Decoding the Tumor Microenvironment: Immune Cell–Tumor Interplay in Breast Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 17

Special Issue Editors


E-Mail Website
Guest Editor
Department of Hematology/Oncology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA
Interests: breast cancer

E-Mail Website
Guest Editor
Mayo Clinic Cancer Center, Rochester, MN 55905, USA
Interests: breast cancer

Special Issue Information

Dear Colleagues,

The Special Issue, entitled "Decoding the Tumor Microenvironment: Immune Cell–Tumor Interplay in Breast Cancer," delves into the complex interactions between immune cells and cancer cells that shape breast cancer development, progression, metastasis, and therapeutic responses or resistance. We highlight recent breakthroughs in understanding the breast tumor immune microenvironment, focusing on the dynamic roles of T cells, macrophages, and dendritic cells. This Issue also features advances in single-cell and spatial transcriptomics, technologies that are revolutionizing the profiling and targeting of the tumor microenvironment. Additionally, we spotlight innovative artificial intelligence-based approaches for assessing the microenvironment’s prognostic and predictive potential. Collectively, these insights are driving the development of personalized immunotherapeutic strategies for breast cancer patients.

We look forward to receiving your contributions.

Dr. Abirami Sivapiragasam
Dr. Roberto A. Leon Ferre
Guest Editors

Manuscript Submission Information

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Keywords

  • tumor microenvironment
  • breast cancer
  • immune cell–tumor interaction
  • immunotherapy
  • T cells
  • macrophages
  • dendritic cells
  • single-cell transcriptomics
  • spatial transcriptomics
  • artificial intelligence
  • prognostic biomarkers
  • predictive biomarkers
  • personalized therapy

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Published Papers

This special issue is now open for submission.
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