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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Research on Porous Polymers for Advanced Separation and Analytical Applications
edited by
submission deadline 20 Jan 2026 | Viewed by 161 | Submission Open
Keywords: microporous polymers; molecular imprinting; ion imprinting; separation; porous surfaces; spectroscopy; chromatography
(This special issue belongs to the Section Macromolecules)
Advances in Targeted Therapy and Immunotherapy for Lung Cancer
edited by
submission deadline 20 Jan 2026 | Viewed by 133 | Submission Open
Keywords: lung cancer; small-cell lung cancer; non-small-cell lung cancer; targeted therapy; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Cellulose and Its Applications, 2nd Edition
edited by and Ce Sun
submission deadline 20 Jan 2026 | Viewed by 132 | Submission Open
Keywords: cellulose; biomedical applications; nanocomposites; biodegradable polymers; water purification; nanocellulose
(This special issue belongs to the Section Macromolecules)
Pathogenesis and Molecular Therapy of Inflammatory Bowel Disease
edited by
submission deadline 20 Jan 2026 | Viewed by 126 | Submission Open
Keywords: intestinal epithelial barrier; gut microbiota; tight junctions; inflammatory bowel disease; mucosal immunity; autophagy; epithelial restitution; host– microbe interaction; barrier dysfunction; gastrointestinal inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapeutic Potential of Natural Compounds
edited by and Adrianna Sławińska-Brych
submission deadline 20 Jan 2026 | Viewed by 126 | Submission Open
Keywords: natural products; biological activity; bioactive compounds; mechanistic study; mechanism of action; drug discovery; pharmacological activity; synergism
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Tumor Progression and New Therapeutic Strategies for Urological Cancers, 3rd Edition submission deadline 20 Jan 2026 | Viewed by 86 | Submission Open
Keywords: prostate cancer; bladder cancer; renal cell carcinoma; upper urinary tract tumors; testicular cancer; predictive and prognostic biomarkers; tumor progression; novel treatment strategies; chemotherapy; immunotherapy; target therapies; drug resistance mechanisms; tumor microenvironment; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Colorectal Cancer—Emerging Trends and Treatment Strategies
edited by Victor Strambu
submission deadline 20 Jan 2026 | Viewed by 84 | Submission Open
Keywords: innovative therapies; colorectal cancer; new therapeutic approach; synchronous tumors
(This special issue belongs to the Section Molecular Oncology)
Mechanisms of Heavy Metal Toxicity: 3rd Edition
edited by
submission deadline 25 Jan 2026 | 9 articles | Viewed by 15291 | Submission Open
Keywords: heavy metal; metal compound; metallothionein; cellular defense mechanism; metal transporter
(This special issue belongs to the Section Molecular Toxicology)
Molecular Mechanisms of Hematologic Disorders
edited by
submission deadline 25 Jan 2026 | Viewed by 643 | Submission Open
Keywords: solid tumors; hematologic disorders; hematology; bone marrow failure; leukemia; myeloma
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cardiovascular Diseases: Molecular Mechanisms and Potential Therapy (2nd Edition)
edited by
submission deadline 25 Jan 2026 | Viewed by 371 | Submission Open
Keywords: cardiovascular diseases; pathogenic mechanisms; genetics; cardiomyopathy; myocardial infarction; cardiac fibrosis; pharmacogenomics; drug discovery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mitochondrial Dysfunction in Disease: Mechanisms, Biomarkers and Emerging Therapies submission deadline 25 Jan 2026 | Viewed by 203 | Submission Open
Keywords: mitochondria; bioenergetic homeostasis; calcium homeostasis; redox homeostasis; oxidative stress; biogenesis; mitophagy; dynamics
(This special issue belongs to the Section Biochemistry)
From Mechanisms to Medicine: Cellular Insights into Pulmonary Hypertension
edited by
submission deadline 25 Jan 2026 | Viewed by 137 | Submission Open
Keywords: vascular remodeling; cellular mechanisms; hypoxia; growth factors; inflammation
(This special issue belongs to the Section Molecular Biology)
New Advance in Polymers: Structuralization to Functionalization
edited by Wei Wu
submission deadline 25 Jan 2026 | Viewed by 124 | Submission Open
Keywords: polymer material; molecular weight; chain configuration; polymer chains; chemical groups
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms and Treatments Targeting Respiratory Diseases
edited by
submission deadline 26 Jan 2026 | 1 articles | Viewed by 783 | Submission Open
Keywords: respiratory diseases; respiratory infections; COPD; cystic fibrosis; lung tumor; therapy TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Antimicrobial Materials: Molecular Developments and Applications
edited by Florina Iliescu
submission deadline 27 Jan 2026 | 3 articles | Viewed by 3051 | Submission Open
Keywords: antimicrobial; polymers; nanotechnology; nanocomposites; molecular; green systems; POC; prophylaxis TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Materials Science)
Hematopoietic Stem Cells: Molecular Insights into Homeostasis, Disease, and Aging
edited by Yoshikazu Matsuoka
submission deadline 29 Jan 2026 | 1 articles | Viewed by 572 | Submission Open
Keywords: hematopoietic stem cells (HSCs); senescence; hematopoietic homeostasis; epigenetic drift; DNA damage responses; metabolic reprogramming; hematological disorders; inflammation; environmental stress
(This special issue belongs to the Section Molecular Biology)
Thyroid-Related Diseases: Molecular Pathology, Diagnosis and Treatment: 2nd Edition submission deadline 30 Jan 2026 | 6 articles | Viewed by 36252 | Submission Open
Keywords: thyroid disease; thyroid nodules; thyroid cancer; thyroid carcinoma; thyroid radiology; thyroid– gut axis; autoimmune thyroid disorders; thyroid hormone; molecular mechanisms; molecular tests
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
25th Anniversary of IJMS: Updates and Advances in Molecular Pathology, Diagnostics, and Therapeutics submission deadline 30 Jan 2026 | 31 articles | Viewed by 27213 | Submission Open
Keywords: molecular mechanisms of diseases; diagnostic approaches; therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Tomato Breeding and Molecular Research
edited by Silvana Grandillo, and
submission deadline 30 Jan 2026 | 7 articles | Viewed by 18002 | Submission Open
Keywords: tomato; natural and induced variation; genetics; genomics; omics; molecular breeding; physiology and development; fruit quality; biochemistry and metabolism; biotic and abiotic stresses
(This special issue belongs to the Section Molecular Plant Sciences)
Neuroinflammation and Neurodegeneration: Molecular Mechanism and Novel Therapy
edited by
submission deadline 30 Jan 2026 | 5 articles | Viewed by 16489 | Submission Open
Keywords: neuroinflammation; neurodegeneration; neuroimmunology; toxic protein aggregates; autolysosomal dysfunction; metabolic defects; aberrant receptor signaling; neuron-glia interactions; glia-immune interactions; omics characterizations; therapeutic development; biomarker discovery
(This special issue belongs to the Section Molecular Neurobiology)
Dopamine, Histamine, Serotonin—Receptors, Ligands and Their Biological Role in Central Nervous System Diseases, 2nd Edition submission deadline 30 Jan 2026 | 4 articles | Viewed by 16300 | Submission Open
Keywords: biogenic amines (histamine; dopamine; serotonin); receptors; ligands; antagonist/inverse agonist; affinity; intrinsic activity; multitarget ligands; molecular modeling; CNS diseases; neurodegeneration; psychiatric disorders; pain; in vitro studies; in silico studies; in vivo studies
(This special issue belongs to the Section Molecular Neurobiology)
Genetic and Epigenetic Influences on Personality Traits and Athletic Performance submission deadline 30 Jan 2026 | 2 articles | Viewed by 15848 | Submission Open
Keywords: genetics; epigenetics; personality traits; athletic performance; polymorphisms; microbiome; neurotransmitters; molecular mechanisms; metabolic health; injury susceptibility
(This special issue belongs to the Section Molecular Genetics and Genomics)
Versatility of Protein Synthesis in a Test Tube
edited by
submission deadline 30 Jan 2026 | 5 articles | Viewed by 14744 | Submission Open
Keywords: protein synthesis; synthetic biology; cell-free translation; in vitro translation
(This special issue belongs to the Section Molecular Biology)
Microbial Enzymes for Biotechnological Applications: 2nd Edition
edited by
submission deadline 30 Jan 2026 | 4 articles | Viewed by 14179 | Submission Open
Keywords: microbial enzymes; whole-cell biocatalysts; extremozyme; enzyme assays; protein engineering
(This special issue belongs to the Section Biochemistry)
The Use of Molecular Markers in Forensic Field as an Element of Scientific Evidence submission deadline 30 Jan 2026 | 3 articles | Viewed by 13753 | Submission Open
Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro; in vivo; and in silico models; hypoxic– ischemic brain injury; pregnancy biomarkers; vitality
