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Cancers
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Chemoprevention Advances in Cancer (2nd Edition)
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Chemoprevention Advances in Cancer (2nd Edition)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1616

Special Issue Editor

Dr. Komal Raina

E-Mail Website
Guest Editor
1. Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
2. Department of Pharmaceutical Sciences, South Dakota State University, Brookings, SD 57007, USA
Interests: cancer chemoprevention/intervention; tumorigenesis; tumor microenvironment; cancer stem cells
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the second edition of a previous issue on the topic of “Chemoprevention Advances in Cancer”.

Over the past few decades, a tremendous amount of research effort has been directed towards identifying non-toxic chemoprevention or intervention strategies that have the potential to prevent cancer initiation and/or prevent the growth and progression of benign/pre-cancerous lesions to more advanced forms of malignancy. The strategies have focused on discovering novel dietary and non-dietary agents, lifestyle changes, gut microbiome modulation, and precision nutrition-based intervention strategies. The preclinical and translational work focused on these compounds or modalities has garnered a lot of scientific interest and gained appreciable momentum in recent years.

Accordingly, in this Special Issue focused on “Chemoprevention Advances in Cancer”, we welcome original research articles or comprehensive review articles focused on the efficacy and/or the delineation of action mechanisms relating to non-toxic natural/synthetic agents or intervention strategies that show protective efficacy against the growth and progression of cancers.

In this Special Issue, original research articles and reviews are welcome.

I look forward to receiving your contributions.

Dr. Komal Raina
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer prevention
  • chemoprevention
  • nutrition and cancer
  • bio-active food components
  • natural products
  • non-toxic anticancer agents
  • precision nutrition in cancer
  • tumor metabolomics
  • gut microbiome in cancer

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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19 pages, 4517 KB  
Article
Cancer Chemopreventive Properties of Glutelin Hydrolysate from Riceberry Bran Residues Against the Early Stage of Liver and Colon Carcinogenesis Induced by Chemicals in Rats
by Aroonrat Pharapirom, Sirinya Taya, Arpamas Vachiraarunwong, Warunyoo Phannasorn, Chonikarn Singai, Rawiwan Wongpoomchai and Jetsada Ruangsuriya
Cancers 2025, 17(16), 2666; https://doi.org/10.3390/cancers17162666 - 15 Aug 2025
Viewed by 305
Abstract
Background: Rice bran proteins and their hydrolysates exhibit anticancer activity. Our previous study demonstrated that Riceberry glutelin and its hydrolysates possessed potent in vitro antioxidant and antimutagenic properties. However, their cancer chemopreventive effects in animals remain unclear. Methods: This study investigated [...] Read more.
Background: Rice bran proteins and their hydrolysates exhibit anticancer activity. Our previous study demonstrated that Riceberry glutelin and its hydrolysates possessed potent in vitro antioxidant and antimutagenic properties. However, their cancer chemopreventive effects in animals remain unclear. Methods: This study investigated chemopreventive mechanisms in diethylnitrosamine (DEN)- and 1,2-dimethylhydrazine (DMH)-induced preneoplastic lesions, including glutathione S-transferase placental form (GST-P)-positive foci in the liver and aberrant crypt foci (ACF) in the colon of rats. Rats received GTL, GTLH, and total protein hydrolysate (TPH) at 500 mg/kg body weight, five days per week for ten weeks. Results: GTLH significantly reduced GST-P-positive foci in the liver and ACF in the colon, while GTL decreased GST-P-positive foci only in the liver. However, TPH did not affect preneoplastic lesions in both the liver and the colon. GTLH suppressed cell proliferation by reducing proliferating cell nuclear antigen (PCNA)-positive cells and promoted apoptosis, as indicated by an increase in terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)-positive cells in both organs. GTL also decreased PCNA-positive cells in the liver and colon. Moreover, GTLH significantly upregulated BAX and CASP3 in the liver, while only BAX in the colon was observed. Conclusions: This study highlighted the cancer chemopreventive potential of Riceberry GTLH with its underlying mechanism to reduce the number of preneoplastic lesions in the liver and colon through cell proliferation inhibition and apoptosis induction. These findings suggested that this protein hydrolysate might be used as a functional food ingredient or dietary supplement for cancer prevention. Full article
(This article belongs to the Special Issue Chemoprevention Advances in Cancer (2nd Edition))
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Review

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38 pages, 2978 KB  
Review
Chemopreventive and Anticancer Activity of Selected Triterpenoids in Melanoma
by Natalia Dycha, Magdalena Michalak-Tomczyk, Jacek Jachuła, Estera Okoń, Agata Jarząb, Joanna Tokarczyk, Wojciech Koch, Katarzyna Gaweł-Bęben, Wirginia Kukula-Koch and Anna Wawruszak
Cancers 2025, 17(10), 1625; https://doi.org/10.3390/cancers17101625 - 11 May 2025
Cited by 2 | Viewed by 1062
Abstract
Melanoma is one of the most aggressive forms of skin cancer, characterized by high metastatic potential and resistance to conventional therapies. Natural compounds, particularly terpenoids, have gained attention for their chemopreventive potential and anticancer properties. These plant-derived compounds exhibit diverse biological activities, e.g., [...] Read more.
Melanoma is one of the most aggressive forms of skin cancer, characterized by high metastatic potential and resistance to conventional therapies. Natural compounds, particularly terpenoids, have gained attention for their chemopreventive potential and anticancer properties. These plant-derived compounds exhibit diverse biological activities, e.g., cell viability and proliferation inhibition, apoptosis induction, cell cycle regulation, and immune system modulation. The review evaluates the current state of the art on the chemopreventive and anticancer activity of lupane- (betulinic acid), oleanane- (oleanolic acid, β-amyrin, escin, hederagenin, glycyrrhetinic acid), and ursane-type (ursolic acid, asiatic acid, madecassic acid, α-amyrin) triterpenoids in melanoma, highlighting their mechanisms of action, therapeutic potential, and challenges in clinical application. Full article
(This article belongs to the Special Issue Chemoprevention Advances in Cancer (2nd Edition))
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