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Molecular Studies in Aging, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 2657

Special Issue Editor

Special Issue Information

Dear Colleagues,

The perspective regarding the lengthening of life raises the fundamental issue of aging in good health, with autonomy and independence, both for the quality of life and the containment of health care costs. This represents a challenge to maintaining efficient tissues, organs, and systems of the body.

Lifestyle and environmental factors play a preponderant role during the early stages of life, while genetics become fundamental to establish the complete life span of an organism.

Today, several approaches are used to both study and better understand the mechanisms underlying the aging processes, as well as to counteract and decelerate them. There are several tissues and systems that undergo aging, and among those most affected are the muscle, bone, nervous system, and cardiovascular system. The rationale of this Special Issue is essentially to collect new discoveries and study approaches on aging processes at the molecular, cellular, and integrative levels, as well as new proposals for the achievement of active aging (for example, mind training, physical activity, and diet).

We have already published 8 papers in Volume I. In Volume II, we invite researchers to provide original research articles and review articles regarding results in the field of the new frontiers that can contribute to the understanding of aging processes and the prospect of healthy old age.

Dr. Rosa Mancinelli
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • senescence
  • active aging
  • sarcopenia
  • osteoporosis
  • oxidative stress
  • brain aging
  • cardiovascular aging

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Published Papers (1 paper)

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Review

29 pages, 916 KiB  
Review
Multiomics of Aging and Aging-Related Diseases
by Olga I. Kiseleva, Viktoriia A. Arzumanian, Yuriy A. Ikhalaynen, Ilya Y. Kurbatov, Polina A. Kryukova and Ekaterina V. Poverennaya
Int. J. Mol. Sci. 2024, 25(24), 13671; https://doi.org/10.3390/ijms252413671 - 21 Dec 2024
Viewed by 2096
Abstract
Despite their astonishing biological diversity, surprisingly few shared traits connect all or nearly all living organisms. Aging, i.e., the progressive and irreversible decline in the function of multiple cells and tissues, is one of these fundamental features of all organisms, ranging from single-cell [...] Read more.
Despite their astonishing biological diversity, surprisingly few shared traits connect all or nearly all living organisms. Aging, i.e., the progressive and irreversible decline in the function of multiple cells and tissues, is one of these fundamental features of all organisms, ranging from single-cell creatures to complex animals, alongside variability, adaptation, growth, healing, reproducibility, mobility, and, finally, death. Age is a key determinant for many pathologies, shaping the risks of incidence, severity, and treatment outcomes for cancer, neurodegeneration, heart failure, sarcopenia, atherosclerosis, osteoporosis, and many other diseases. In this review, we aim to systematically investigate the age-related features of the development of several diseases through the lens of multiomics: from genome instability and somatic mutations to pathway alterations and dysregulated metabolism. Full article
(This article belongs to the Special Issue Molecular Studies in Aging, 2nd Edition)
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