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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Effects and Mechanisms of Environmental Toxicants and Nanoparticles on Germ Cells, Gonads, Embryos and Stem Cells

edited by

Silvia Garagna

Maurizio Zuccotti

Danilo Cimadomo

and Giulia Fiorentino

submission deadline 15 Nov 2025 | 1 articles | Viewed by 3489 | Submission Open

Keywords: environmental toxicants; gonadal steroid hormones; ovary; folliculogenesis; oogenesis and oocyte; testis; spermatogenesis and sperm; embryo development; epigenetics; omics; cells lines and stem cells; embryoid bodies; gastruloids and organoids; 3D cell culture and imaging; nanoparticles; nanomaterials

(This special issue belongs to the Section Stem Cells)

Advances in Intestinal Epithelial Plasticity and Regeneration

edited by

Aiguo Tian

submission deadline 15 Nov 2025 | 1 articles | Viewed by 3488 | Submission Open

Keywords: intestinal epithelium; epithelial plasticity; stem cells; tissue repair; self-renewal; regeneration

Innate-Like T Cells: The Variegated Roles of Semi-Invariant TCRs in Health and Disease

edited by

Ethan Shevach

and Akshat Sharma

submission deadline 15 Nov 2025 | Viewed by 2243 | Submission Open

Keywords: innate-like T cells; cancer; autoimmunity; cytokines; immune mechanisms

(This special issue belongs to the Section Cellular Pathology)

Lipids and Lipidomics in Neurodegenerative Diseases

edited by

Nathalie Bernoud-Hubac

and Catherine Malaplate

submission deadline 20 Nov 2025 | 2 articles | Viewed by 13779 | Submission Open

Keywords: lipids; lipidomics; neurodegenerative disease diagnosis; prevention; or treatment; cellular and molecular mechanisms

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Advances in Prenatal Exposure to Environmental Toxicants

edited by

Douglas M. Ruden

and

Sudipta Dutta

submission deadline 20 Nov 2025 | 4 articles | Viewed by 12182 | Submission Open

Keywords: prenatal exposures; toxicogenomics; epigenomics; placenta; perinatal outcomes; neurodevelopmental outcomes; respiratory outcomes

Second Edition of Advances in Adipose Tissue Biology

edited by

Melvin K. S. Leow

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4254 | Submission Open

Keywords: adipocyte differentiation; progenitors; and stem cells; adipokines; myokines; hepatokines; cytokines; cellular signaling; and molecular crosstalk; white adipose tissue (WAT) and brown adipose tissue (BAT); beige fat and browning of WAT; research techniques and methodologies; diagnostics and therapeutics; genomics; metabolomics; other ‘ omics’ technologies; metabolic syndrome; obesity; insulin resistance; cancer

(This special issue belongs to the Section Tissues and Organs)

Molecular Mechanism of Liver Transplantation

edited by Carmen Peralta and Juan Carlos Cutrin

submission deadline 20 Nov 2025 | 1 articles | Viewed by 4126 | Submission Open

Keywords: liver transplantation; ischemia-reperfusion injury; signaling pathways; graft dysfunction; sterile inflammation; liver regeneration; fatty grafts; normothermic machine perfusion; defatting strategies

(This special issue belongs to the Section Tissues and Organs)

Recent Advances in the Study of Tau Protein

edited by

Santosh Jadhav

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3339 | Submission Open

Keywords: tau protein; post-translational modification; tauopathy filaments; neuro-immune interactions

(This special issue belongs to the Section Cells of the Nervous System)

Tumor Stroma Interaction

edited by

Vladimir Jurisic

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2466 | Submission Open

Keywords: cells; cancer; inflammation; exocytosis; immune system; tumor stroma

Decoding the Complexity of Angiogenesis: Insights into Vascular Formation and Disease

edited by

Kay-Dietrich Wagner

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1962 | Submission Open

Keywords: angiogenesis; vasculogenesis; development; physiological angiogenesis; pathophysiology; cell– cell communication; cell signaling

