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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Artificial Intelligence, Multi-Omics, and Molecular Modelling in Modern Drug Discovery
edited by
submission deadline 30 Nov 2026 | Viewed by 3795 | Submission Open
Keywords: artificial intelligence (AI); machine learning; multi-omics integration; molecular modelling; computational drug discovery; virtual screening; generative AI; explainable AI (XAI); ADMET prediction; pharmacogenomics; systems biology
(This special issue belongs to the Section Molecular Pharmacology)
Environmental Influences on Cellular Responses
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 3787 | Submission Open
Keywords: cell/environment interaction; cell signaling; mechanobiology; photobiology; thermobiology; enviromics; cell-cell communication; cell-cell interaction
(This special issue belongs to the Section Molecular Biology)
Unraveling Neuroimmune Disorders: From Pathogenic Pathways to Biomarker-Driven Precision Medicine
edited by
submission deadline 30 Nov 2026 | 4 articles | Viewed by 3702 | Submission Open
Keywords: innate immunity; adaptive immunity; inflammation; autoantibodies; peptides; cytokines; receptors; leukocytes; extracellular vesicles; signal transduction; apoptosis
(This special issue belongs to the Section Molecular Immunology)
New Perspectives in Cardiovascular Disease: From Molecular Mechanisms to Clinical Innovations
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 3571 | Submission Open
Keywords: cardiovascular disease; molecular mechanisms; biomarkers; atrial fibrillation; translational medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Latest Molecular Research on Renal Disease
edited by Niels Henrik Buus and Marco Eijken
submission deadline 30 Nov 2026 | 2 articles | Viewed by 3438 | Submission Open
Keywords: renal disease; chronic kidney disease; renal regeneration; kidney injury
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Plant Breeding
edited by , Sandra Correia and
submission deadline 30 Nov 2026 | 3 articles | Viewed by 3388 | Submission Open
Keywords: plant breeding; proteomics; metabolomics; epigenomics; gene editing
(This special issue belongs to the Section Molecular Plant Sciences)
The Role of Extracellular Vesicles in Disease and Therapeutic Applications
edited by Sunyoung Park
submission deadline 30 Nov 2026 | 3 articles | Viewed by 3327 | Submission Open
Keywords: extracellular vesicles (EVs); disease biomarkers; EV-based therapeutics; cancer diagnosis; drug delivery; immune modulation; regenerative medicine
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Allergy and Asthma: 4th Edition
edited by
submission deadline 30 Nov 2026 | 3 articles | Viewed by 3273 | Submission Open
Keywords: allergy; asthma; epigenetics/epigenomics; genetics/genomics; inflammation; molecular biology
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Macroporous, Mesoporous, and Microporous Materials submission deadline 30 Nov 2026 | 2 articles | Viewed by 3143 | Submission Open
Keywords: functional materials; nanomaterials; nanostructures; molecular systems; porous materials
(This special issue belongs to the Section Materials Science)
Natural Products as Therapeutic Agents: From Molecular Targets to Cellular and Functional Modulation
edited by Su-Yun Lyu
submission deadline 30 Nov 2026 | 2 articles | Viewed by 3037 | Submission Open
Keywords: natural products; molecular targets; cellular modulation; functional modulation; therapeutic agents
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Perspectives on Fish Nutrition, Physiology and Molecular Regulatory Networks
edited by Linghong Miao
submission deadline 30 Nov 2026 | 2 articles | Viewed by 3020 | Submission Open
Keywords: fish nutrition; feed ingredients; intestinal physiology; molecular regulation; stress response and welfare; genetic mechanisms; aquaculture sustainability; omics technologies
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Neurofibromatosis Type 1: From Molecular Insights to Novel Therapies
edited by László Szabó and
submission deadline 30 Nov 2026 | 1 articles | Viewed by 2864 | Submission Open
Keywords: neurofibromatosis type 1; genotype–phenotype analyses; molecular pathogenesis; next-generation sequencing (NGS); molecular targeted therapy; MEK inhibitors; imaging studies
(This special issue belongs to the Section Molecular Neurobiology)
Computer Simulation Insight into Ligand–Receptor Interaction submission deadline 30 Nov 2026 | 2 articles | Viewed by 2755 | Submission Open
