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Molecular Mechanisms of Natural Product-Induced Immune Modulation: From Signaling Pathways to Therapeutic Targets

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".

Deadline for manuscript submissions: 28 February 2026

Special Issue Editor

Special Issue Information

Dear Colleagues,

Natural products represent an invaluable source of bioactive compounds with diverse immunomodulatory properties. Despite their long history in traditional medicine, the molecular mechanisms underlying their immune-regulating effects remain incompletely understood. This Special Issue aims to explore how natural products modulate immune responses at the molecular level, bridging traditional knowledge with modern molecular biology. We welcome original research articles, reviews, and communications that investigate the molecular basis of natural-product-induced immunomodulation.

Topics of interest include, but are not limited to, the following: mechanisms of immune cell activation or suppression; inflammatory and anti-inflammatory pathways; innate and adaptive immune responses; molecular targets in autoimmune diseases, chronic inflammation, and cancer immunity; host–pathogen interactions and antimicrobial immunity; structure–activity relationships and target identification; biomarker discovery and mechanism-based therapeutic applications; synergistic effects and molecular interactions of natural product combinations; and novel methodologies for studying natural product immunology.

This Special Issue provides a platform for researchers from diverse fields—including natural product chemistry, immunology, molecular biology, and pharmacology—to share discoveries that advance our understanding of how natural molecules influence immune function and disease.

Prof. Dr. Suyun Lyu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • immunomodulation
  • immune responses
  • molecular mechanisms
  • immune cell activation
  • inflammation pathways
  • autoimmune diseases

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Published Papers

This special issue is now open for submission.
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