(This special issue belongs to the Section Cells of the Cardiovascular System)

Ripening and Degradation Mechanisms of Neutrophil Extracellular Traps

edited by

Martin Herrmann

and Maximilian Dölling

submission deadline 20 Nov 2025 | Viewed by 502 | Submission Open

Keywords: neutrophil extracellular traps; degradation of NETs; ripening of NETs

(This special issue belongs to the Section Cellular Immunology)

Aging and Metabolic Diseases

edited by

Carlos Guillen

submission deadline 20 Nov 2025 | Viewed by 479 | Submission Open

Keywords: aging; insulin resistance; diabetes; obesity; mitochondrial dysfunction; beta-galactosidase; senescent-associated secretory phenotype; pancreatic beta cells

(This special issue belongs to the Section Cellular Aging)

Extracellular Vesicles Based Drug Delivery

edited by

Giovanni Camussi

and

Cristina Grange

submission deadline 20 Nov 2025 | Viewed by 398 | Submission Open

Keywords: EV engineering; targeting; therapy; natural carrier; exosomes

Genetic and Genomic Insights into Complex Human Diseases: Advances, Challenges and Integrative Approaches

edited by Tianxiao Huan and Chan Zhou

submission deadline 20 Nov 2025 | Viewed by 266 | Submission Open

Keywords: genetics; genomics; proteomics; complex diseases; multi-omics; machine learning

Transient Receptor Potential (TRP) Channels and Health and Disease

edited by Hiroki Kittaka and Makoto Tominaga

submission deadline 20 Nov 2025 | Viewed by 241 | Submission Open

Keywords: Transient Receptor Potential (TRP) channels; cell signaling; cell physiology

Epigenetic Regulation in Plant–Microbe Interactions and Environmental Adaptation

edited by Zhongshou Wu and Bochen Jiang

submission deadline 20 Nov 2025 | Viewed by 227 | Submission Open

Keywords: epigenetic regulation; plant– microbe interactions; environmental adaptation

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Methane Biosynthesis

edited by

Divya Prakash

, James Ferry and

Shikha Singh Chauhan

submission deadline 20 Nov 2025 | Viewed by 195 | Submission Open

Keywords: methane; methanogenesis; methanogens; carbon cycle; gut microbiota; energy conservation; human diseases

The Metabolic Interactions and Pathways in Cancers

edited by Mohamed Elgendy

submission deadline 20 Nov 2025 | Viewed by 179 | Submission Open

Keywords: cancer metabolism; metastasis; drug resistance; oncometabolites; metabolic plasticity; diet; bioenergetics; metabolic crosstalk; immunotherapy

Acute Liver Failure: Molecular Actors in Liver–Adipose Tissue Interplay

edited by Marika Crescenzi

submission deadline 20 Nov 2025 | Viewed by 161 | Submission Open

Keywords: inflammasome; adipose tissue; acute liver injury; adipokines; liver macrophages; hepatic stellate cells; liver sinusoidal endothelial cells

(This special issue belongs to the Section Tissues and Organs)

New Insights into Astrocytes in Health and Disease

edited by

Tao Tao

submission deadline 20 Nov 2025 | Viewed by 115 | Submission Open

Keywords: astrocytes heterogeneity; blood-brain barrier (BBB); synaptic modulation; metabolic support; neuroinflammation; ageing; neurodegenerative disorders; neurodevelopmental disorders; stress response

(This special issue belongs to the Section Cells of the Nervous System)

Targeting Tumor Metabolism and Epigenetics: Mechanisms and Therapeutic Strategies

edited by

Jorge Mata-Garrido

Raquel Francés

and Íñigo Casafont

submission deadline 22 Nov 2025 | Viewed by 282 | Submission Open

Keywords: tumor metabolism; epigenetics; metabolic reprogramming; DNA methylation; histone modification; warburg effect; glycolysis inhibitors; fatty acid synthesis; chromatin remodeling; cancer therapy

