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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Clinical Trials: Outcome, Innovations, Challenges, and Ethical Practice in Cancer Research 2025–2026

edited by

Naoto T. Ueno

and David R. Gandara

submission deadline 30 Jun 2026 | 5 articles | Viewed by 25144 | Submission Open

Keywords: phase I; phase II; phase III; phase IV; clinical trials; features; design; implementation; outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in the Prevention and Treatment of Liver Cancer

edited by Ewa Janczewska

submission deadline 30 Jun 2026 | 8 articles | Viewed by 23865 | Submission Open

Keywords: new screening techniques; enhanced imaging; biomarker tests; radiofrequency ablation; transarterial chemoembolization

(This special issue belongs to the Section Cancer Therapy)

Advances in Bacteria and Cancer

edited by

Alain P. Gobert

submission deadline 30 Jun 2026 | 5 articles | Viewed by 19242 | Submission Open

Keywords: pathogenic bacteria; microbiota; tumor-associated bacteria; probiotics; oncogenesis; metastasis; chemotherapy; cancerous cells; tumor microenvironment; cell signaling

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Epidermal Growth Factor Receptor-Driven Non-Small-Cell Lung Cancer: Diagnostic Technologies and Therapeutic Strategies

edited by

Fang Wei

submission deadline 30 Jun 2026 | 4 articles | Viewed by 17441 | Submission Open

Keywords: EGFR-targeted therapy; non-small-cell lung cancer diagnosis; diagnostic technologies and devices; biological discoveries in NSCLC; AI-assisted diagnosis in oncology; clinical practice in NSCLC detection; therapeutic– diagnostic integration; early-stage lung cancer monitoring; advanced NSCLC diagnostic approaches; precision medicine in lung cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Gynecologic Oncology: Clinical and Translational Research

edited by

Gennaro Daniele

, Pasquale Lombardi and Gaia Giannone

submission deadline 30 Jun 2026 | 7 articles | Viewed by 15626 | Submission Open

Keywords: gynecological cancer; ovarian cancer; translational research; effectiveness; toxicity; immunotherapy; PARP inhibitors

(This special issue belongs to the Section Cancer Therapy)

New Insights into Thyroid Cancer Surgery

edited by

Maurizio Iacobone

and Francesca Torresan

submission deadline 30 Jun 2026 | 6 articles | Viewed by 15294 | Submission Open

Keywords: total thyroidectomy; differentiated thyroid cancer; lymph node dissection; parathyroid autofluorescence; medullary thyroid carcinoma; recurrent laryngeal nerve neuromonitoring

(This special issue belongs to the Section Cancer Therapy)

Study on Epidemiology of Childhood Cancer

edited by

Francesco Giusti

and

Carmen Martos

submission deadline 30 Jun 2026 | 5 articles | Viewed by 14940 | Submission Open

Keywords: childhood cancer; epidemiology; childhood cancer registries; incidence; prevalence; mortality; survival; time trends; special analysis; environmental factors; perinatal factors; inequalities

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Role of Cancer Biomarkers for Diagnosis, Prognosis and Targeted Therapy in Gastrointestinal Cancers

edited by

Ali Zaidi

submission deadline 30 Jun 2026 | 8 articles | Viewed by 13233 | Submission Open

Keywords: liquid biopsy; esophageal cancer; gastric cancer; colorectal cancer; pancreatic cancer; hepatocellular cancer; appendiceal cancer; cancer biomarker; DNA sequencing; transcriptomics; proteomics; immunohistochemistry

(This special issue belongs to the Section Cancer Biomarkers)

The Applications of Artificial Intelligence in Gastroenterology

edited by

Marcello F. Maida

Ciro Celsa

and Louis H. S. Lau

submission deadline 30 Jun 2026 | 3 articles | Viewed by 12833 | Submission Open

Keywords: artificial intelligence; gastroenterology; endoscopy; inflammatory bowel diseases

(This special issue belongs to the Section Cancer Therapy)

Advances in Spine Oncology: Research and Clinical Studies

edited by Oluwaseun O. Akinduro

submission deadline 30 Jun 2026 | 8 articles | Viewed by 12832 | Submission Open

Keywords: metastatic spine cancer; targeted therapy; stereotactic body radiotherapy; proton radiotherapy; chordoma; chondrosarcoma; spondylectomy

(This special issue belongs to the Section Clinical Research of Cancer)

