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Cancers
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Advances in Dermato-Oncology
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Advances in Dermato-Oncology

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 1723

Special Issue Editor

Dr. Carmen Cantisani

E-Mail Website
Guest Editor
UOC of Dermatology, Policlinico Umberto I Hospital, Sapienza Medical School of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Interests: skin cancer; treatment; noninvasive diagnostic imaging

Special Issue Information

Dear Colleagues,

This Special Issue welcomes submissions that delve into cutting-edge advancements in dermatology–oncology, with a particular focus on noninvasive diagnostic methods and innovative treatment approaches for skin cancer. As the incidence of skin cancer continues to rise globally, the need for effective and patient-friendly diagnostic techniques becomes increasingly paramount. This Special Issue aims to highlight the latest research and developments in technologies such as imaging techniques, dermoscopy, and molecular diagnostics that facilitate early detection while minimizing patient discomfort. Additionally, we encourage contributions that explore novel therapeutic strategies, including targeted therapies and immunotherapies, aimed at treating various skin malignancies. By bringing together interdisciplinary research and clinical expertise, this Special Issue aspires to foster collaboration and knowledge-sharing among dermatologists, oncologists, researchers, and healthcare professionals committed to improving patient outcomes in dermatology–oncology. We welcome the submission of original research articles, reviews, case studies, and commentaries that can contribute to this vital field of study. Join us in advancing the landscape of skin cancer diagnosis and treatment!

Dr. Carmen Cantisani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • melanoma
  • line-field confocal optical coherence tomography (LC-OCT)
  • confocal microscopy
  • dermoscopy
  • non-melanoma skin cancers
  • treatment

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Published Papers (2 papers)

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Research

18 pages, 1127 KB  
Article
Genomic Insights into Cutaneous Squamous Cell Carcinoma
by Grace S. Saglimbeni, Tyson J Morris, Beau Hsia and Abubakar Tauseef
Cancers 2026, 18(4), 558; https://doi.org/10.3390/cancers18040558 - 9 Feb 2026
Cited by 1 | Viewed by 847
Abstract
Background: Cutaneous squamous cell carcinoma (cSCC) represents one of the most common keratinocyte-derived malignancies encountered in clinical practice; however, its genomic landscape remains far less comprehensively characterized than that of other cutaneous cancers. This study aims to identify key molecular drivers and [...] Read more.
Background: Cutaneous squamous cell carcinoma (cSCC) represents one of the most common keratinocyte-derived malignancies encountered in clinical practice; however, its genomic landscape remains far less comprehensively characterized than that of other cutaneous cancers. This study aims to identify key molecular drivers and potential therapeutic targets by comprehensively characterizing the genomic landscape of cSCC using data from the American Association for Cancer Research (AACR) Project Genomics, Evidence, Neoplasia, Information, Exchange (GENIE) consortium. Methods: A retrospective cohort analysis of cSCC samples was performed utilizing AACR Project GENIE data accessed via the cBioPortal platform (v18.0-public) on 22 November 2025. Analyses included identification of recurrent somatic and copy-number alterations, pairwise gene–gene co-occurrence testing using Fisher’s exact tests with Benjamini–Hochberg False Discovery Rate (FDR) correction, and exploratory subgroup comparisons by sex and race, with statistical significance defined as p < 0.05. Results: Recurrent mutations were identified in TP53 (83.5%), NOTCH1 (56.3%), KMT2D (47.0%), CDKN2A (44.4%), TERT (41.4%), ROS1 (34.3%), FAT1 (33.3%), NOTCH2 (31.2%), ERBB4 (28.4%), and KMT2A (24.3%), reflecting disruption of the p53 pathway, cell-cycle control, Notch signaling, epigenetic regulation, telomere maintenance, RTK/MAPK pathways, and Wnt signaling. Statistically significant co-occurrence patterns were observed, and exploratory subgroup analyses evaluated mutation frequency differences by sex and race. Conclusions: This large, multi-institutional genomic analysis defines recurrent mutational and structural alterations in cSCC and highlights an integrated pattern of pathway disruption involving genomic integrity, differentiation, epigenetic control, and proliferative signaling. These findings enhance current understandings of the molecular architecture underlying this common yet genomically understudied malignancy and provide a foundation for future mechanistic studies and development of targeted diagnostic and therapeutic strategies. Full article
(This article belongs to the Special Issue Advances in Dermato-Oncology)
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13 pages, 1457 KB  
Article
Structured Symptom Assessment in Dermato-Oncology Patients—A Prospective Observational Study of the Usability of a Symptom Questionnaire
by Martin Gschnell, Jannis Thole, Lisa Kroenig, Marianne Arz, Armin Bender, Michael Hertl and Christian Volberg
Cancers 2025, 17(23), 3763; https://doi.org/10.3390/cancers17233763 - 25 Nov 2025
Viewed by 578
Abstract
Background: A focused anamnesis of symptoms is essential in medical practice, especially in oncology, where new or increasing symptoms often indicate disease progression or therapy side effects. However, there are only a few studies in dermato-oncology that address the question of how symptoms [...] Read more.
Background: A focused anamnesis of symptoms is essential in medical practice, especially in oncology, where new or increasing symptoms often indicate disease progression or therapy side effects. However, there are only a few studies in dermato-oncology that address the question of how symptoms should ideally be recorded. There are no validated questionnaires specifically tailored to the needs of dermato-oncology. Patients and Methods: Over a one-year period, all patients at the skin cancer centre were given a standardised questionnaire to record relevant symptoms before consultation. This was followed by the attending dermato-oncologist completing an additional section regarding therapeutic measures based on the reported symptoms. Results: 809 patients with 1879 consultations were included. In most patient contacts, patients did not report an increase in symptoms (n = 840; 44.7%). Fatigue, restlessness/anxiety, pruritus, and pain were the most recorded distressing symptoms. The chi-square test revealed that increased symptoms led to significantly more frequent interventions. Overall, symptom relief was observed at follow-up. Analysis using Generalised Estimating Equations showed patients benefited significantly from interventions for sleep disorders. Subgroup analysis showed that patients in ongoing therapy benefitted significantly from interventions for pain and nausea. Those in advanced disease stages benefitted significantly from interventions for pain. In those groups, if symptoms were explicitly stated as having worsened using the questionnaire, measures taken by physicians also showed significant benefit for obstipation and nausea along with pruritus. Conclusions: Targeted symptom screening is feasible and provides valuable insights for guiding diagnostic or therapeutic interventions. However, the questionnaire is most useful at higher tumour stages, as it is only effective when distressing symptoms are present. Full article
(This article belongs to the Special Issue Advances in Dermato-Oncology)
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