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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Targeting Epigenetic Complexes and Alternative Protein Degradation Pathways in Medicinal Chemistry

edited by Jean Leandro Dos Santos

submission deadline 25 Dec 2026 | 2 articles | Viewed by 4963 | Submission Open

Keywords: protein degradation; LYTAC; AUTAC; ATTEC; epigenetics; NuRD; HDAC; BRD; SWI/SNF; PRC2; chromatin; conjugates; lysosome; autophagy; drug discovery

(This special issue belongs to the Section Biochemistry)

Antiviral Drug Targets: Structure, Function, and Drug Design—3rd Edition

edited by

Mattia Mori

and

Ilaria Vicenti

submission deadline 25 Dec 2026 | 3 articles | Viewed by 4898 | Submission Open

Keywords: viral infections; drug design; protein structures; functional studies; viruses; antiviral drugs

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research on the Pathology and Treatment of Sepsis and Non-Infectious Inflammatory Conditions

edited by

Andressa Freitas

submission deadline 25 Dec 2026 | 3 articles | Viewed by 4569 | Submission Open

Keywords: sepsis; comorbidities; inflammation; molecular mechanisms; cytokine signaling; oxidative stress; leukocyte recruitment; therapeutic targets

(This special issue belongs to the Section Molecular Immunology)

MicroRNAs in Physiology and Pathophysiology

edited by Małgorzata Guz

submission deadline 25 Dec 2026 | 3 articles | Viewed by 4535 | Submission Open

Keywords: miRNA; cell physiology; metabolism; cancer; biomarkers; disease; molecular mechanisms; diagnosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Research on Bioactive Natural Products: 2nd Edition

edited by

Alexandros Tsoupras

submission deadline 25 Dec 2026 | 1 articles | Viewed by 4353 | Submission Open

Keywords: chronic disorders; bioactives; natural sources; sustainable sources; biomolecular; structure–activity relationship; synergism; health promoting; bio-functional; products; supplements; nutraceuticals; drugs

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Molecular Targets for Treatment and Drug Delivery in Tumors: 2nd Edition

edited by

Emily Capone

submission deadline 25 Dec 2026 | 2 articles | Viewed by 4218 | Submission Open

Keywords: targeted therapy; tumor; molecular target; drug delivery; drug design

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights in Diabetes

edited by

Mariann Harangi

and

Ferenc Sztanek

submission deadline 25 Dec 2026 | 2 articles | Viewed by 4171 | Submission Open

Keywords: insulin signalling pathway; pancreatic beta-cell dysfunction; oxidative stress; epigenetic modifications; metabolic memory; small regulatory RNAs (miRNAs); inflammation and insulin resistance; glucagon-like peptide-1 (GLP-1); glucose-dependent insulinotropic polypeptide (GIP); molecular therapeutic targets; glucose homeostasis regulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Highlights in Pathophysiology of the Musculoskeletal System, 3rd Edition

edited by

Marta Anna Szychlinska

Rosario Barone

and

Giovanna Calabrese

submission deadline 25 Dec 2026 | 2 articles | Viewed by 4170 | Submission Open

Keywords: musculoskeletal; skeletal; tendon; ligament; intervertebral; articular cartilage; osteoarthritis; rheumatoid arthritis; sarcopenia; muscle wasting; osteoporosis; bone necrosis; synovium; pain; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Assisted Reproductive Technologies

edited by

Sung Tae Kim

submission deadline 25 Dec 2026 | 2 articles | Viewed by 4160 | Submission Open

Keywords: preimplantation genetic testing; embryo selection; in vitro fertilization; infertility; implantation failure; miscarriage; mosaicism; segmental aneuploidy; non-invasive technology; morpho kinetics; in vitro gametogenesis; in vitro oocyte maturation; reproductive tissue cryopreservation; artificial intelligence (AI)

(This special issue belongs to the Section Molecular Biology)

Advances in Obesity Research: Metabolic Pathways and Pathophysiological Factors

edited by Aleksandra Stefanović

submission deadline 25 Dec 2026 | 5 articles | Viewed by 4089 | Submission Open

Keywords: obesity; inflammation; oxidative stress; obesity-related diseases; adypocitokines

