Advances in Epigenetics of Mental Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 67
Special Issue Editor
Interests: schizophrenia; psychoses; neuroimaging; omic sicence
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The study of epigenetics has emerged as a critical frontier in our understanding of the intricate relationship between genes and the environment in the development and progression of mental disorders. Epigenetic processes, which regulate gene expression without altering the underlying DNA sequence, have been increasingly recognized as a key mechanism by which environmental factors can influence the risk and manifestation of conditions such as schizophrenia, bipolar disorder, major depressive disorder, and eating disorders.
Mounting evidence suggests that epigenetic modifications, driven by factors like nutrition, stress, and early-life experiences, can lead to long-lasting changes in brain function and behavior, ultimately contributing to the onset and trajectory of mental disorders. Whereas genetic studies have identified numerous risk loci associated with these conditions, the complex interplay between genes and environment remains incompletely understood. Studies on the epigenetics of mental disorders have the potential to elucidate novel pathways and targets for prevention and intervention, as epigenetic changes may be reversible or amenable to pharmacological modulation.
Potential topics include, but are not limited to:
- Epigenetic or epigenomic studies in patients with mental disorders;
- Epigenetic or epigenomic studies on animal or cellular models of mental disorders;
- Studies on the gene–environment interactions in mental disorders.
Dr. Claudio Brasso
Guest Editor
Manuscript Submission Information
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Keywords
- mental disorders
- epigenetic
- epigenomic
- gene–environment interactions
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