Neuroinflammation and Neurodegeneration: Molecular Mechanism and Novel Therapy

Dear Colleagues,

Neuroinflammation and neuronal cell death are hallmarks of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. While some of these neurological disorders are associated with the accumulation of toxic protein aggregates, including tau, β-amyloid, and α-synuclein, others are related to chronic inflammation and dysregulated immune cell functions. Impairments in lysosomal, autophagic, and mitochondrial functions have also been shown to play major roles in further promoting the accumulation of toxic protein aggregates, while the crosstalk of different organelles remains to be investigated. On the other hand, aberrant receptor signaling is detrimental to neurons and glial cells as it can trigger various types of cell death. Besides understanding the pathogenic molecular pathways, it is also important to elucidate cellular phenotypes and cell–cell interactions in these diseases, including neuron–glia and glia–immune interactions, especially through omics characterizations. Together, these molecular mechanisms will provide insights into novel therapeutic developments and biomarker discovery for translational neuroscience applications. We invite authors to submit original articles and review articles highlighting the latest advances in probing molecular mechanisms and developing novel therapies for neuroinflammation and neurodegeneration.

Dr. Chih Hung Lo
Guest Editor

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