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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Cellular Senescence in Health, Disease, and Aging

edited by

Yasumichi Inoue

submission deadline 20 Mar 2026 | 10 articles | Viewed by 28291 | Submission Open

Keywords: apoptosis; cancer; cell cycle; DNA damage; metabolic diseases; oxidative stress; senolysis; senescence; therapeutic approach

(This special issue belongs to the Section Cellular Aging)

Highlights in Red Blood Cell Research

edited by

Anna Bogdanova

and

Lars Kaestner

submission deadline 20 Mar 2026 | 5 articles | Viewed by 25925 | Submission Open

Keywords: red blood cells; anemia; transfusion; erythropoiesis; signaling

New Advances and Perspectives in Nanotechnology for the Treatment of Cancer Cells

edited by

Karuppusamy Shanmugapriya

submission deadline 20 Mar 2026 | 8 articles | Viewed by 24085 | Submission Open

Keywords: nanotechnology; immunotherapeutics; cancer biotherapeutics; proliferation; regulating factors; cell culture; biomedical application; nutraceuticals; cancer treatment

(This special issue belongs to the Section Cell Methods)

Insight into Cardiomyopathy

edited by Sobuj Mia

submission deadline 20 Mar 2026 | 1 articles | Viewed by 17770 | Submission Open

Keywords: heart failure; ventricular dysfunction; hypertrophic cardiomyopathy; dilated cardiomyopathy; cardiac fibrosis; cardiac hypertrophy; biomarkers

(This special issue belongs to the Section Cells of the Cardiovascular System)

Advances and Breakthroughs in Stem Cell Research

edited by

Alexander E. Kalyuzhny

and

Hemant Kumar Mishra

submission deadline 20 Mar 2026 | 5 articles | Viewed by 13353 | Submission Open

Keywords: stem cell; induced pluripotent stem cell; iPSC; hematopoietic stem cell

(This special issue belongs to the Section Stem Cells)

New Concepts Relating Mesenchymal Tumors Based on Genetics and Epigenetics

edited by

Uta Flucke

submission deadline 20 Mar 2026 | 4 articles | Viewed by 10927 | Submission Open

Keywords: mesenchymal tumors; soft tissue; sarcoma; genetics; epigenetics

(This special issue belongs to the Section Cell Microenvironment)

The Role of Cilia in Health and Diseases—2nd Edition

edited by Rim Hjeij

submission deadline 20 Mar 2026 | 5 articles | Viewed by 9283 | Submission Open

Keywords: motile cilia; motile ciliopathy; Primary Ciliary Dyskinesia; genetic screening; bronchiectasis; hydrocephalus; laterality defects; infertility; gene therapy

Non-Traditional Roles of Protein Ubiquitination in Cellular Processes and Health

edited by

Chuanjin Wu

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4717 | Submission Open

Keywords: Protein Ubiquitination; ; Ubiquitin chain; ; k63-linked ubiquitination; ; linear ubiquitination; ; ubiquitin-binding proteins; ; deubiquitinases; ; NF-kB; ; autophagy; ; inflammation; ; immunodeficiency; ; neurodegenerative diseases.

(This special issue belongs to the Section Cellular Pathology)

Targeting Tumor Microenvironments for Enhanced Cancer Immunotherapy

edited by

Xin Lu

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3962 | Submission Open

Keywords: tumor microenvironment; cancer immunotherapy; immune modulation; immunosuppressive mechanisms; combination therapies

(This special issue belongs to the Section Cell Microenvironment)

Human Immunodeficiency Virus/Simian Immunodeficiency Virus and Host Interactions

edited by

Nongthombam Boby

and Susanta Pahari

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2354 | Submission Open

Keywords: HIV/SIV/SHIV infection; rhesus macaques; host immunity; chronic inflammation; mucosal immunity; immune evasion; therapeutic intervention; immune checkpoints; microbiota; substance use

(This special issue belongs to the Section Cellular Immunology)

Immune Response in HIV Infection, Pathogenesis and Persistence

edited by Suvadip Mallick

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2054 | Submission Open

Keywords: HIV infection; immune response; chronic inflammation; immune activation; antiretroviral therapy (ART); immune reconstitution; immune checkpoints

