cimb-logo

Journal Browser

Journal Browser

Exploring Molecular Pathways in Skin Health and Diseases

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 764

Special Issue Editor

Department of Life Science, College of Bio-Nano Technology, Gachon University, Seongnam, Republic of Korea
Interests: oxidative stress; inflammation; antioxidant effect; anti-inflammatory effect; anti-skin aging; skin disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skin health is regulated by complex molecular pathways that preserve its structure and function while enabling responses to internal and external stressors. These pathways play pivotal roles in processes such as oxidative stress regulation, cytokine signaling, collagen metabolism, and immune responses, which are crucial in maintaining skin homeostasis. However, disruptions to these pathways can result in various skin conditions, including chronic inflammation, premature aging, and skin cancer.

This Special Issue will explore the molecular mechanisms underpinning skin health and disease, focusing on cutting-edge research in this field. A particular emphasis will be placed on the discovery of biomarkers and the development of innovative therapeutic strategies to elucidate the causes of skin diseases and identify potential treatments.

By addressing these critical topics, this Special Issue will provide novel insights into skin biology and facilitate the advancement of effective prevention and treatment approaches. We invite submissions spanning a wide range of research areas, from basic science to clinical applications, with the aim of fostering significant contributions to the study of skin health and disease.

Dr. Sullim Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin health
  • skin aging
  • skin disease
  • molecular pathways
  • oxidative stress
  • immune response
  • inflammatory skin diseases

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

18 pages, 2683 KiB  
Article
Evaluation of the Antiaging Potential of the Dendropanax morbiferus-Derived Compound Dendropanoxide in TNF-α-Stimulated Human Dermal Fibroblasts
by Si-Young Ahn, Sanghyun Lee, Daeyoung Kim and Sullim Lee
Curr. Issues Mol. Biol. 2025, 47(3), 188; https://doi.org/10.3390/cimb47030188 - 14 Mar 2025
Viewed by 653
Abstract
In this study, we investigated the antiaging potential of dendropanoxide (DP), an active compound derived from Dendropanax morbiferus, in human dermal fibroblasts (NHDFs) induced by Tumor Necrosis Factor-alpha (TNF-α) and in human epidermal keratinocytes (NHEKs) induced by TNF-α and interferon gamma (IFN-γ). [...] Read more.
In this study, we investigated the antiaging potential of dendropanoxide (DP), an active compound derived from Dendropanax morbiferus, in human dermal fibroblasts (NHDFs) induced by Tumor Necrosis Factor-alpha (TNF-α) and in human epidermal keratinocytes (NHEKs) induced by TNF-α and interferon gamma (IFN-γ). We induced oxidative stress related to ultraviolet (UV) radiation with TNF-α and IFN-γ and then treated the cells with various concentrations of DP to evaluate its effects on reactive oxygen species (ROS) production, matrix metalloproteinase-1 (MMP-1) expression, collagen synthesis, inflammatory cytokine expression, and skin barrier protection. The results showed that DP significantly reduced ROS production, indicating its potential to alleviate oxidative stress in the skin. Additionally, DP effectively inhibited MMP-1 production, suggesting that it could prevent collagen degradation in the dermis, significantly increase the secretion of pro-collagen I, promote collagen synthesis, and protect the dermal extracellular matrix (ECM). Moreover, DP significantly reduced the expression of inflammatory cytokines IL-1β and IL-6, thereby inhibiting excessive inflammatory responses in the skin. DP also enhanced the gene expression of key factors involved in skin barrier maintenance, including Kazal-type 5 (SPINK5), loricrin (LOR), aquaporin-3 (AQP3), filaggrin (FLG), and keratin 1 (KRT1), suggesting its potential to maintain and protect the skin barrier. Western blot analysis revealed that DP inhibited TNF-α-induced phosphorylation of JNK and p38, implying that DP exerts antiaging effects through the regulation of the JNK and p38 signaling pathways. Collectively, these findings suggest that DP has significant potential as an antiaging agent. Full article
(This article belongs to the Special Issue Exploring Molecular Pathways in Skin Health and Diseases)
Show Figures

Graphical abstract

Back to TopTop