Extracellular Vesicles—New Findings on the Block in Liquid Biopsy

Dear Colleagues,

Extracellular vesicles (EVs) have emerged as pivotal mediators of intercellular communication, carrying diverse cargos such as proteins, lipids, and nucleic acids that reflect the physiological and pathological states of their cells of origin. Once considered cellular debris, EVs are now recognized as dynamic regulators of biological processes, influencing immunity, metabolism, cancer progression, and tissue regeneration. The high abundance of EVs in readily accessible biofluids (e.g., blood, urine, saliva), together with their extraordinary stability and ability to encapsulate cell-of-origin molecular information, make EVs particularly attractive as minimally invasive biomarkers. Advances in isolation technologies, high-throughput omics, and single-vesicle analysis are accelerating their translation from bench to bedside.

This Special Issue aims to highlight the expanding landscape of EV research and application, with a focus on their utility as novel liquid biopsy biomarkers for diagnosis, prognosis, and therapeutic monitoring across a range of diseases. By bringing together recent discoveries and methodological innovations, we aim to come up with a diverse and comprehensive overview of how EVs are reshaping biomedical research and liquid biopsy-based precision medicine.

We aim for submissions of research articles or reviews. In line with the journal’s mission—IJMS is a journal of molecular science—purely clinical studies will not be suitable for submission.

Dr. Christa Nöhammer
Guest Editor

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