(This special issue belongs to the Section Cellular Immunology)

Protein Misfolding and Aggregation: From Molecular Mechanisms to Human Diseases

edited by Xinrui Gui and Jinjun Wu

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1760 | Submission Open

Keywords: protein aggregation; amyloid fibrils; protein quality control; neurodegenerative diseases

(This special issue belongs to the Section Cellular Biophysics)

Targeting Cellular Microenvironment in Aging and Disease

edited by

Alexander Dityatev

and Egor Dzyubenko

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1750 | Submission Open

Keywords: proteoglycans; glycans; glycoproteins; matricellular proteins; integrins; matrix metalloproteinases; extracellular vesicles; EV release; exosomes; extracellular scaffold; ECM remodeling; fibrosis; ECM gene therapy; ECM pharmacology; synthetic ECM

(This special issue belongs to the Section Cellular Aging)

Cell Biology: The State of the Art and Perspectives in Japan 2025

edited by

Yasumichi Inoue

submission deadline 20 Mar 2026 | Viewed by 791 | Submission Open

Keywords: cell biology; physiology; molecular biology

Cancer Cell Signaling, Autophagy and Tumorigenesis

edited by Debanjan Bhattacharya

submission deadline 20 Mar 2026 | Viewed by 263 | Submission Open

Keywords: cancer cell signaling; autophagy; tumorigenesis; PI3K/AKT/mTOR pathway; Ras/Raf/MEK/ERK (MAPK) pathway

Chronic Obstructive Pulmonary Disease (COPD): From Molecular and Cellular Mechanisms to Therapeutic Opportunities

edited by

Renat Shaykhiev

, Bradley W. Richmond and

Umadevi Sajjan

submission deadline 20 Mar 2026 | Viewed by 202 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); small airway disease; vascular remodeling; emphysema

(This special issue belongs to the Section Cellular Immunology)

Cell and Molecular Mechanisms of Cytogenesis

edited by

Luisa Alexandra Meireles Pinto

and

Teresa Correia Soares Canedo Calado

submission deadline 20 Mar 2026 | Viewed by 181 | Submission Open

Keywords: cytogenesis; central nervous system; neurogenesis; gliogenesis; neuroplasticity; signaling pathways; cell proliferation; differentiation; CNS homeostasis; neuropsychiatric and neurodegenerative disorders

Cellular and Molecular Mechanisms of Neurotoxicity

edited by

Anna Andrioli

Idris Azeez

, Tiziana Cotrufo and

Olumayowa Igado

submission deadline 20 Mar 2026 | Viewed by 134 | Submission Open

Keywords: neurotoxicity; neurodegeneration; neuronal cell death; neurodegenerative disorders; nerve regeneration; heavy metals; air pollution; endogenous neurotoxins; oxidative stress; glutamate

Novel Insights into Endothelial Cells in Vascular Disease

edited by

LI Zhang

submission deadline 20 Mar 2026 | Viewed by 126 | Submission Open

Keywords: endothelial cells; vascular diseases; vascular signaling

Novel Immunotherapies for Diffuse Large B-Cell Lymphoma

edited by

Waseem Lone

submission deadline 20 Mar 2026 | Viewed by 92 | Submission Open

Keywords: diffuse large B-cell lymphoma; immunotherapy; CAR-T cells; bispecific antibodies; immune checkpoint inhibitors; antibody– drug conjugates; tumor microenvironment; biomarkers; translational research

Lipid Homeostasis: Mechanisms, Regulation, and Implications for Health and Disease

edited by

Roger Schneiter

and Museer Ahmad Lone

submission deadline 25 Mar 2026 | 3 articles | Viewed by 5494 | Submission Open

Keywords: lipid metabolism; lipid synthesis and degradation; triglyceride storage; fatty acid oxidation; cholesterol homeostasis; adipogenesis; lipid droplets; lipid signaling pathways; lipid transport proteins; phospholipid balance; sphingolipid metabolism; sterol regulatory element-binding proteins (SREBPs); AMP-activated protein kinase (AMPK); peroxisome proliferator-activated receptors (PPARs); insulin signaling and lipid storage; endoplasmic reticulum stress and lipids; lipoprotein metabolism; non-alcoholic fatty liver disease (NAFLD); lipidomics; autophagy and lipid recycling; lysosomal lipid degradation; lipid-binding proteins; oxidized lipids; lipid imbalance and disease; energy homeostasis and lipid storage; lipid transport vesicles; membrane lipid composition; lipid peroxidation; lipid-related genetic disorders; nutrient sensing and lipid regulation

