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Cancers
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New Trends in Urologic Oncology: Surgical Treatments, Robotics, Biomarkers, Diagnostic...
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New Trends in Urologic Oncology: Surgical Treatments, Robotics, Biomarkers, Diagnostic Tools, and Innovative Therapies

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 262

Special Issue Editors

Dr. Alessandro Uleri

E-Mail Website
Guest Editor
Department of Urology, UROSUD, La Croix du Sud Hospital, Quint Fonsegrives, France
Interests: prostate cancer; BPH; urothelial cancer
Dr. Roberto Contieri

E-Mail Website
Guest Editor
Department of Urology, Istituto Nazionale Tumori “Fondazione Pascale”, 80131 Naples, Italy
Interests: bladder cancer; urothelial carcinoma; non-muscle-invasive bladder cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Urologic oncology is undergoing rapid development, with significant progress across surgical, diagnostic, and therapeutic domains. This Special Issue, “New Trends in Urologic Oncology: Surgical Treatments, Robotics, Biomarkers, Diagnostic Tools, and Innovative Therapies”, will provide an overview of the most recent advances shaping the management of genitourinary malignancies. Particular attention will be given to the evolution of minimally invasive and robotic-assisted techniques, the refinement of surgical outcomes, and the integration of novel systemic and targeted treatment strategies.

In parallel, the identification and clinical implementation of biomarkers, together with advances in molecular and imaging-based diagnostics, are enabling earlier detection, more precise risk stratification, and individualized therapeutic approaches. These developments are progressively moving the field toward a model of precision oncology, in which treatment decisions are informed by both technological innovation and molecular characterization.

We welcome contributions in the form of original research articles, reviews, and clinical studies that reflect these advances and will help in defining new standards of care.

Dr. Alessandro Uleri
Dr. Roberto Contieri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prostate cancer
  • renal cancer
  • bladder cancer
  • UTUC
  • testicular cancer
  • penile cancer
  • biomarkers

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Published Papers (1 paper)

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Review

13 pages, 281 KB  
Review
Therapeutic Intensification Based on Immune Checkpoint Inhibitors in Non-Muscle Invasive Bladder Cancer: State of the Art and Future Perspectives
by Pierre-Etienne Gabriel, Amir Horowitz, Felix Guerrero-Ramos, Francesco Soria, Marco Moschini, David D’Andrea, Benjamin Pradère, John P. Sfakianos and Evanguelos Xylinas
Cancers 2025, 17(21), 3555; https://doi.org/10.3390/cancers17213555 - 2 Nov 2025
Viewed by 171
Abstract
Background/Objectives: Systemic immunotherapy, previously used mainly for advanced urothelial carcinoma, now plays an important role in the treatment of non-muscle invasive bladder cancer (NMIBC), either alone or combined with intravesical BCG instillations. Methods: We conducted a collaborative, comprehensive review to summarize the key [...] Read more.
Background/Objectives: Systemic immunotherapy, previously used mainly for advanced urothelial carcinoma, now plays an important role in the treatment of non-muscle invasive bladder cancer (NMIBC), either alone or combined with intravesical BCG instillations. Methods: We conducted a collaborative, comprehensive review to summarize the key evidence and future perspectives on therapeutic intensification strategies involving immune checkpoint inhibitors in NMIBC. A total of 51 references published between 2000 and 2025 were included. Results: Four phase II studies evaluated pembrolizumab, atezolizumab, durvalumab, and cetrelimab as monotherapy in 28 to 132 BCG-unresponsive NMIBC patients. They reported complete response rates ranging from 12% to 43% after 3 to 12 months of treatment, with a durable response rate ranging from 49% to 57.4% at 12 months. To improve these results, a phase II trial launched this year tests a new systemic combination targeting both the PD-1/PD-L1 axis and the emerging HLA-E/NKG2A pathway. Regarding BCG-naïve high-risk (HR) NMIBC, four phase III studies are evaluating BCG instillations combined with systemic immunotherapy: sasanlimab (CREST), durvalumab (POTOMAC), atezolizumab (ALBAN), and pembrolizumab (KEYNOTE-676), with significant results reported for the CREST and POTOMAC trials. The key challenge remains selecting patients most likely to benefit from this combination therapy while avoiding overtreatment. Identifying predictive biomarkers of tumor aggressiveness and response to immunotherapy also represents a major future challenge. Conclusions: Therapeutic intensification using systemic immunotherapy applies to both BCG-unresponsive NMIBC, with a new target pathway (HLA-E/NKG2A), and BCG-naïve HR NMIBC, where the combination of BCG instillations and immunotherapy represents a major breakthrough. Full article
(This article belongs to the Special Issue New Trends in Urologic Oncology: Surgical Treatments, Robotics, Biomarkers, Diagnostic Tools, and Innovative Therapies)
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