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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular and Molecular Biology of Cardiac Hypertrophy and Heart Failure: Pathogenesis, Diagnostics and Treatment—2nd Edition

edited by

Morris Karmazyn

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4610 | Submission Open

Keywords: cardiac hypertrophy; myocardial remodelling; heart failure; cellular mechanisms; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanistic Insights into Pharmacological and Non-Pharmacological Pain Therapies: From Cellular Responses to Therapy Outcomes

edited by

Sungtae Koo

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4586 | Submission Open

Keywords: neuromodulation; neural plasticity; glial activation; endogenous pain modulation; neuroinflammation; therapeutic mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Pathology and Next-Generation Biomarkers in Nephrology

edited by

Marijn Speeckaert

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4545 | Submission Open

Keywords: nephrology; genetic mutations; epigenetics; next-generation biomarkers; proteomics; metabolomics; single-cell sequencing; spatial transcriptomics; liquid biopsy; cfDNA; exosomes; microRNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bridging Molecules and Reactions: Next-Generation Approaches for Advancing Electrocatalytic Efficiency

edited by

Abu Talha Aqueel Ahmed

submission deadline 30 Nov 2026 | 1 articles | Viewed by 4517 | Submission Open

Keywords: electrochemical nanomaterials; energy storage and conversion; electrocatalysis and reaction mechanisms; photoelectrochemical water splitting; electrochemical energy storage devices; nanocomposites and functionalized materials; molecular-level electrocatalysis; electrocatalyst and photocatalysts; in-situ spectroscopy and atomistic modeling; hybrid molecular–nanostructured systems; sustainable and natural resource–derived materials; DFT related to reaction kinetics; AOP

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Research on Crop Quality

edited by

Jinsong Bao

submission deadline 30 Nov 2026 | 5 articles | Viewed by 4223 | Submission Open

Keywords: crop quality; molecular breeding; multi-omics; gene editing; precision agriculture; functional genomics; rice; wheat; maize; barley; sorghum; millet; potato; cotton; molecular markers; genome-wide association studies; genome editing; genome selection; molecular selection; transcriptomics; omics; post-translational regulation; starch; protein; lipids; vitamin; processing quality; eating quality

(This special issue belongs to the Section Molecular Plant Sciences)

Hemolytic Anemia: From Molecular Mechanisms to Therapeutic Exploitation

edited by Joan-Lluis Vives-Corrons

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4149 | Submission Open

Keywords: hemolytic anemias; red blood cells; sickle cell disease; targeted therapies; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Ataxia

edited by

Jose Miguel Laffita-Mesa

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4135 | Submission Open

Keywords: ataxia; molecular mechanisms; repeat expansion disorders; gene discovery; biomarkers; RNA biology; protein aggregation; epigenetics; gene therapy; neurodegeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Application of Germplasm Innovation Technology in Aquatic Genetic Breeding

edited by

Hui Qiao

submission deadline 30 Nov 2026 | 4 articles | Viewed by 4112 | Submission Open

Keywords: aquaculture; biotechnology; germplasm improvement; genetic breeding; gene function; genomics; gene editing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genomic, Transcriptomic, and Epigenetic Approaches in Fish Research

edited by

Feng Liu

submission deadline 30 Nov 2026 | 6 articles | Viewed by 4103 | Submission Open

Keywords: fish biology; omics technologies; genomics and transcriptomics; environmental adaptation; aquaculture traits

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Environmental Stress-Induced Human Diseases

edited by

Silvia Cantara

submission deadline 30 Nov 2026 | 1 articles | Viewed by 3965 | Submission Open

Keywords: environmental stress; oxidative stress; inflammation; epigenetic modifications; DNA damage and repair; cellular signaling pathways; mitochondrial dysfunction; autophagy; air pollution; heavy metal toxicity; endocrine disruptors; climate change and health; neurodegeneration; cancer biology; immune system dysregulation; gene–environment interactions; biomarkers of exposure and disease; systems biology; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Viral Vector-Mediated Genome Editing Therapy

edited by

Izumu Saito

submission deadline 30 Nov 2026 | 1 articles | Viewed by 3897 | Submission Open

Keywords: CRISPR; genome editing; base editing; AAV vector; adenovirus vector; lentivirus vector; viral vectors; inherited disease; genetic disorders