(This special issue belongs to the Section Cellular Biophysics)

The Silent Regulators: Non-Coding RNAs in Cell Function and Disease

edited by

Christiane Branlant

and

Mirolyuba Simeonova Ilieva

submission deadline 25 Mar 2026 | 3 articles | Viewed by 2704 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs (lncRNAs); regulatory RNAs; RNA interference; epigenetic regulation; RNA editing; cellular signaling; disease biomarkers; RNA therapeutics

(This special issue belongs to the Section Cell and Gene Therapy)

Ischemic Heart Disease: From Cellular Level to Clinical Approaches

edited by

Stefan A. Juričić

and

Milan R. Dobrić

submission deadline 25 Mar 2026 | 1 articles | Viewed by 545 | Submission Open

Keywords: ischemic heart disease; myocardial ischemia; reperfusion injury; oxidative stress; mitochondrial dysfunction; cardiomyocyte death; endothelial dysfunction; inflammation; fibrosis; epigenetics; non-coding RNAs; immunometabolism; single-cell transcriptomics; angiogenesis; ischemic preconditioning; nanomedicine; molecular cardiology; targeted therapy

Gene Editing Therapies for Hereditary Diseases

edited by

Jacques P. Tremblay

submission deadline 25 Mar 2026 | Viewed by 269 | Submission Open

Keywords: gene therapy; base editing; prime editing; genome editing; hereditary diseases

(This special issue belongs to the Section Cell and Gene Therapy)

Cell and Molecular Mechanisms of Bacterial Meningitis

edited by

Lars Ove Brandenburg

submission deadline 25 Mar 2026 | Viewed by 158 | Submission Open

Keywords: bacterial meningitis; innate immunity; inflammation; immune response; central nervous system; neuron; microglia; astrocytes; granulocytes; blood– brain barrier

Mitochondria: Multifaceted Regulators of Cell Death

edited by Rasa Banienė and Sonata Trumbeckaite

submission deadline 25 Mar 2026 | Viewed by 151 | Submission Open

Keywords: mitochondria; cell death; multifaceted regulators; reactive oxygen species (ROS); cell metabolism; mitochondrial transfer

From Signals to Shape: Molecular Control of Cellular Plasticity Through Epigenetic, Transcriptomic, and Immune Mechanisms

edited by

Ines Schoberleitner

and

Salvatore Fusco

submission deadline 25 Mar 2026 | Viewed by 148 | Submission Open

Keywords: cellular plasticity; epigenetics; transcriptomics; mechanotransduction; immune signaling; cell fate regulation; RNA methylation; biomaterials interaction; molecular cytology; cell adaptation

Cancer Stem Cells in Triple-Negative Breast Cancer

edited by

Antonella Zannetti

and

Maria Grazia Caprio

submission deadline 25 Mar 2026 | Viewed by 126 | Submission Open

Keywords: cancer stem cells; TNBC; signal pathways; epithelial– mesenchymal transition; tumor microenvironment; targeted therapy; biomarkers

Breaking the Balance: Cellular Stress, Proteostasis, Aggregates and Neurodegeneration

edited by

Zhaoyu Li

submission deadline 25 Mar 2026 | Viewed by 121 | Submission Open

Keywords: proteostasis; cellular stress; protein aggregation; neurodegeneration; autophagy; unfolded protein response; oxidative stress; aging; molecular chaperones; protein quality control

Molecular Mechanisms of Trophoblast Differentiation

edited by Milica Jovanović Krivokuća and

Jianjun Wei

submission deadline 25 Mar 2026 | Viewed by 120 | Submission Open

Keywords: trophoblast differentiation; cytotrophoblast; syncytiotrophoblast; extravillous trophoblast; trophoblast stem cells; molecular mechanisms; signaling pathways; epigenetic regulation

