Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular Mechanisms in Pregnancy and Foetal Development submission deadline 15 Oct 2026 | 4 articles | Viewed by 5622 | Submission Open
Keywords: pregnancy; fetus; reproduction; placenta; maternal; fertility; preeclampsia; fetal growth restriction; gestational diabetes; stillbirth
Gut Dysbiosis in Inflammatory Diseases
edited by Weiwei Liu
submission deadline 15 Oct 2026 | 2 articles | Viewed by 5568 | Submission Open
Keywords: gut microbiota; innate and adaptive immunity; dysbiosis; metabolism; inflammatory bowel diseases; autoimmune diseases; metabolic disorders; fecal microbiota transplantation
(This special issue belongs to the Section Cellular Pathology)
Lung Diseases: From Cellular and Molecular Mechanisms to Targeted Therapies submission deadline 15 Oct 2026 | 1 articles | Viewed by 4067 | Submission Open
Keywords: lung diseases; cellular and molecular mechanisms; targeted therapies; OMICS; single-cell sequencing
The Artificial Intelligence to the Rescue of Cancer Research submission deadline 15 Oct 2026 | 2 articles | Viewed by 3846 | Submission Open
Keywords: cancer research; artificial intelligence; personalized medicine; multi-omics data integration; AI-driven drug discovery; precision medicine
(This special issue belongs to the Section Cell Methods)
Cellular and Molecular Studies of the Adrenal Gland
edited by Wen-Jun Shen, and Salman Azhar
submission deadline 15 Oct 2026 | 1 articles | Viewed by 728 | Submission Open
Keywords: adrenal zonation; steroid hormones; steroidogenesis; congenital adrenal hyperplasia; hyperaldosteronism; Cushing’s syndrome
Regenerative Medicine for Bone and Dental Tissues: Biology and Applications submission deadline 15 Oct 2026 | Viewed by 168 | Submission Open
Keywords: bone regeneration; dental tissue regeneration; stem and progenitor cells; biomaterials and bioactive scaffolds; translational regenerative strategies
(This special issue belongs to the Section Tissues and Organs)
Molecular and Cellular Mechanisms of Inherited Retinal Dystrophies
edited by Rosellina Guarascio, and
submission deadline 15 Oct 2026 | Viewed by 156 | Submission Open
Keywords: retinal degeneration; photoreceptors; RPE; phototransduction; connecting cilium; retinoid cycle; protein folding; inflammation; oxidative stress; light damage
(This special issue belongs to the Section Cellular Pathology)
Age-Related Macular Degeneration (AMD): From Cellular and Molecular Mechanisms to Therapies
edited by
submission deadline 15 Oct 2026 | Viewed by 115 | Submission Open
Keywords: age‑related macular degeneration; cellular mechanism; molecular mechanism; gene therapies; neuroprotective strategies
(This special issue belongs to the Section Cellular Aging)
Advances in Skin Physiopathology
edited by Monica Ottaviani, and
submission deadline 15 Oct 2026 | Viewed by 89 | Submission Open
Keywords: dermatological diseases; skin aging; inflammation-associated skin diseases; skin cancer; skin microbiome; 3D cell models
(This special issue belongs to the Section Cellular Pathology)
Advances in Muscle Research in Health and Disease—2nd Edition
edited by
submission deadline 20 Oct 2026 | 4 articles | Viewed by 12980 | Submission Open
Keywords: skeletal muscle; cardiac muscle; smooth muscle; myocyte; vascular smooth muscle cell; stem cell; development; homeostasis; regeneration; biomarker; therapeutic target
(This special issue belongs to the Section Tissues and Organs)
Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance
edited by , and Yuancheng Li
submission deadline 20 Oct 2026 | 4 articles | Viewed by 11047 | Submission Open
Keywords: cancer; tumor progression; therapeutic resistance; molecular targets; tumor microenvironment; innovative therapies; targeted drug delivery; natural product
(This special issue belongs to the Section Cell Microenvironment)
Lung Cancer: Molecular Mechanisms and Therapeutic Opportunities submission deadline 20 Oct 2026 | 3 articles | Viewed by 5234 | Submission Open
Keywords: precision oncology; immunotherapy; targeted therapy; genomic characterization; biomarker; microenvironment; non-small cell lung cancer; small cell lung cancer
(This special issue belongs to the Section Cell Microenvironment)
From Energy Metabolism to Disease: The Multifaceted Roles of Mitochondria
edited by Amy H. Attaway and Saurabh Mishra
submission deadline 20 Oct 2026 | 2 articles | Viewed by 3785 | Submission Open
Keywords: mitochondrial oxidation; ROS; aging; disease
Vascular Biology: From Molecular Mechanisms to Precision Therapies
edited by Payaningal R. Somanath
submission deadline 20 Oct 2026 | 2 articles | Viewed by 2346 | Submission Open
