Advances in the Molecular Pathogenesis of Gastrointestinal Malignancies with Implications for Diagnosis and Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 24
Special Issue Editor
Special Issue Information
Dear Colleagues,
Gastrointestinal cancers, including colorectal, gastric, esophageal, pancreatic, and liver cancers, represent a major medical and economic burden worldwide, accounting for more than one-fourth of all cancer cases and one-third of cancer-related mortality. Although there has been much progress in screening colorectal cancer, the prognosis of other gastrointestinal cancers tends to be poor. Their worse prognosis is often due to the late onset of symptoms, diagnosis at advanced stages, and challenges in treatment. These cancers are characterized by critical genetic and epigenetic alterations, such as mutations in oncogenes and tumor suppressor genes, as well as dysregulation of key signalling pathways. The influence of the tumor microenvironment on cancer progression also contributes to therapeutic resistance. The aim of this Special Issue is to present new findings related to the molecular pathogenesis of gastrointestinal malignancies. We welcome both original research articles and comprehensive reviews focusing on emerging molecular biomarkers and potential clinical utility in early detection, prognosis, and the development of targeted therapies for these cancers.
I look forward to receiving your contributions.
Dr. Laura Necula
Guest Editor
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Keywords
- gastrointestinal cancers
- biomarkers
- early diagnosis
- circulating molecules
- non-invasive tests
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