Mitochondrial Dysfunction in Disease: Mechanisms, Biomarkers and Emerging Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 25 January 2026 | Viewed by 25
Special Issue Editor
Interests: mitochondrial function; redox homeostasis; calcium homeostasis; oxidative stress; planarian; metabolic diseases
Special Issue Information
Dear Colleagues,
Mitochondria are responsible for critical functions in the maintenance of cellular homeostasis. These organelles supply most of the ATP required for cell physiology, collaborate with the endoplasmic reticulum in maintaining low and controlled cytosolic calcium levels, and regulate redox homeostasis by generating and scavenging reactive oxygen species. Mitochondria are also involved in apoptosis, immune regulation, and metabolic reprogramming. A sophisticated regulatory network involving mitochondrial biogenesis, mitophagy, and dynamics plays a significant role in preserving the stability of mitochondrial structure and function. Therefore, damage to enzyme activities, protein functions, or mitochondrial quality control processes can produce dysfunctional mitochondria, possibly resulting in catastrophic events that disrupt bioenergetics, calcium, or redox homeostasis, ultimately leading to cell death.
A substantial body of evidence in recent decades has demonstrated that dysfunctional mitochondria contribute to numerous pathological processes involving a variety of tissues. Moreover, recent studies have targeted improvements in mitochondrial function as a potential therapeutic approach, opening new avenues for the treatment of mitochondrion-related diseases in the future.
We invite the submission of high-quality research and review articles to this Special Issue, which will synthesize current knowledge concerning the role of mitochondria in disease and novel therapies to restore mitochondrial function. Submissions may include both in vitro and in vivo studies using various experimental approaches, such as cellular and animal disease models. Clinical research is also welcome.
We look forward to receiving your contributions.
Dr. Alexandre Umpierrez Amaral
Guest Editor
Manuscript Submission Information
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Keywords
- mitochondria
- bioenergetic homeostasis
- calcium homeostasis
- redox homeostasis
- oxidative stress
- biogenesis
- mitophagy
- dynamics
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