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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Inflammatory Biomarkers in Ischemic Stroke

edited by Hanna Pawluk and

Renata Kołodziejska

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4716 | Submission Open

Keywords: stroke; brain tissue damage; ischemic stroke; inflammatory markers; immune response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pain: From Molecular Basis to Therapy

edited by Samuel J. Lin

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4648 | Submission Open

Keywords: pain mechanisms; molecular signaling; neurotransmitters; ion channels; genetic predisposition; epigenetic regulation; immune– neuron interaction; pharmacological therapy; gene therapy; neuromodulation; regenerative medicine

(This special issue belongs to the Section Molecular Neurobiology)

Targeted Therapies and Molecular Methods in Cancer, 3rd Edition

edited by

Julita Kulbacka

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4606 | Submission Open

Keywords: immunotherapy; radiotherapy; methods using facilitated drug delivery such as electroporation; sonoporation; and magnetic fields; nanotechnology and nanocarriers; gene electrotherapy; intelligent predicting methods with AI

(This special issue belongs to the Section Molecular Oncology)

Editorial Board Members’ Collection Series: “Protein Biophysics”

edited by

Vladimir N. Uversky

and

Assaf Friedler

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4564 | Submission Open

Keywords: protein structure and prediction; protein biophysics; protein dynamics; peptide and protein aggregation; protein misfolding; protein folding; protein stability; protein function; posttranslational modifications; intrinsically disordered proteins; protein– ligand interactions; protein– protein interactions; protein– nucleic acid interactions; membrane proteins; liquid– liquid phase separation

(This special issue belongs to the Section Molecular Biophysics)

Genetic Testing in Molecular Pathology and Diagnosis

edited by

Marco Fabiani

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4504 | Submission Open

Keywords: genetic testing; molecular pathology; personalized medicine; genetic diagnostics; disease mechanisms; novel genetic tests; clinical integration; patient management

(This special issue belongs to the Section Molecular Biology)

Rheumatoid Arthritis: From Molecular Basis to Therapies

edited by

Gabriella Sármay

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4477 | Submission Open

Keywords: rheumatoid arthritis; autoimmune; intracellular signaling pathways; targeted therapy; inflammation; immunometabolic reprogramming; CD40; CD40 ligand; GM-CSF; PD-1; inhibitors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Tissue Engineering Related Biomaterials: Progress and Challenges

edited by

Mihaela Violeta Ghica

Lacramioara Popa

and Cristina Elena Dinu-Pirvu

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4444 | Submission Open

Keywords: biomaterials; tissue engineering; scaffold materials; regenerative medicine; cell– material interactions; tissue regeneration; bioactive materials; nanotechnology in tissue engineering; electrospinning; 3D printing; biodegradable materials; growth factors

(This special issue belongs to the Section Materials Science)

Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook

edited by Alfredo Cappariello

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4347 | Submission Open

Keywords: mammalian extracellular vesicles; plant-derived extracellular vesicles; bacterial-derived extracellular vesicles; cancer progression; cell migration and invasion; tumor microenvironment; epithelial-to-mesenchymal transition (EMT); drug delivery; diagnostics; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Cholangiocarcinoma: From Bench to Bedside

edited by

Masaru Katoh

, Simona Tavolari and

Giovanni Brandi

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4297 | Submission Open

Keywords: risk factors; next-generation sequencing; actionable targets; FGFR2; BAP1; IDH1; tissular/circulating biomarkers; cancer resistance; immune microenvironment; in vitro and in vivo models; clinical trials

(This special issue belongs to the Section Molecular Oncology)

Therapeutic Potential of Antioxidants in the Prevention of Human Diseases, 2nd Edition

edited by

Kota V. Ramana

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4291 | Submission Open

Keywords: antioxidants; vitamins; inflammation; cancer; neurological complications; diabetes; flavonoids; natural compounds; cancer; infections; COVID-19

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarkers in Precision Medicine

edited by

Zhidong Zhou

submission deadline 20 Nov 2025 | 1 articles | Viewed by 4166 | Submission Open

Keywords: biomarkers; precision medicine; novel techniques; artificial intelligence

