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Hyperlipidemia and Molecular Mechanism in Human and Animals

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1463

Special Issue Editor


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Guest Editor
1. Department of Veterinary Pathology, College of Veterinary Medicine, Seoul Na-tional University Seoul, Seoul 08826, Republic of Korea
2. Bundang New York Animal Hospital, Bundang-Gu, Seongnam-si 13637, Gyeonggi-do, Republic of Korea
Interests: small animal medicine; hyperlipidemia; endocrine disease; cancer; veterinary pathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear colleagues,

Maintaining lipid profiles such as high density lipoprotein and total cholesterol is essential to health not only human but also in animals. The aim of this special issue is to investigate the molecular mechanism of hyperlipidemia related genes and proteins such as ApoA-1 which is related to high density lipoprotein expression and to review the effect of diet and medicaiton, and environmental factor to gene expression. Using the techique of metabolomics, metabolic biochemstry to investigate is welcome. We also welcome novel biomarker for ealry diagnosis and monitoring of hyperlipidemia related disease. Submissions are welcome on wide range of hyperlipidemia related endocrine disease such as diabetes mellitus, Cushing's disease, pancreatitis, gall bladder mucoceles.

Dr. Kyuhyung Choi
Guest Editor

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Keywords

  • hyperlipidemia
  • diabetes mellitus
  • Cushing’s disease
  • pancreatitis
  • gall bladder mucoceles

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Published Papers (1 paper)

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Research

9 pages, 1058 KiB  
Communication
A Pilot Study of the Total Cholesterol/High-Density Lipoprotein Ratio as a Prognostic Indicator of Hyperlipidemia-Related Diseases in Dogs and Cats
by Kyuhyung Choi
Curr. Issues Mol. Biol. 2024, 46(11), 12174-12182; https://doi.org/10.3390/cimb46110722 - 30 Oct 2024
Cited by 1 | Viewed by 1252
Abstract
In veterinary medicine, the significance of high-density lipoprotein (HDL) measurements is not as well documented as it is in humans. The HDL level can be measured in dogs as well and, through referring to the normal range, it is possible to find out [...] Read more.
In veterinary medicine, the significance of high-density lipoprotein (HDL) measurements is not as well documented as it is in humans. The HDL level can be measured in dogs as well and, through referring to the normal range, it is possible to find out what this means in relation to various endocrine diseases and hyperlipidemia diseases. The aim of this study is to measure the HDL levels in dogs with various conditions and to evaluate whether the total cholesterol (TC)-to-HDL ratio is effective as a prognostic indicator in various hyperlipidemia and endocrine diseases, which is significant since it is the first trial in dogs. Through a retrospective study design, sixteen client-owned dogs and cats visiting a local private practice were divided into three groups: five dogs without hyperlipidemia or metabolic disease (Group 1), eight dogs with Cushing’s, hypothyroidism, and gallbladder sludge (Group 2), and three cats, including one with diabetes, one with a urinary disorder, and one healthy cat (Group 3). In two dogs, the TC/HDL values were between 2 and 3; in two dogs, the values were between 3 and 4; and in two dogs, the values were between 4 and 5. In three dogs, the TC/HDL values were between 5 and 6 and in three dogs the ratio values were between 6 and 7. The other value was higher than 8. Except for two dogs that showed lower values than 3, all dogs in Group 1 and Group 2 had concurrent endocrine disease. This means that TC/HDL values can be an excellent indicator of endocrine disease in dogs as well. In cats, although it is a very small batch of samples, a high TC/HDL value of 9 points was shown in the cat that had diabetes mellitus. However, for more statistically significant results, a larger sample group for further investigation is needed. Full article
(This article belongs to the Special Issue Hyperlipidemia and Molecular Mechanism in Human and Animals)
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