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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Fertility Disorders in Testes and Ovaries

edited by

Paweł Kordowitzki

and Joanna Kochan

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1898 | Submission Open

Keywords: fertility; ovary; testis; aging; epigenetics; in vitro fertilization; IVF

(This special issue belongs to the Section Tissues and Organs)

Emerging Roles of Glial Cells in Human Health and Disease

edited by

Dan Frenkel

and

Menachem Hanani

submission deadline 31 Dec 2025 | 10 articles | Viewed by 48369 | Submission Open

Keywords: neurodegenerative diseases; glia cells; astrocyte; microglia; stroke; pain; epilepsy; trauma; demyelinating diseases’ inflammatory diseases; satellite glia; Schwann cells; enteric glia

(This special issue belongs to the Section Cellular Neuroscience)

Gene Therapy for Rare Diseases

edited by

Cord Brakebusch

submission deadline 31 Dec 2025 | 8 articles | Viewed by 43895 | Submission Open

Keywords: gene therapy; gene editing; rare diseases; CRISPR; viral vectors; base editing; prime editing

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Understanding Spinal Cord Injury and Repair: From Molecules to Neurocircuits and Multimodal Prostheses

edited by

Yang D. Teng

submission deadline 31 Dec 2025 | 9 articles | Viewed by 27401 | Submission Open

(This special issue belongs to the Section Cellular Neuroscience)

New Insights into Vascular Biology in Health and Disease

edited by Bashir M. Rezk

submission deadline 31 Dec 2025 | 7 articles | Viewed by 20604 | Submission Open

Keywords: vascular diseases; cardiovascular; cancer; hyperhomocyteinemia; endothelial dysfunction; vascular smooth muscle cell; autophagy; alcohol; galectins; angiogenesis; neovascularization

(This special issue belongs to the Section Cells of the Cardiovascular System)

Biological Mechanisms in the Treatment of Neuropsychiatric Diseases

edited by Randall D Marshall and Frank S. Menniti

submission deadline 31 Dec 2025 | 8 articles | Viewed by 20235 | Submission Open

Keywords: neurodevelopmental conditions; rare neurological disease; molecular mechanisms of novel CNS treatments; precision medicine in neuropsychiatry; organoids; molecular mechanisms of effective treatments

(This special issue belongs to the Section Cellular Pathology)

Select Topics in Molecular and Cellular Mechanisms of Mammalian Reproduction

edited by Zhengui Zheng,

Brent M. Bany

and Liang Ma

submission deadline 31 Dec 2025 | 7 articles | Viewed by 15489 | Submission Open

Keywords: reproductive organ development; sexual differentiation; reproductive tract function; fertilization; implantation; placentation; parturition; lactation

(This special issue belongs to the Section Reproductive Cells and Development)

Cell Stress and Intervention in Neurological Disease: In Honor of Dr. Jang-Yen Wu for His Long and Distinguished Career in Neuroscience

edited by Howard Prentice and

Jang-Yen Wu

submission deadline 31 Dec 2025 | 6 articles | Viewed by 10415 | Submission Open

Keywords: neurodegenerative disease; gene therapy; excitotoxicity; calcium dysregulation; Alzheimer’ s disease; stroke; neuroprotection; neurogenesis

(This special issue belongs to the Section Cellular Neuroscience)

Molecular Mechanisms Involved in Musculoskeletal and Other Tissue Injuries and Disruptions—Regenerative Potential of Exercise

edited by

Eugenia Murawska-Ciałowicz

Ana Filipa Silva

and

Gilmara Gomes De Assis

submission deadline 31 Dec 2025 | 2 articles | Viewed by 9542 | Submission Open

Keywords: tissue injury; tissue regeneration; growth factors; inflammation; oxidative stress; metabolic stress; myokines; adipokines; neurokines; hypertrophy; biochemical pathways; skeletal muscles; liver/hepatic regeneration; brain/neuroplasticity; adipose tissue; varia

(This special issue belongs to the Section Tissues and Organs)