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Male Reproductive Physiology, Pathophysiology, and Contraception

edited by Gustavo G. Blanco

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4146 | Submission Open

Keywords: spermatogenesis; spermiogenesis; testis; epididymis; sperm function; sperm motility; sperm capacitation; acrosome reaction; male reproduction; male fertility; male infertility; male contraception

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Perspectives in the Diagnosis, Prevention, Treatment, and Vaccination Against Parasitic Diseases

edited by

Bartłomiej Tomasz Ferra

and Anna Lass

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4126 | Submission Open

Keywords: parasitoses; vaccines; diagnostic; epidemiology; prevention; antibodies; cytokines; immune system; treatment; native antigen; recombinant protein; chimeric recombinant protein; multiepitope recombinant protein; pharmaceutical analogues; PCR; molecular techniques

(This special issue belongs to the Section Molecular Microbiology)

TGF-β Signaling in Immunity, Inflammation, Fibrosis and Cancer

edited by

Isabel Fabregat

and

Gianluigi Giannelli

submission deadline 20 Nov 2025 | 1 articles | Viewed by 4123 | Submission Open

Keywords: TGF-beta; fibrosis; inflammation; cancer; immune cells; fibroblasts; EMT; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Research on Sjögren’s Syndrome: From Pathogenesis to Therapy

edited by Alexandru Emil Caraba

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4068 | Submission Open

Keywords: Sjö gren's syndrome; salivary glands; lacrimal glands; T and B cells; macrophage; dendritic cells; salivary gland epithelial cells; inflammatory mediators (cytokines; chemokines; antibodies); intracellular signaling pathways (IFN; TLR; BAFF/BAFF-R; PI3K/Akt/mTOR); atherosclerosis; lymphoma; novel therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism in Multiple Sclerosis and Related Disorders: 3rd Edition

edited by

Hans-Peter Hartung

and Kazuo Fujihara

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4037 | Submission Open

Keywords: neurodegeneration; multiple sclerosis; NMOSD; MOGAD; disease-modifying treatments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Colorectal Cancer: From Pathophysiology to Novel Therapies

edited by

Fabio Gelsomino

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3993 | Submission Open

Keywords: colorectal cancer; immunotherapy; targeted therapy; biomarkers; multidisciplinary management; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanisms and Implications of Traumatic Brain Injury and Neuroinflammation

edited by

Kwang Choi

submission deadline 20 Nov 2025 | 3 articles | Viewed by 3951 | Submission Open

Keywords: traumatic brain injury; head trauma; neuroinflammation; secondary injury; microglia

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Plant–Environment Interactions

edited by

Magdalena Pawełkowicz

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3795 | Submission Open

Keywords: vascular biology; floral development; sex expression; fruit development; grafting; source– sink interactions; genetic resources; stress tolerance; molecular breeding; gene regulation; resistance to biotic and abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Research in Immunotoxicity and Oxidative Stress

edited by

Soo-Jin Choi

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3773 | Submission Open

Keywords: toxicity; macrophage activation; pro-inflammation; anti-inflammation; oxidative stress; foods; food additives; nanomaterials; toxicants; natural compounds

(This special issue belongs to the Section Molecular Toxicology)

New Insights in Artificial Intelligence for Drug Design and Target Discovery

edited by

Yanjing Wang

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3745 | Submission Open

Keywords: pre-trained language models; generative models; drug prediction; binding site prediction; peptides; multi-omics; deep learning; QSAR modeling; molecular dynamics (MD) simulations

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights into Placental Pathology

edited by

Mary Wallingford

and Ana Correia-Branco

submission deadline 20 Nov 2025 | 3 articles | Viewed by 3682 | Submission Open

Keywords: placenta; trophoblast; implantation; obstetrics; pre-eclampsia; placentation; maternal– fetal interface; pregnancy health; placenta diagnostics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Regulatory Network of Bone Metabolism

edited by

Kazunori Hamamura

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3653 | Submission Open

Keywords: osteoblasts; osteoclasts; osteocytes; mesenchymal stem cells; bone metabolism; bone formation; bone resorption

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Role of Amyloid in Neurological Diseases

edited by Silvia Purro

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3642 | Submission Open

Keywords: amyloid-beta (Aβ ); tau protein; TDP43; synuclein; huntingtin; prion-like mechanisms; amyloid structures; genetic factors; cell-to-cell transmission; pathogenesis mechanisms; protein aggregation; Biomarkers; CNS amyloid clearance and degradation

