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Current Issues in Molecular Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovative Therapeutics and Biomarkers in Hepatocellular Carcinoma Research

edited by

Alok Raghav

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4274 | Submission Open

Keywords: hepatocellular carcinoma; biomarkers; therapeutics; imaging; artificial intelligence; diagnostics

(This special issue belongs to the Section Molecular Medicine)

Molecular Approaches in Early Detection and Targeted Therapies for Pancreatic Cancer

edited by

Hassan Mubarak Ishqi

submission deadline 25 Jan 2026 | Viewed by 109 | Submission Open

Keywords: pancreatic cancer; early detection; molecular biomarkers; targeted therapy; genomics; tumor microenvironment; precision medicine; transcriptomics; proteomics; cancer diagnostics

(This special issue belongs to the Section Molecular Medicine)

Radiation-Induced Cellular and Molecular Responses

edited by

Carlo Aprile

submission deadline 31 Jan 2026 | 3 articles | Viewed by 11329 | Submission Open

Keywords: radiation; radiobiology; space radiobiology; heavy ions carcinogenesis; LinearNonTreshold; radionuclide therapy; alpha emitters; beta emitters; radiobiology

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms in Plant Stress Tolerance

edited by

Sajid Ali

submission deadline 31 Jan 2026 | 10 articles | Viewed by 10513 | Submission Open

Keywords: plant stress tolerance; molecular mechanisms; stress-responsive gene; signal transduction pathways; epigenetic modifications; phytohormones (ethylene; ABA; SA; JA); reactive oxygen species (ROS); plant– microbe interactions; microbial plant bio-stimulants; omics approaches (genomics; transcriptomics; proteomics; and metabolomics)

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Molecular Research on Hypertensive Disorders of Pregnancy (HDPs)

edited by

Melissa Wilson

submission deadline 31 Jan 2026 | 7 articles | Viewed by 10480 | Submission Open

Keywords: DNA; RNA; protein; microbiome; hypertensive disorders of pregnancy; preeclampsia; epidemiology; meta-analysis

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms Underlying Fatty Liver Disease: From Pathogenesis to Treatment, 2nd Edition

edited by Haibo Dong and

Wei Guo

submission deadline 31 Jan 2026 | 6 articles | Viewed by 8678 | Submission Open

Keywords: non-alcoholic fatty liver disease (NAFLD); alcohol-associated liver disease (ALD); lipotoxicity; bile acid metabolism; novel biomarker identification; organelle dysfunction and communication; inflammation and oxidative stress; cell signaling and cell death pathways; lipid metabolism and dysregulation; epigenetic modifications (DNA/RNA/non-coding RNA); therapeutic targets and interventions

(This special issue belongs to the Section Molecular Medicine)

Tumor Microenvironment: Crosstalk Between Epigenetics, Metabolism and Immunity

edited by

Liang Chen

submission deadline 31 Jan 2026 | 4 articles | Viewed by 5314 | Submission Open

Keywords: tumor microenvironment; epigenetic modifications; metabolic reprogramming; immune escape; tumor metastasis; therapeutic resistance

(This special issue belongs to the Section Molecular Medicine)

Exploring Molecular Pathways in Skin Health and Diseases

edited by

Sullim Lee

submission deadline 31 Jan 2026 | 2 articles | Viewed by 4535 | Submission Open

Keywords: skin health; skin aging; skin disease; molecular pathways; oxidative stress; immune response; inflammatory skin diseases

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Insights into Food-Derived Natural Products and Their Biological Activities—2nd Edition

edited by

Yanfang Li

submission deadline 31 Jan 2026 | 4 articles | Viewed by 4360 | Submission Open

Keywords: food compounds; natural products; biologically active compounds; oxidative stress; anticancer; functionality of foods

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Insights: Mechanisms Underlying the Biological Activities of Natural Products—2nd Edition

edited by

Premalatha Balachandran

submission deadline 31 Jan 2026 | 4 articles | Viewed by 3674 | Submission Open

Keywords: natural products; molecular mechanisms; biological activities; pharmacodynamics; drug discovery; therapeutic potential; signaling pathways; target identification; pharmacological properties; bioactive compounds

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Insights into Pathogenesis and Targeted Therapy of Gynaecological Cancers

edited by

Stergios Boussios

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3495 | Submission Open

Keywords: ovarian cancers; cervical cancers; endometrial cancers; targeted therapy; molecular markers; immunotherapy

(This special issue belongs to the Section Molecular Medicine)

Autophagy and the Ubiquitin–Proteasome System: Regulators of Protein Homeostasis, Cell Death, and Disease Pathogenesis

edited by

Lei Dong

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2083 | Submission Open

Keywords: autophagy; ubiquitin– proteasome system; protein homeostasis; autophagosome; cell death regulation; cancer; Alzheimer's disease