(This special issue belongs to the Section Molecular Genetics and Genomics)

Environmental Influences on Cellular Responses

edited by

Marcus Krüger

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3857 | Submission Open

Keywords: cell/environment interaction; cell signaling; mechanobiology; photobiology; thermobiology; enviromics; cell-cell communication; cell-cell interaction

(This special issue belongs to the Section Molecular Biology)

Artificial Intelligence, Multi-Omics, and Molecular Modelling in Modern Drug Discovery

edited by

Shaban Ahmad

submission deadline 30 Nov 2026 | Viewed by 3851 | Submission Open

Keywords: artificial intelligence (AI); machine learning; multi-omics integration; molecular modelling; computational drug discovery; virtual screening; generative AI; explainable AI (XAI); ADMET prediction; pharmacogenomics; systems biology

(This special issue belongs to the Section Molecular Pharmacology)

Unraveling Neuroimmune Disorders: From Pathogenic Pathways to Biomarker-Driven Precision Medicine

edited by

Mariapaola Marino

submission deadline 30 Nov 2026 | 4 articles | Viewed by 3811 | Submission Open

Keywords: innate immunity; adaptive immunity; inflammation; autoantibodies; peptides; cytokines; receptors; leukocytes; extracellular vesicles; signal transduction; apoptosis

(This special issue belongs to the Section Molecular Immunology)

New Perspectives in Cardiovascular Disease: From Molecular Mechanisms to Clinical Innovations

edited by

Yunglung Chen

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3648 | Submission Open

Keywords: cardiovascular disease; molecular mechanisms; biomarkers; atrial fibrillation; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Latest Molecular Research on Renal Disease

edited by Niels Henrik Buus and Marco Eijken

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3483 | Submission Open

Keywords: renal disease; chronic kidney disease; renal regeneration; kidney injury

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Plant Breeding

edited by

Hélia Cardoso

, Sandra Correia and

Isaura Castro

submission deadline 30 Nov 2026 | 3 articles | Viewed by 3453 | Submission Open

Keywords: plant breeding; proteomics; metabolomics; epigenomics; gene editing

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Extracellular Vesicles in Disease and Therapeutic Applications

edited by Sunyoung Park

submission deadline 30 Nov 2026 | 3 articles | Viewed by 3416 | Submission Open

Keywords: extracellular vesicles (EVs); disease biomarkers; EV-based therapeutics; cancer diagnosis; drug delivery; immune modulation; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Allergy and Asthma: 4th Edition

edited by

Daniel P. Potaczek

submission deadline 30 Nov 2026 | 3 articles | Viewed by 3409 | Submission Open

Keywords: allergy; asthma; epigenetics/epigenomics; genetics/genomics; inflammation; molecular biology

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Macroporous, Mesoporous, and Microporous Materials

edited by

Magdalena Laskowska

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3160 | Submission Open

Keywords: functional materials; nanomaterials; nanostructures; molecular systems; porous materials

(This special issue belongs to the Section Materials Science)

Natural Products as Therapeutic Agents: From Molecular Targets to Cellular and Functional Modulation

edited by Su-Yun Lyu

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3120 | Submission Open

Keywords: natural products; molecular targets; cellular modulation; functional modulation; therapeutic agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Perspectives on Fish Nutrition, Physiology and Molecular Regulatory Networks

edited by Linghong Miao

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3051 | Submission Open

Keywords: fish nutrition; feed ingredients; intestinal physiology; molecular regulation; stress response and welfare; genetic mechanisms; aquaculture sustainability; omics technologies

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Neurofibromatosis Type 1: From Molecular Insights to Novel Therapies

edited by László Szabó and

Márta Medvecz

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2934 | Submission Open

Keywords: neurofibromatosis type 1; genotype–phenotype analyses; molecular pathogenesis; next-generation sequencing (NGS); molecular targeted therapy; MEK inhibitors; imaging studies

(This special issue belongs to the Section Molecular Neurobiology)

Precision Nutrition and Cancer: Molecular Insights into Cancer Prevention and Development

edited by

Da Pan

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2825 | Submission Open

Keywords: precision nutrition; cancer prevention; cancer development; nutrigenomics; personalized diets; tumor metabolism; dietary interventions

(This special issue belongs to the Section Molecular Oncology)