(This special issue belongs to the Section Molecular Biology)
The Molecular Basis of Vascular Pathology submission deadline 30 Jan 2026 | 6 articles | Viewed by 12978 | Submission Open
Keywords: vascular pathologies; blood vessels; dysfunction; vascular damage; blood flow; biomarkers; biomolecules; cytokines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Precision Medicine: Unraveling Novel Mechanisms and Delivery Strategies in Complex Diseases
edited by
submission deadline 30 Jan 2026 | 4 articles | Viewed by 10748 | Submission Open
Keywords: molecular precision therapeutics; disease biomarkers; novel therapeutic molecules; drug delivery strategies; personalized medicine; bioinformatics; nanotechnology; synthetic biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Molecular Research on Cancer Treatments: Apoptosis, Autophagy, and Drug Selection
edited by
submission deadline 30 Jan 2026 | 4 articles | Viewed by 10632 | Submission Open
Keywords: autophagy; apoptosis; bioactive natural products; nanoparticles and drug delivery; cancer immunotherapy; in silico and network pharmacology; bioinformatics
(This special issue belongs to the Section Molecular Oncology)
Molecular Advances in Liposome-Based Drug Delivery Systems
edited by
submission deadline 30 Jan 2026 | 4 articles | Viewed by 10373 | Submission Open
Keywords: liposomes; targeted delivery; controlled release; nanotechnology; drug delivery; diagnostics; therapeutics; multifunctional liposomes; phospholipids
(This special issue belongs to the Section Molecular Pharmacology)
Programmed Cell Death and Oxidative Stress: 3rd Edition
edited by
submission deadline 30 Jan 2026 | 9 articles | Viewed by 9640 | Submission Open
Keywords: oxidative stress; programmed cell death; cellular stresses; senescence; cytotoxicity; cancer; neurodegenerative disease; inflammatory disease; organelle stress
(This special issue belongs to the Section Biochemistry)
New Trends in Biologically Active Compounds in Age-Related Diseases
edited by Celia Andrés Juan
submission deadline 30 Jan 2026 | 3 articles | Viewed by 8567 | Submission Open
Keywords: age-related diseases; oxidative stress and inflammation; energy failure; mitochondrial dysfunction; deregulated autophagy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Role of Glia in Human Health and Disease
edited by and
submission deadline 30 Jan 2026 | 7 articles | Viewed by 7914 | Submission Open
Keywords: astrocytes; microglia; oligodendrocytes; Schwann cells; neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Engineering in Dental Restorative and Regenerative Materials
edited by
submission deadline 30 Jan 2026 | 5 articles | Viewed by 7554 | Submission Open
Keywords: dental composites; ceramics; additive manufacturing; dental adhesives; bioactive; 3D printing; photopolymerization; curing devices; microstructure; degree of conversion; bulk-fill composites; lasers in dentistry; infrared spectroscopy; biocompatibility; bone regeneration; osseointegration; soft tissue regeneration
(This special issue belongs to the Section Materials Science)
High Fat Diet Metabolism and Diseases submission deadline 30 Jan 2026 | 6 articles | Viewed by 7521 | Submission Open
Keywords: diet; fat; high-fat diets; obesity; NAFLD; metabolism; reproductive system; lungs; pathology
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Mechanisms of Zinc Finger Proteins in Biological Processes and Diseases
edited by and Patrizia Gazzerro
submission deadline 30 Jan 2026 | 4 articles | Viewed by 7515 | Submission Open
Keywords: zinc finger domain; CTCF; PRDM family; nuclear receptors; human diseases; transcriptional regulation; epigenetic modifications
(This special issue belongs to the Section Molecular Biophysics)
Advances in Antimicrobial Nanomaterials 2.0
edited by
submission deadline 30 Jan 2026 | 3 articles | Viewed by 7514 | Submission Open
Keywords: metallic nanoparticles; bimetallic nanoparticles; antimicrobial activity; polymeric nanomaterials; nanoplatforms; nanoparticle functionalization; delivery of antimicrobial agents
(This special issue belongs to the Section Molecular Nanoscience)
New Molecular Aspects of Colorectal Cancer
edited by
submission deadline 30 Jan 2026 | 3 articles | Viewed by 7184 | Submission Open
Keywords: colorectal adenocarcinoma; cancer pathobiology; molecular biomarkers; diagnosis and prognosis; prediction of therapy selection; therapeutic targets; RNA molecules; microRNA; long non-coding RNA; circular RNA
(This special issue belongs to the Section Molecular Oncology)