Physiotherapy in Advanced Cancer and Palliative Care

edited by Nele Adriaenssens

submission deadline 30 Jun 2026 | 3 articles | Viewed by 12662 | Submission Open

Keywords: advanced cancer; palliative care; palliative needs; physiotherapy; physical therapy modalities; quality of life; physical autonomy

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Updates on Urologic Oncology: From Diagnosis to Localized and Systemic Therapy Options (2nd Edition)

edited by

Giuseppe Palermo

submission deadline 30 Jun 2026 | 5 articles | Viewed by 11969 | Submission Open

Keywords: bladder cancer; prostate cancer; renal cancer; urologic cancer treatment; urologic cancer diagnosis; urologic cancer innovation; urologic neoplasm therapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Gastrointestinal Cancer Surgery

edited by Florian Primavesi and

Daniel Neureiter

submission deadline 30 Jun 2026 | 6 articles | Viewed by 11172 | Submission Open

Keywords: gastrointestinal cancer surgery; precision surgery; personalized medicine; robotics; pathology; colorectal cancer; stomach cancer; pancreatic cancer; hepatocellular cancer; biliary tract cancer

(This special issue belongs to the Section Cancer Therapy)

Human Papillomavirus (HPV) and Related Cancer

edited by

Beata Biesaga

submission deadline 30 Jun 2026 | 5 articles | Viewed by 10832 | Submission Open

Keywords: HPV; carcinogenesis; methods of virus identification diagnostics; prognostification

(This special issue belongs to the Section Infectious Agents and Cancer)

Clinical Diagnosis, Treatment, and Prognosis of Uveal Melanoma

edited by Josep Maria Caminal Mitjana

submission deadline 30 Jun 2026 | 5 articles | Viewed by 10622 | Submission Open

Keywords: uveal melanoma; choroidal melanoma; gene expression profiling; immunotherapy; metastasis; radiotherapy; liquid biopsy; circulating tumor cells; brachytherapy; next-generation sequencing; proton therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Application of Artificial Intelligence-Based Approaches in Cancer Diagnosis, Treatment and Prognosis

edited by

Wei Wu

submission deadline 30 Jun 2026 | 6 articles | Viewed by 10573 | Submission Open

Keywords: cancer genomics; artificial intelligence; machine learning; deep learning; tumor microenvironment; graph-based convolutional neural network; computational cancer biology

(This special issue belongs to the Section Methods and Technologies Development)

News and How Much to Improve in Management of Soft Tissue Sarcomas

edited by Vicente Artigas-Raventós and

José Manuel Asencio

submission deadline 30 Jun 2026 | 5 articles | Viewed by 10519 | Submission Open

Keywords: soft tissue sarcomas; prevalent types; multidisciplinary board; reference centers; news diagnosis methods and treatments; implication of IA and 3D in sarcomas; implication of minimally aggressive surgical techniques

(This special issue belongs to the Section Cancer Therapy)

The Progress of Pancreatectomy for Pancreatic Cancer Treatment

edited by

Reinhold Függer

and

Matthias Biebl

submission deadline 30 Jun 2026 | 5 articles | Viewed by 10484 | Submission Open

Keywords: pancreatic ductal adenocarcinoma (PDAC); pancreatectomy timing in multimodal regimen; minimally invasive pancreatectomy for PDAC; pancreatectomy and resectability; extended pancreatectomy; vascular resection and reconstruction; outcome research— pancreatectomy for cancer in unselected patient cohorts; interaction of postoperative complications and preoperative or adjuvant therapy; postoperative pancreatic fistula

(This special issue belongs to the Section Clinical Research of Cancer)

The Role of Neutrophils in Tumor Progression and Metastasis

edited by

Rakesh K. Singh

and Leah M. Cook

submission deadline 30 Jun 2026 | 5 articles | Viewed by 9715 | Submission Open

Keywords: neutrophils; innate immunity; tumor; microenvironment; metastasis; targeted therapeutics

(This special issue belongs to the Section Cancer Metastasis)

Perspectives on the Efficacy and Biomarkers of Immunotherapy and Targeted Therapy for Patients with Colorectal Cancer

edited by

Ibrahim Halil Sahin

submission deadline 30 Jun 2026 | 2 articles | Viewed by 8391 | Submission Open

Keywords: colorectal cancer; precision medicine; targeted therapeutics; immunotherapy; KRAS; BRAF; HER2; biomarkers