(This special issue belongs to the Section Cellular Metabolism)

Cellular and Molecular Basis in Chronic Kidney Disease

edited by

Prabhatchandra Dube

submission deadline 25 Nov 2025 | 8 articles | Viewed by 21679 | Submission Open

Keywords: CKD; renal inflammation; renal fibrosis; RAAS; aldosterone; TGF-B1; uremic toxins; hypertension; GFR; albuminuria

(This special issue belongs to the Section Cellular Pathology)

Glial Cells in Aging Neuroscience

edited by

Renato Socodato

submission deadline 25 Nov 2025 | 2 articles | Viewed by 9030 | Submission Open

Keywords: glial cells; aging; neuroinflammation; neurodegeneration; glial– neuronal interactions; glial– glial crosstalk; astrocytes; oligodendrocytes; microglia; ependymal cells

(This special issue belongs to the Section Cellular Aging)

Biomolecular Condensates in Oncology and Immunology

edited by

Andrzej Mackiewicz

Pravin B. Sehgal

and

Mariusz Kaczmarek

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1461 | Submission Open

Keywords: liquid-liquid phase separation (LLPS); biomolecular condensates; pro-oncogenic signaling; innate and adaptive immunity; transcriptional regulation; epigenetic regulation; condensate targeting; antiviral mechanisms; intercellular adhesion; cell migration and metastasis

(This special issue belongs to the Section Cellular Immunology)

CAR T Cells in Human Cancers

edited by

Tabish H. Khan

and

Naoshad Muhammad

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1408 | Submission Open

Keywords: CAR T cells; engineered immune cell therapies; CAR T cell engineering

Pathology and Treatments of Amyotrophic Lateral Sclerosis (ALS)

edited by Laxman Gangwani

submission deadline 28 Nov 2025 | 2 articles | Viewed by 3649 | Submission Open

Keywords: amyotrophic lateral sclerosis (ALS); pathology; molecular mechanisms; treatments; symptom management; biological mechanisms; risk factors; innovative treatments

(This special issue belongs to the Section Cellular Pathology)

Cellular Senescence and Senotherapies in the Aging Retina

edited by

Bhavana Chhunchha

submission deadline 28 Nov 2025 | Viewed by 349 | Submission Open

Keywords: retina; senescence; aging; inflammasome; oxidative stress; antioxidant; gene therapy; senotherapies; glaucoma; diabetic retinopathy

(This special issue belongs to the Section Cellular Aging)

Cell-to-Cell Crosstalk as a Target of Therapies

edited by

Agnieszka Gizak

and

Dominika Drulis-Fajdasz

submission deadline 30 Nov 2025 | 2 articles | Viewed by 12981 | Submission Open

Keywords: cell-to-cell crosstalk; cellular communication; microenvironment; extracellular vesicles; diagnostic tools; membrane nanotubes; pathogenesis; therapy; cell metabolism; homeostasis

(This special issue belongs to the Section Cell Microenvironment)

Emerging Insights into Natural Killer Cell Immunity in Infection and Cancer

edited by Sumit Sen Santara,

Engin Berber

, Weshely Kujur and Sachin Mulik

submission deadline 30 Nov 2025 | 5 articles | Viewed by 10523 | Submission Open

Keywords: CAR NK cells; cancer immunotherapy; cell therapy; viral infection; memory NK cells; NK cell targeted therapies; NK-immune cell crosstalk; exosomes

(This special issue belongs to the Section Cellular Immunology)

Gastrointestinal Cancer: From Cellular and Molecular Mechanisms to Therapeutic Opportunities

edited by

Federica Laudisi

and

Carmine Stolfi

submission deadline 30 Nov 2025 | 4 articles | Viewed by 10389 | Submission Open

Keywords: colorectal cancer; gastric cancer; liver cancer; pancreatic cancer; tumor microenvironment; cytokines; epigenetic; checkpoint inhibitors; biomarkers; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