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Phytochemicals: Therapeutic Potential in Metabolic Disorders and Cancer

edited by

Mohamed Addi

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1876 | Submission Open

Keywords: phytochemicals; molecular mechanisms; cancer therapeutics; metabolic disorders; natural compounds; signal transduction; epigenetic regulation; oxidative stress; anti-inflammatory agents; plant-based

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Advances in Phytochemical Research: Molecular Pathways in Health and Disease

edited by

Christiana Charalambous

and

Christiana Neophytou

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1848 | Submission Open

Keywords: phytochemicals; molecular mechanisms; cancer signaling pathways; anti-inflammatory properties; anti-oxidant properties; apoptosis; cardiovascular disorders; metabolic syndromes; chemoprevention

(This special issue belongs to the Section Molecular Medicine)

Advances in Multi-Omics for Functional Genomics Studies and Molecular Breeding, 2nd Edition

edited by Chen Chen

submission deadline 31 Jan 2026 | 3 articles | Viewed by 1676 | Submission Open

Keywords: sequencing technologies; plant genomics; transcriptomics; proteomics; metabolomics; epigenomics; single-cell sequencing; functional genomics; transformation methods; gene identification

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular and Pharmacological Insights into Bioactive Compounds: Pathways to Therapeutics

edited by

Mosharraf Sarker

and

Talat Nasim

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1531 | Submission Open

Keywords: bioactive compounds; natural products; drug discovery; pharmacology; therapeutic pathways; molecular mechanisms; signal transduction; medicinal chemistry; target identification

(This special issue belongs to the Section Molecular Pharmacology)

Plant Hormones, Development, and Stress Tolerance

edited by

Zhaohui Chu

and

Wei Yang

submission deadline 31 Jan 2026 | 1 articles | Viewed by 936 | Submission Open

Keywords: plant hormones; abiotic stress; auxins; jasmonic acid; signal pathway

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Molecular Biology Methods in Hepatology Research, 2nd Edition

edited by

Ralf Weiskirchen

and

Dileep G. Nair

submission deadline 31 Jan 2026 | 2 articles | Viewed by 700 | Submission Open

Keywords: hepatic diseases; molecular biology methods; single-cell genomics; single-cell proteomics; hepatic organoids; biomarkers

(This special issue belongs to the Section Molecular Medicine)

Molecular and Real-World Evidence Research of Respiratory Diseases and Infections, 2nd Edition

edited by

Chingyuan Wu

submission deadline 31 Jan 2026 | Viewed by 332 | Submission Open

Keywords: respiratory diseases; pathogenesis; vaccines; therapies; COVID-19

(This special issue belongs to the Section Molecular Medicine)

Cutting-Edge Microscopy and Electron Microscopy Innovations in Molecular Biology Research

edited by

Diana Torge

submission deadline 31 Jan 2026 | Viewed by 264 | Submission Open

Keywords: morphology; microscopy; transmission electron microscopy; molecular biology; medicine; dentistry

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Impacts of DNA Methylation as Epigenetic Drivers of Disease Onset and Progression

edited by Adam G. Marsh

submission deadline 31 Jan 2026 | Viewed by 157 | Submission Open

Keywords: epigenetics; DNA methylation; disease onset; disease progression; molecular mechanisms; molecular biomarkers; gene silencing; gene expression

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Allergic Diseases: Molecular Pathways and Pathogenesis

edited by

Jing Gao

submission deadline 31 Jan 2026 | Viewed by 116 | Submission Open

Keywords: allergic diseases; allergic responses; allergic inflammation; immune response; genetics and susceptibility

(This special issue belongs to the Section Molecular Medicine)

Unraveling the Role of Epigenetics and Molecular Genetics in Disease Progression via the Gut–Brain Axis

edited by Yong-Chan Kim

submission deadline 31 Jan 2026 | Viewed by 85 | Submission Open

Keywords: prion diseases; Parkinson’ s disease; Alzheimer’ s disease; neurodegenerative disease; inflammatory bowel diseases; ulcerative colitis; Crohn’ s disease; brain– gut axis; bioinformatics; polymorphism

(This special issue belongs to the Section Molecular Medicine)

Innovative Approaches in Bone and Cartilage Regeneration: From Stem Cells to Organoids

edited by

Maria Giovanna Rizzo

submission deadline 31 Jan 2026 | Viewed by 82 | Submission Open

Keywords: bone and cartilage biology; physiology; molecular biology; nutraceuticals; regenerative medicine

(This special issue belongs to the Section Molecular Medicine)