Cellular and Molecular Mechanisms in Oxidative Stress-Related Chronic Diseases

edited by Sara Spinelli,

Alessia Remigante

and

Rossana Morabito

submission deadline 31 Dec 2025 | 2 articles | Viewed by 8914 | Submission Open

Keywords: aging; age-related diseases; redox system; cellular and molecular mechanisms; oxidative stress biomarkers; synthetic and natural antioxidant molecules

(This special issue belongs to the Section Cellular Pathology)

Ageing and Neurodegenerative Diseases, Second Edition

edited by Feng Wang and

Antonella Caccamo

submission deadline 31 Dec 2025 | 3 articles | Viewed by 8745 | Submission Open

Keywords: ageing; miRNAs; lncRNA; circRNAs; diabetes; neurodegenerative disease; insulin signaling

(This special issue belongs to the Section Cellular Pathology)

Signaling Pathways and Mechanisms in Cancer Therapy Resistance

edited by

Natarajan Aravindan

submission deadline 31 Dec 2025 | 3 articles | Viewed by 8536 | Submission Open

Keywords: cancer therapy; therapy resistance; molecular mechanisms; cell signaling pathways; genetic and epigenetic modifications; combination therapies

(This special issue belongs to the Section Cellular Pathology)

Redox and Metabolic Profile of Cancer

edited by

Bato Korac

submission deadline 31 Dec 2025 | 2 articles | Viewed by 8411 | Submission Open

Keywords: cancer; metabolism; redox biology; redox-metabolic reprogramming; reactive species: oxygen; nitrogen; sulfur; etc; cancer microenvironment; cancer-tissue cooperation; mitochondria

(This special issue belongs to the Section Cellular Metabolism)

Cell Biology: State of the Art and Perspectives in Italy 2025

edited by

Vincenzo Carafa

submission deadline 31 Dec 2025 | 1 articles | Viewed by 8274 | Submission Open

Keywords: cell biology; physiology; molecular biology

Kynurenic Acid: Unveiling Its Impact on the Brain’s Neurotransmission and Neurological Disorders

edited by Korrapati V. Sathyasaikumar, Sarah Beggiato and

Verónica Pérez de la Cruz

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7267 | Submission Open

Keywords: kynurenic acid; cognition; aging; neuromodulation; neurodegeneration; neurodevelopment; neuroinflammation; tryptophan catabolism

(This special issue belongs to the Section Cell Signaling)

Understanding Aging Mechanisms to Prevent Age-Related Diseases: 2nd Edition

edited by

Gérard Lizard

, Pierre Jouanny,

Anne Vejux

and Sonia Hammami

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5736 | Submission Open

Keywords: aging; age-related diseases; pathophysiology; cell mechanisms; therapies; biomarkers

(This special issue belongs to the Section Cellular Aging)

Organelle Contact and Its Physiological Implications

edited by

Patricia Gómez-Suaga

and

Estela Area Gomez

submission deadline 31 Dec 2025 | 1 articles | Viewed by 4809 | Submission Open

Keywords: inter-organelle communication; membrane contact sites; organelle dynamics; mitochondria-associated membranes; cellular homeostasis

Interplay Between Intestinal Bacteria and Epigenetic Markers in Pathogenesis of Metabolic and Neuropsychiatric Disorders

edited by

Shabnam Nohesara

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3916 | Submission Open

Keywords: gut microbiome; epigenetic marks; metabolic diseases; neuropsychiatric disorders; probiotics; prebiotics; postbiotics; indole derivatives; epigeneic metabolites

(This special issue belongs to the Section Cellular Neuroscience)

The Role of Mitochondria in Cell Development and Regeneration

edited by

Kenny Rodriguez-Wallberg

and

Xia Hao

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2953 | Submission Open

Keywords: mitochondria; fusion and fission; mtDNA; programmed cell death; cell development; mitochondria-ER contact; organelle

(This special issue belongs to the Section Mitochondria)

The Role of Stem Cells and Circadian Clock in Cancer Immunotherapy

edited by Yool Lee

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2357 | Submission Open

Keywords: circadian clock; circadian disruption; neural stem cells; cancer stem cells; tumor– immune microenvironment; cancer chronotherapy

(This special issue belongs to the Section Stem Cells)

