Nanotechnology-Enhanced Photodynamic Therapy for Precision Medicines
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 27
Special Issue Editors
Interests: photodynamic therapy; targeted delivery; nanoparticles; controlled release; nanotheranostics; photosensitizers; PDT light sources
Special Issues, Collections and Topics in MDPI journals
Interests: photosensitisers; nanotheranostics; pharmacogenetic testing
Special Issue Information
Dear Colleagues,
Photodynamic therapy (PDT) is a noninvasive therapeutic approach with a lower incidence of side effects and high precision in targeting compared to conventional treatments. PDT has demonstrated promising results in treating various types of cancer, infections, inflammation, and wound healing and its minimally invasive nature using non-ionising radiation.
Personalised medicine recognises an individual’s specific healthcare needs due to the heterogeneity of patients. Pharmacogenetics is one of the fundamental paradigms of personalised medicine, which analyses genetic associations with the pharmacokinetics and pharmacodynamics of drugs. Testing for single nucleotide polymorphisms can enable a customised approach for each individual in regard to drug delivery, managing side effects/adverse effects, and enabling better photosensitive drug response. Integrating pharmacogenetics and nanotechnology can enable novel designs based on pharmacotyping for individualised dose and dosage-form-adjusted therapy.
On the other hand, active targeting encompasses specific targeting of a molecule, cellular compartment, or tissue by the nanodrug, enabling precision medicine by selecting the best possible ligand to selectively direct the correct dose of nanodrug to the correct site. This technology relies on the attachment of various molecules on the nanoparticle surface, which distinguishes ligand-, protein-, and oligonucleotide-based active targeting. Genomics, metabolomics, and proteomics are great tools to facilitate diagnosis and therapy for precision medicine.
This Special Issue seeks original research articles, reviews, and perspectives addressing recent advancements in nanotechnology-enhanced PDT for precision medicine. Topics of interest include the following:
- Photodynamic therapy;
- Photosensitisers;
- Targeting nanocarriers;
- Multifunctional nanoplatforms;
- Nanotheranostics;
- Active targeting of cancer;
- Molecular drug targeting;
- Drug metabolism and toxicity;
- Pharmacogenetic testing;
- Cancer microenvironment remodelling.
We look forward to receiving your inspiring contributions.
Prof. Dr. Milutin Stepić
Dr. Iva A. Popović
Guest Editors
Manuscript Submission Information
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Keywords
- photodynamic therapy
- photosensitisers
- targeting nanocarriers
- multifunctional nanoplatforms
- nanotheranostics
- active targeting of cancer
- molecular drug targeting
- drug metabolism and toxicity
- pharmacogenetic testing
- cancer microenvironment remodelling
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