Biomarkers and Therapeutic Targets in Insulin Resistance

edited by

Mohamed Elrayess

submission deadline 30 Mar 2026 | 1 articles | Viewed by 2525 | Submission Open

Keywords: insulin resistance; biomarkers; therapeutic targets; type 2 diabetes; metabolic syndrome; obesity; molecular mechanisms; pharmacologic treatments; precision medicine; cardiovascular diseases

(This special issue belongs to the Section Cellular Pathology)

Neuroimaging of Cerebrovascular Diseases

edited by Dragan Stojanov

submission deadline 30 Mar 2026 | Viewed by 197 | Submission Open

Keywords: neuroimaging; cerebrovascular diseases; stroke; intracerebral hemorrhage; SAHA neurysms; AVM; small vessels diseases; CT; MRI; advance MRI techniques; DSA; AI

Mechanisms of miRNA Metabolism and Extracellular Transport

edited by

Suvendra N Bhattacharyya

submission deadline 30 Mar 2026 | Viewed by 182 | Submission Open

Keywords: miRNA metabolism; miRNA transport; miRNA exchange; miRNA storage; mRNA biogenesis; extracellular vesicles and miRNA; non-EV miRNA export; miRNA binding proteins; miRNA sponge and inhibitors; miRNA biomarkers

Novel Insights into Cancer Immune Responsiveness

edited by

Luigi Racioppi

and

Tanmoy Mondal

submission deadline 30 Mar 2026 | Viewed by 158 | Submission Open

Keywords: cancers; tumors; immune cells; tumor immunology; cancer immunology; onco-immunology; immunotherapies; resistance; immunotherapy resistance; immune checkpoint; CAR; antibody; cancer vaccines

Novel Insights into Molecular and Cellular Mechanisms Underlying Chronic Pain

edited by

Mariacristina Mazzitelli

submission deadline 30 Mar 2026 | Viewed by 134 | Submission Open

Keywords: pain; pain management; sexual dimorphism; neurons; non-neuronal factors

(This special issue belongs to the Section Cellular Pathology)

Impact of Chronic Substance Exposure on Hematopoiesis and Immunity

edited by

Mary Mohrin

and

Hami Hemati

submission deadline 30 Mar 2026 | Viewed by 121 | Submission Open

Keywords: Substance Use Alcohol Immunity Inflammation Hematopoietic stem and progenitor cells Monocytes Neutrophils Macrophages T cells

Nanoparticle-Mediated Immunotherapy: Reshaping the Tumor Microenvironment for Enhanced Cancer Treatment

edited by

Mohd Ahmar Rauf

submission deadline 30 Mar 2026 | Viewed by 116 | Submission Open

Keywords: tumor microenvironment; drug delivery; nanoparticle

(This special issue belongs to the Section Cell Methods)

Cellular and Molecular Mechanisms of Cardiomyopathy

edited by

Zaglia Tania

and

Maurizio Forte

submission deadline 30 Mar 2026 | Viewed by 108 | Submission Open

Keywords: genetic cardiomyopathies; acquired cardiomyopathies; cardiac arrhythmias; disease mechanisms; disease cause; pathogenesis

(This special issue belongs to the Section Tissues and Organs)

Molecular Mechanisms and Biomarker Development in Prostate Cancer

edited by Vikas Mehta and Behtash Ghazi Nezami

submission deadline 30 Mar 2026 | Viewed by 83 | Submission Open

Keywords: androgen receptor; prostate molecular alterations; biomarkers

Potential of CAR-Based Cellular Immunotherapy for Non-oncologic Disorders

edited by

Györgyi Műzes

and

Ferenc Sipos

submission deadline 31 Mar 2026 | 5 articles | Viewed by 24983 | Submission Open

Keywords: adoptive cell transfer; CAR-T cells; cell engineering; CAR products; CAR-T cell therapy; non-oncologic disorders; autoimmune diseases; cardiometabolic diseases; inflammatory organ fibrosis; senescent cell pathologies; infections