Integrated Approaches Between Metabolomics and Cellular Aging

edited by Maria Nikolaou and

Nikolaos Theodorakis

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2231 | Submission Open

Keywords: metabolomics; cellular aging; senescence; mitochondrial dysfunction; DNA damage; biomarkers; metabolism

(This special issue belongs to the Section Cellular Aging)

Novel Autoantibodies in Systemic Autoimmune Diseases: Challenges and Perspectives

edited by

Clio Mavragani

Nikolaos Marketos

and

Charalampos Skarlis

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1889 | Submission Open

Keywords: autoantibodies; autoimmune diseases; innate and adaptive immunity

(This special issue belongs to the Section Cellular Immunology)

The Role of T-Cells in Lymphomas and Leukemias

edited by

Huda Salman

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1417 | Submission Open

Keywords: T cells; regulatory T cells; leukemia; lymphoma; hematological malignancies; chimeric antigen receptor; CAR T cells; tumor microenvironment; tumor-infiltrating T cells; TCR; adoptive T cell therapy; TCR-engineered T cells

(This special issue belongs to the Section Cellular Immunology)

Colorectal Cancer: Molecular Mechanisms and Treatment Progress

edited by

Maurizio Capuozzo

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1147 | Submission Open

Keywords: colorectal cancer (CRC); tumor microenvironment; genetic and epigenetic alterations; immune evasion; targeted therapy and personalized medicine

(This special issue belongs to the Section Tissues and Organs)

Epigenetic Mechanisms and Aging

edited by

Nicholas Tolwinski

submission deadline 31 Dec 2025 | Viewed by 499 | Submission Open

Keywords: drosophila melanogaster; model organism; cell biology; developmental biology; genetics; molecular biology; cell signaling; cellular differentiation; cell proliferation; cell cycle; cellular morphogenesis; cell-cell communication; stem cells; cell migration; apoptosis; cytoskeleton; cell adhesion; cellular metabolism; functional genomics; CRISPR/Cas9 in drosophila; omics technologies; disease models; drug discovery; regeneration; genetic screens; cellular stress responses

(This special issue belongs to the Section Cellular Aging)

Rho Family Small GTPases in Health and Diseases

edited by

Katalin Szászi

submission deadline 31 Dec 2025 | Viewed by 302 | Submission Open

Keywords: Rho signalling; Rho guanine nucleotide exchange factor; Rho GTPase-activating protein; Rho effector; dysregulation of Rho GTPases; Rho pathway inhibitors

(This special issue belongs to the Section Cell Signaling)

How Does Gene Regulation Affect Cancer Development?

edited by

Ru Chih C. Huang

and

Kotohiko Kimura

submission deadline 31 Dec 2025 | Viewed by 300 | Submission Open

Keywords: cancer; mutation; transcription factor; non-coding RNA; micro-RNA; gene regulation; histones; gene promoters; anticancer drugs

(This special issue belongs to the Section Cell Microenvironment)

Immunology and Immune Therapies for Cancer

edited by

Mei Yu

submission deadline 31 Dec 2025 | Viewed by 205 | Submission Open

Keywords: cancer immunotherapy; tumor microenvironment; CAR-T cells; immune checkpoint inhibitors; immune surveillance; cancer vaccines; immuno-oncology

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Mechanisms of Traumatic Injury and Resolution

edited by

Upendra K. Kar

and

Hamed Moheimani

submission deadline 31 Dec 2025 | Viewed by 184 | Submission Open

Keywords: traumatic injury-associated immunometabolism; trauma-induced coagulopathy; endothelial dysfunction; cell death pathways; extracellular vesicles; single-cell and spatial omics; multi-omics; damage-associated molecular patterns; biomarker discovery; precision therapeutics

(This special issue belongs to the Section Cellular Pathology)

Inflammation and Aging in Acute and Chronic Kidney Injury

edited by

Massimiliano Migliori

Vincenzo Cantaluppi

and

Marita Marengo

submission deadline 31 Dec 2025 | Viewed by 169 | Submission Open

Keywords: chronic kidney disease; acute kidney injury; inflammation; aging

(This special issue belongs to the Section Cellular Aging)