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research and Application of Platelet-Rich Plasma

edited by

Jorge U. Carmona

submission deadline 25 Dec 2026 | 1 articles | Viewed by 3902 | Submission Open

Keywords: platelet-rich plasma; fibrin scaffold; regenerative medicine; molecular biology; translational medicine

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Mechanisms Underlying Taste and Smell

edited by

Naina Bhatia-Dey

and

Thomas Heinbockel

submission deadline 25 Dec 2026 | 4 articles | Viewed by 3796 | Submission Open

Keywords: olfaction; anosmia; hyposmia; ageusia; dysgeusia; gustation; chemesthesis; receptors; chemosensory processing; epigenome

(This special issue belongs to the Section Molecular Biology)

Targeting MAPK in Human Diseases

edited by

Elisabetta Rovida

submission deadline 25 Dec 2026 | 1 articles | Viewed by 3790 | Submission Open

Keywords: ERK; DUSP; cancer; inflammation; neurodegenerative diseases; autoimmune diseases; targeted therapy; cell signaling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drug and Non-Drug Treatment of Cerebral Diseases

edited by

Silvia Carloni

submission deadline 25 Dec 2026 | 1 articles | Viewed by 3707 | Submission Open

Keywords: cerebral diseases; cerebral ischemia; neonatal hypoxic-ischemic encephalopathy (HIE); neuroprotection; therapeutic hypothermia; neurorehabilitation; oxidative stress; stem cell therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Pulmonary Hypertension and Interstitial Lung Diseases: Mechanisms and Treatments

edited by

Katarzyna B. Lewandowska

and

Monika Szturmowicz

submission deadline 25 Dec 2026 | 2 articles | Viewed by 3700 | Submission Open

Keywords: pulmonary hypertension; interstitial lung disease; lung fibrosis; pulmonary hemodynamics; pulmonary function testing; pathogenesis; prognosis; survival; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Medicinal Plants in Health and Diseases

edited by

Hamza El Moudden

submission deadline 25 Dec 2026 | 2 articles | Viewed by 3684 | Submission Open

Keywords: medicinal plants; phytochemicals; natural products; pharmacological activity; herbal medicine; drug discovery; traditional medicine; therapeutic potential

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms and Therapeutic Targets in Systemic Vasculitis

edited by Andrés González-García

submission deadline 25 Dec 2026 | 1 articles | Viewed by 3631 | Submission Open

Keywords: vasculitis; ANCA-associated vasculitis; EGPA; complement activation; molecular immunopathogenesis; endothelial dysfunction; cytokine signaling; biomarkers; therapeutic targets; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Advances in the Role of Cytoskeletal Proteins in Diseases

edited by

Urko Del Castillo

submission deadline 25 Dec 2026 | 2 articles | Viewed by 3624 | Submission Open

Keywords: cytoskeleton; microtubules; actin filaments; intermediate filaments; neurodegeneration; cancer metastasis; cell migration; cellular mechanotransduction; cytoskeletal remodeling

(This special issue belongs to the Section Molecular Biology)

Molecular Tools in Environmental Microbiology

edited by

Živilė Strazdaitė-Žielienė

and

Juliana Lukša

submission deadline 25 Dec 2026 | 2 articles | Viewed by 3621 | Submission Open

Keywords: environmental microbiology; molecular methods; microbial community analysis; low-abundance microorganisms; microbial identification; environmental DNA; next-generation sequencing (NGS); high-throughput sequencing

(This special issue belongs to the Section Molecular Microbiology)

Exploring Molecular Mechanisms of Prostate Cancer

edited by

Estefania Labanca

submission deadline 25 Dec 2026 | 3 articles | Viewed by 3585 | Submission Open

Keywords: genetic alterations; signlaing pathways; cellular dysregulation; non-coding RNAs; epigenetics; tumor microenvironment; metabolic factors; therapuetic targeting; multi-modal approaches

