Epigenetics and Chromatin Remodeling in Cancer
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 52
Special Issue Editor
Interests: hereditary cancer; next-generation sequencing; cancer genetics; cancer epigenetics; molecular characterization
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Epigenetic modifications and chromatin remodeling play central roles in cancer by dynamically regulating gene expression without altering DNA sequences. Aberrant DNA methylation, histone modifications, and chromatin accessibility changes can activate oncogenes or silence tumor suppressors, contributing to tumor initiation and progression. This Special Issue explores recent advances in understanding the molecular mechanisms underlying epigenetic dysregulation and chromatin remodeling in cancer. We highlight novel technologies such as ATAC-seq, ChIP-seq, single-cell epigenomics, and liquid biopsy approaches for detecting epigenetic alterations in circulating tumor DNA (ctDNA), which offer promising non-invasive cancer biomarkers. Additionally, we discuss the role of key chromatin remodelers, histone-modifying enzymes, and non-coding RNAs in shaping the cancer epigenome. The Special Issue also covers emerging therapeutic strategies, including epigenetic inhibitors and targeted chromatin-modifying drugs. By integrating findings from epigenetics, functional genomics, and precision oncology, this collection aims to provide a comprehensive perspective on chromatin dynamics in cancer and their potential for clinical applications.
Dr. Gianluca Tedaldi
Guest Editor
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Keywords
- epigenetics
- chromatin remodeling
- DNA methylation
- histone modifications
- non-coding RNAs
- circulating tumor DNA
- liquid biopsy
- epigenetic therapy
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