Molecular Mechanisms of Natural Product-Induced Immune Modulation: From Signaling Pathways to Therapeutic Targets

Dear Colleagues,

Natural products represent an invaluable source of bioactive compounds with diverse immunomodulatory properties. Despite their long history in traditional medicine, the molecular mechanisms underlying their immune-regulating effects remain incompletely understood. This Special Issue aims to explore how natural products modulate immune responses at the molecular level, bridging traditional knowledge with modern molecular biology. We welcome original research articles, reviews, and communications that investigate the molecular basis of natural-product-induced immunomodulation.

Topics of interest include, but are not limited to, the following: mechanisms of immune cell activation or suppression; inflammatory and anti-inflammatory pathways; innate and adaptive immune responses; molecular targets in autoimmune diseases, chronic inflammation, and cancer immunity; host–pathogen interactions and antimicrobial immunity; structure–activity relationships and target identification; biomarker discovery and mechanism-based therapeutic applications; synergistic effects and molecular interactions of natural product combinations; and novel methodologies for studying natural product immunology.

This Special Issue provides a platform for researchers from diverse fields—including natural product chemistry, immunology, molecular biology, and pharmacology—to share discoveries that advance our understanding of how natural molecules influence immune function and disease.

Prof. Dr. Suyun Lyu
Guest Editor

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