Keywords: angiogenesis; endothelium; vascular permeability; blood–tissue barrier; organ injury
PI3K/AKT/mTOR Signaling Network in Human Health and Diseases, 3rd Edition
edited by , and
submission deadline 20 Oct 2026 | 1 articles | Viewed by 2075 | Submission Open
Keywords: acne; ageing; Akt; Alzheimer’s disease; autophagy; autoimmunity; PI3K; mTOR; cancer; cardiovascular diseases; diabetes; growth; hamartoma; hypertrophy; inflammation; neurologic; tuberous sclerosis; systemic sclerosis; obesity; Parkinson’s disease; psoriasis; atopic dermatitis; burns/wound healing; targeted therapy; natural products; biologics
Cellular Pathophysiology of Intensive Care Unit-Acquired Muscle Dysfunction
edited by Lars Larsson
submission deadline 20 Oct 2026 | 1 articles | Viewed by 762 | Submission Open
Keywords: intensive care unit-acquired weakness; ventilator-induced diaphragm dysfunction; skeletal muscle atrophy; protein degradation; mitochondrial dysfunction; JAK-STAT signaling; oxidative stress; critical illness myopathy; autophagy; muscle proteostasis
(This special issue belongs to the Section Cellular Pathology)
Exclusive Review Papers in 'Cellular Biophysics'
edited by
submission deadline 20 Oct 2026 | Viewed by 299 | Submission Open
Keywords: cellular biophysics; membrane biophysics; cytoskeletal dynamics; cellular mechanics; mechanotransduction; phase separation; molecular motors; bioelectricity; single-molecule techniques; computational biophysics; mechanobiology; active matter
(This special issue belongs to the Section Cellular Biophysics)
New Advances and Perspectives in the Molecular Mechanisms of Aging and Skin Cancer: Potential Options for Prevention and Treatment
edited by and Ewelina Musielak
submission deadline 20 Oct 2026 | Viewed by 135 | Submission Open
Keywords: skin cancer; malignancy; melanoma; non-melanoma; prevention; skin aging; skin photo-aging; skin inflammation; treatment; inflammaging; immune dysfunction; senescent cell
(This special issue belongs to the Section Cellular Aging)
Polyadenylation-Mediated Regulation of Pulmonary Diseases submission deadline 20 Oct 2026 | Viewed by 102 | Submission Open
Keywords: polyadenylation; lung remodeling; pulmonary fibrosis; epitranscriptomics; alveolar epithelial cells
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Regulatory Factors and Signaling Pathways of Anti-Tumor Immune Responses
edited by
submission deadline 22 Oct 2026 | 1 articles | Viewed by 899 | Submission Open
Keywords: anti-tumor immunity; immunotherapy; immune checkpoint blockade; immune receptor and ligand; immune evasion; tumor immune microenvironment; inflammation; T-cell activation and inhibition; myeloid-derived suppressor cell; macrophage; dendritic cell
(This special issue belongs to the Section Cellular Immunology)
The Dual Role of Extracellular Vesicles in Neurodegeneration: Disease Biomarkers and Drug Delivery Platforms Within the Matrix Microenvironment submission deadline 25 Oct 2026 | 1 articles | Viewed by 934 | Submission Open
Keywords: extracellular vesicles; neurodegenerative diseases; extracellular matrix; biomarkers; therapeutic applications; drug delivery
(This special issue belongs to the Section Intracellular and Plasma Membranes)
Caveolae Function in Cell Membrane Dynamics and Signal Transduction submission deadline 25 Oct 2026 | Viewed by 363 | Submission Open
Keywords: caveolae; caveolin and cavin proteins; plasma membrane organization; endocytosis and vesicular trafficking; mechanotransduction; lipid rafts and cholesterol metabolism; signal transduction; vascular biology and angiogenesis; cancer cell biology; membrane remodeling in disease
Vascular Microenvironment and Atherosclerosis submission deadline 25 Oct 2026 | Viewed by 208 | Submission Open
Keywords: vascular microenvironment; atherosclerosis; vascular inflammation; endothelial cells; smooth muscle cells; vascular–immune cell interactions; extracellular matrix; vascular remodeling; mechanotransduction; vascular biology
(This special issue belongs to the Section Cells of the Cardiovascular System)
Nuclear Receptors, Drug Discovery, Nutraceuticals, and Neurodegenerative Diseases
edited by Rajesh Haresh Amin, and Meenakshi Singh
submission deadline 25 Oct 2026 | Viewed by 139 | Submission Open
Keywords: nuclear receptors; neurodegenerative diseases; metabolic dysfunction; inflammation; drug design
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Tumor Microenvironment and Immune Regulation
edited by
submission deadline 25 Oct 2026 | Viewed by 137 | Submission Open
Keywords: cellular immunology; tumor microenvironment; intra- and extracellular signaling; immunometabolism; experimental cytology; tumor-infiltrating lymphocytes; spatial transcriptomics
