Molecular Approaches in Early Detection and Targeted Therapies for Pancreatic Cancer
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 December 2025
Special Issue Editor
Interests: cancer; inflammation; immunology; RNA biology; molecular biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Pancreatic cancer remains one of the most lethal malignancies, with an overall five-year survival rate of approximately 11% and projected to become the second leading cause of cancer death by 2030. Late diagnosis, with only 10-15% of patients presenting with resectable disease, emphasizes the urgent need for innovative molecular detection strategies across all pancreatic cancer subtypes.
Molecular approaches have shown great promise in addressing these challenges. Recent advances in multi-omics technologies, understanding of tumor–stroma interactions, and tumor immune microenvironment are enabling the discovery of novel biomarkers for early diagnosis, elucidating key oncogenic pathways, and facilitating the development of targeted therapies that disrupt specific oncogenic pathways and tumor microenvironment components.
This Special Issue welcomes original research and comprehensive reviews focusing on molecular strategies for the early detection and personalized treatment of pancreatic cancer. Priority areas include novel biomarker discovery, liquid biopsy applications, mechanistic studies of tumor biology, targeted therapeutic development, and the clinical translation of molecular diagnostics. We seek contributions that advance our understanding of pancreatic cancer molecular pathogenesis and accelerate the development of clinically meaningful diagnostic and therapeutic innovations.
Dr. Hassan Mubarak Ishqi
Guest Editor
Manuscript Submission Information
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Keywords
- pancreatic cancer
- early detection
- molecular biomarkers
- targeted therapy
- genomics
- tumor microenvironment
- precision medicine
- transcriptomics
- proteomics
- cancer diagnostics
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