Computer Simulation Insight into Ligand–Receptor Interaction

edited by

Antonios Drakopoulos

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2802 | Submission Open

Keywords: structure–activity relationship (SAR); free energy perturbation (FEP); structure-based drug design (SBDD); machine learning in drug discovery; hybrid qm/mm methods; binding affinity prediction; enhanced sampling techniques; target binding kinetics

(This special issue belongs to the Section Molecular Informatics)

Application of Natural Products in Biomedicine and Pharmacotherapy: 3rd Edition

edited by

George Miloshev

submission deadline 30 Nov 2026 | 4 articles | Viewed by 2780 | Submission Open

Keywords: natural products; biomedicine; genotoxicity; epigenetics; aging

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research on Aquatic Organisms

edited by

Nguyen Vu Linh

submission deadline 30 Nov 2026 | 5 articles | Viewed by 2779 | Submission Open

Keywords: aquatic biotechnology; fish immunomodulation; antimicrobial resistance; omics technologies; natural feed additives

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanism and Pharmacological Target of Neuroprotection

edited by

Pietro Cacialli

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2638 | Submission Open

Keywords: neurodegeneration; animal model; brain regeneration; pharmacological drug; molecular analysis

(This special issue belongs to the Section Molecular Neurobiology)

Synthesis and Application of Natural and Inspired-Natural Products

edited by Mauro de Nisco

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2576 | Submission Open

Keywords: natural products; natural substances; derivative; synthesis; application

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Synthesis and Activity Studies of Anticancer Compounds

edited by Agata Pacuła-Miszewska

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2552 | Submission Open

Keywords: anticancer agents; structure-activity relationship; cytotoxicity mechanisms; medicinal chemistry; drug design

(This special issue belongs to the Section Molecular Pharmacology)

Dietary Interventions for Type 2 Diabetes: Current Evidence and Emerging Perspectives on Underlying Molecular Mechanisms

edited by Caterina Formichi

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2546 | Submission Open

Keywords: type 2 diabetes; nutritional intervention; dietary strategies; nutrients; personalized nutrition; diet; metabolic health

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Artificial Intelligence in Molecular Biomarker Screening

edited by

Tony Hsiu-Hsi Chen

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2527 | Submission Open

Keywords: molecular biomarkers; imaging biomarkers; screening; artificial intelligence; metaverse

(This special issue belongs to the Section Molecular Informatics)

Molecular Studies of Hematologic Malignancies

edited by

Myunggon Ko

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2487 | Submission Open

Keywords: hematologic malignancies; molecular mechanisms; genetic and epigenetic aberrations; molecular diagnosis; targeted therapy and biomarkers

(This special issue belongs to the Section Molecular Oncology)

New Molecular Insights into Antibacterial Materials

edited by

Rahela Carpa

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2468 | Submission Open

Keywords: antimicrobial resistance; nanoparticles; biopolymers; antimicrobial peptides; antimicrobial materials

(This special issue belongs to the Section Materials Science)

New Advances in Bioactive Compounds

edited by

Samuel Cota Teixeira

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2418 | Submission Open

Keywords: bioactive compound; natural products; polyphenols; carotenoids; alkaloids

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Emerging Biological Markers and Molecular Targets in Bladder Cancer

edited by Stanislav Žiaran

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2392 | Submission Open

Keywords: bladder cancer; biomarkers; urothelial carcinoma; molecular pathways; liquid biopsy; extracellular matrix; omics profiling; precision medicine; tissue engineering; translational urology

(This special issue belongs to the Section Molecular Oncology)

Preservation of Testicular Function: From Andrological Pathologies to Testis Cancer

edited by

Elisa Dalla Pozza

and

Ilaria Dando

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2333 | Submission Open

Keywords: testicular function; male infertility; fertility preservation; spermatogenesis; oxidative stress; cell death; testicular cancer; testosterone

(This special issue belongs to the Section Molecular Pharmacology)

Domestic Animal Genetics, Genomics, and Molecular Breeding

edited by

Ke Wang

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2314 | Submission Open

Keywords: genomic selection; molecular breeding; domestic animals; functional genomics; genetic improvement; product quality; reproduction

(This special issue belongs to the Section Molecular Genetics and Genomics)