New Research on Immunity and Inflammation in Cardiovascular Disease

edited by Pavel Poredoš

submission deadline 30 Nov 2025 | 7 articles | Viewed by 9591 | Submission Open

Keywords: inflammation; atherosclerosis; coronary artery disease; peripheral arterial disease; cerebrovascular disease; venous thromboembolic disease; circulating biomarkers; anti-innflammatory treatment of cardiovascular disease

(This special issue belongs to the Section Cells of the Cardiovascular System)

Recent Advances in Metabolism and Oxidative Stress in Human Diseases: 2nd Edition

edited by

Isabella Panfoli

and Vanessa Cossu

submission deadline 30 Nov 2025 | 4 articles | Viewed by 8175 | Submission Open

Keywords: antioxidant responses; redox balance; ROS; hematologic oncology; solid tumors; immune response; ATP; cancer cells; mitochondria-ER interactions; endoplasmic reticulum; glucose metabolism; inflammation; mitochondria; mitochondrial dynamics; autophagy; mitophagy; metabolic plasticity; metabolism

(This special issue belongs to the Section Cellular Metabolism)

Advances in Muscle Research in Health and Disease—2nd Edition

edited by

Wan Lee

submission deadline 30 Nov 2025 | 4 articles | Viewed by 7196 | Submission Open

Keywords: skeletal muscle; cardiac muscle; smooth muscle; myocyte; vascular smooth muscle cell; stem cell; development; homeostasis; regeneration; biomarker; therapeutic target

(This special issue belongs to the Section Tissues and Organs)

Role of Calpains in Health and Diseases

edited by

Michel Baudry

and Peter A. Greer

submission deadline 30 Nov 2025 | 4 articles | Viewed by 6032 | Submission Open

Keywords: calpain; physiology; biochemistry; disease; mutation; target; inhibitor

(This special issue belongs to the Section Cellular Pathology)

Retinal Pigment Epithelium in Degenerative Retinal Diseases

edited by Jian Liu and Shintaro Horie

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5538 | Submission Open

Keywords: RPE; degenerative retinal diseases; macular degeneration; diabetic retinopathy; glaucoma; photoreceptor; vascular endothelium; microglia; macrophage; inflammation; oxidative stress; autophagy; mitochondria; lipid metabolism; senescence; neuropeptide; therapeutics; biomarkers

(This special issue belongs to the Section Cellular Pathology)

Genetic and Cellular Basis of Autoimmune Diseases

edited by

Christian Sadik

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5395 | Submission Open

Keywords: autoimmune disease; break of tolerance; effector cells; immunodysregulation; risk genes

(This special issue belongs to the Section Cellular Immunology)

Cellular Mechanisms in Mitochondrial Function and Calcium Signaling

edited by Sergio De la Fuente and Jaime Santo-Domingo

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4472 | Submission Open

Keywords: mitochondria; calcium; MCU; uniporter; NCLX; energy metabolism; disease; MAMs; signaling

(This special issue belongs to the Section Cellular Metabolism)

CRISPR-Based Genome Editing Approaches in Cancer Therapy

edited by Martin Pal

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3817 | Submission Open

Keywords: CRISPR; genome editing; cancer therapy; precision medicine

(This special issue belongs to the Section Cell and Gene Therapy)

Myocardial Ischemia/Reperfusion Injury: Mechanisms and New Directions in Cardioprotection

edited by Sauri Hernandez-Resendiz

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3341 | Submission Open

Keywords: myocardial infarction; heart failure; ischemia/reperfusion injury; no-reflow phenomenon; oxidative stress; cell death; cardiac metabolism; mitochondrial quality control; inflammation; cardioprotection

(This special issue belongs to the Section Tissues and Organs)

