Omics-Driven Unveiling of the Structure and Function of Nanoparticles
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".
Deadline for manuscript submissions: closed (20 July 2025) | Viewed by 558
Special Issue Editor
Interests: functional proteomics; global proteomics; drug-target deconvolution; mass spectrometry; biochemistry; metabolomics; metabolites quantification
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nanoparticles (NPs) are chemical entities endowed with enhanced physical and chemical characteristics, due to their lower-than-100 nm dimensions and tunable surface properties. Thus, NPs have great success in a wide variety of fields, such as in medicinal, environmental, and energy-based research, as well as in imaging and in biochemical sensing. In the biomedical area, NP-based formulations hold great promise, being particularly suited for the delivery of biomolecules and drugs, thus allowing for the development of targeted therapies for precision medicine. When administrated, upon exposure to complex biological environments, NPs quickly form a layer of adsorbed biomolecules, called the biomolecular corona. This dynamic structure comprises lipids, sugars, nucleic acids, and, mostly, proteins. After its formation, the corona dictates the fate and function of the NPs inside the body. As such, a thorough characterization of the physical and chemical properties of NPs, as well as of the biomolecular corona they acquire in different biological contexts, appears fundamental for the design of tunable delivery systems. In this scenario, omics-based approaches appear as a powerful tool for a comprehensive understanding of NPs’ properties and potential. Thus, this Special Issue welcomes both original research and review papers devoted to the characterization of the structure and function of NPs through omics strategies.
Dr. Elva Morretta
Guest Editor
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Keywords
- nanoparticles
- nanotechnology
- drug delivery
- protein corona
- proteomics
- nano-proteomics
- matabolomics
- lipidomics
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