Organ Regeneration: Cells, Organoids and Organs

Dear Colleagues,

Organ regeneration is significant in biomedical research, harnessing the potential of cells, organoids, and engineered organs to repair or replace damaged tissues. Advances in stem cell biology, tissue engineering, and organoid technologies have deepened our understanding of cellular differentiation, tissue morphogenesis, and organ functionality. Pluripotent stem cells and adult progenitor cells offer avenues to establish new regenerative treatments, and organoids—miniature, self-organizing tissue models—are revolutionizing studies of diseases and their development. Bioengineering approaches, including 3D bioprinting and decellularized scaffolds, pave the way for transplantable organs, addressing critical shortages in organ transplantation. Despite these advancements, challenges persist, such as ensuring the long-term functionality, vascularization, and immune compatibility of regenerated organs and translating findings from bench to bedside.

This Special Issue of Cells, titled "Organ Regeneration: Cells, Organoids and Organs", aims to showcase cutting-edge research and comprehensive reviews that explore the mechanisms, innovations, and applications of organ regeneration. We welcome contributions that address cellular reprogramming, organoid-based disease modeling, tissue engineering, and clinical translation, fostering a multidisciplinary dialogue to accelerate progress in regenerative medicine.

Dr. Jia Huang
Guest Editor

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