The Role of the Gene Expression and Regulation of the Pathogenesis of Oral Submucous Fibrosis

edited by

Sanjit Mukherjee

submission deadline 31 Dec 2025 | Viewed by 120 | Submission Open

Keywords: oral submucous fibrosis (OSMF); collagen deposition; epigenetic modifications; next-generation sequencing; oral cancer; progressive fibrosis

(This special issue belongs to the Section Cellular Pathology)

Molecular and Genetic Pathogenesis of Hematological Disorders

edited by

Hong Chang

submission deadline 10 Jan 2026 | 1 articles | Viewed by 2292 | Submission Open

Keywords: hematological disorders; molecular and genetic mechanisms; signal transduction pathways; microenvironment; gene editing technologies; targeted therapies; novel biomarkers; mechanisms of treatment resistance; innovative therapeutic strategies

(This special issue belongs to the Section Cellular Pathology)

New Insights into Therapeutic Targets for Cardiovascular Diseases

edited by

Tamer Elbayoumi

and

Molly (Mingyi) Yao

submission deadline 15 Jan 2026 | 3 articles | Viewed by 15601 | Submission Open

Keywords: cardiovascular disease prevention and treatment; ischemic cardiomyopathies; endothelium injury/damage; cardiac remuscularization and repair; cardiovascular/angiogenic targets and biomarkers; targeted delivery platforms/systems/formulations; precision nanomedicine; targeted nano-theranostic applications; localized and systemic administration; safety and efficacy

(This special issue belongs to the Section Cells of the Cardiovascular System)

Mechanisms of Lung Growth and Regeneration

edited by

Saverio Bellusci

and

Yuanlin Song

submission deadline 15 Jan 2026 | 2 articles | Viewed by 4236 | Submission Open

Keywords: stem cells; niche; aging; growth factors; extracellular matrix; organoids; fibrosis; single-cell RNAseq

(This special issue belongs to the Section Cell Microenvironment)

Organ Regeneration: Cells, Organoids and Organs

edited by Jia Huang

submission deadline 15 Jan 2026 | 2 articles | Viewed by 2418 | Submission Open

Keywords: organ regeneration; stem cells; organoids; tissue engineering; 3D bioprinting; regenerative medicine; interspecies chimera; blastocyst complementation; vascularization; immune compatibility

(This special issue belongs to the Section Tissues and Organs)

Recent Progress on Fibrosis and Cardiac Dysfunction

edited by

Tabito Kino

and

Tomoaki Ishigami

submission deadline 15 Jan 2026 | Viewed by 483 | Submission Open

Keywords: regeneration; cardiac fibrosis; cardiac dysfunction; ischemic heart disease; hypertension; atrial fibrillation; inflammation

(This special issue belongs to the Section Cells of the Cardiovascular System)

New Insights into Gene Research and Therapy for Diabetes Mellitus

edited by

Ann Simpson

and

Najah Therese Nassif

submission deadline 15 Jan 2026 | Viewed by 183 | Submission Open

Keywords: gene therapy; type 1 diabetes; type 2 diabetes; glycemic control; beta-cell transcription factors; insulin granules; viral vectors

Targeting Breast Cancer: Mechanisms of Resistance and Innovative Therapeutic Strategies

edited by Stefania Belli,

Daniela Esposito

and

Roberto Bianco

submission deadline 15 Jan 2026 | Viewed by 167 | Submission Open

Keywords: breast cancer; targeted therapies; novel therapeutic targets; mechanisms of drug resistance; innovative therapeutic strategies; targeting tumor microenvironment; immunotherapy in breast cancer

(This special issue belongs to the Section Cell Microenvironment)

Oral Stem Cells in Regenerative Biology

edited by

Oriana Trubiani

submission deadline 15 Jan 2026 | Viewed by 148 | Submission Open

Keywords: stem cells; differentiation; regenerative medicine; angiogenesis; inflammation; secretome; oral tissue induced pluripotent stem cells

(This special issue belongs to the Section Stem Cells)

Signaling Pathways in Endometrial Cancer Cells

edited by

Tomohiko Fukuda

submission deadline 20 Jan 2026 | 4 articles | Viewed by 12934 | Submission Open

Keywords: endometrial cancer; cellular signaling; cell metabolism; DNA damage repair pathway; the PI3K/AKT/mTOR pathway; the RAS/MAPK pathway; molecular classification