Molecular Dynamics Simulations in Structural Biology: From Proteins to Complex Biomolecular Systems

edited by

Ana E. Ledesma

submission deadline 31 Jan 2026 | Viewed by 77 | Submission Open

Keywords: protein; molecular docking; dynamic simulation; biomolecular systems; molecular interactions; structural modification; enzyme activity; biological function; antioxidant activity; infrared spectroscopy

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular and Cellular Mechanisms of Vascular Function and Dysfunction: Roles of the Endothelium and G-Protein Coupled Receptors

edited by John J. McGuire

submission deadline 31 Jan 2026 | Viewed by 73 | Submission Open

Keywords: endothelium; endothelial cells; vascular smooth muscle; platelets; G-protein coupled receptor; signal transduction; metabolic dysfunction; diabetes; inflammation; angiogenesis

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms of Animal Metabolism: Pathophysiological Implications in Tumor Progression

edited by

Cristian Gabriel Torres Mendoza

submission deadline 31 Jan 2026 | Viewed by 71 | Submission Open

Keywords: animal cancer metabolism; animal tumor diseases; Warburg effect; drug-resistance; therapeutic targets

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Pharmacological Activities and Mechanisms of Action of Natural Products, 2nd Edition

edited by

Shining Loo

Antony Kam

and Lee Simon Ming-Yuen

submission deadline 31 Jan 2026 | Viewed by 56 | Submission Open

Keywords: natural products; pharmacological activity; molecular mechanisms; therapeutic targets; structure– activity relationships; protein– ligand interactions; cell signaling pathways; enzyme inhibition/activation; molecular targets

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Mechanisms and Therapeutic Approaches in Fibrosis and Tissue Remodeling

edited by Pulin Che

submission deadline 31 Jan 2026 | Viewed by 51 | Submission Open

Keywords: fibrosis; tissue remodeling; biomarkers; molecular pathways; translational medicine; therapeutic strategies

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms and Treatment of Kidney Diseases

edited by Junyi Zhu

submission deadline 10 Feb 2026 | Viewed by 63 | Submission Open

Keywords: nephrotic syndrome; kidney disease; kidney injury

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Omics Approaches in Plant Stress Tolerance

edited by

Dipali Srivastava

and

Romit Seth

submission deadline 15 Feb 2026 | Viewed by 69 | Submission Open

Keywords: environmental stress; gene regulation; transcriptomics; molecular pathways; stress tolerance; genetic engineering; CRISP; molecular biology

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of the Neuro-Musculoskeletal System

edited by

Adriano Polican Ciena

submission deadline 20 Feb 2026 | Viewed by 122 | Submission Open

Keywords: morphology; molecular biology; microscopy; neuromuscular junction; myotendinous junction

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Hyperlipidemia and Molecular Mechanism in Human and Animals

edited by

Kyuhyung Choi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2718 | Submission Open

Keywords: hyperlipidemia; diabetes mellitus; Cushing’ s disease; pancreatitis; gall bladder mucoceles

(This special issue belongs to the Section Molecular Medicine)

The Modulatory Effects of Plants with Therapeutic Potential in Neuropsychiatric Disorder

edited by

Alin Ciobica

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2376 | Submission Open

Keywords: plant biodiversity; antioxidant effects; therapeutic potential; neuropsychiatric disorders; oxidative stress markers; inflammatory markers

(This special issue belongs to the Section Molecular Pharmacology)

Bioinformatics Research in Bacterial Genomics, Metagenomics and Metatranscriptomics: 2nd Edition

edited by

Vesselin Baev

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2317 | Submission Open

Keywords: bacterial genomics and functional analysis; genome-wide comparative genomics; bioinformatics methods and tools; metagenomics; metatranscriptomics

(This special issue belongs to the Section Molecular Microbiology)

Hormonal Regulation in Germ Cell Development

edited by

Kwan Sik Min

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2275 | Submission Open

Keywords: spermatogenesis; steroidogenesis; sex hormones; sex hormone receptors; gonadotropin; germ cell differentiation; androgen; luteinizing hormone; follicle-stimulating hormone; glycoprotein hormone receptors

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms of Plant Adaptation and Stress Tolerance Under Changing Environmental Conditions

edited by

Naveed Ahmad

submission deadline 28 Feb 2026 | Viewed by 625 | Submission Open

Keywords: elevated CO2; drought– heat– salinity; carbon– nitrogen balance; TOR/SnRK1; hormone crosstalk; redox signaling; microbiome; single-cell/spatial omics; phenomics; genome editing; predictive breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Innovations in Antimicrobial Resistance

edited by

Rúben Fernandes

submission deadline 28 Feb 2026 | Viewed by 500 | Submission Open

Keywords: antimicrobial resistance (AMR); molecular mechanisms; genomics; personalized medicine; resistance mechanisms; translational research

