematology: Molecular Biology and Targeted Therapies

edited by Fabio Stagno and

Stefania Stella

submission deadline 20 Feb 2026 | 5 articles | Viewed by 7364 | Submission Open

Keywords: hematological disorders; leukemia; lymphoma; anemia; blood malignancies; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hearing Loss: Recent Progress in Molecular Genomics

edited by

Chen-Chi Wu

submission deadline 20 Feb 2026 | 4 articles | Viewed by 7352 | Submission Open

Keywords: hearing loss; high-throughput sequencing; prognostic analyses; translational medicine; gene therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Peripheral Neuropathies: Molecular Research and Novel Therapy—2nd Edition

edited by

Zhidong Zhou

submission deadline 20 Feb 2026 | 2 articles | Viewed by 7182 | Submission Open

Keywords: axonal degeneration; demyelination; schwann cells; dorsal root ganglia; diabetic neuropathy; chemotherapy-induced peripheral neuropathies; immune-mediated neuropathies; immune checkpoint inhibitors; charcot-marie-tooth disease; autonomic neuropathies

(This special issue belongs to the Section Molecular Neurobiology)

Food-Derived Bioactive Peptides

edited by

Fidel Toldrá

and

Leticia Mora

submission deadline 20 Feb 2026 | 3 articles | Viewed by 7082 | Submission Open

Keywords: peptides identification; peptides characterization; functional foods; biological activity; peptidomics; proteomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exploring Novel Molecular, Metabolic and Cellular Mechanisms for Developing New Therapeutic Targets Against Childhood Cancers, 2nd Edition

edited by

Alessandro Fanzani

and

Silvia Codenotti

submission deadline 20 Feb 2026 | 3 articles | Viewed by 6966 | Submission Open

Keywords: childhood cancers; rhabdomyosarcoma; leukemias; lymphomas; central nervous system tumors; sarcomas of bone and soft tissue; neuroblastoma; retinoblastoma; rhabdoid tumors; rare cancers; genomic alterations; molecular drivers; tissue microenvironment; development of drugs; therapies

(This special issue belongs to the Section Molecular Oncology)

Feature Papers in ‘Physical Chemistry and Chemical Physics’: Fourth Edition

edited by

Dongho Kim

submission deadline 20 Feb 2026 | 8 articles | Viewed by 6934 | Submission Open

Keywords: heterogeneous structures; alignment and surface phenomena; quantum theory; mathematical physics; statistical and classical mechanics; molecular structure; chemical kinetics; laser physics; dynamics; kinetics; photochemistry; spectroscopy; exciton dynamics; statistical mechanics; thermodynamics; electrochemistry; catalysis; surface science; quantum mechanics; theoretical developments; fundamental aspects of catalysis; solar energy conversion; polymer dynamics

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Circulating Non-Coding RNAs as Diagnostic and Prognostic Markers of Human Diseases: 3rd Edition

edited by

Kyriacos N. Felekkis

and

Christos Papaneophytou

submission deadline 20 Feb 2026 | 7 articles | Viewed by 6894 | Submission Open

Keywords: miRNA; gene expression regulation; diagnosis; prognosis; therapy; biomarkers

(This special issue belongs to the Section Biochemistry)

New Insights into Plant and Insect Interactions (Second Edition)

edited by

Yonggen Lou

and Xiaoling Sun

submission deadline 20 Feb 2026 | 5 articles | Viewed by 6812 | Submission Open

Keywords: plant defense responses; elicitors; effectors; defense-related signaling; insect– plant interactions; tritrophic interactions; detoxification; defensive compounds; defensive genes

(This special issue belongs to the Section Molecular Plant Sciences)

Gut Microbiota and Nutrition in Human Health (2nd Edition)

edited by

Sunmin Park

submission deadline 20 Feb 2026 | 1 articles | Viewed by 6797 | Submission Open

Keywords: microbiome; gut; brain; obesity; diabetes; inflammation; liver; nutrition; probiotic; prebiotic