(This special issue belongs to the Section Molecular Oncology)

Bioactive Molecules in Infection and Toxicity: Antimicrobial Peptides and Drug-Induced Damage in Disease Models

edited by

Oleksii Skorokhod

submission deadline 25 Dec 2026 | 3 articles | Viewed by 3475 | Submission Open

Keywords: antimicrobial peptides (AMPs); infectious diseases; drug-induced toxicity; disease models; therapeutic strategies; drug delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Gene Regulation in Endocrine Disease, 2nd Edition

edited by

Alberto Falchetti

submission deadline 25 Dec 2026 | 2 articles | Viewed by 3361 | Submission Open

Keywords: gene regulation; endocrine disease; endocrinology; diabetes mellitus; thyroid disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Psychobiotics as Next-Generation Probiotics: A Holistic Approach to Mental Health and Gut–Brain Axis Modulation

edited by

Edyta Juszczuk-Kubiak

submission deadline 25 Dec 2026 | 1 articles | Viewed by 3355 | Submission Open

Keywords: probiotics; gut microbiota; gut–brain axis; mental health

(This special issue belongs to the Section Molecular Biology)

Molecular and Physiological Strategies for Plant Drought Resilience

edited by

Mariapina Rocco

submission deadline 25 Dec 2026 | 1 articles | Viewed by 3301 | Submission Open

Keywords: abiotic stress; reactive oxygen species; oxidative stress; adaptive response; signaling pathways; phytohormones; physiological adaptation; molecular adaptation

(This special issue belongs to the Section Molecular Plant Sciences)

The Gene, Genomics, and Molecular Breeding in Cruciferae Plants (3rd Edition)

edited by

Maoteng Li

submission deadline 25 Dec 2026 | 3 articles | Viewed by 3291 | Submission Open

Keywords: Cruciferae plants; genome analysis; genetic dissection; gene function; molecular breeding

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Complement Regulation in Kidney Disease

edited by Jasmina Marković Lipkovski

submission deadline 25 Dec 2026 | 2 articles | Viewed by 3276 | Submission Open

Keywords: complement system; kidney disease; glomerulonephritis; C3 glomerulopathy; membranous nephropathy; complement regulation; innate immunity; molecular pathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Molecular Advances in Prostate Cancer

edited by Rejane Maira Góes

submission deadline 25 Dec 2026 | 2 articles | Viewed by 3226 | Submission Open

Keywords: prostate cancer; androgen signaling; metabolic reprogramming; tumor microenvironment; inflammation; immunotherapy; chemoprotection; phytotherapy

(This special issue belongs to the Section Molecular Oncology)

Gut Microbiota-Derived Metabolites in Human Health and Disease

edited by Zeneng Wang

submission deadline 25 Dec 2026 | 3 articles | Viewed by 3010 | Submission Open

Keywords: microbiome; microbiota; gut; metabolomics; health; disease; inflammation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Plant Extracts and Natural Products: Molecular Insights into the Biofunctional Properties

edited by

Komgrit Eawsakul

and

Chawan Manaspon

submission deadline 25 Dec 2026 | 6 articles | Viewed by 2987 | Submission Open

Keywords: plant-derived bioactive compounds; molecular mechanisms and signaling pathways; drug delivery systems; bioavailability enhancement; multi-omics platforms; network pharmacology and molecular docking; cellular targets and receptor interactions; natural product drug discovery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Antimicrobial Agents: Mechanisms and Applications

edited by

Aleksandra Maria Kocot

submission deadline 25 Dec 2026 | 3 articles | Viewed by 2940 | Submission Open

Keywords: antimicrobial compounds; antibacterial activity; antibiotic resistance; pathogen-tailored therapeutic targeting; novel antimicrobials; molecular aspects of the mechanisms of action of antibacterial substances; effectiveness of antibacterial substances

(This special issue belongs to the Section Biochemistry)

