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Cancers
Special Issues
Recent Advances in Hematological Malignancies in Children
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Recent Advances in Hematological Malignancies in Children

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Pediatric Oncology".

Deadline for manuscript submissions: 30 December 2025 | Viewed by 1467

Special Issue Editor

Dr. Radosław Chaber

E-Mail Website
Guest Editor
Department of Pediatrics, Institute of Medical Sciences, University of Rzeszow, Rzeszow, Poland
Interests: pediatric hematology; the use of vibration spectroscopy in pediatric oncology; epigenetics in childhood leukemia; iron management
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) are the most common hematological malignancies in children. The progress made in their treatment over the past few decades, since the end of the 20th century, has been remarkable. Today, we are able to achieve long-term cures in 85-90% of children with ALL and 60-70% of those with AML, compared to approximately 10% in the 1970s. This advancement has been made possible through improved therapeutic protocols based on risk stratification, advancements in diagnostics and supportive care, as well as the introduction of stem cell transplantation, immunotherapy, and targeted therapies.

The purpose of this Special Issue "Recent Advances in Hematological Malignancies in Children" is to showcase the achievements in the treatment of pediatric ALL and AML in recent decades, with a particular focus on new diagnostic and therapeutic methods, including supportive care strategies, that have contributed to the improved outcomes in these malignancies. This Special Issue welcomes review articles as well as original research contributions. The deadline for submissions is 30 December 2025.

We look forward to your valuable contributions.

Dr. Radosław Chaber
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute lymphoblastic leukemia
  • acute myeloid leukemia
  • hematological malignancies in children
  • diagnostic and therapeutic methods
  • supportive care strategies

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Published Papers (1 paper)

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Research

16 pages, 1152 KiB  
Article
Pre- and Postnatal Exposures to Residential Pesticides and Survival of Childhood Acute Lymphoblastic Leukemia
by Seema Desai, Libby M. Morimoto, Alice Y. Kang, Mark D. Miller, Joseph L. Wiemels, Lena E. Winestone and Catherine Metayer
Cancers 2025, 17(6), 978; https://doi.org/10.3390/cancers17060978 - 14 Mar 2025
Viewed by 1188
Abstract
Background: Exposure to pesticides has been associated with an increased risk of developing childhood leukemia. However, the impact of pesticides on childhood leukemia survival has not been examined. We investigated the associations between residential pesticide use during key developmental periods and 5-year survival [...] Read more.
Background: Exposure to pesticides has been associated with an increased risk of developing childhood leukemia. However, the impact of pesticides on childhood leukemia survival has not been examined. We investigated the associations between residential pesticide use during key developmental periods and 5-year survival in children treated for acute lymphoblastic leukemia (ALL). Methods: Residential use of insecticides, herbicides, rodenticides, and flea control products from preconception up to 12 months prior to diagnosis and sociodemographic characteristics were collected via parental interview among 837 children diagnosed with ALL between 1995 and 2008 in California, USA. Data on clinical features were abstracted from medical records. Vital status was obtained through linkage to the National Death Index (NDI) up to 2020. Cox proportional hazards regression models were used to estimate hazard ratios (HRs), adjusting for sociodemographic factors and clinical risk group. Results: A total of 108 children with ALL (~13%) died within 5 years of diagnosis. Exposure to any pesticides pre- and/or postnatally was slightly higher among deceased compared to alive children (95.4% vs. 91.5%; p = 0.23), while use of rodenticides was significantly higher in children who died (25.0%) vs. those who survived (15.5%; p = 0.02). In fully adjusted models, exposure to rodenticides was associated with an increased risk of mortality (HR 1.70; 95% confidence interval (CI) 1.08–2.64; p = 0.02), especially when the child was exposed during pregnancy (HR 1.90; 95% CI 1.15–3.16; p = 0.01) and possibly 12 months before diagnosis (HR 1.60; 95% CI 0.98–2.61; p = 0.06). Increased hazards of death were also observed with other types of pesticides during pregnancy, but those associations were not statistically significant. Conclusions: This study is the first to report reduced survival among children with ALL previously exposed to rodenticides, particularly during pregnancy, underscoring the need to further evaluate mechanisms by which environmental exposures during key developmental stages may later impact cancer outcomes. Full article
(This article belongs to the Special Issue Recent Advances in Hematological Malignancies in Children)
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