Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.1
4.9
Journals
IJMS
Special Issues
Molecular Advances in Liposome-Based Drug Delivery Systems
ijms-logo
Submit to Special Issue Submit Abstract to Special Issue Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Molecular Advances in Liposome-Based Drug Delivery Systems

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 3038

Special Issue Editor

Dr. Shao-Ling Huang

E-Mail Website
Guest Editor
Division of Cardiology, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Interests: lipid membrane biochemistry; liposomal design; cell biology; molecular biology

Special Issue Information

Dear Colleagues,

This Special Issue, entitled “Molecular Advances in Liposome-Based Drug Delivery Systems”, delves into cutting-edge developments in the application of liposomes at the molecular level. It explores innovative methodologies, intricate mechanisms, and groundbreaking advancements in liposomal formulation design and synthesis, targeted delivery, controlled release, nanotechnology integration, and their translational potential for therapeutic and diagnostic applications.

This Special Issue also covers trends and future directions in the field, including the development of multifunctional and stimuli-responsive liposomes and personalized medicine approaches.

Serving as a valuable resource for researchers, clinicians, and industry professionals, this Special Issue provides a detailed understanding of the molecular underpinnings of liposome-based drug delivery systems and their transformative potential in medicine.

This special issue is supervised by Dr. Shao-Ling Huang and assisted by our Topical Advisory Panel Member Dr. Vicente Domínguez-Arca (Universidad de Santiago de Compostela).

Dr. Shao-Ling Huang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liposomes
  • targeted delivery
  • controlled release
  • nanotechnology
  • drug delivery
  • diagnostics
  • therapeutics
  • multifunctional liposomes
  • phospholipids

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

21 pages, 3750 KiB  
Article
Exploring Nano-Delivery Systems to Enhance the Edaravone Performance in Amyotrophic Lateral Sclerosis Treatment
by Brandon Aguiar, Ana Rita Alfenim, Cláudia Sofia Machado, Joana Moreira, Miguel Pinto, Francisco J. Otero-Espinar, Fernanda Borges and Carlos Fernandes
Int. J. Mol. Sci. 2025, 26(5), 2146; https://doi.org/10.3390/ijms26052146 - 27 Feb 2025
Viewed by 605
Abstract
Edaravone is one of the treatment options for Amyotrophic Lateral Sclerosis, but its therapeutic efficacy is limited due to the incapacity to cross the blood–brain barrier, as well as its short life span and poor stability, which is ultimately caused by its tautomerism [...] Read more.
Edaravone is one of the treatment options for Amyotrophic Lateral Sclerosis, but its therapeutic efficacy is limited due to the incapacity to cross the blood–brain barrier, as well as its short life span and poor stability, which is ultimately caused by its tautomerism in physiological condions. This work presents an overview about the use of several nanoformulations based on polymeric, protein, lipidic, or hybrid structure as suitable and stable drug delivery systems for encapsulating edaravone. We also evaluated the functionalization of nanoparticles with pegylated chains using the polyethylene glycol or tocopherol polyethylene glycol succinate and the possibility of preparing polymeric nanoparticles at different pH (7.4, 9, and 11). Edaravone was sucessfully encapsulated in polymeric, lipid–polymer hybrid, and lipidic nanoparticles. The use of higher pH values in the synthesis of polymeric nanoparticles has led to a decrease in nanoparticle size and an increase in the percentage of encapsulation efficiency. However, the resulting nanoformulations are not stable. Only polymeric and hybrid nanoparticles showed good stability over 80 days of storage, mainly at 4 °C. Overall, the nanoformulations tested did not show cytotoxicity in the SH-SY5Y cell line except the nanostructured lipid carrier formulations that showed some cytotoxicity possibly due to lipidic peroxidation. In conclusion, this work shows that edaravone can be encapsulated in different nanocarriers that could act as an interesting alternative for the treatment of Amyotrophic Lateral Sclerosis. Full article
(This article belongs to the Special Issue Molecular Advances in Liposome-Based Drug Delivery Systems)
►▼ Show Figures

Figure 1

Review

Jump to: Research

15 pages, 1130 KiB  
Review
Phospholipid-Based Vesicular Systems as Carriers for the Delivery of Active Cosmeceutical Ingredients
by Marko Lens
Int. J. Mol. Sci. 2025, 26(6), 2484; https://doi.org/10.3390/ijms26062484 - 11 Mar 2025
Cited by 1 | Viewed by 662
Abstract
Cosmeceuticals are cosmetic products containing biologically active ingredients claiming to have drug-like benefits. In recent years, there has been a growing global demand for cosmeceuticals focusing on visible improvement of skin appearance and health. However, modern consumers are increasingly more concerned about the [...] Read more.
Cosmeceuticals are cosmetic products containing biologically active ingredients claiming to have drug-like benefits. In recent years, there has been a growing global demand for cosmeceuticals focusing on visible improvement of skin appearance and health. However, modern consumers are increasingly more concerned about the performance and clinical efficacy of cosmetic formulations. One of the main disadvantages of cosmeceutical preparations is the poor transdermal delivery of active ingredients included in the formulation. In response to this challenge, many phospholipid-based nanovesicular delivery systems have been developed and tested in recent years to increase the skin penetration of active cosmetic molecules. This review provides a comprehensive overview of current knowledge in the research and development of liposomal encapsulation used as delivery system in skincare and cosmeceutical products. Full article
(This article belongs to the Special Issue Molecular Advances in Liposome-Based Drug Delivery Systems)
►▼ Show Figures

Figure 1

27 pages, 5078 KiB  
Review
Boosting Lipofection Efficiency Through Enhanced Membrane Fusion Mechanisms
by Rais V. Pavlov, Sergey A. Akimov, Erdem B. Dashinimaev and Pavel V. Bashkirov
Int. J. Mol. Sci. 2024, 25(24), 13540; https://doi.org/10.3390/ijms252413540 - 18 Dec 2024
Viewed by 1377
Abstract
Gene transfection is a fundamental technique in the fields of biological research and therapeutic innovation. Due to their biocompatibility and membrane-mimetic properties, lipid vectors serve as essential tools in transfection. The successful delivery of genetic material into the cytoplasm is contingent upon the [...] Read more.
Gene transfection is a fundamental technique in the fields of biological research and therapeutic innovation. Due to their biocompatibility and membrane-mimetic properties, lipid vectors serve as essential tools in transfection. The successful delivery of genetic material into the cytoplasm is contingent upon the fusion of the vector and cellular membranes, which enables hydrophilic polynucleic acids to traverse the hydrophobic barriers of two intervening membranes. This review examines the critical role of membrane fusion in lipofection efficiency, with a particular focus on the molecular mechanisms that govern lipoplex–membrane interactions. This analysis will examine the key challenges inherent to the fusion process, from achieving initial membrane proximity to facilitating final content release through membrane remodeling. In contrast to viral vectors, which utilize specialized fusion proteins, lipid vectors necessitate a strategic formulation and environmental optimization to enhance their fusogenicity. This review discusses recent advances in vector design and fusion-promoting strategies, emphasizing their potential to improve gene delivery yield. It highlights the importance of understanding lipoplex–membrane fusion mechanisms for developing next-generation delivery systems and emphasizes the need for continued fundamental research to advance lipid-mediated transfection technology. Full article
(This article belongs to the Special Issue Molecular Advances in Liposome-Based Drug Delivery Systems)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop