Advances in Phytochemical Research: Molecular Pathways in Health and Disease
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 603
Special Issue Editors
Interests: breast cancer; natural compounds; phytochemicals; estrogen receptors; tamoxifen resistance; chemoprevention
Special Issues, Collections and Topics in MDPI journals
Interests: targeted cancer therapy; apoptosis; metastasis; cancer chemoresistance; pancreatic cancer; breast cancer; lung cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Bioactive phytochemicals, including flavonoids, alkaloids, and terpenoids, have been reported to regulate cellular processes such as inflammation, oxidative stress, and apoptosis. Based on these mechanisms, we can develop new therapeutic strategies for diseases such as cancer, cardiovascular disorders, and metabolic syndromes, promoting the use of natural products in preventive and therapeutic medicine. Clinical trials and epidemiological studies continue to support the notion that a diet rich in phytochemicals correlates with improved health outcomes and may help prevent various diseases. Importantly, recent advancements in bioinformatics and molecular biology techniques have led to a better understand of the mechanisms through which these phytochemicals exert their effects. By studying specific molecular pathways, such as NF-kB and MAPK signaling, we can uncover how phytochemicals can modulate gene expression and protein function. Therefore, the aim of this Special Issue is to provide an overview of advances in phytochemical research by exploring how plant-derived compounds affect molecular pathways implicated in health and disease.
For this collection, we invite submissions on the following topics:
- Isolation and characterization of phytochemicals with potential medicinal properties.
- Anti-oxidant properties of phytochemicals and their role in combating oxidative stress.
- Anti-inflammatory effects and the modulation of immune responses.
- Phytochemicals’ effect on cell signaling pathways (e.g., NF-kB, MAPK, apoptosis signaling).
- The role of phytochemicals in cancer prevention and treatment.
- Impacts on cardiovascular health and metabolic syndromes.
- Neuroprotective effects of phytochemicals in neurodegenerative diseases.
- The development of phytochemical-based drugs and nutraceuticals.
- Synergistic effects of phytochemicals with conventional therapies.
- Research on phytochemicals in clinical trials.
- Genetic and epigenetic regulation by phytochemicals.
- Interactions between phytochemicals and gut microbiota.
- Advances in methodologies for studying phytochemicals (e.g., metabolomics, transcriptomics).
- Potential for developing precision medicine approaches using phytochemicals.
- Explorations of traditional medicinal plants and their phytochemical constituents.
These topics collectively contribute to a deeper understanding of how phytochemicals influence health outcomes and provide insights into potential therapeutic applications in the context of various diseases.
Dr. Christiana Charalambous
Dr. Christiana Neophytou
Guest Editors
Manuscript Submission Information
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Keywords
- phytochemicals
- molecular mechanisms
- cancer signaling pathways
- anti-inflammatory properties
- anti-oxidant properties
- apoptosis
- cardiovascular disorders
- metabolic syndromes
- chemoprevention
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