(This special issue belongs to the Section Cell Microenvironment)
Advances in Annexin Biology
edited by , and Nunzia Novizio
submission deadline 28 Oct 2026 | 1 articles | Viewed by 1269 | Submission Open
Keywords: annexin family; calcium-dependent membrane binding; cell signaling; inflammation and immune response; membrane repair; cancer biology; cell motility; cell differentiation; tumor microenvironment; diagnostic/prognostic biomarkers; therapeutic targets
Role of Thyroid Hormone in Neurodegenerative and Neurodevelopmental Disorders
edited by Janaína Sena de Souza
submission deadline 30 Oct 2026 | 6 articles | Viewed by 17860 | Submission Open
Keywords: thyroid hormones; neurodevelopmental and neurodegenerative disorders; central nervous system
(This special issue belongs to the Section Cellular Neuroscience)
Advances in Reproductive Biology: Cellular and Molecular Mechanisms
edited by and Clara González-Marín
submission deadline 30 Oct 2026 | 6 articles | Viewed by 10898 | Submission Open
Keywords: gametogenesis; fertilization; embryo implantation; reproductive genetics; epigenetics in reproduction; hormonal signaling; stem cells and reproduction; assisted reproductive technologies (ARTs); molecular fertility regulation; reproductive health innovations
(This special issue belongs to the Section Reproductive Cells and Development)
Identifying Functional Genomics and Pathways in Cancer Pathogenesis and Therapy Resistance
edited by and Ramkrishna Mitra
submission deadline 30 Oct 2026 | 3 articles | Viewed by 7451 | Submission Open
Keywords: functional genomics; cancer signaling pathways; targeted therapy; drug resistance; tumor microenvironment; oncogenomics; acquired resistance; tumor mutations
(This special issue belongs to the Section Cellular Pathology)
Translational Aspects of Cell Signaling
edited by
submission deadline 30 Oct 2026 | 4 articles | Viewed by 6123 | Submission Open
Keywords: cell signaling; drug development; prognostic markers; bioinformatics; translational research
Regulation of Iron Homeostasis
edited by
submission deadline 30 Oct 2026 | 2 articles | Viewed by 2909 | Submission Open
Keywords: iron homeostasis; iron transport; iron storage; iron-containing proteins
Mechanisms and Therapies of Cell Death Pathways
edited by and Deniz Gulfem Ozturk
submission deadline 30 Oct 2026 | 1 articles | Viewed by 2463 | Submission Open
Keywords: cell death; mitochondrial regulation; BCL-2 family; non-apoptotic cell death; cell death pathways interactions; small molecules; therapeutic strategy; therapy resistance
(This special issue belongs to the Section Cellular Pathology)
New Therapeutic Approaches to Cardiac Repair
edited by Dinakar Iyer
submission deadline 30 Oct 2026 | 1 articles | Viewed by 1120 | Submission Open
Keywords: cardiac regeneration; CRISPR/base editing; mRNA therapeutics; circular RNA (circRNA); lipid nanoparticles (LNPs); engineered exosomes/extracellular vesicles; direct cardiac reprogramming; engineered heart muscle/3D cardiac patches; myocardial infarction repair; translational cardiology
Cellular and Molecular Basis in Chronic Kidney Disease—2nd Edition
edited by and Dulat Bekbolsynov
submission deadline 30 Oct 2026 | 1 articles | Viewed by 699 | Submission Open
Keywords: CKD; renal inflammation; renal fibrosis; RAAS; aldosterone; TGF-B1; uremic toxins; hypertension; GFR; albuminuria
(This special issue belongs to the Section Cellular Pathology)
Mechanism of Endocrine Therapy Resistance in Breast Cancer
edited by and Clodia Osipo
submission deadline 30 Oct 2026 | Viewed by 480 | Submission Open
Keywords: estrogen receptor, endocrine resistance, mechanism of action; predictive biomarkers; signal transduction; novel therapeutics; drug sequencing; drug targets; pathological findings
(This special issue belongs to the Section Cellular Pathology)
Extracellular Vesicles in Chronic Obstructive Pulmonary Disease: A 2025 Update
edited by and
submission deadline 30 Oct 2026 | Viewed by 415 | Submission Open
Keywords: extracellular vesicles (EVs); chronic obstructive pulmonary disease (COPD); inflammation; epithelial barrier; cellular senescence; tissue remodeling; biomarkers; exacerbations; microbiota; therapeutic targets
Advancements in Research on Metabolic Syndrome
edited by Gautam Kumar Pandey
submission deadline 30 Oct 2026 | Viewed by 237 | Submission Open
Keywords: metabolic syndrome; multi-omics; insulin resistance; cell signaling in metabolic disease
Gut Microbiota as a Regulator and Target in Cancer Immunology
edited by and Pazhanichamy Kalailingam
submission deadline 30 Oct 2026 | Viewed by 173 | Submission Open
