Unraveling the Role of Epigenetics and Molecular Genetics in Disease Progression via the Gut–Brain Axis
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 42
Special Issue Editor
Interests: prion diseases; Parkinson’s disease; inflammatory bowel diseases; ulcerative colitis; Crohn’s disease; brain-gut axis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue focuses on unraveling the complex roles of epigenetics and molecular genetics in disease progression mediated by the gut–brain axis. Emerging research has shown that epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNAs, along with genetic variants and polymorphisms, critically shape the gut microbiome, intestinal barrier function, and neuroimmune responses. Disruptions in these regulatory mechanisms can lead to increased gut permeability and systemic inflammation. Moreover, they may contribute to the pathogenesis of neurodegenerative and gastrointestinal diseases. By integrating insights from multi-omics technologies, bioinformatics analyses, and experimental studies in cellular and animal models, this Special Issue aims to shed light on how the gut–brain axis serves as a pivotal conduit linking genetic and epigenetic alterations to disease outcomes. We welcome original research articles, reviews, and perspectives that explore molecular pathways, identify novel biomarkers, and propose therapeutic strategies targeting the gut–brain interplay. Ultimately, this collection seeks to advance our understanding of how gut-driven molecular mechanisms influence brain health and systemic diseases, opening avenues for precision medicine approaches in complex disorders involving the gut–brain axis.
Prof. Dr. Yong-Chan Kim
Guest Editor
Manuscript Submission Information
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Keywords
- prion diseases
- Parkinson’s disease
- Alzheimer’s disease
- neurodegenerative disease
- inflammatory bowel diseases
- ulcerative colitis
- Crohn’s disease
- brain–gut axis
- bioinformatics
- polymorphism
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