Pathogenesis and Molecular Therapy of Inflammatory Bowel Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 January 2026 | Viewed by 15
Special Issue Editor
Interests: gut microbiome; gut barrier function; inflammatory bowel disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The intestinal epithelium plays a central role in maintaining gut homeostasis by serving as a physical and immunological barrier between the host and its luminal environment, including the microbiota. Disruption of epithelial integrity and impaired barrier function are hallmarks of various gastrointestinal diseases, including inflammatory bowel disease (IBD), infectious colitis, and colorectal cancer. Recent advances have highlighted the complex interplay between epithelial cells, immune mediators, and microbial signals in shaping mucosal responses and driving pathophysiology.
This Special Issue aims to bring together original research and comprehensive reviews that advance our understanding of epithelial biology, barrier regulation, and host–microbe interactions in the gut. We welcome studies focusing on molecular mechanisms of tight junction regulation, epithelial restitution, autophagy, mucosal immunity, microbiota-mediated modulation of epithelial functions, and novel therapeutic targets aimed at restoring barrier integrity. By integrating multidisciplinary insights, this Issue will provide a timely platform for researchers exploring the dynamic epithelial interface and its role in gastrointestinal health and diseases.
Dr. Anoop Kumar
Guest Editor
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Keywords
- intestinal epithelial barrier
- gut microbiota
- tight junctions
- inflammatory bowel disease
- mucosal immunity
- autophagy
- epithelial restitution
- host–microbe interaction
- barrier dysfunction
- gastrointestinal inflammation
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