(This special issue belongs to the Section Cancer Therapy)

Epigenetic Regulation in Hematologic Malignancies

edited by Travis S. Johnson

submission deadline 30 Jun 2026 | 3 articles | Viewed by 8162 | Submission Open

Keywords: epigenetic regulation; hematologic malignancies; DNA methylation; non-coding RNA; therapeutic targeting

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Abdominal Surgical Oncology and Intraperitoneal Therapies

edited by

Juan Jose Segura-Sampedro

and

Constantino Fondevila

submission deadline 30 Jun 2026 | 5 articles | Viewed by 7962 | Submission Open

Keywords: abdominal oncologic surgery; minimally invasive techniques; laparoscopy; robotics; fluorescence; artificial intelligence; augmented vision; peritoneal carcinomatosis; intraperitoneal chemotherapy; liquid biopsy

(This special issue belongs to the Section Cancer Therapy)

Hereditary and Familial Colorectal Cancer

edited by Bryson W. Katona and Peter P. Stanich

submission deadline 30 Jun 2026 | 4 articles | Viewed by 7591 | Submission Open

Keywords: hereditary colorectal cancer; familial colorectal cancer; genetic predisposition; polyposis; Lynch syndrome; familial adenomatous polyposis (FAP); MUTYH-associated polyposis (MAP); genetic testing

(This special issue belongs to the Section Cancer Pathophysiology)

Recent Advances in Hematological Malignancies in Children

edited by

Radosław Chaber

submission deadline 30 Jun 2026 | 3 articles | Viewed by 7505 | Submission Open

Keywords: acute lymphoblastic leukemia; acute myeloid leukemia; hematological malignancies in children; diagnostic and therapeutic methods; supportive care strategies

(This special issue belongs to the Section Pediatric Oncology)

Clinical Research on Thoracic Cancer

edited by

Yuichi Saito

and

Hiroyuki Adachi

submission deadline 30 Jun 2026 | 4 articles | Viewed by 7331 | Submission Open

Keywords: thoracic cancer; lung cancer; thymic cancer; malignant mesothelioma; radiotherapy; surgery; chemotherapy; immunotherapy; driver mutation

(This special issue belongs to the Section Clinical Research of Cancer)

Novel Diagnosis and Treatment Approaches in Pancreatic Cancer

edited by

Atsushi Masamune

submission deadline 30 Jun 2026 | 3 articles | Viewed by 7030 | Submission Open

Keywords: pancreatic cancer; pancreatic fibrosis; biomarker; risk factor; genetic testing; artificial intelligence; endoscopic ultrasound; stroma; cancer-associated fibroblasts; familial pancreatic cancer

(This special issue belongs to the Section Cancer Therapy)

Enhancing Cancer Treatments through Fluorescence-Guided Surgery

edited by Ibrahim Khot and Yazan Sulaiman Khaled

submission deadline 30 Jun 2026 | 3 articles | Viewed by 6656 | Submission Open

Keywords: fluorescence-guided resection; fluorescent imaging; cancer surgery; tumour targeting; intraoperative staging; oncological fluorescence; precision medicine

(This special issue belongs to the Section Methods and Technologies Development)

Natural Compounds in Cancers: 2nd Edition

edited by

Ivan Cruz-Chamorro

and

Guillermo Santos-Sánchez

submission deadline 30 Jun 2026 | 1 articles | Viewed by 6372 | Submission Open

Keywords: nutrition; bioactive molecules; inflammation; natural extracts; nutraceuticals; immunotherapy; chemotherapy

(This special issue belongs to the Section Molecular Cancer Biology)

Advancements in the Diagnosis and Surgical Treatment of Prostate Cancer

edited by

Christian Peter Gilfrich

and Christian Thomas

submission deadline 30 Jun 2026 | 3 articles | Viewed by 6293 | Submission Open

Keywords: robotic-assisted radical prostatectomy; significance of pelvic lymph node dissection in the context of radical prostatectomy; complications of surgical therapy for prostate cancer; magnetic resonance imaging/ultrasound-guided target biopsy of the prostate; comparison of various robotic systems for radical prostatectomy; learning curves; hospital volume; prostate cancer centers

(This special issue belongs to the Section Clinical Research of Cancer)