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Nanoparticles in Molecular Biology: Second Edition

edited by

Maciej Monedeiro-Milanowski

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3604 | Submission Open

Keywords: nanoparticles; nanomedicine; biomolecules; nanoparticle– cell interactions; organic– inorganic hybrid; cytotoxic potential

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Design of Artificial Receptors Using Virtual Approaches

edited by Houjin Zhang

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3603 | Submission Open

Keywords: artificial receptors; protein design; computational biology; drug targeting; biosensors; tissue engineering; synthetic biology

(This special issue belongs to the Section Molecular Biophysics)

Endothelial-to-Mesenchymal Transition: A Key Driver of Tumor Progression and Therapeutic Resistance

edited by

Gabriella Doronzo

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3576 | Submission Open

Keywords: Endothelial-to-Mesenchymal Transition; wound healing and fibrosis; tumor progression; abnormal blood vessel formation; cancer therapy

(This special issue belongs to the Section Molecular Biology)

Phytohormone Signaling and Crosstalk in Regulation of Plant Growth and Environmental Stress Responses: 2nd Edition

edited by

Lam-Son Phan Tran

and Mohammad G. Mostofa

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3572 | Submission Open

Keywords: plant hormones; hormonal crosstalk; signal transduction; stress signaling; root system architecture; shoot branching; leaf development; phytohormone-responsive factors; transcriptional regulators; gene expression; plant physiology; senescence; plant plasticity; regulatory mechanisms; hormone homeostasis; stress adaptation/acclimatization

(This special issue belongs to the Section Molecular Plant Sciences)

Computational Approaches for Protein Design

edited by Livija Jakaite and

Mahesh Narayan

submission deadline 20 Nov 2025 | 3 articles | Viewed by 3418 | Submission Open

Keywords: computational protein design; molecular structure prediction; deep learning; protein structure and function prediction

(This special issue belongs to the Section Molecular Biophysics)

Advances in Molecular Mechanisms of Kidney Disease: Integrating Renal Tumorigenesis

edited by

Michele Marchioni

and

Luigi Schips

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3380 | Submission Open

Keywords: molecular pathogenesis; renal cell carcinoma; genomic profiling; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biological Hallmarks and Therapeutic Strategies in Cancer

edited by Ramesh Kumar

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3365 | Submission Open

Keywords: hallmarks of cancer; cancer progression; chemotherapy; tumorigenesis; oncogenic signaling

(This special issue belongs to the Section Molecular Oncology)

Regenerative Medicine: Molecular Mechanisms Driving Tissue Regeneration and Repair

edited by

Christopher Robinson

and Paul Jordan Christo

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3348 | Submission Open

Keywords: stem cell; cell signaling; immune modulation; extracellular matrix; remodeling; gene regulation; gene editing; growth factors; extracellular vesicles; small molecules

(This special issue belongs to the Section Molecular Biology)

MicroRNA (miRNA) Technology in Cancer

edited by

Duncan Ayers

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3298 | Submission Open

Keywords: miRNA; microRNA; cancer; oncology; drug delivery; technology; non-coding RNA

(This special issue belongs to the Section Molecular Oncology)

Computational Design and Therapeutic Applications of Peptide-Based Drugs

edited by

Shayon Bhattacharya

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3246 | Submission Open

Keywords: peptide drug design; in silico drug discovery; peptide– protein interactions; therapeutic peptides

(This special issue belongs to the Section Molecular Biology)

New Advances in Germ Cell Research

edited by

Sheng-Hsiang Li

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3176 | Submission Open

Keywords: spermatogenesis; sperm capacitation; oogenesis; oocyte maturation; cumulus cells; fertilization; gene expression; biomarkers; exosomes; infertility

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Semiconductor Materials

edited by Tarek Hidouri

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3175 | Submission Open

Keywords: optoelectronics; hybrid materials; power devices; III– V materials; advanced characterization; modeling; molecular advances; semiconductors; biophysics

(This special issue belongs to the Section Materials Science)

