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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Olfactory Neurobiology, Adult Neurogenesis and Dopaminergic Neuron Research

edited by

Angela Pignatelli

submission deadline 20 Nov 2026 | 1 articles | Viewed by 180 | Submission Open

Keywords: olfaction; olfactory bulb; dopaminergic neurons; Parkinson’s disease; Alzheimer’s disease; adult neurogenesis; early biomarker; neurodegenerative disease; smell impairment; smell test

(This special issue belongs to the Section Molecular Neurobiology)

Role of MicroRNAs in Human Diseases: 2nd Edition

edited by

Lorenzo F. Sempere

submission deadline 25 Nov 2026 | 10 articles | Viewed by 20761 | Submission Open

Keywords: microRNAs, miRNAs, miRs; preclinical models; target interaction; regulatory networks; oncology; cancer biology; cardiovascular disease; neurodegenerative conditions; diagnostic applications; therapeutic development and clinical trials

(This special issue belongs to the Section Molecular Genetics and Genomics)

Novel Antiviral Agents: Challenges and Opportunities from Molecular Targeting to Validation

edited by

Luis Adrián De Jesús-González

and

Moises Leon-Juarez

submission deadline 25 Nov 2026 | 2 articles | Viewed by 509 | Submission Open

Keywords: antiviral agents; molecular targeting; virus–host interactions; drug repurposing; host-directed antivirals; combination therapy; antiviral resistance; translational virology

(This special issue belongs to the Section Molecular Pharmacology)

Nutrition and Cardiovascular Development, from Fetal Origins to Adulthood

edited by

Deanne H. Hryciw

submission deadline 25 Nov 2026 | Viewed by 333 | Submission Open

Keywords: fetal programming; developmental origins of health and disease; maternal nutrition; placental function; offspring; cardiovascular function; cardiometabolic risk; cardio renal development; essential fatty acids; linoleic acid

(This special issue belongs to the Section Molecular Biology)

Advanced 3D-Bioprinting for Next-Generation In Vitro Models: Molecular and Technological Perspectives

edited by

Alberto Portone

and

Laura Sercia

submission deadline 25 Nov 2026 | Viewed by 205 | Submission Open

Keywords: 3D bioprinting; in vitro models; biofabrication; bioinks; hydrogels; disease modeling; toxicology; drug screening; biomaterials; organ-on-a-chip

(This special issue belongs to the Section Macromolecules)

Nanomaterial: Synthesis and Application

edited by

Hesam Kamyab

submission deadline 25 Nov 2026 | Viewed by 199 | Submission Open

Keywords: nanomaterials; green synthesis; surface functionalization; nanoparticle engineering; drug delivery systems; energy storage; catalysis; environmental remediation; biocompatibility; molecular nanotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Mitochondrial Functions and Dynamics

edited by

Raffaella Isola

submission deadline 27 Nov 2026 | 4 articles | Viewed by 16918 | Submission Open

Keywords: bioenergetics; mitochondrial biogenesis; mitochondrial morphology; apoptosis; mitophagy; reactive oxygen species; calcium homeostasis; cardiovascular diseases; neurodegenerative diseases; in vitro, cellular, and animal models; myopathies; mitochondria and immune system

(This special issue belongs to the Section Molecular Biology)

Molecular Insight into Catalysis of Nanomaterials

edited by Dandan Liu

submission deadline 27 Nov 2026 | 3 articles | Viewed by 5295 | Submission Open

Keywords: nanomaterial catalyst; thermal catalysis; photocatalysis; electrocatalysis; DFT calculation

(This special issue belongs to the Section Molecular Nanoscience)

Mechanisms and Effects of Endocrine Disruptors and Environmental Contaminants on Human Health

edited by

Margarida Ferreira Lorigo

submission deadline 27 Nov 2026 | 3 articles | Viewed by 5146 | Submission Open

Keywords: environmental exposure; emerging compounds; human health; risk assessment; adverse outcome pathway; new approach methodologies; one health

(This special issue belongs to the Section Molecular Toxicology)