Exploring Immunotherapy in Colorectal Cancer

edited by

Alessandro Passardi

Luca Esposito

and

Chiara Gallio

submission deadline 30 Jun 2026 | 1 articles | Viewed by 6247 | Submission Open

Keywords: colorectal cancer; immunotherapy; immune checkpoint inhibitors; mismatch repair; microsatellite instability; biomarkers

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Pancreatic Cancer: Clinical Standards, Unmet Needs and Future Directions

edited by

Dimitrios H. Roukos

submission deadline 30 Jun 2026 | 3 articles | Viewed by 5522 | Submission Open

Keywords: standard clinical management; surgery; neoadjuvant and/or adjuvant treatment; cancer immunotherapy; targeted therapy; detection and elimination of MRD

(This special issue belongs to the Section Clinical Research of Cancer)

Novel Treatments for Ocular and Periocular Cancers

edited by

Vidhya R. Rao

submission deadline 30 Jun 2026 | 3 articles | Viewed by 5371 | Submission Open

Keywords: ocular cancer; intraocular tumor; retinoblastoma; uveal melanoma

(This special issue belongs to the Section Cancer Therapy)

Applications of Ex Vivo Microscopy in Cancer Detection and Diagnosis

edited by J. Quincy Brown

submission deadline 30 Jun 2026 | 4 articles | Viewed by 5353 | Submission Open

Keywords: microscopy; cancer; optical sectioning; diagnosis; detection

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances in Cancer Data and Statistics: 2nd Edition

edited by

Vesna Zadnik

submission deadline 30 Jun 2026 | 3 articles | Viewed by 5160 | Submission Open

Keywords: cancer registries; cancer incidence; cancer survival; population-based studies; cancer risk factors

(This special issue belongs to the Section Cancer Informatics and Big Data)

Next-Generation Cancer Therapies

edited by

Achilleas Mitrakas

, Ioannis Lamprou and Erasmia Xanthopoulou

submission deadline 30 Jun 2026 | 2 articles | Viewed by 4763 | Submission Open

Keywords: cancer; current therapies; cancer cells metabolism; autophagy; immunotherapy; targeted treatments; oncolytic viruses; vaccines

(This special issue belongs to the Section Cancer Therapy)

New Challenges in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia

edited by Federico Mosna and Irene Cavattoni

submission deadline 30 Jun 2026 | 4 articles | Viewed by 4640 | Submission Open

Keywords: acute myeloid leukemia (AML); allogeneic hematopoietic stem cells transplantation (allo-HSCT); immunotherapy; leukemic stem cells; graft versus host disease (GVHD); infections in immunodepressed patients; immune reconstitution; post-transplant management; long-term results; clinical

(This special issue belongs to the Section Cancer Therapy)

Sequence Variants in Breast/Ovarian Cancer Susceptibility Genes: From Risk Assessment to Clinical Management in Carrier Individuals and Their Blood Relatives

edited by Arcangela De Nicolo and

Miguel De la Hoya

submission deadline 30 Jun 2026 | 3 articles | Viewed by 4628 | Submission Open

Keywords: breast/ovarian cancer susceptibility genes; risk assessment and clinical management of carrier individuals and their blood relatives; risk models; variant classification; multifactorial approaches

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Integrating Precision Medicine with Nanotechnology to Overcome Drug Resistance in Cancer

edited by Yan Li

submission deadline 30 Jun 2026 | 1 articles | Viewed by 4583 | Submission Open

Keywords: precision medicine; nanotechnology; drug resistance

(This special issue belongs to the Section Methods and Technologies Development)

Unraveling the Connections Between the Microenvironment, Angiogenesis, Immunity and Mechanobiology in Cancer

edited by Meenal Datta and Xin Tang

submission deadline 30 Jun 2026 | 1 articles | Viewed by 4488 | Submission Open

Keywords: cancer mechanosensing; mechanotransduction; mechanical cues; mechanosensitive ion channels; focal adhesions; cytoskeletal elements; tumor microenvironments; fluid shear stress; stiffness; cell compression; tumor progression; metastasis; drug resistance; immune response; biophysical tools

(This special issue belongs to the Section Cancer Pathophysiology)

NK Cells in the Tumor Microenvironment: Immunosuppressive Mechanisms and Therapy

edited by

Alexander Barrow

and Julian Vivian

submission deadline 30 Jun 2026 | 2 articles | Viewed by 4343 | Submission Open

Keywords: immunosuppression; activation; inhibition; receptor; NK-CAR; checkpoint; adoptive cell therapy; immunotherapy; tumor microenvironment; nanoparticles

