MDPI’s 2021 Best Paper Awards in “Biology & Life Sciences”—Winners Announced

The purpose of our Best Paper Awards is to promote and recognize the most impactful contributions published within MDPI journals.

The editors of each journal carefully selected reviews and research papers through a rigorous judging process based on criteria such as the scientific merit, overall impact, and the quality of presentation of the papers published in the journal last year.

We are honored to present the winners in the subject areas of “Biology & Life Sciences”, who were selected amongst extensive competition, and congratulate the authors for their outstanding scientific publications.

MDPI will continue to provide support and recognition to the academic community.

Animals:

• “Effects of Dietary Betaine on Growth Performance, Digestive Function, Carcass Traitsand Meat Quality in Indigenous Yellow-Feathered Broilers under Long-Term Heat Stress”

by Wenchao Liu, Yilin Yuan, Chenyu Sun, Balamuralikrishnan Balasubramanian, Zhihui Zhao and Lilong An

Animals 2019, 9(8), 506, doi 10.3390/ani9080506

• “The Ethics of Human–Animal Relationships and Public Discourse: A Case Study of Lions Bred for Their Bones”

by Peter Coals, Dawn Burnham, Andrew Loveridge, David W. Macdonald, Michael ’t Sas-Rolfes, Vivienne L. Williams and John A. Vucetich

Animals 2019, 9(2), 52; doi 10.3390/ani9020052

• “The Potential Role of Insects as Feed: A Multi-Perspective Review”

by Giovanni Sogari, Mario Amato, Ilaria Biasato, Silvana Chiesa and Laura Gasco

Animals 2019, 9(4), 119; doi 10.3390/ani9040119

Antibodies:

• “Antibody Structure and Function: The Basis for Engineering Therapeutics”

by Mark L. Chiu; Dennis R. Goulet; Alexey Teplyakov and Gary L. Gilliland

Antibodies 2019, 8(4), 55; doi 10.3390/antib8040055

Antioxidants:

• “Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathway”

by Luca Frattaruolo, Gabriele Carullo, Matteo Brindisi, Sarah Mazzotta, Luca Bellissimo, Vittoria Rago, Rosita Curcio, Vincenza Dolce, Francesca Aiello and Anna Rita Cappello

Antioxidants 2019, 8(6), 186; doi 10.3390/antiox8060186

• “LC-ESI-QTOF/MS Characterisation of Phenolic Acids and Flavonoids in Polyphenol-Rich Fruits and Vegetables and Their Potential Antioxidant Activities”

by Chunhe Gu, Kate Howell, Frank R. Dunshea and Hafiz A. R. Suleria

Antioxidants 2019, 8(9), 405; doi 10.3390/antiox8090405

• “Nutritional Value, Chemical Composition and Cytotoxic Properties of Common Purslane (Portulaca oleracea L.) in Relation to Harvesting Stage and Plant Part”

by Spyridon A. Petropoulos, Ângela Fernandes, Maria Inês Dias, Ioannis B. Vasilakoglou, Konstantinos Petrotos, Lillian Barros and Isabel C. F. R. Ferreira

Antioxidants 2019, 8(8), 293; doi 10.3390/antiox8080293

• “A Comprehensive Review on Lipid Oxidation in Meat and Meat Products”

by Rubén Domínguez, Mirian Pateiro, Mohammed Gagaoua, Francisco J. Barba, Wangang Zhang and José M. Lorenzo

Antioxidants 2019, 8(10), 429; doi 10.3390/antiox8100429

Biology:

• “The Mammalian Circadian Timing System and the Suprachiasmatic Nucleus as Its Pacemaker”

by Michael H. Hastings, Elizabeth S. Maywood and Marco Brancaccio

Biology 2019, 8(1), 13; doi 10.3390/biology8010013

• “Combined Effects of Acute Temperature Change and Elevated pCO₂ on the Metabolic Rates and Hypoxia Tolerances of Clearnose Skate (Rostaraja eglanteria), Summer Flounder (Paralichthys dentatus), and Thorny Skate (Amblyraja radiata)”

by Gail D. Schwieterman, Daniel P. Crear, Brooke N. Anderson, Danielle R. Lavoie, James A. Sulikowski, Peter G. Bushnell and Richard W. Brill