Recent Approaches for Wound Treatment: 3rd Edition

edited by

Cinzia Pagano

Luana Perioli

and

César Viseras

submission deadline 27 Nov 2026 | 1 articles | Viewed by 3571 | Submission Open

Keywords: wound healing; inflammation; angiogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Insights into Buckwheat Reproductive Biology

edited by

Agnieszka Płażek

submission deadline 27 Nov 2026 | 1 articles | Viewed by 2031 | Submission Open

Keywords: antioxidant properties; biotechnological methods; embryology; seed chemical composition; yield

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Various Diseases and Drugs Involved in Vascular Tone Regulation in Cardiovascular Disease

edited by

Ju-Tae Sohn

submission deadline 27 Nov 2026 | 1 articles | Viewed by 1941 | Submission Open

Keywords: vasoconstriction; vasodilation; calcium; protein kinase C; Rho-kinase; hypertension; nitric oxide

(This special issue belongs to the Section Molecular Biology)

Solid Tumours in Focus: Tissue Biomarkers and Spatial Technologies in Cancer Pathology

edited by Kathryn Pennel

submission deadline 27 Nov 2026 | 2 articles | Viewed by 1758 | Submission Open

Keywords: biomarkers; cancer pathology; spatial biology; molecular mechanisms; tumour microenvironment; cell signalling and communication

(This special issue belongs to the Section Molecular Oncology)

Tissue Engineering and Advanced Biomaterials for Regenerative Medicine

edited by

Hak Soo Choi

Motoichi Kurisawa

and

Joo Eun Chung

submission deadline 27 Nov 2026 | 1 articles | Viewed by 1385 | Submission Open

Keywords: tissue engineering; regenerative medicine; drug delivery; bioengineering; angiogenesis

(This special issue belongs to the Section Molecular Biology)

Targeting Receptor Tyrosine Kinases and Related Signalling Pathways in Cancer: Mechanisms, Resistance, and Therapeutic Advances

edited by

Athina-Myrto Chioni

and

Richard Grose

submission deadline 27 Nov 2026 | 1 articles | Viewed by 980 | Submission Open

Keywords: tyrosine kinase receptors (TKRs); tyrosine kinase inhibitors (TKIs); cancer; therapeutic resistance/cancer drug resistance/chemotherapy resistance; signaling pathways; metastasis; combination therapy; targeted therapy; next-generation inhibitors; allosteric inhibitors; personalized medicine; tumor microenvironment; immune evasion; immunotherapy; crosstalk in cancer signaling; miRNAs; lncRNAs; cancer therapeutics; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Cellular Plasticity in Cancer: Mechanisms, Measurement and Therapeutic Opportunities

edited by Costa Frangou and

Jianmin Zhang

submission deadline 27 Nov 2026 | 1 articles | Viewed by 969 | Submission Open

Keywords: cellular plasticity; cancer progression; EMT/MET; lineage infidelity; therapy-induced reprogramming; stem-like states; single-cell analysis; spatial transcriptomics; lineage tracing; computational modeling; biomarkers; therapeutic re-sistance; metastasis; solid tumors

(This special issue belongs to the Section Molecular Oncology)

Harnessing Natural Compounds to Combat Cancer and Metastasis

edited by

Mohd Farhan

submission deadline 27 Nov 2026 | Viewed by 968 | Submission Open

Keywords: natural compounds; bioactive molecules; natural extracts; chemotherapy; immunomodulatory compounds; anti-metastatic compounds; anti-angiogenic compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in DNA Nanotechnology

edited by Zhaoqi Yang

submission deadline 27 Nov 2026 | Viewed by 655 | Submission Open

Keywords: DNA nanotechnology; DNA-based drug delivery; DNA cages and DNA polyhedra; DNA origami; DNA-based electronic circuits; DNA-based sensors; DNA-based catalysis; DNA-based data storage

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Targeting and Pharmacology of Neuroinflammation

edited by

Lisa Lione

submission deadline 27 Nov 2026 | Viewed by 630 | Submission Open

Keywords: glia-targeted therapeutics; neuroinflammation; CNS drug development; astrocyte; microglia; neurodegeneration; translational neuroscience; biomarkers; human genetics; cytokine signaling