Keywords: gut microbiota; cancer immunology; tumor microenvironment; immune checkpoint inhibitors; cellular immunotherapy; tumor infiltrating lymphocytes; dysbiosis; microbiota targeted therapy; microbiome biomarkers; immunotherapy resistance
(This special issue belongs to the Section Cellular Immunology)
Cellular and Molecular Mechanisms of Leukemia
edited by Xiangguo Shi
submission deadline 30 Oct 2026 | Viewed by 158 | Submission Open
Keywords: leukemia; genomics; epigenetics; therapeutic resistance; metabolic reprogramming; clonal evolution; immunotherapy
(This special issue belongs to the Section Cellular Pathology)
Decoding Melanoma: Molecular and Cellular Mechanisms and Therapeutic Opportunities submission deadline 30 Oct 2026 | Viewed by 151 | Submission Open
Keywords: translational oncology; tumor biology; melanoma-targeted therapy; precision medicine; biomarker discovery
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms in Bone and Cartilage Damage and Regeneration
edited by
submission deadline 31 Oct 2026 | 9 articles | Viewed by 19545 | Submission Open
Keywords: bone morphogenic proteins (BMPs); bone union with cell therapy; advances in stem cell therapies for fracture non-union and cartilage regeneration; novel cell-based therapies for cartilage repair; functional of collagen/PLA scaffolds in cartilage regeneration; regeneration and revascularization of bone osteonecrosis; evaluation of osteonecrosis regeneration with MRI and histology, and arteriography; identification and validation of new cartilage biomarkers; diaphyseal regeneration with callostasis; union with the membrane technique
(This special issue belongs to the Section Cellular Pathology)
Gene Expression in Adipocytes During Obesity: Understanding Challenges and Future Prospects
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 4607 | Submission Open
Keywords: adipocytes; adipose tissue; obesity; hypoxia; transcription factor; metabolism; epigenetics
Immunoregulation in Cardiovascular Disease
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 4271 | Submission Open
Keywords: cardiovascular disease (CVD); immunoregulation; inflammation; immune cells; immune mediators; immunomodulatory therapies; biomarkers; epigenetics; microbiome; cellular methods/technologies
Advances in Liquid Biopsy for Early Detection and Monitoring of Cancer
edited by Nicola Normanno, and
submission deadline 31 Oct 2026 | 4 articles | Viewed by 4082 | Submission Open
Keywords: ctDNA; circulating tumor cells; microRNAs; exosomes; methylation; fragmentomics; early detection; minimal residual disease; artificial intelligence
Novel Immunotherapies for Diffuse Large B-Cell Lymphoma
edited by
submission deadline 31 Oct 2026 | 3 articles | Viewed by 3597 | Submission Open
Keywords: diffuse large B-cell lymphoma; immunotherapy; CAR-T cells; bispecific antibodies; immune checkpoint inhibitors; antibody–drug conjugates; tumor microenvironment; biomarkers; translational research
Spatial Biology: Decoding Cellular Complexity in Tissues submission deadline 31 Oct 2026 | 2 articles | Viewed by 3358 | Submission Open
Keywords: spatial biology; spatial tissue profiling; proteomics; transcriptomics; cell and tissue
(This special issue belongs to the Section Tissues and Organs)
Signalling Mechanisms Regulating Cardiac Fibroblast Function
edited by Haofei Wang and
submission deadline 31 Oct 2026 | 1 articles | Viewed by 2550 | Submission Open
Keywords: cardiac fibroblasts; myofibroblast activation; extracellular matrix remodeling; fibrosis; intercellular communication; mechanotransduction; single-cell and spatial insights; regeneration; therapeutic targeting
Cellular and Molecular Mechanisms of Cardiomyopathy submission deadline 31 Oct 2026 | 2 articles | Viewed by 2524 | Submission Open
Keywords: genetic cardiomyopathies; acquired cardiomyopathies; cardiac arrhythmias; disease mechanisms; disease cause; pathogenesis
(This special issue belongs to the Section Tissues and Organs)
Molecular Signaling and Mechanism on Vascular Remodeling
edited by and Yitao Huang
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2070 | Submission Open
Keywords: vascular diseases; atherosclerosis; aneurysm; intimal hyperplasia; vascular remodeling; cellular mechanisms; cellular signaling
Targeting of Cancer Cells with Small Molecule Drugs
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2013 | Submission Open
Keywords: small molecule drugs; cancer cell targeting; targeted cancer therapy; drug delivery systems; precision oncology
(This special issue belongs to the Section Cellular Pathology)
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