Neuroinflammation in Developmental Brain Diseases

edited by

Evelyne Gozal

Jun Cai

and

Gregory Neal Barnes

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2686 | Submission Open

Keywords: neuroinflammation; endothelial injury; blood brain barrier; microglia; immune dysfunction; oxidative stress; autism spectrum disorders; epilepsy; cerebral palsy; schizophrenia; neurodevelopment; neurovascular brain signaling; inflammatory cytokines; immune cells

(This special issue belongs to the Section Cells of the Nervous System)

Aging and Neurodegeneration: Molecular Insights and Emerging Strategies

edited by

Piotr Paweł Chmielewski

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2527 | Submission Open

Keywords: Alzheimer’ s disease; biomarkers; endolysosomal pathway; extracellular vesicles; inflammation; mitophagy; neurodegeneration; neuroinflammation; Parkinson’ s disease; translational research

(This special issue belongs to the Section Cellular Aging)

Modulation of Senescence and Differentiation in Human Mesenchymal Stem Cells

edited by

Federica Facchin

and

Silvia Canaider

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2284 | Submission Open

Keywords: tissue-specific mesenchymal stem cells; cell senescence; cell differentiation; natural and synthetic molecules; tissue engineering; regenerative medicine

(This special issue belongs to the Section Stem Cells)

Adipose-Derived Stem Cells for Tissue Regeneration

edited by

Lukas Prantl, MD, PhD, MHBA, FACS

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2210 | Submission Open

Keywords: adipose stem cells (ASCs); stromal vascular fraction (SVF); cell enriched lipotransfer (CELT and CELT-PLUS); extracellular vesicles (EVs); tissue processing; basic biology; mechanisms of action; regenerative medicine; cell-bases therapies

(This special issue belongs to the Section Tissues and Organs)

Molecular and Cellular Mechanisms of Brain Development and Neurodevelopmental Disorders

edited by

Mojgan Rastegar

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1926 | Submission Open

Keywords: brain development; neural stem cells; neurodevelopmental disorders; brain diseases; cellular and molecular mechanisms; embryonic and adult brain

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms of Wound Repair

edited by

Elia Ranzato

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1549 | Submission Open

Keywords: wound healing; cellular mechanisms; tissue remodeling; growth factors; extracellular matrix; tissue regeneration

(This special issue belongs to the Section Cellular Pathology)

Updates of Stem Cell Applications in Bone Tissue Engineering

edited by Fahad Karim Kidwai

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1536 | Submission Open

Keywords: stem cells; bone tissue engineering; bone diseases; bone repair; bone defect; bone healing; bone regeneration; osteogenic progenitor cells

(This special issue belongs to the Section Stem Cells)

Non-Coding RNAs as Regulators of Cellular Function and Disease

edited by

Lucia Natarelli

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1429 | Submission Open

Keywords: non-coding RNAs; gene regulation; disease mechanisms; therapeutic targets; molecular mechanisms

Brain Organoids for Disease Modeling

edited by

Jonghun Kim

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1086 | Submission Open

Keywords: brain organoids; induced pluripotent stem cells (iPSCs); neurodevelopmental disorders; neurodegenerative diseases; neuronal activity; organoid-based drug screening

(This special issue belongs to the Section Stem Cells)

The Cellular and Molecular Basis of Lifestyle Factors in Cancer Progression and Prevention

edited by Vivek Kumar Kashyap and Himanshu Narayan Singh

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1030 | Submission Open

Keywords: lifestyle factors; smoking; alcohol consumption; cancer risk; cancer prevention recommendations; modifiable risk factors

(This special issue belongs to the Section Cellular Pathology)

Drug Resistance in Breast and Ovarian Cancers

edited by

Tuula Kallunki

submission deadline 30 Nov 2025 | Viewed by 424 | Submission Open

Keywords: breast cancer; endocrine resistance; ESR1 mutations; Trop-2; ovarian cancer; drug resistance; predictive biomarkers; personalized medicine

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