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Endocrine and Metabolic Diseases

edited by

Ferenc Sztanek

submission deadline 27 Nov 2026 | Viewed by 356 | Submission Open

Keywords: systems biology; metabolomics; fluxomics; organoid models; epigenetic regulation; precision medicine; endocrine–metabolic crosstalk

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Nanocomplexes and Drug Delivery Systems for Cancer Therapy

edited by

Ângela Sousa

submission deadline 27 Nov 2026 | Viewed by 346 | Submission Open

Keywords: nanocomplexes; drug delivery systems; cancer therapy; nanocarriers; stimuli-responsive systems; theranostics; biomolecules delivery; tumor microenvironment; personalized medicine; multidrug resistance

(This special issue belongs to the Section Molecular Nanoscience)

Current Research for Heart Disease Biology and Therapeutics: Fourth Edition

edited by Claudia Kusmic

submission deadline 29 Nov 2026 | 3 articles | Viewed by 2359 | Submission Open

Keywords: myocardial hypertrophy; cardiac remodeling; heart failure; drug therapy; molecular therapeutic targets; myocardial gene therapy; heart disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Ethylene Signaling in Plants: Molecular Mechanisms from Growth Regulation to Postharvest Biology

edited by

María Serrano

and

Nasratullah Habibi

submission deadline 29 Nov 2026 | Viewed by 330 | Submission Open

Keywords: ethylene signaling networks; ethylene in plant development and senescence; ethylene-responsive gene expression; ethylene control of senescence and ripening; ethylene in postharvest biology

(This special issue belongs to the Section Molecular Plant Sciences)

Viruses as Therapeutic Tools: Medical and Biotechnological Applications

edited by

Víctor Romanowski

submission deadline 30 Nov 2026 | 8 articles | Viewed by 29128 | Submission Open

Keywords: molecular virology; virus–host interactions; immunology; gene therapy vectors; vaccines; antivirals

(This special issue belongs to the Section Molecular Microbiology)

Antimicrobial and Antiviral Peptides: 2nd Edition

edited by

Tecla Ciociola

submission deadline 30 Nov 2026 | 6 articles | Viewed by 22209 | Submission Open

Keywords: antimicrobial peptides; antiviral peptides; peptide mining; molecular mechanism of biological activity; structure–activity relationship; molecular targets; in silico design; in vivo models; peptide delivery strategies; biomedical applications

(This special issue belongs to the Section Biochemistry)

Lifestyle Interventions in MASLD: Molecular and Clinical Perspectives

edited by Muhammad Y. Sheikh

submission deadline 30 Nov 2026 | 1 articles | Viewed by 18149 | Submission Open

Keywords: NAFLD (nonalcoholic fatty liver disease); MASLD (metabolic syndrome-associated steatotic liver disease); metabolic syndrome; dyslipidemia; diabetes mellitus 2; hypertension; natural bioactive

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances on Cannabinoid and Endocannabinoid Research, 3rd Edition

edited by

Rosaria Meccariello

submission deadline 30 Nov 2026 | 5 articles | Viewed by 18127 | Submission Open

Keywords: cannabinoid; endocannabinoid; cannabinoid receptor; endogenous cannabinoid; pharmacological research

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Epigenetics of Mental Disorders

edited by

Claudio Brasso

submission deadline 30 Nov 2026 | 2 articles | Viewed by 18093 | Submission Open

Keywords: mental disorders; epigenetic; epigenomic; gene–environment interactions

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Studies in Aging, 2nd Edition

edited by

Rosa Mancinelli

submission deadline 30 Nov 2026 | 8 articles | Viewed by 17496 | Submission Open

Keywords: senescence; active aging; sarcopenia; osteoporosis; oxidative stress; brain aging; cardiovascular aging

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms Linked to Exercise

edited by

Igor Zubrzycki

submission deadline 30 Nov 2026 | 2 articles | Viewed by 16083 | Submission Open

Keywords: molecular mechanisms; exercise adaptations; translational health

(This special issue belongs to the Section Molecular Biology)

