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Cardiovascular Diseases: Molecular Mechanisms and Potential Therapy (2nd Edition)

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 25 January 2026 | Viewed by 614

Special Issue Editor


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Guest Editor
1. Institute of Molecular and Translational Cardiology of IRCCS Policlinico San Donato, San Donato Milanese, Italy
2. New Drug Incubator, Italfarmaco SpA, Milan, Italy
Interests: cardiovascular diseases; biomarker discovery; biochemistry; brugada syndrome; Ischemia and reperfusion injury; sphingolipids
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Special Issue Information

Dear Colleagues,

Cardiovascular diseases (CVDs) are a leading cause of death and disability worldwide. They are a group of conditions that affect the heart and blood vessels, including coronary artery disease, heart failure, and stroke. The pathogenic mechanism of CVDs is complex and multifactorial, involving a combination of genetic, environmental, and lifestyle factors.

Studying the pathogenic mechanism of CVDs is crucial for developing effective prevention and treatment strategies. Understanding the underlying causes of CVDs can lead to the identification of new therapeutic targets and the development of novel drugs. Additionally, knowledge of the pathogenic mechanism can inform the development of targeted prevention and early detection programs, which can reduce the burden of CVDs on individuals and society.

Research on the pathogenic mechanism of CVDs has made significant progress in recent years, with the identification of novel risk factors and the discovery of new genetic and molecular mechanisms. However, much remains to be understood, and ongoing research is needed to further our understanding of the underlying causes of CVDs.

This Special Issue will gather articles on the research advancement in CVDs in terms of pathogenic mechanism, genetic association, and novel therapeutical approach.

Dr. Andrea Ghiroldi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular diseases
  • pathogenic mechanisms
  • genetics
  • cardiomyopathy
  • myocardial infarction
  • cardiac fibrosis
  • pharmacogenomics
  • drug discovery

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Published Papers (1 paper)

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Review

41 pages, 5516 KB  
Review
Therapeutic Potential of the β3-Adrenergic Receptor and Its Ligands in Cardiovascular Diseases
by Marcel Kempiński, Paweł Jańczak, Adrianna Porębska, Patrycja Sandra Zawadzka, Paulina Jastrzębska, Marcin Mateusz Granat and Małgorzata Wojciechowska
Int. J. Mol. Sci. 2025, 26(24), 11844; https://doi.org/10.3390/ijms262411844 - 8 Dec 2025
Viewed by 198
Abstract
The β3-adrenergic receptor is an exceptional member of the β-adrenergic receptor family. Recent findings suggest that it may play a more significant role in the cardiovascular system than previously recognized, partly through its potential anti-inflammatory actions. For this reason, it has been extensively [...] Read more.
The β3-adrenergic receptor is an exceptional member of the β-adrenergic receptor family. Recent findings suggest that it may play a more significant role in the cardiovascular system than previously recognized, partly through its potential anti-inflammatory actions. For this reason, it has been extensively studied as a potential target in cardiovascular therapy. In this review, we focus on the β3 receptor agonists and their pharmacodynamics regarding receptor binding and activation. We then describe the mechanisms of action mediated by the β3-adrenergic receptor in blood vessels and in the heart under both physiological and pathological conditions. We particularly concentrate on the therapeutic potential in the arterial, pulmonary, and portal hypertension as well as cardiac arrhythmias, ischemia, and heart failure, considering both receptor agonism and antagonism. Full article
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