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advances in PET/CT for Predicting Cancer Outcomes

edited by Ahmad Shariftabrizi

submission deadline 30 Jun 2026 | 1 articles | Viewed by 4075 | Submission Open

Keywords: FDG PET/CT; PSMA PET/CT; dotatate PET/CT; tumor heterogeneity; radiomics; CAR T-cell therapy; rare tumors; radiogenomics; immunotherapy; targeted therapy; PET physics; radiotracer metabolism

(This special issue belongs to the Section Methods and Technologies Development)

Stereotactic Body Radiation and Stereotactic Ablative Radiotherapy Therapy for Cancers 2nd edition

edited by

Sam Beddar

and Michael D. Chuong

submission deadline 30 Jun 2026 | 3 articles | Viewed by 3961 | Submission Open

Keywords: radiation therapy (oncology); stereotactic body radiation therapy (SBRT) and stereotactic ablative radiotherapy (SABR); ultra-hypofractionated and hypofractionated studies; ablative/dose-escalated studies; SBRT; SABR; and cyberknife technology; MRI guidance; tumor motion techniques and management; frame and frameless immobilization devices; SBRT/SABR dose constraints and toxicities; artificial intelligence/machine learning

(This special issue belongs to the Section Cancer Therapy)

Molecular and Genetic Biomarkers in Oral Squamous Cell Carcinoma

edited by

Kalu U.E. Ogbureke

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3809 | Submission Open

Keywords: oral cancer; oropharyngeal cancer; biomarkers; liquid biopsy; genetic determinants

(This special issue belongs to the Section Cancer Biomarkers)

Classification, Risk Assessment and Clinical Management of Malignant Thyroid Nodules: 2nd Edition

edited by Claudio Spinelli and Marco Ghionzoli

submission deadline 30 Jun 2026 | 3 articles | Viewed by 3746 | Submission Open

Keywords: thyroid nodule; thyroid cancer; guidelines; surgery

(This special issue belongs to the Section Clinical Research of Cancer)

New Insights into Microbial-Based Cancer Therapy

edited by Amitabha Ray

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3740 | Submission Open

Keywords: microbial therapy; cancer immunotherapy; bioengineering; immune modulation; tumor microenvironment

(This special issue belongs to the Section Cancer Therapy)

Neurosurgical Advances in Brain Tumor Surgery

edited by Camilla Bonaudo, Alessandro Della Puppa and

Antonello Grippo

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3653 | Submission Open

Keywords: brain lesions/tumors; preoperative mapping; neuro-oncology; navigated TMS (n TMS); brain stimulation; optical imaging; cognitive mapping; awake surgery; functional mapping; functional preservation; intraoperative monitoring; neurophysiological monitoring

(This special issue belongs to the Section Clinical Research of Cancer)

Neuroscience of Brain Tumors

edited by Zefferino Rossini,

Miguel Segura Ginard

and Maria Pia Tropeano

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3598 | Submission Open

Keywords: neurosurgery; neuroscience; brain tumors (gliomas; meningiomas; and pituitary tumors); neural pathway; neuroimaging; neurogenetics

(This special issue belongs to the Section Molecular Cancer Biology)

Chemoprevention Advances in Cancer (2nd Edition)

edited by

Komal Raina

submission deadline 30 Jun 2026 | 3 articles | Viewed by 3565 | Submission Open

Keywords: cancer prevention; chemoprevention; nutrition and cancer; bio-active food components; natural products; non-toxic anticancer agents; precision nutrition in cancer; tumor metabolomics; gut microbiome in cancer

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Fertility Preservation in Gynecological Cancer

edited by

Giuseppe Gullo

and

Luigi Della Corte

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3508 | Submission Open

Keywords: gynecological cancer; fertility preservation; surgery treatments; fertility sparing; psychological implication

(This special issue belongs to the Section Methods and Technologies Development)

Image-Guided Adaptive Radiation Therapy (IGART): Advancing Precision Oncology

edited by An Liu, Bin Cai and Murat Surucu

submission deadline 30 Jun 2026 | 3 articles | Viewed by 3426 | Submission Open

Keywords: advanced imaging techniques; adaptive radiotherapy; computational models

(This special issue belongs to the Section Methods and Technologies Development)

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