Keywords: structure–activity relationship (SAR); free energy perturbation (FEP); structure-based drug design (SBDD); machine learning in drug discovery; hybrid qm/mm methods; binding affinity prediction; enhanced sampling techniques; target binding kinetics
(This special issue belongs to the Section Molecular Informatics)
Precision Nutrition and Cancer: Molecular Insights into Cancer Prevention and Development
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 2737 | Submission Open
Keywords: precision nutrition; cancer prevention; cancer development; nutrigenomics; personalized diets; tumor metabolism; dietary interventions
(This special issue belongs to the Section Molecular Oncology)
Application of Natural Products in Biomedicine and Pharmacotherapy: 3rd Edition
edited by
submission deadline 30 Nov 2026 | 4 articles | Viewed by 2684 | Submission Open
Keywords: natural products; biomedicine; genotoxicity; epigenetics; aging
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanism and Pharmacological Target of Neuroprotection
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 2566 | Submission Open
Keywords: neurodegeneration; animal model; brain regeneration; pharmacological drug; molecular analysis
(This special issue belongs to the Section Molecular Neurobiology)
Synthesis and Application of Natural and Inspired-Natural Products
edited by Mauro de Nisco
submission deadline 30 Nov 2026 | 2 articles | Viewed by 2520 | Submission Open
Keywords: natural products; natural substances; derivative; synthesis; application
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Artificial Intelligence in Molecular Biomarker Screening
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 2495 | Submission Open
Keywords: molecular biomarkers; imaging biomarkers; screening; artificial intelligence; metaverse
(This special issue belongs to the Section Molecular Informatics)
Synthesis and Activity Studies of Anticancer Compounds
edited by Agata Pacuła-Miszewska
submission deadline 30 Nov 2026 | 1 articles | Viewed by 2480 | Submission Open
Keywords: anticancer agents; structure-activity relationship; cytotoxicity mechanisms; medicinal chemistry; drug design
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Studies of Hematologic Malignancies
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 2436 | Submission Open
Keywords: hematologic malignancies; molecular mechanisms; genetic and epigenetic aberrations; molecular diagnosis; targeted therapy and biomarkers
(This special issue belongs to the Section Molecular Oncology)
New Molecular Insights into Antibacterial Materials
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 2433 | Submission Open
Keywords: antimicrobial resistance; nanoparticles; biopolymers; antimicrobial peptides; antimicrobial materials
(This special issue belongs to the Section Materials Science)
Dietary Interventions for Type 2 Diabetes: Current Evidence and Emerging Perspectives on Underlying Molecular Mechanisms
edited by Caterina Formichi
submission deadline 30 Nov 2026 | 2 articles | Viewed by 2416 | Submission Open
Keywords: type 2 diabetes; nutritional intervention; dietary strategies; nutrients; personalized nutrition; diet; metabolic health
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Aquatic Organisms
edited by
submission deadline 30 Nov 2026 | 4 articles | Viewed by 2368 | Submission Open
Keywords: aquatic biotechnology; fish immunomodulation; antimicrobial resistance; omics technologies; natural feed additives
(This special issue belongs to the Section Molecular Biology)
New Advances in Bioactive Compounds submission deadline 30 Nov 2026 | 2 articles | Viewed by 2334 | Submission Open
Keywords: bioactive compound; natural products; polyphenols; carotenoids; alkaloids
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Emerging Biological Markers and Molecular Targets in Bladder Cancer
edited by Stanislav Žiaran
submission deadline 30 Nov 2026 | 2 articles | Viewed by 2298 | Submission Open
Keywords: bladder cancer; biomarkers; urothelial carcinoma; molecular pathways; liquid biopsy; extracellular matrix; omics profiling; precision medicine; tissue engineering; translational urology
(This special issue belongs to the Section Molecular Oncology)
Domestic Animal Genetics, Genomics, and Molecular Breeding
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 2268 | Submission Open
Keywords: genomic selection; molecular breeding; domestic animals; functional genomics; genetic improvement; product quality; reproduction