Biology 2019, 8(3), 56; doi 10.3390/biology8030056

Biomolecules:

• “Flagella-Driven Motility of Bacteria”

by Shuichi Nakamura and Tohru Minamino

Biomolecules 2019, 9(7), 279; doi 10.3390/biom9070279

• “Systematic FTIR Spectroscopy Study of the Secondary Structure Changes in Human Serum Albumin under Various Denaturation Conditions”

by Dmitrii Usoltsev, Vera Sitnikovaandrey Kajava and Mayya Uspenskaya

Biomolecules 2019, 9(8), 359; doi 10.3390/biom9080359

• “Quantification of Fecal Short Chain Fatty Acids by Liquid Chromatography Tandem Mass Spectrometry—Investigation of Pre-Analytic Stability”

by Gerhard Liebisch, Josef Ecker, Sebastian Roth, Sabine Schweizer, Veronika Öttl, Hans-Frieder Schött, Hongsup Yoon, Dirk Haller, Ernst Holler, Ralph Burkhardt and Silke Matysik

Biomolecules 2019, 9(4), 121; doi 10.3390/biom9040121

• “Cytotoxicity of Dendrimers”

by Anna Janaszewska, Joanna Lazniewska, Przemysław Trzepiński, Monika Marcinkowska and Barbara Klajnert-Maculewicz

Biomolecules 2019, 9(8), 330; doi 10.3390/biom9080330

Cells:

• “Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models”

by Heng Sheng Sow, Jiang Ren, Marcel Camps, Ferry Ossendorp and Peter ten Dijke

Cells 2019, 8(4), 320; doi 10.3390/cells8040320

• “Exosome Treatment Enhances Anti-Inflammatory M2 Macrophages and Reduces Inflammation-Induced Pyroptosis in Doxorubicin-Induced Cardiomyopathy”

by Dinender K. Singla, Taylor A. Johnson and Zahra Tavakoli Dargani

Cells 2019, 8(10), 1224; doi 10.3390/cells8101224

• “Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis”

by Laura M. Doyle and Michael Zhuo Wang

Cells 2019, 8(7), 727; doi 10.3390/cells8070727

• “Mesenchymal Stem Cells for Regenerative Medicine”

by Yu Han, Xuezhou Li, Yanbo Zhang, Yuping Han, Fei Chang and Jianxun Ding

Cells 2019, 8(8), 886; doi 10.3390/cells8080886

Genes:

• “A High-Quality De novo Genome Assembly from a Single Mosquito Using PacBio Sequencing”

by Sarah B. Kingan, Haynes Heaton, Juliana Cudini, Christine C. Lambert, Primo Baybayan, Brendan D. Galvin, Richard Durbin, Jonas Korlach and Mara K. N. Lawniczak

Genes 2019, 10(1), 62; doi 10.3390/genes10010062

• “Eukaryotic 5-methylcytosine (m⁵C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease”

by Katherine E Bohnsack, Claudia Höbartner and Markus T Bohnsack

Genes 2019, 10(2), 102; doi 10.3390/genes10020102

• “Tree Lab: Portable Genomics for Early Detection of Plant Viruses and Pests in Sub-Saharan Africa”

by Laura M. Boykin, Peter Sseruwagi, Titus Alicai, Elijah Ateka, Ibrahim Umar Mohammed, Jo-Ann L. Stanton, Charles Kayuki, Deogratius Mark, Tarcisius Fute, Joel Erasto, Hilda Bachwenkizi, Brenda Muga, Naomi Mumo, Jenniffer Mwangi, Phillip Abidrabo, Geoffrey Okao-Okuja, Geresemu Omuut, Jacinta Akol, Hellen B. Apio, Francis Osingada, Monica A. Kehoe, David Eccles, Anders Savill, Stephen Lamb, Tonny Kinene, Christopher B. Rawle, Abishek Muralidhar, Kirsty Mayall, Fred Tairo and Joseph Ndunguru

Genes 2019, 10(9), 632; doi 10.3390/genes10090632

• “Transcription Factors Associated with Abiotic and Biotic Stress Tolerance and Their Potential for Crops Improvement”

by Elamin Hafiz Baillo, Roy Njoroge Kimotho, Zhengbin Zhang and Ping Xu

Genes 2019, 10(10), 771; doi 10.3390/genes10100771

Horticulturae:

• “Recent Advances in Hormonal Regulation and Cross-Talk during Non-Climacteric Fruit Development and Ripening”

by Lida Fuentes, Carlos R. Figueroa and Monika Valdenegro

Horticulturae 2019, 5(2), 45; doi 10.3390/horticulturae5020045

• “Evaluation of Two Wild Populations of Hedge Mustard (Sisymbrium officinale (L.) Scop.) as a Potential Leafy Vegetable”

by Marta Guarise, Gigliola Borgonovo, Angela Bassoli and Antonio Ferrante

Horticulturae 2019, 5(1), 13; doi 10.3390/horticulturae5010013

Insects:

• “Olfactory Preference of Drosophila suzukii Shifts between Fruit and Fermentation Cues over the Season: Effects of Physiological Status”

by Rik Clymans, Vincent Van Kerckvoorde, Eva Bangels, Wannes Akkermans, Ammar Alhmedi, Patrick De Clercq, Tim Beliën and Dany bylemans

Insects 2019, 10(7), 200; doi 10.3390/insects10070200

• “Telenomus remus, a Candidate Parasitoid for the Biological Control of Spodoptera frugiperda in Africa, is already Present on the Continent”

by Marc Kenis, Hannalene du Plessis, Johnnie Van den Berg, Malick Niango Ba, Georg Goergen, Koffi Eric Kwadjo, Ibrahim Baoua, Tadele Tefera, Alan Buddie, Giovanni Cafà, Lisa Offord, Ivan Rwomushana and Andrew Polaszek

Insects 2019, 10(4), 92; doi 10.3390/insects10040092

• “Symbiotic Plant Biomass Decomposition in Fungus-Growing Termites”

by Rafael R. da Costa, Haofu Hu, Hongjie Li and Michael Poulsen

Insects 2019, 10(4), 87; doi 10.3390/insects10040087

International Journal of Molecular Sciences:

• “Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks”

by Rüdiger Hardeland

Int. J. Mol. Sci. 2019, 20(5), 1223; doi 10.3390/ijms20051223

• “Causative Links between Protein Aggregation and Oxidative Stress: A Review”

by Elise Lévy, Nadine El Banna, Dorothée Baïlle, Amélie Heneman-Masurel, Sandrine Truchet, Human Rezaei, Meng-Er Huang, Vincent Béringue, Davy Martin and Laurence Vernis

Int. J. Mol. Sci. 2019, 20(16), 3896; doi 10.3390/ijms20163896

• “Immunobiology of Atherosclerosis: A Complex Net of Interactions”

by Beatriz Herrero-Fernandez, Raquel Gomez-Bris, Beatriz Somovilla-Crespo and Jose Maria Gonzalez-Granado

Int. J. Mol. Sci. 2019, 20(21), 5293; doi 10.3390/ijms20215293

• “Development of a Gut-on-a-Chip Model for High Throughput Disease Modeling and Drug Discovery”

by Claudia Beaurivage, Elena Naumovska, Yee Xiang Chang, Edo D. Elstak, Arnaud Nicolas, Heidi Wouters, Guido van Moolenbroek, Henriëtte L. Lanz, Sebastiaan J. Trietsch, Jos Joore, Paul Vulto, Richard A.J. Janssen, Kai S. Erdmann, Jan Stallen and Dorota Kurek

Int. J. Mol. Sci. 2019, 20(22), 5661; doi 10.3390/ijms20225661

• “Triple-Negative Breast Cancer with High Levels of Annexin A1 Expression Is Associated with Mast Cell Infiltration, Inflammationand Angiogenesis”

by Maiko Okano, Masanori Oshi, Ali Linsk Butash, Eriko Katsuta, Kazunoshin Tachibana, Katsuharu Saito, Hirokazu Okayama, Xuan Peng, Li Yan, Koji Kono, Toru Ohtake and Kazuaki Takabe