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research of Cancer Metabolism and Biomarkers

edited by

Mario Cioce

submission deadline 20 Feb 2026 | 2 articles | Viewed by 6717 | Submission Open

Keywords: metabolic reprogramming; tumor microenvironment (TME); resistance; metabolic modulator; multidisciplinary omics approach; cancer metabolism; biomarkers; cancer stem cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathology and Treatment of Spinal Cord Injury

edited by James Hong

submission deadline 20 Feb 2026 | 1 articles | Viewed by 6710 | Submission Open

Keywords: spinal cord injury; neuroinflammation; gene targets; neural regeneration; synaptic plasticity; molecular pathways; biomarkers; oxidative stress; apoptosis; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Enzymes in Biocatalysis

edited by

Simona Varriale

Samuel De Visser

and

Salvatore Fusco

submission deadline 20 Feb 2026 | 7 articles | Viewed by 6617 | Submission Open

Keywords: biocatalysis; bioprocess; enzyme immobilization; enzyme production; response surface methodology (RSM); enzymatic-assisted extraction; enzymatic-catalyzed synthesis; enzyme modelling; bioreactor; bioconversion; cascade biocatalysis; enzymatic kinetic; enzyme engineering; ultrasound-assisted enzymatic reaction; directed evolution; machine learning-assisted enzyme engineering; waste-to-value bioprocesses

(This special issue belongs to the Section Biochemistry)

The Interplay Between Cellular Stress and Human Diseases

edited by

Daniele Vergara

submission deadline 20 Feb 2026 | 3 articles | Viewed by 6417 | Submission Open

Keywords: cellular stress; DNA damage response; unfolded protein response; autophagy; senescence; apoptosis; repair pathways; mitochondrial stress; nutrient deprivation; oxidative stress

(This special issue belongs to the Section Biochemistry)

Artificial Intelligence and Computer-Aided Design: Molecular Simulation Technology in Exploring Bioactive Compounds for Health Promotion

edited by

Baojun Xu

submission deadline 20 Feb 2026 | 4 articles | Viewed by 6353 | Submission Open

Keywords: molecular simulation; bioactive compounds; molecular docking; molecular dynamics; quantum mechanics; functional mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Urological Cancer

edited by Andrea Zivi and Sara Merler

submission deadline 20 Feb 2026 | 1 articles | Viewed by 6262 | Submission Open

Keywords: genitourinary oncology; urologic surgery; urologic radiotherapy innovations; translational research; emerging therapies

(This special issue belongs to the Section Molecular Oncology)

Biosynthesis of Phytochemicals and Their Applications in Novel Drug Lead Development

edited by

Piotr Szymczyk

submission deadline 20 Feb 2026 | 4 articles | Viewed by 6139 | Submission Open

Keywords: biosynthesis of phytochemicals in plants; phytochemical isolation; phytochemical structure; animal and human protein targets of phytochemicals; chemical derivatives of phytochemicals

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Diagnosis in Cardiovascular Diseases

edited by Calogera Pisano,

Carmela Rita Balistreri

and Giuseppe Raffa

submission deadline 20 Feb 2026 | 4 articles | Viewed by 5947 | Submission Open

Keywords: cardiac diseases; molecular diagnosis; aortopathy; aneurysm; dissection; heart failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Treatment Strategies of Myocardial Infarction

edited by Abdul-Majeed Salmasi

submission deadline 20 Feb 2026 | 2 articles | Viewed by 5924 | Submission Open

Keywords: myocardial infarction; genetics; molecular biology; chromosomes; genes; atherosclerosis; coronary artery disease; risk factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research in Asthma and Allergy

edited by

Sylwia Smolińska

submission deadline 20 Feb 2026 | 4 articles | Viewed by 5908 | Submission Open

Keywords: asthma; allergy; molecular mechanisms; exposome; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the Molecular, Physiological, and Biochemical Responses of Crops to Stress

edited by

Hakim Manghwar

submission deadline 20 Feb 2026 | 4 articles | Viewed by 5816 | Submission Open

Keywords: molecular signaling pathways in response to biotic stresses (e.g.; bacteria; viruses; fungi; and insects); plant responses to abiotic stresses (e.g.; salinity; cold; drought; waterlogging; heat; heavy metals; and UV light); mechanisms of stress adaptation and tolerance; stress adaptation

