Mechanisms of Therapy Resistance in Cancers—2nd Edition
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Drug Development".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 806
Special Issue Editor
Interests: oxidative stress; nitric oxide; topoisomerases; pharmacology of anticancer drugs; mechanism of drug resistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the second edition of a previous Special Issue entitled “Mechanisms of Therapy Resistance in Cancers”.
Cancer is one of the leading causes of death in the US and across the world. The current management techniques for cancers include cytoreductive surgery, chemotherapy, targeted therapy, radiation therapy, endocrine therapy and immunotherapy. Despite the significant success achieved in treating cancers over the past few decades, the development of resistance to cytotoxic chemotherapeutic agents and/or novel targeted drugs continues to be a major problem in cancer therapies. Drug resistance, either before treatment (intrinsic) or following therapy (acquired), is responsible for most relapses of cancer and death. Cancer therapeutic resistance occurs as cancer cells develop resistance to therapy through various mechanisms, including (a) alterations and/or mutations of drug targets, e.g., topoisomerases; (b) overexpression of ABC-dependent transporter proteins, e.g., P-glycoprotein 170; (c) enhanced expression of detoxification proteins, e.g., SOD, and (d) enhanced expression of DNA damage repair proteins. Therapeutic failure cannot be an option, and we need to understand the dynamics of tumor adaptation in order to adequately adjust therapies. Therefore, a clear understanding of the mechanisms of drug resistance is essential to provide future guidance for successful treatment and to achieve better outcomes. In this Special Issue, new discoveries in the mechanisms of drug resistance will be discussed. In particular, we will highlight the roles of ATP-dependent transporters in multi-drug resistance, as well as the roles of enhanced detoxification in drug resistance. Furthermore, novel and emerging roles of resistance to immunotherapy will be emphasized. The complexity of the development of drug resistance indicates that combinational and personalized therapies might provide better strategies and improved efficacy for fighting drug resistance in clinics.
Dr. Birandra K. Sinha
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- ATP-binding cassette transporters
- cancer stem cells
- extracellular ATP
- repair of DNA damage
- immunotherapy resistance
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Related Special Issue
- Mechanisms of Therapy Resistance in Cancers in Cancers (3 articles)