Molecular Research in Animal Reproduction

edited by

Zhongliang Jiang

submission deadline 20 Nov 2025 | 3 articles | Viewed by 3151 | Submission Open

Keywords: spermatogenesis; follicular atresia; oocyte maturation; granulosa cells; hormone regulation; autophagy; apoptosis; miRNA; signaling regulation

(This special issue belongs to the Section Molecular Biology)

Anti-Inflammatory Strategies and Cell Models for Alzheimer’s Disease

edited by Sophia Lavrentiadou

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3133 | Submission Open

Keywords: Alzheimer’ s disease; neuroinflammation; anti-inflammatory strategies; cell models

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Diagnostics in Neurological Diseases

edited by

Julián Benito-León

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3129 | Submission Open

Keywords: neurological diseases; biomarkers; translational research; precision medicine; diagnosis; prognosis

(This special issue belongs to the Section Molecular Neurobiology)

Whole-Cell System and Synthetic Biology, 2nd Edition

edited by

Jingjing Tian

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3115 | Submission Open

Keywords: synthesis biology; molecular biology; functional nucleic acids; biosensor; CRISPR-Cas; directed evolution; whole-cell system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Peptides and Peptidomimetics for Targeting Protein-Protein Interactions

edited by

Giacomo Rossino

and

Pasquale Linciano

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3090 | Submission Open

Keywords: protein– protein interactions; peptide– protein interactions; interactome; proteomics; peptides; modified peptides; peptidomimetics; molecular glues; drug discovery; medicinal chemistry; rule of five; biophysical assays; molecular modelling; cancer; neurodegenerative diseases; orphan diseases; antimicrobial resistance; PROTAC

(This special issue belongs to the Section Biochemistry)

Effects of Ionizing Radiation in Cancer Radiotherapy: 2nd Edition

edited by

François Chevalier

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3076 | Submission Open

Keywords: non-targeted effects; radiation-induced bystander effect; abscopal effect; genomic instability; low dose effects; radioprotection; circulating biomarkers; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multi-Omics Analysis and Application of Plant Natural Products (2nd Edition)

edited by

Qiang Zhang

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3018 | Submission Open

Keywords: omics; plant components; bioactivity; signaling; pathway; target; mechanism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Platelets at the Intersection of Atherosclerosis Processes

edited by

Maria Greabu

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2989 | Submission Open

Keywords: platelets; inflammation; atherosclerosis; endothelial cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein Dynamics, Binding and Allostery

edited by

Beatriz Ibarra-Molero

Raquel Godoy-Ruiz

and

Encarnación Medina Carmona

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2968 | Submission Open

Keywords: proteins dynamics; enzyme catalysis; conformational changes; allosteric regulation; signal transduction; neurodegenerative disorders; cancer; computational methods; therapeutic interventions

(This special issue belongs to the Section Biochemistry)

Plant Tolerance to Stress

edited by

Xingguo Li

submission deadline 20 Nov 2025 | 5 articles | Viewed by 2931 | Submission Open

Keywords: plant; genetic breeding; biotic stress; abiotic stress; gene regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Fruit Tree Physiology, Breeding and Genetic Research

edited by Jiangping Mao

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2877 | Submission Open

Keywords: fruit tree; genetic breeding; fruit tree physiology; gene functional identification

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms, Biomarkers, and Therapeutic Targets for Endometriosis

edited by Katharina Proestling and

Iveta Yotova

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2795 | Submission Open

Keywords: endometriosis; biomarkers; inflammation; fibrosis; oxidative stress; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomaterials for Tissue Regeneration: Current Progress and Future Directions

edited by

Ana Caruntu

and Horia Barbu

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2784 | Submission Open

Keywords: biomaterials; biocompatibility; tissue engineering; tissue defect; rehabilitation; scaffolds; regenerative medicine; angiogenesis; stem cells; antimicrobial

(This special issue belongs to the Section Materials Science)

Synapse Dynamics: From Molecular Mechanisms to Functional Plasticity

edited by

Maria Bykhovskaia

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2783 | Submission Open

Keywords: synaptic plasticiy; neuronal transmitters; molecular dynamics; neuronal networks; dendritic spines; synapse formation; synaptic vesicles; active zones; axonal transport

(This special issue belongs to the Section Molecular Neurobiology)

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