(This special issue belongs to the Section Molecular Genetics and Genomics)
Preservation of Testicular Function: From Andrological Pathologies to Testis Cancer submission deadline 30 Nov 2026 | 2 articles | Viewed by 2258 | Submission Open
Keywords: testicular function; male infertility; fertility preservation; spermatogenesis; oxidative stress; cell death; testicular cancer; testosterone
(This special issue belongs to the Section Molecular Pharmacology)
The Anti-Inflammatory and Antioxidant Potential of Phytochemicals
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 2236 | Submission Open
Keywords: phytochemicals; dietary bioactives; inflammation; natural compounds; functional foods; oxidative stress; cytokine modulation; NF-κB signaling; chronic diseases; plant-derived metabolites
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research and Cellular Biology of Breast Cancer: 2nd Edition submission deadline 30 Nov 2026 | 2 articles | Viewed by 2203 | Submission Open
Keywords: molecular mechanisms of tumor growth and diffusion; cancer cell biology; biology of tumor micro-environmental cells; MDR; hormone dependency; HER2 positive breast cancer; TNBC; genetic and epigenetic alterations; pro-tumor and anti-tumor; immune responses; conventional and biological therapies; blood and tissue biomarkers
(This special issue belongs to the Section Molecular Oncology)
Extracellular Vesicles—New Findings on the Block in Liquid Biopsy
edited by Christa Nöhammer
submission deadline 30 Nov 2026 | 2 articles | Viewed by 2190 | Submission Open
Keywords: extracellular vesicles; biological fluids; liquid biopsy; multi-omics; biomarkers; EV technologies
(This special issue belongs to the Section Molecular Biology)
Unveiling Molecular Mysteries of Brain Barriers
edited by Ana Catarina Duarte
submission deadline 30 Nov 2026 | 2 articles | Viewed by 2185 | Submission Open
Keywords: blood–brain barrier; blood–cerebrospinal fluid barrier; arachnoid barrier; transport mechanisms; drug delivery; drug metabolism; ATP-binding cassete (ABC) transporters
(This special issue belongs to the Section Molecular Neurobiology)
Innovations in Analytical Chemistry for Environmental and Food Safety: Methodologies and Molecular Insights submission deadline 30 Nov 2026 | 1 articles | Viewed by 2066 | Submission Open
Keywords: innovative sample preparation; food quality and safety; advanced analytical techniques; risk assessment
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Focus on Heterocyclic Compounds and Their Various Applications
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 2058 | Submission Open
Keywords: heterocyclic compounds; heterocyclic organic synthesis; medicinal heterocycles; bioactive heterocycles; heterocycles in materials sciences
(This special issue belongs to the Section Biochemistry)
New Insights in Antibiotic Resistance/Tolerance
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 2032 | Submission Open
Keywords: antibiotic resistance; biofilm; innovative antimicrobial strategies and compounds; synergistic actions; One Health; bacterial tolerant phenotypes; resistant pathogenic microorganisms; mechanisms of antimicrobial resistance
(This special issue belongs to the Section Molecular Microbiology)
Epigenetic Mechanisms in Human Diseases: From Molecular Pathogenesis to Therapeutic Interventions
edited by Silvia Consalvi
submission deadline 30 Nov 2026 | 3 articles | Viewed by 2019 | Submission Open
Keywords: epigenetics; DNA methylation; histone modifications; chromatin remodeling; non-coding RNAs; epigenomic profiling; epigenetic biomarkers; epigenetic therapy; epigenetic drugs; epigenome editing; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Therapeutic Targets in Cancers: 5th Edition
edited by
submission deadline 30 Nov 2026 | 3 articles | Viewed by 1966 | Submission Open
Keywords: targeted therapy; precision oncology; immune modulation; cancer stem cell targeting; RNA-based therapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Studies in Gynecological Oncology: Advancing Diagnosis and Treatment
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 1918 | Submission Open
Keywords: biomarker; cancer screening; clinical trial; DNA repair; invasion; metastasis; methylation; molecular diagnostics; molecular tumor pathology; next-generation sequencing; omics; personalized medicine; prognosis; single-cell analysis; targeted therapy; translational cancer research; treatment response; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