Advances in Burn Wound Healing and Skin Regeneration: Innovations and Insights
edited by
submission deadline 30 Jan 2026 | 2 articles | Viewed by 6856 | Submission Open
Keywords: burn wound healing; skin regeneration; novel biomaterials; wound dressings; regenerative therapies
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms and Regulation in Blood-Brain Barrier
edited by Rajkumar Vutukuri
submission deadline 30 Jan 2026 | 1 articles | Viewed by 6755 | Submission Open
Keywords: blood brain barrier (BBB); tight junctions; NVU cell types; neurodegenerative diseases; neuro-inflammation
(This special issue belongs to the Section Molecular Neurobiology)
The Role of the IGF Axis in Disease, 4th Edition
edited by Claire M. Perks
submission deadline 30 Jan 2026 | 3 articles | Viewed by 6716 | Submission Open
Keywords: IGF axis; cancer; obesity; hallmarks of cancer
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Advances in Combinatorial Therapies for Spinal Cord Injury
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 6642 | Submission Open
Keywords: molecular; cellular; engineering; spinal cord injury
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease
edited by David Rohde
submission deadline 30 Jan 2026 | 5 articles | Viewed by 5839 | Submission Open
Keywords: myocardial infarction; heart failure; atherosclerosis; arterial hypertension; myocarditis; arrhythmia; inflammation; hematopoiesis; myelopoiesis; tissue macrophages; neutrophil biology; lymphocytes; endothelial cells; megakaryocytes; platelet biology; biomarkers
(This special issue belongs to the Section Molecular Immunology)
Novel Treatment Strategies for Head and Neck Cancer
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 5826 | Submission Open
Keywords: head and neck cancer; drug resistance; cancer initiation; biomarker
(This special issue belongs to the Section Molecular Oncology)
Advances in Photobiomodulation Therapy
edited by Maria Fernanda Setúbal Destro Rodrigues
submission deadline 30 Jan 2026 | 3 articles | Viewed by 5719 | Submission Open
Keywords: photobiomodulation; dosimetric parameters; human diseases; modulation of inflammation; photobiomodulation therapy; molecular mechanisms; preclinical and clinical studies; therapeutic applications of PBM
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Retinal Diseases: From Molecular Pathology to Therapies—2nd Edition
edited by
submission deadline 30 Jan 2026 | 3 articles | Viewed by 5718 | Submission Open
Keywords: diabetic retinopathy; age-related macular degeneration; neuroprotection; retina; diabetic macular edema; therapy development; pathophysiology; retinitis pigmentosa; aging; eye trauma; vitreous; macula; choroideremia; stargardt disease; cone– rod dystrophy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Toxic Liver Injury: Molecular, Mechanistic, and Medical Challenges 3.0
edited by
submission deadline 30 Jan 2026 | 3 articles | Viewed by 5623 | Submission Open
Keywords: liver injury; nonalcoholic fatty liver disease; nonalcoholic steatonecrosis; nonalcoholic liver cirrhosis; hepatocellular carcinoma
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Food Science and Molecular Nutrition
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 5251 | Submission Open
Keywords: food science; antioxidants; bioactive compounds; mitochondria; nutrigenomics; metabolomics
(This special issue belongs to the Section Biochemistry)
From Kidney Disease to Hypertension: Molecular Basis and Pathophysiology
edited by
submission deadline 30 Jan 2026 | 3 articles | Viewed by 5058 | Submission Open
Keywords: renin-angiotensin-aldosterone system; endothelial cell dysfunction; systemic inflammation; hypertension; oxidative stress; vascular remodeling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Studies of Age-Related Diseases: Immunosenescence and Inflammaging
edited by
submission deadline 30 Jan 2026 | 2 articles | Viewed by 4780 | Submission Open
Keywords: aging; age-related; immunosenescence; immune system; inflammaging
(This special issue belongs to the Section Molecular Immunology)
Molecular Aspects of Forensic Toxicology
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 4774 | Submission Open
Keywords: forensic toxicology; molecular mechanism; toxicological biomarkers; post-mortem interval; in vitro; in vivo; and in silico models; new psychoactive substances (NPSs); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-tandem mass spectrometry (GC-MS/MS)
(This special issue belongs to the Section Molecular Toxicology)
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