(This special issue belongs to the Section Molecular Plant Sciences)

Advancing Climate Resilience in Horticultural Crops Through Omics Technologies

edited by

Yonghua Qin

and

Guibing Hu

submission deadline 20 Feb 2026 | 4 articles | Viewed by 5785 | Submission Open

Keywords: horticultural crops; climate change; omics technologies; stress responses; abiotic stresses; food security; agricultural sustainability; genomics; transcriptomic; proteomics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Type 1 Diabetes and Its Complications: 2nd Edition

edited by

Jolanta Neubauer-Geryk

submission deadline 20 Feb 2026 | 5 articles | Viewed by 5752 | Submission Open

Keywords: type 1 diabetes mellitus; diabetic microangiopathy; diabetic macroangiopathy; continuous glucose monitoring; experimental diabetic models; biomarkers; endothelium dysfunction; diabetes-related diseases; comorbidities; pregnancy; pathophysiology; metabolic syndrome; treatment; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research Progress of Cereal Crop Disease Resistance

edited by

Hongjie Li

and Zhenqi Su

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5641 | Submission Open

Keywords: cereal crops; disease resistance; resistance genes; breeding; molecular marker-assisted selection; molecular regulatory network

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Autoimmunity in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

edited by Yang Mao-Draayer

submission deadline 20 Feb 2026 | 1 articles | Viewed by 5641 | Submission Open

Keywords: multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); immunomodulatory; neuroprotection; neuroregeneration; biomarker; imaging

(This special issue belongs to the Section Molecular Neurobiology)

Recent Research of Nanomaterials in Molecular Science: 2nd Edition

edited by

Giovanna Iezzi

submission deadline 20 Feb 2026 | 6 articles | Viewed by 5556 | Submission Open

Keywords: nanomaterials; medical research; synthesis and characterization; molecular formula; molecular dynamics; molecular imaging; cell signaling; cellular metabolism; tissue regeneration; biocompatibility; molecular biology; nanomedicine; functional nanomaterials; drug and gene delivery; tissue engineering; cancer therapy

(This special issue belongs to the Section Molecular Nanoscience)

Sperm Oxidative Stress and Male Infertility

edited by

Kamil Gill

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5441 | Submission Open

Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility

(This special issue belongs to the Section Molecular Biology)

Non-Coding RNA in Physiology and Pathophysiology: Second Edition

edited by Maria Rosaria Tumolo

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5432 | Submission Open

Keywords: microRNA; long non-coding RNA; circular RNA; epigenetics; musculoskeletal pain; cardiovascular disease; metabolic disease; nervous system disorders; cancer; aging

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanism of Extracellular Vesicles in Human Diseases

edited by Eszter Ágnes Tóth

submission deadline 20 Feb 2026 | 1 articles | Viewed by 5369 | Submission Open

Keywords: extracellular vesicles; intercellular communication; disease pathophysiology; biomarkers; nanoscience; biomolecular interactions

(This special issue belongs to the Section Molecular Biology)

Molecular Pharmacology of Medicinal Plants

edited by

Bruno Eto

submission deadline 20 Feb 2026 | 2 articles | Viewed by 5352 | Submission Open

Keywords: medicinal plants; drug development; molecular pharmacology; clinical phytopharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Roles of Lipid Rafts in the Regulation of Cellular Processes and Diseases

edited by

Kohji Kasahara

submission deadline 20 Feb 2026 | 1 articles | Viewed by 5259 | Submission Open

Keywords: lipid rafts; glycosphingolipid; ganglioside; sphingomyelin; cholesterol; GPI-anchored proteins; caveolae; detergent-resistant membrane; signal transduction; disease

