Molecular Mechanisms Underlying Fatty Liver Disease: From Pathogenesis to Treatment, 2nd Edition
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 169
Special Issue Editors
Interests: fatty liver diseases; cellular redox balance; cell death; inflammation; oxidative stress; autophagy; mitochondrial dysfunction; NAD+ homeostasis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are pleased to announce a new Special Issue of Current Issues in Molecular Biology that aims to explore the cellular and molecular mechanisms involved in the development and progression of both non-alcoholic fatty liver disease (NAFLD) and alcohol-associated liver disease (ALD).
NAFLD and ALD are significant contributors to the global burden of liver disease. NAFLD, often associated with metabolic syndrome, obesity, diabetes, and cardiovascular disease, has emerged as the most common cause of chronic liver disease worldwide. ALD, on the other hand, is primarily caused by excessive alcohol consumption and encompasses a wide range of liver conditions, including steatosis, alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. NAFLD and ALD are both steatohepatitic processes and share several common features, yet they differ in many aspects. Therefore, understanding the development and progression of both NAFLD and ALD, in addition to uncovering the underlying cellular and molecular mechanisms, is crucial to advancing our knowledge and developing effective therapeutic strategies for the treatment of these liver diseases.
In this Special Issue, we welcome articles that investigate or summarize the cellular and molecular mechanisms that contribute to the pathogenesis and progression of NAFLD, NASH, ALD, and related diseases. We encourage researchers to explore a broad range of topics, including, but not limited to, impaired lipid metabolism, inflammation, oxidative stress, insulin resistance, genetic/epigenetic modifications, and the interplay between alcohol metabolism and liver injury.
Dr. Haibo Dong
Dr. Wei Guo
Guest Editors
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Keywords
- non-alcoholic fatty liver disease (NAFLD)
- alcohol-associated liver disease (ALD)
- lipotoxicity
- bile acid metabolism
- novel biomarker identification
- organelle dysfunction and communication
- inflammation and oxidative stress
- cell signaling and cell death pathways
- lipid metabolism and dysregulation
- epigenetic modifications (DNA/RNA/non-coding RNA)
- therapeutic targets and interventions
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