Int. J. Mol. Sci. 2019, 20(17), 4197; doi 10.3390/ijms20174197

• “CGRP Induces Differential Regulation of Cytokines from Satellite Glial Cells in Trigeminal Ganglia and Orofacial Nociception”

by Shaista Afroz, Rieko Arakaki, Takuma Iwasa, Masamitsu Oshima, Maki Hosoki, Miho Inoue, Otto Baba, Yoshihiro Okayama and Yoshizo Matsuka

Int. J. Mol. Sci. 2019, 20(3), 711; doi 10.3390/ijms20030711

Life:

• “Characterization of Resistance in Gram-Negative Urinary Isolates Using Existing and Novel Indicators of Clinical Relevance: A 10-Year Data Analysis”

by Márió Gajdács, Zoltán Bátori, Marianna Ábrók, Andrea Lázár and Katalin Burián

Life 2020, 10(2), 16; doi 10.3390/life10020016

• “Neuroprotection or Neurotoxicity of Illicit Drugs on Parkinson’s Disease”

by Carla Ferreira, Catarina Almeida, Sandra Tenreiro and Alexandre Quintas

Life 2020, 10(6), 86; doi 10.3390/life10060086

Nutrients:

• “Gut Microbiome: Profound Implications for Diet and Disease”

by Ronald D. Hills, Benjamin A. Pontefract, Hillary R. Mishcon, Cody A. Black, Steven C. Sutton and Cory R. Theberge

Nutrients 2019, 11(7), 1613; doi 10.3390/nu11071613

• “Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis”

by Harri Hemilä and Elizabeth Chalker

Nutrients 2019, 11(4), 708; doi 10.3390/nu11040708

• “Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans”

by Humaira Jamshed, Robbie A. Beyl, Deborah L. Della Manna, Eddy S. Yang, Eric Ravussin and Courtney M. Peterson

Nutrients 2019, 11(6), 1234; doi 10.3390/nu11061234

Pathogens:

• “Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome”

by Israr Kha, Naeem Ullah, Lajia Zha, Yanrui Bai, Ashiq Khan, Tang Zhao, Tuanjie Che and Chunjiang Zhang

Pathogens 2019, 8(3), 126; doi 10.3390/pathogens8030126

• “Candida albicans Interactions with Mucosal Surfaces during Health and Disease”

by Spyridoula-Angeliki Nikou,Nessim Kichik, Rhys Brown, Nicole O. Ponde, Jemima Ho, Julian R. Naglik and Jonathan P. Richardson

Pathogens 2019, 8(2), 53; doi 10.3390/pathogens8020053

• “Bacteriophages in Natural and Artificial Environments”

by Steven Batinovic, Flavia Wassef, Sarah A. Knowler, Daniel T.F. Rice, Cassandra R. Stanton, Jayson Rose, Joseph Tucci, Tadashi Nittami, Antony Vinh, Grant R. Drummond, Christopher G. Sobey, Hiu Tat Chan, Robert J. Seviour, Steve Petrovski and Ashley E. Franks

Pathogens 2019, 8(3), 100; doi 10.3390/pathogens8030100

Plants:

• “Plant Disease Detection and Classification by Deep Learning”

by Muhammad Hammad Saleem, Johan Potgieter and Khalid Mahmood Arif 

Plants 2019, 8(11), 468; doi 10.3390/plants8110468

• “Involvement of Phenolic Acids in Short-Term Adaptation to Salinity Stress is Species-Specific among Brassicaceae”

by Ida Linić, Dunja Šamec, Jiří Grúz, Valerija Vujčić Bok, Miroslav Strnad and Branka Salopek-Sondi

Plants 2019, 8(6), 155; doi 10.3390/plants8060155

• “Isoform-Specific NO Synthesis by Arabidopsis thaliana Nitrate Reductase”

by Marie Agatha Mohn, Besarta Thaqi and Katrin Fischer-Schrader

Plants 2019, 8(3), 67; doi 10.3390/plants8030067

• “GWAS for Starch-Related Parameters in Japonica Rice (Oryza sativa L.)”

by Chiara Biselliandrea Volante, Francesca Desiderio, Alessandro Tondelli, Alberto Gianinetti, Franca Finocchiaro, Federica Taddei, Laura Gazza, Daniela Sgrulletta, Luigi Cattivelli and Giampiero Valè

Plants 2019, 8(8), 292; doi 10.3390/plants8080292