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Molecular Research on Porous Polymers for Advanced Separation and Analytical Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 760

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Department of Synthesis and Characterization of Polymers, Polymer Institute of Slovak Academy of Sciences, 841 45 Bratislava, Slovakia
Interests: polymerisation; analysis of polymers; microplastics; chromatography; physical chemistry
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Special Issue Information

Dear Colleagues,

The simultaneous development of polymer chemistry methods and analytical methods represents new opportunities for the design, synthesis, and application of porous polymers. Currently, new challenges are emerging in some fields. Separation technology is continuously developing not only because of the need for sustainable filtration and purification techniques but also in terms of the separation of metals, gases, or organic chemicals and the application of recycling and green chemistry approaches. Porous polymers could play a role in this. No less important an application is the possibility of using specific porosities in analytical tools for the selective recognition or pre-concentration of trace analytes. This Special Issue focuses on the synthesis, application, and analysis of (micro)porous polymers and related systems. We welcome the submission of original research papers and review articles to this Special Issue.

Dr. Dmitrij Bondarev
Guest Editor

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Keywords

  • microporous polymers
  • molecular imprinting
  • ion imprinting
  • separation
  • porous surfaces
  • spectroscopy
  • chromatography

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Published Papers (1 paper)

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Research

13 pages, 1232 KB  
Article
Ultra-Sensitive Bioanalytical Separations Using a New 4-Tritylphenyl Methacrylate-Based Monolithic Nano-Column with an Inner Diameter of 20 µm for Nano-LC
by Cemil Aydoğan
Int. J. Mol. Sci. 2026, 27(1), 224; https://doi.org/10.3390/ijms27010224 - 25 Dec 2025
Viewed by 465
Abstract
Low-flow liquid chromatography has become the primary tool for advanced chromatographic analysis and is an indispensable technique for the sensitive detection of biomolecules. In this study, we developed a new 4-tritylphenyl methacrylate-based monolithic nano-column with an internal diameter of 20 µm for bioanalytical [...] Read more.
Low-flow liquid chromatography has become the primary tool for advanced chromatographic analysis and is an indispensable technique for the sensitive detection of biomolecules. In this study, we developed a new 4-tritylphenyl methacrylate-based monolithic nano-column with an internal diameter of 20 µm for bioanalytical separations in nano-liquid chromatography (nano-LC). The composition of the monolith was optimized with regard to the monomer and porogenic solvent. The column was characterized using Fourier Transformed Infrared Spectroscopy (FT-IR) spectroscopy, scanning electron microscopy (SEM) and chromatographic analyses. Chromatographic characterization was performed using homologous alkylbenzenes (ABs) and polyaromatic hydrocarbons (PAHs), which facilitate hydrophobic and π–π interactions. Run-to-run and column-to-column reproducibility values were found to be <2.51% and 2.4–3.2%, respectively. The final monolith was then used to separate six standard proteins, including β-lactoglobulin A, carbonic anhydrase, ribonuclease A (RNase A), α-chymotrypsinogen (α-chym), lysozyme (Lys), cytochrome C (Cyt C) and myoglobin (Myo), as well as three dipeptides: Alanine-tyrosine (Ala-Tyr), Glycine-phenylalanine (Gly-Phe) and L-carnosine. The nano-column was then applied to profiling peptides and proteins in the MCF-7 cell line, enabling high-resolution peptide analysis. Full article
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