Molecular and Genetic Insights into Neuropsychiatric Disorders: From Mechanisms to Management

edited by

James Alan Bourgeois

submission deadline 25 Dec 2026 | 3 articles | Viewed by 2923 | Submission Open

Keywords: psychiatry; neurology; psychotic disorders; depressive disorders; neurocognitive disorders; neuropsychiatry; genetics; psychopharmacology; neuromodulation; genome-wide association studies (GWAS); transcriptomics; epigenetics; gene-environment interactions

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Biology of 3D Cell and Tissue Culture Systems: Benefits to Research and Disease Diagnostics

edited by

Thomas J. Goodwin

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2917 | Submission Open

Keywords: 3D physiological relevance vs. 2D biology, 3D research, and diagnostic systems; evolving 3D “omics” applications; research and clinical medicine; drug applications; toxicity evaluations; “Omics” ; spatial biology of 3D

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Biomaterials for Tissue Regeneration

edited by

Liviu Duta

and

Valentina Grumezescu

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2884 | Submission Open

Keywords: biomaterials; tissue regeneration; molecular mechanisms; cell-instructive scaffolds; injectable hydrogels; ECM-mimetic materials; bioactive ceramics; bioactive surface coatings; mechanotransduction/mechanobiology; immunomodulation; angiogenesis and vascularization; biofabrication (3D/4D printing)

(This special issue belongs to the Section Materials Science)

Atherosclerosis and Comorbidities: From Molecular Pathogenesis to Diagnosis and Therapeutic Targets

edited by

Alexandr Ceasovschih

Victoriţa Şorodoc

and

Yusuf Ziya Şener

submission deadline 25 Dec 2026 | 1 articles | Viewed by 2854 | Submission Open

Keywords: atherosclerosis; comorbidities; lipidology; inflammation; obesity; arterial stiffness; vascular remodeling; cardiovascular risk; cardiovascular diseases; targeted therapies; lifestyle

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Genome-Edited Animal Models

edited by Takayuki Sakurai and

Masahiro Sato

submission deadline 25 Dec 2026 | 1 articles | Viewed by 2850 | Submission Open

Keywords: genome editing; prime editing; base editing; CRISPRa/CRISPRi; knock-in/out; conditional genome editing; multiplex genome editing; manipulation of early embryos and germ cells; in vivo gene delivery; genome-edited animals; disease animal model

(This special issue belongs to the Section Molecular Genetics and Genomics)

Progress in Prevention and Treatment of Cardiovascular Diseases and Arrhythmias

edited by

Narcis Tribulova

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2828 | Submission Open

Keywords: translational research; novel animal models; novel treatment targets; pleiotropic drugs; harnessing of molecular H

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Modern Approaches in Regenerative Therapy

edited by

Daria Chudakova

and

Vladimir P. Baklaushev

submission deadline 25 Dec 2026 | 3 articles | Viewed by 2817 | Submission Open

Keywords: regenerative therapy; regeneration; neuroregeneration; cell reprogramming; cell therapy; regenerative bio-scaffolds; extracellular vesicles; mesenchymal stromal/stem cells (MSCs); cell differentiation; omics technologies

(This special issue belongs to the Section Molecular Biology)

Deciphering the Molecular Mechanisms That Regulate Plant Disease and Immunity

edited by Bourlaye Fofana and

Champa Wijekoon

submission deadline 25 Dec 2026 | 3 articles | Viewed by 2801 | Submission Open

Keywords: plants; biotic stressors; molecular mechanisms; omics technologies; plant immunity

(This special issue belongs to the Section Molecular Plant Sciences)

Toxicology Research: Understanding and Predicting Compound—Induced Toxicity

edited by

Georgios Pampalakis

and

Eleni Zingkou

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2727 | Submission Open

Keywords: molecular toxicology; emerging toxicology; drug-induced toxicity; organ toxicology; animal models; in silico toxicology; in vitro models; pesticides; industrial chemicals

(This special issue belongs to the Section Molecular Toxicology)