(This special issue belongs to the Section Cell Signaling)

New Trends and Advances in Diagnosis and Prognosis of Head and Neck Cancer from Carcinogenesis to Future Molecular Targeted Therapies: 2nd Edition

edited by

Piotr Cierpikowski

and

Julia Bar

submission deadline 20 Jan 2026 | 6 articles | Viewed by 11004 | Submission Open

Keywords: head and neck cancer; oral cancer; biomarker; prognosis; carcinogenesis; oral premalignant lesions; cancer stem cells; signaling pathways; molecular targeted therapy

(This special issue belongs to the Section Cellular Pathology)

Adipose-Derived Stem Cells: Current Applications and Future Directions

edited by

Yasuhito Ishigaki

submission deadline 20 Jan 2026 | 4 articles | Viewed by 8418 | Submission Open

Keywords: cell therapy; regenerative medicine; adipose-derived stem cells (ADSCs); exosome; cytokine

(This special issue belongs to the Section Stem Cells)

Pathophysiology of Signal Transduction in Cardiovascular and Pulmonary Disease: 2nd Edition

edited by

Yung-Hsin Yeh

and

Ying-Ju Lai

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2895 | Submission Open

Keywords: cardiac arrhythmia; atrium; ventricle; pulmonary; vascular; signal transduction

(This special issue belongs to the Section Cellular Pathology)

Mitochondria at the Crossroad of Health and Disease—Second Edition

edited by

Nickolay Brustovetsky

submission deadline 20 Jan 2026 | 3 articles | Viewed by 2838 | Submission Open

Keywords: mitochondria; oxidative phosphorylation; mitochondrial ion transport; permeability transition pore; mitochondrial ROS generation; mitochondrial quality control; mitochondrial traffic; mitochondrial morphology; mitochondrial dynamics; mitophagy

(This special issue belongs to the Section Cellular Aging)

Neurotoxicity and Neurodegenerative Diseases: The Potential of Regenerative Medicine

edited by Elisabetta Mormone, Paola Crociani and

Gianluigi Ubaldo Mazzoccoli

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1917 | Submission Open

Keywords: inflammation; iPSCs; MSCs; neural stem cells niche; neurodegeneration; regenerative medicine; ROS; PRP

(This special issue belongs to the Section Cellular Aging)

Applications of Proteomics in Human Diseases and Treatments

edited by

Giovanni Cuda

and

Marco Gaspari

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1549 | Submission Open

Keywords: biomarkers; clinical proteomics; single-cell proteomics; next-generation proteomics; biofluids; high-throughput proteomics

(This special issue belongs to the Section Cell Methods)

Study on Human Mesenchymal Stem Cells—2nd Edition

edited by

Michela Noseda

submission deadline 20 Jan 2026 | 1 articles | Viewed by 849 | Submission Open

Keywords: mesenchymal stem cells; disease; cardiac; therapy

(This special issue belongs to the Section Stem Cells)

Role of Cell Organelles in Normal Aging, Senescence, and Cancer

edited by

Michael Lisanti

and Christopher Albanese

submission deadline 20 Jan 2026 | Viewed by 541 | Submission Open

Keywords: aging; accumulated damage; ROS-induced damage; protein aggregation; senescence; cancer; senescence escape; cell organelles; mitochondria; lysosomes; SASP; inflammation; IL1-beta/IL-6/IL-8

(This special issue belongs to the Section Cellular Aging)

The Evolving Landscape of Cell and Gene Therapy—Opportunities, Challenges and the Road Ahead

edited by

Rai Ajit K. Srivastava

submission deadline 20 Jan 2026 | Viewed by 220 | Submission Open

Keywords: cell therapy; gene therapy/gene editing; micro RNAs; rare diseases; metabolic disease; cancer; diabetes; proatherogenic lipoproteins; drug discovery; ASO

Gliomas: Molecular Insights, Next-Generation Therapies, and Precision Targeting

edited by

Mehdi Sanati

submission deadline 20 Jan 2026 | Viewed by 175 | Submission Open

Keywords: gliomas; molecular targets; precision oncology; immunotherapy; gene editing; tumor microenvironment

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