Molecular and Cellular Mechanisms of Vascular Function and Dysfunction: Roles of the Endothelium and G-Protein Coupled Receptors
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 35
Special Issue Editor
Interests: protease-activated receptor 2; endothelium; vascular smooth muscle; nitric oxide; cardiovascular
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The vascular endothelium is critical to the circulatory system’s normal functioning. Endothelial cells regulate vascular tone, the transport of molecules and cells, platelet activation, thrombosis, tissue inflammation, injury, blood vessel growth, and remodeling. G-protein coupled receptors (GPCRs) are fundamental to the cellular and molecular mechanisms of endothelial cell function. Dysfunction of the endothelium contributes to diseases of the heart, lung, kidney, and brain, clinical complications of type 2 diabetes, and metabolic syndrome. Research targeting GPCRs and endothelial cell mechanisms advances the discovery of new therapeutics and treatments for human diseases.
This Special Issue welcomes original research articles and reviews covering the research areas above. The goal for this Issue is to provide a collection of articles focused on mechanisms and innovative studies investigating both normal and pathological endothelium functions regulated via GPCRs.
Dr. John J. McGuire
Guest Editor
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Keywords
- endothelium
- endothelial cells
- vascular smooth muscle
- platelets
- G-protein coupled receptor
- signal transduction
- metabolic dysfunction
- diabetes
- inflammation
- angiogenesis
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