Bioinspired and Emerging Functionalized Nanostructures for Precision Drug Delivery

edited by

Adelina-Gabriela Niculescu

and

Alexandra Catalina Birca

submission deadline 25 Dec 2026 | 1 articles | Viewed by 2615 | Submission Open

Keywords: nanostructured materials; nanobiomaterials; nanocomposites; drug delivery systems; targeted therapies; controlled release; responsive functionalities; theranostics; biomedical applications; therapeutic innovations; bioinspired nanostructures; personalized medicine

(This special issue belongs to the Section Molecular Nanoscience)

Genetic Variations in Human Diseases: 3rd Edition

edited by

Paweł Niemiec

submission deadline 25 Dec 2026 | 4 articles | Viewed by 2555 | Submission Open

Keywords: genetic polymorphism; gene–gene interaction; gene–environment interaction; monogenic disorder; mutation phenotype; quantitative trait locus; family-based study; cohort study; association study

(This special issue belongs to the Section Molecular Genetics and Genomics)

Organoid Models in Host–Pathogen Interactions and Disease Pathogenesis

edited by

Apichai Tuanyok

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2534 | Submission Open

Keywords: organoids; host–pathogen interaction; infectious disease models; mucosal immunity; tissue engineering; microbial pathogenesis; immune organoids; 3D culture systems

(This special issue belongs to the Section Molecular Biology)

Preimplantation Genetic Testing in Assisted Reproductive Technologies

edited by

Sung Tae Kim

submission deadline 25 Dec 2026 | 1 articles | Viewed by 2531 | Submission Open

Keywords: preimplantation genetic testing; embryo selection; in vitro fertilization; infertility; implantation failure; miscarriage; mosaicism; segmental aneuploidy; non-invasive technology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Exploring the Interplay Between Food Components and the Gut: From Mechanisms to Microbiome Interaction

edited by

Mattia Di Nunzio

and Lorenzo Nissen

submission deadline 25 Dec 2026 | 1 articles | Viewed by 2511 | Submission Open

Keywords: intestinal cells; nutrients; in vitro digestion; nutrigenomics; nutrigenetics; gut microbiota

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research and Immune Landscape of Breast Cancer

edited by

Robson Monteiro

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2457 | Submission Open

Keywords: breast cancer; immune landscape; single-cell analysis; omics; therapy resistance; metastasis

(This special issue belongs to the Section Molecular Immunology)

New Advances in Metal Nanoparticles

edited by

Emilia Konował

submission deadline 25 Dec 2026 | 3 articles | Viewed by 2456 | Submission Open

Keywords: metal nanoparticles; molecular-level mechanisms; functional nanostructures; environmental nanotechnology; nanoparticle stability; catalysis; hybrid nanomaterials; bimetallic systems; ligand–nanoparticle interactions

(This special issue belongs to the Section Molecular Nanoscience)

Advancements in Cardiovascular Health Research: Investigating Novel Biomaterials, Cellular Responses and Therapies

edited by Magdalena Wawrzyńska

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2445 | Submission Open

Keywords: cardiovascular biomaterials; nanomaterials; surface coatings; drug delivery systems; polymers; biocompatibility; hemocompatibility; molecular response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insights into Immunodeficiency and Immunotherapy in Multiple Myeloma

edited by

Marjorie Pick

and

Eyal Lebel

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2413 | Submission Open

Keywords: multiple myeloma; plasma cells; monoclonality; immunodeficient

(This special issue belongs to the Section Molecular Immunology)

Antibacterial Nanomaterials for Medicinal Applications

edited by

Tsung-Rong Kuo

submission deadline 25 Dec 2026 | 1 articles | Viewed by 2403 | Submission Open

Keywords: nanotechnology; antibacterial; nanomaterials; toxicity; biocompatibility; medicinal applications

(This special issue belongs to the Section Molecular Nanoscience)

Viral Infections and Viral Pathogenesis

edited by

Shymaa E. Bilasy

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2390 | Submission Open

Keywords: viral pathogenesis; viral–host interactions; viral persistence; long COVID; molecular virology; immune dysregulation; diagnosis; vaccines; oncoviruses; antiviral and gene therapy

(This special issue belongs to the Section Molecular Microbiology)

Displaying special issue 1451-1500 on page 30 of 62.

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