(This special issue belongs to the Section Cellular Immunology)

Flow Cytometry in Immunology Research

edited by

Ziv Porat

and Ekaterina Kopitman

submission deadline 31 Mar 2026 | 3 articles | Viewed by 13513 | Submission Open

Keywords: multi-parametric analysis; full-spectrum flow cytometry; imaging flow cytometry; immuno-phenotyping; immune synapse; cytokines; activation markers; cancer immunology; host-pathogen interactions; functional immune assays

(This special issue belongs to the Section Cell Methods)

Organoids and Models from Stem Cells

edited by Tiziana A. L. Brevini and

Georgia Pennarossa

submission deadline 31 Mar 2026 | 3 articles | Viewed by 8224 | Submission Open

Keywords: cellular microenvironment; 3D culture; organoid

(This special issue belongs to the Section Stem Cells)

mRNA Vaccines and Therapeutics in Melanoma: From Mechanisms to Cellular Impact

edited by

Stefano Zoroddu

and

Luigi M. Bagella

submission deadline 31 Mar 2026 | 3 articles | Viewed by 6854 | Submission Open

Keywords: mRNA vaccines; melanoma; tumor immunology; mRNA vaccine designs; delivery systems

(This special issue belongs to the Section Cellular Pathology)

Axonal Transport: Mechanisms, Disorders, and Therapeutic Approaches

edited by Yuxiang Xie and Jingqi Yan

submission deadline 31 Mar 2026 | 1 articles | Viewed by 4010 | Submission Open

Keywords: axonal transport; motor proteins; autophagy– lysosome pathway; neurodegenerative diseases; therapeutic strategies

(This special issue belongs to the Section Cellular Neuroscience)

Signaling Pathways Involved in Tumor Microenvironment and Tumor Adaptation to Stresses

edited by Nianli Sang

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3941 | Submission Open

Keywords: microenvironment; metabolic stress; hypoxia; chemoresistance; radiation resistance; apoptosis; metabolic reprogramming; metastasis

(This special issue belongs to the Section Cell Signaling)

Advances in Reproductive Biology: Cellular and Molecular Mechanisms

edited by

Rosa Roy

and Clara González-Marín

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3467 | Submission Open

Keywords: gametogenesis; fertilization; embryo implantation; reproductive genetics; epigenetics in reproduction; hormonal signaling; stem cells and reproduction; assisted reproductive technologies (ARTs); molecular fertility regulation; reproductive health innovations

(This special issue belongs to the Section Reproductive Cells and Development)

Drosophila as a Model for Understanding Human Disease

edited by Zhe Han

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3101 | Submission Open

Keywords: Drosophila melanogaster; human disease models; genetic and molecular mechanisms; neurodegenerative diseases; cardiovascular diseases; cancer biology; metabolic disorders; high-throughput screening; precision medicine; translational research

(This special issue belongs to the Section Cellular Pathology)

Kidney Injury Biomarkers: From Early Detection to Transition to Chronic Kidney Disease

edited by

Alexander E. Berezin

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2399 | Submission Open

Keywords: acute kidney injury; acute kidney disease; chronic kidney disease; circulating biomarkers; urinary biomarkers; multiple biomarker panel; diagnosis; prediction; management

(This special issue belongs to the Section Tissues and Organs)

Modulation of Senescence and Differentiation in Human Mesenchymal Stem Cells

edited by

Federica Facchin

and

Silvia Canaider

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2398 | Submission Open

Keywords: tissue-specific mesenchymal stem cells; cell senescence; cell differentiation; natural and synthetic molecules; tissue engineering; regenerative medicine

(This special issue belongs to the Section Stem Cells)

Molecular Insights into Vascular Physiology and Pathology

edited by Suravi Majumder

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2078 | Submission Open

Keywords: vascular physiology; vascular pathology; endothelial cells; vascular smooth muscle cells; vascular inflammation; vascular signaling; vascular aging; vascular remodeling; atherosclerosis; cardiovascular diseases; biomarkers; novel therapeutic approaches

(This special issue belongs to the Section Cellular Pathology)

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