(This special issue belongs to the Section Biochemistry)

Research on Gene Mutations in Cancer and Chronic Diseases

edited by Adam Szpechciński

submission deadline 20 Feb 2026 | 2 articles | Viewed by 5249 | Submission Open

Keywords: germline and somatic mutation; pathogenesis of cancer and chronic diseases; molecular techniques for gene mutation detection; biomarkers; molecular diagnostics; bioinformatics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Marine Natural Compounds: Biotechnological Potential and Pharmacological Targets

edited by

Elena Leychenko

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5186 | Submission Open

Keywords: marine natural compounds; structure elucidation; biologic activity; structure-activity relationships; biosynthesis; biotechnology; pharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Essential Molecules in Life: Regulation, Defense, and Longevity, 2nd Edition

edited by

Eva E. Rufino Palomares

Amalia Pérez-Jiménez

and

José Antonio Lupiáñez

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5091 | Submission Open

Keywords: glucose metabolism and its regulation; enzimology and kinetics; metabolism and evolution; cell growth; protein synthesis and degradation; cell proliferation and apoptosis; cancer; metastasis and angiogenesis; oxidative stress; genomic; proteomic and metab

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms of Neutrophil Extracellular Traps (Nets) in Human Diseases

edited by Eisuke F. Sato

submission deadline 20 Feb 2026 | 1 articles | Viewed by 5087 | Submission Open

Keywords: neutrophil extracellular traps (NETs); neutrophils; inflammation; autoimmune diseases; cardiovascular diseases; tumor metastasis; thrombosis; molecular mechanisms; disease progression; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Omics-Driven Unveiling of the Structure and Function of Nanoparticles

edited by

Elva Morretta

submission deadline 20 Feb 2026 | 4 articles | Viewed by 5039 | Submission Open

Keywords: nanoparticles; nanotechnology; drug delivery; protein corona; proteomics; nano-proteomics; matabolomics; lipidomics

(This special issue belongs to the Section Molecular Biophysics)

New Advances in Metabolic Engineering and Synthetic Biology of Yeasts

edited by

Justyna Ruchała

submission deadline 20 Feb 2026 | 1 articles | Viewed by 5024 | Submission Open

Keywords: yeast metabolic engineering; synthetic biology; CRISPR-Cas9; metabolic pathways; bio-based chemicals; bioprocess engineering; yeast strain optimization; industrial biotechnology

(This special issue belongs to the Section Molecular Microbiology)

Cutting-Edge Innovations in Molecular and Nanoscale Engineering for Energy Applications

edited by

Mohammad R. Thalji

and

Farzaneh Mahmoudi

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4978 | Submission Open

Keywords: nanostructured electrode materials; energy storage; energy conversion; energy materials

(This special issue belongs to the Section Materials Science)

Skin Microbiome and Skin Health: Molecular Interactions

edited by

Terenzio Cosio

submission deadline 20 Feb 2026 | 3 articles | Viewed by 4853 | Submission Open

Keywords: skin microbiota; human disease; human health; omics; microbiota– host interactions; microbiota manipulation; microbiota; virota; inflammatory diseases; dysbiosis

(This special issue belongs to the Section Molecular Immunology)

Gut Microbiome Stability in Health and Disease

edited by

Tomomi Kuwahara

and Yoshitohi Ogura

submission deadline 20 Feb 2026 | 4 articles | Viewed by 4814 | Submission Open

Keywords: gut microbiome stability; immune system; epithelial cell; mucous layer; antibiotics; diet; inflammatory bowel disease; gut microbial metabolites

(This special issue belongs to the Section Molecular Microbiology)

Elucidating How Chondrocytes Maintain Cartilage Stability

edited by James A. Martin

submission deadline 20 Feb 2026 | 4 articles | Viewed by 4807 | Submission Open

Keywords: chondrocytes; articular cartilage; chondrogenesis; osteoarthritis; mechano-transduction; aging; extracellular matrix

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 801-850 on page 17 of 67.

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