(This special issue belongs to the Section Molecular Microbiology)

Latest Review Papers in Molecular Plant Science 2026

edited by

Zhaohui Chu

submission deadline 28 Feb 2026 | Viewed by 216 | Submission Open

Keywords: multi-omics; plant bioreactor; plant genomics; plant-pathogens interaction; crop domestication; crop yield traits

(This special issue belongs to the Section Molecular Plant Sciences)

Exploring Symmetry and Asymmetry in Molecular Design for Anticancer and Antioxidant Therapies

edited by

Anca Stana

submission deadline 28 Feb 2026 | Viewed by 204 | Submission Open

Keywords: symmetry; asymmetry; antioxidant; anticancer; synergy; oxidative stress; cytotoxicity; molecular design; synthesis

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Nanotechnology-Enhanced Photodynamic Therapy for Precision Medicines

edited by

Milutin Stepić

and

Iva A. Popović

submission deadline 28 Feb 2026 | Viewed by 181 | Submission Open

Keywords: photodynamic therapy; photosensitisers; targeting nanocarriers; multifunctional nanoplatforms; nanotheranostics; active targeting of cancer; molecular drug targeting; drug metabolism and toxicity; pharmacogenetic testing; cancer microenvironment remodelling

(This special issue belongs to the Section Molecular Medicine)

Epigenetics and Chromatin Remodeling in Cancer

edited by

Gianluca Tedaldi

submission deadline 28 Feb 2026 | Viewed by 177 | Submission Open

Keywords: epigenetics; chromatin remodeling; DNA methylation; histone modifications; non-coding RNAs; circulating tumor DNA; liquid biopsy; epigenetic therapy

(This special issue belongs to the Section Molecular Medicine)

Phagocytosis in Neurological Disorders: Molecular Mechanisms and Therapeutic Targets

edited by

Dimitrios I. Tsiptsios

and Konstantinos Anagnostopoulos

submission deadline 28 Feb 2026 | Viewed by 175 | Submission Open

Keywords: phagocytosis; endothelial cells; microglial cells; stroke; dementia; inflammation

(This special issue belongs to the Section Molecular Medicine)

Molecular Research in Osteoarthritis and Osteoarticular Diseases, 2nd Edition

edited by

Ye Liu

submission deadline 28 Feb 2026 | Viewed by 172 | Submission Open

Keywords: osteoarthritis; cartilage regeneration; bioinformatics; biomarkers; inflammation; cartilage; metabolic imbalance

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms of Natural Product-Induced Immune Modulation: From Signaling Pathways to Therapeutic Targets

edited by Suyun Lyu

submission deadline 28 Feb 2026 | Viewed by 123 | Submission Open

Keywords: natural products; immunomodulation; immune responses; molecular mechanisms; immune cell activation; inflammation pathways; autoimmune diseases

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Current Advances in Oxytocin Research, 2nd Edition

edited by

Claudia Camerino

submission deadline 28 Feb 2026 | Viewed by 90 | Submission Open

Keywords: oxytocin; thermoregulation; skeletal muscle; obesity; Prader– Willi syndrome

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Advances in Phytochemicals: Biological Activities and Applications

edited by

Mohammed Kara

submission deadline 28 Feb 2026 | Viewed by 85 | Submission Open

Keywords: plants; phytochemicals; natural compounds; molecular biology; antibiotics; anticancer

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Biology and Functional Roles of Tumor Suppressor Genes in Cancer

edited by

Yun Zhang

submission deadline 28 Feb 2026 | Viewed by 73 | Submission Open

Keywords: tumor suppressor genes; cancer biology; TP53; RB1; PTEN; genomic instability; tumor microenvironment; cancer therapy; epigenetic regulation; cell signaling

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Innovative Models for SARS-CoV-2 Pathogenesis

edited by

Virginia Lotti

submission deadline 28 Feb 2026 | Viewed by 65 | Submission Open

Keywords: SARS-CoV-2; coronavirus; virus infection; pathogenesis; innovative models

(This special issue belongs to the Section Molecular Medicine)

The Role of Microglia in Neuroinflammation and Neurodegenerative Diseases

edited by

Shunqi Wang

submission deadline 28 Feb 2026 | Viewed by 60 | Submission Open

Keywords: microglia; neuroinflammation; neurodegeneration; synaptic pruning; microglial activation states; innate immune signaling; TLR signaling; TREM2; CX3CR1; NF-κ B; glia– neuron interactions; neuroimmune crosstalk; therapeutic targeting of microglia

(This special issue belongs to the Section Molecular Medicine)

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