Unveiling Molecular Mysteries of Brain Barriers

edited by Ana Catarina Duarte

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2274 | Submission Open

Keywords: blood–brain barrier; blood–cerebrospinal fluid barrier; arachnoid barrier; transport mechanisms; drug delivery; drug metabolism; ATP-binding cassete (ABC) transporters

(This special issue belongs to the Section Molecular Neurobiology)

The Anti-Inflammatory and Antioxidant Potential of Phytochemicals

edited by

Woo-Sik Jeong

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2264 | Submission Open

Keywords: phytochemicals; dietary bioactives; inflammation; natural compounds; functional foods; oxidative stress; cytokine modulation; NF-κB signaling; chronic diseases; plant-derived metabolites

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Extracellular Vesicles—New Findings on the Block in Liquid Biopsy

edited by Christa Nöhammer

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2255 | Submission Open

Keywords: extracellular vesicles; biological fluids; liquid biopsy; multi-omics; biomarkers; EV technologies

(This special issue belongs to the Section Molecular Biology)

Molecular Research and Cellular Biology of Breast Cancer: 2nd Edition

edited by

Andrea Nicolini

and

Cristian Scatena

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2253 | Submission Open

Keywords: molecular mechanisms of tumor growth and diffusion; cancer cell biology; biology of tumor micro-environmental cells; MDR; hormone dependency; HER2 positive breast cancer; TNBC; genetic and epigenetic alterations; pro-tumor and anti-tumor; immune responses; conventional and biological therapies; blood and tissue biomarkers

(This special issue belongs to the Section Molecular Oncology)

Novel Therapeutic Targets in Cancers: 5th Edition

edited by

Elena Levantini

submission deadline 30 Nov 2026 | 3 articles | Viewed by 2171 | Submission Open

Keywords: targeted therapy; precision oncology; immune modulation; cancer stem cell targeting; RNA-based therapy

(This special issue belongs to the Section Molecular Oncology)

Innovations in Analytical Chemistry for Environmental and Food Safety: Methodologies and Molecular Insights

edited by

Cosima Damiana Calvano

and

Francesco Longobardi

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2152 | Submission Open

Keywords: innovative sample preparation; food quality and safety; advanced analytical techniques; risk assessment

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Epigenetic Mechanisms in Human Diseases: From Molecular Pathogenesis to Therapeutic Interventions

edited by Silvia Consalvi

submission deadline 30 Nov 2026 | 3 articles | Viewed by 2124 | Submission Open

Keywords: epigenetics; DNA methylation; histone modifications; chromatin remodeling; non-coding RNAs; epigenomic profiling; epigenetic biomarkers; epigenetic therapy; epigenetic drugs; epigenome editing; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Focus on Heterocyclic Compounds and Their Various Applications

edited by

Georgia Zissimou

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2104 | Submission Open

Keywords: heterocyclic compounds; heterocyclic organic synthesis; medicinal heterocycles; bioactive heterocycles; heterocycles in materials sciences

(This special issue belongs to the Section Biochemistry)

New Insights in Antibiotic Resistance/Tolerance

edited by

Mara Di Giulio

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2079 | Submission Open

Keywords: antibiotic resistance; biofilm; innovative antimicrobial strategies and compounds; synergistic actions; One Health; bacterial tolerant phenotypes; resistant pathogenic microorganisms; mechanisms of antimicrobial resistance

(This special issue belongs to the Section Molecular Microbiology)

Latest Advances in Natural Bioactive Molecules and Polysaccharides

edited by Loredana Marcolongo

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2076 | Submission Open

Keywords: natural products; bioactive compounds; polysaccharides; extraction technologies; bioprocesses; value-added products; one-health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Research on New Targets and New Drugs for Dementia

edited by

Jianrong Xu

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2004 | Submission Open

Keywords: Alzheimer’s disease; disease-modifying therapy; neuroinflammation; monoclonal antibodies; natural products

(This special issue belongs to the Section Molecular Neurobiology)

Regenerative Medicine: Biomaterials and Stem Cell Research: 2nd Edition

edited by Silvia María Díaz-Prado

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2004 | Submission Open

Keywords: regenerative medicine; stem cell; biomaterial; bioprinting; tissue engineering; tissue and organ transplant; organ scarcity

(This special issue belongs to the Section Materials Science)

Displaying special issue 1251-1300 on page 26 of 63.

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