Natural Active Substances in Human Diseases

edited by

Hyeung-Jin Jang

submission deadline 30 Nov 2026 | 4 articles | Viewed by 15059 | Submission Open

Keywords: natural active substances; bioactive compounds; molecular mechanisms; traditional medicine; metabolic disorders; inflammatory diseases; neurodegenerative diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights in Biomarkers of Autoimmune and Autoinflammatory Diseases: 2nd Edition

edited by

Mariapaola Marino

submission deadline 30 Nov 2026 | 5 articles | Viewed by 14688 | Submission Open

Keywords: inflammaging; inflammasome; autoantibodies; free light chains; cytokines; receptor; signal transduction; innate immunity; adaptive immunity

(This special issue belongs to the Section Molecular Immunology)

Modulation of the Immune System and Oxidative Stress in Liver Illnesses

edited by

Vlad Pădureanu

and Dan Ionuț Gheonea

submission deadline 30 Nov 2026 | 2 articles | Viewed by 14658 | Submission Open

Keywords: oxidative stress; liver illnesses; immune system; inflammatory

(This special issue belongs to the Section Molecular Immunology)

Steatotic Liver Disease: From Bench to Bedside and Back

edited by

Federico Salomone

submission deadline 30 Nov 2026 | 2 articles | Viewed by 12220 | Submission Open

Keywords: MASLD; ALD; MetALD; fibrosis; hepatocellular carcinoma; molecular mechanisms; molecular markers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurogenesis and Neurodegeneration: Insights into Regeneration and the Impact of Neurotrophins

edited by

Eva Terzibasi Tozzini

submission deadline 30 Nov 2026 | 4 articles | Viewed by 11799 | Submission Open

Keywords: neurogenesis; neurodegeneration and regeneration; neurotrophins; brain plasticity

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Vitamin D in Human Health and Diseases, 5th Edition

edited by

Loredana Bergandi

and

Francesca Silvagno

submission deadline 30 Nov 2026 | 6 articles | Viewed by 11657 | Submission Open

Keywords: vitamin D; vitamin D receptor; calciferol; health; disease; inflammation; gene transcription; cell metabolism; differentiation; vitamin D deficiency; vitamin D supplementation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Multidrug Resistance in Cancer: Molecular Mechanisms and Therapeutic Challenges

edited by

Odília Queirós

and

Patrícia M. A. Silva

submission deadline 30 Nov 2026 | 3 articles | Viewed by 11386 | Submission Open

Keywords: cancer therapy; MultiDrug Resistance (MDR); Pgp; efflux pumps; tumor microenvironment; anticancer drug target; combination therapy; novel anticancer agents

(This special issue belongs to the Section Molecular Biology)

Neurological Diseases: From Physiology to Therapy

edited by

Vasileios Papaliagkas

submission deadline 30 Nov 2026 | 2 articles | Viewed by 11216 | Submission Open

Keywords: neurophysiology; genetics; Alzheimer’s disease; neurological diseases; neurodegenerative diseases

(This special issue belongs to the Section Molecular Neurobiology)

Functional Food Ingredients in Immunity Improvement

edited by

Prodromos Skenderidis

submission deadline 30 Nov 2026 | 1 articles | Viewed by 11146 | Submission Open

Keywords: functional food ingredients; bioactive compounds; health potentials; food processing and immunomodulation; green extraction techniques; molecular mechanisms; nutritional immunology; dietary intervention

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Focus on Endocrine and Metabolic Research Priorities in PCOS/PMOS

edited by

Jim Parker

submission deadline 30 Nov 2026 | 3 articles | Viewed by 11068 | Submission Open

Keywords: polycystic ovary syndrome; metabolism; insulin resistance; inflammation; hyperandrogenism

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Roles of Diet and Nutrition in Metabolic Diseases: Advancements in Molecular Insights

edited by Ramos-López Omar

submission deadline 30 Nov 2026 | 6 articles | Viewed by 10882 | Submission Open

Keywords: diet; nutrition; metabolic diseases; obesity; genetics; microbiota; epigenetics; metabolomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnosis and Treatment in Cardiovascular Diseases

edited by Calogera Pisano,

Carmela Rita Balistreri

and Giuseppe Raffa

submission deadline 30 Nov 2026 | 4 articles | Viewed by 10687 | Submission Open

Keywords: cardiac diseases; molecular diagnosis; aortopathy; aneurysm; dissection; heart failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

CRISPR/Cas Systems and Genome Editing—3rd Edition

edited by

Dmitry Karpov

submission deadline 30 Nov 2026 | 6 articles | Viewed by 9953 | Submission Open

Keywords: CRISPR/Cas; bacterial argonauts; transcription regulation; genome editing; genome editing tools

(This special issue belongs to the Section Molecular Genetics and Genomics)

Recent Advances in Urological Cancer

edited by Andrea Zivi and

Sara Merler

submission deadline 30 Nov 2026 | 1 articles | Viewed by 9389 | Submission Open

Keywords: genitourinary oncology; urologic surgery; urologic radiotherapy innovations; translational research; emerging therapies

(This special issue belongs to the Section Molecular Oncology)

Plant Physiology and Molecular Nutrition: 2nd Edition

edited by

Shu Yuan

and

Guijie Lei

submission deadline 30 Nov 2026 | 6 articles | Viewed by 9166 | Submission Open

Keywords: plant nutritional physiology; nutrient signaling; phytohormones; gene regulation network; environment and nutrition crosstalk

(This special issue belongs to the Section Molecular Plant Sciences)

Redox Homeostasis and Oxidative Stress in Human Metabolism and Disease: 3rd Edition

edited by

Jarosław Nuszkiewicz

and

Alina Woźniak

submission deadline 30 Nov 2026 | 6 articles | Viewed by 8705 | Submission Open

Keywords: oxidative stress; redox homeostasis; reactive oxygen species (ROS); redox signaling; antioxidants and defense mechanisms; metabolic regulation; inflammation and redox imbalance; mitochondrial dysfunction; biomarkers of oxidative stress; therapeutic redox modulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advanced Molecular Research in Cardiology and Treatment Approaches

edited by Ludger Hauck

submission deadline 30 Nov 2026 | 3 articles | Viewed by 8671 | Submission Open

Keywords: TAp63; EzH2; histone methyltransferase; cardiomyocyte proliferation; myocardial infarction; heart regeneration; heart repair; epigenetic regulation; cardiac regeneration; Skp2-p27KIP1 pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Insights into Glycobiology

edited by

Csaba Váradi

and

Cheorl-Ho Kim

submission deadline 30 Nov 2026 | 6 articles | Viewed by 8577 | Submission Open

Keywords: glycosylation; biomarkers; separation techniques; mass spectrometry; multivariate data analysis

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Mechanisms in Neuroinflammation Research

edited by

Robert P. Ostrowski

submission deadline 30 Nov 2026 | 3 articles | Viewed by 8346 | Submission Open

Keywords: non-coding RNA; nucleic acids; inflammatory cells; inflammatory mediators; neurotransmitters; neuroinflammation; immune cells; neurodegenerative diseases; cerebrovascular diseases; brain tumors

(This special issue belongs to the Section Molecular Neurobiology)

Emerging Plastic-Related Toxicity: From Environmental Exposure to Human Health

edited by

Antonietta Santoro

and

Marta Anna Szychlinska

submission deadline 30 Nov 2026 | 4 articles | Viewed by 7602 | Submission Open

Keywords: (bio)plastic- and (bio)polymer-related toxicity; microplastic and nanoplastic accumulation/degradation in mammals; cell cultures; human health; in vivo models; epigenetics effects; endocrine disruptor properties of bioplastics; plastics and inflammation; plastics in neurodegeneration and neuroinflammation; reproduction; cell metabolism; immunomodulation

(This special issue belongs to the Section Molecular Toxicology)

Displaying special issue 1001-1050 on page 21 of 63.

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