Ligament/Tendon and Cartilage Tissue Engineering and Reconstruction, 2nd Edition submission deadline 30 Nov 2026 | 1 articles | Viewed by 1896 | Submission Open
Keywords: cartilage; tendon; ligament; anterior cruciate ligament; bioprinting; scaffold; bioreactor; tissue engineering
(This special issue belongs to the Section Molecular Biology)
Regenerative Medicine: Biomaterials and Stem Cell Research: 2nd Edition
edited by Silvia María Díaz-Prado
submission deadline 30 Nov 2026 | 2 articles | Viewed by 1893 | Submission Open
Keywords: regenerative medicine; stem cell; biomaterial; bioprinting; tissue engineering; tissue and organ transplant; organ scarcity
(This special issue belongs to the Section Materials Science)
Microbial Involvement in Cancer: Stem Cell Regulation, Immunity, and Therapy Response submission deadline 30 Nov 2026 | 1 articles | Viewed by 1885 | Submission Open
Keywords: microbiota stem cell cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Latest Advances in Natural Bioactive Molecules and Polysaccharides
edited by Loredana Marcolongo
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1882 | Submission Open
Keywords: natural products; bioactive compounds; polysaccharides; extraction technologies; bioprocesses; value-added products; one-health
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Research on New Targets and New Drugs for Dementia
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 1852 | Submission Open
Keywords: Alzheimer’s disease; disease-modifying therapy; neuroinflammation; monoclonal antibodies; natural products
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Metalloproteinase, 2nd Edition
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1783 | Submission Open
Keywords: matrix metalloproteinases (MMPs); substrate specificity; pathological condition; metalloproteinases inhibitors
(This special issue belongs to the Section Biochemistry)
X-Linked Disorders: Epigenetic and Environmental Modulation of Phenotypes
edited by Yoram Chaiter and
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1714 | Submission Open
Keywords: X-linked disorders; epigenetics; environmental factors; gene expression; clinical manifestations
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in the Molecular Pathogenesis of Gastrointestinal Malignancies with Implications for Diagnosis and Therapy
edited by Laura Necula
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1710 | Submission Open
Keywords: gastrointestinal cancers; biomarkers; early diagnosis; circulating molecules; non-invasive tests
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of RNA Interactions and Biomarker Discovery for Human Diseases
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 1704 | Submission Open
Keywords: biomarker discovery; RNA interactions; RNA–disease associations; drug–RNA interactions; therapeutic targets
(This special issue belongs to the Section Molecular Informatics)
Molecular Advances in Parkinson’s Disease: Current Insights and Future Directions
edited by Laura Adalid-Peralta
submission deadline 30 Nov 2026 | Viewed by 1650 | Submission Open
Keywords: Parkinson’s disease; neurodegenerative mechanisms; genetic susceptibility; alpha-synuclein aggregation; neuroinflammation; mitochondrial dysfunction; oxidative stress; autophagy–lysosomal pathway; gut–brain axis; microbiome dysbiosis
(This special issue belongs to the Section Molecular Neurobiology)
Viral Infections and Cancer: Recent Advances and Future Perspectives (2nd Edition)
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1645 | Submission Open
Keywords: virus; infection; cancer; immune response
(This special issue belongs to the Section Molecular Oncology)
The Role of Melatonin in Plants: 3rd Edition submission deadline 30 Nov 2026 | 1 articles | Viewed by 1627 | Submission Open
Keywords: melatonin; phytomelatonin; plants; seed germination; seasonal and circadian rhythms; flowering; fruit ripening; plant immunity; abiotic stresses
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular and Cellular Mechanisms in Amyotrophic Lateral Sclerosis
edited by Nilo Riva
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1563 | Submission Open
Keywords: amyotrophic lateral sclerosis; motor neuron vulnerability; TDP-43; axonal degeneration; proteinopathy; stress granules; C9orf72; SOD1; RNA metabolism; FTD
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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