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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Non-Melanoma Skin Cancer: Promises and Challenges submission deadline 30 Apr 2026 | Viewed by 104 | Submission Open
Keywords: non-melanoma skin cancer; AI; radiotherapy; immunotherapy; surgery; biomarker; technique
(This special issue belongs to the Section Cancer Therapy)
Lung Cancer: Major Pulmonary Resections and Lymph Node Dissection in the Era of Evolving Therapies
edited by Giuseppe Marulli
submission deadline 30 Apr 2026 | Viewed by 101 | Submission Open
Keywords: non-small cell lung cancer (NSCLC); pneumonectomy; bilobectomy; perioperative management; postoperative drainage; complications of major lung resections; immune checkpoint inhibitors; targeted therapies; surgical oncology; thoracic surgery
(This special issue belongs to the Section Cancer Therapy)
Liquid Biopsies in Gynecologic Cancer
edited by , and Ludovica Pepe
submission deadline 30 Apr 2026 | Viewed by 94 | Submission Open
Keywords: liquid biopsy; gynecologic cancer; circulating tumor DNA (ctDNA); ovarian cancer; endometrial cancer; cervical cancer; early detection; personalized medicine; cancer monitoring; non-invasive diagnostics
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Clinical Research on the Relationship Between Diet and Cancer Development (2nd Edition) submission deadline 30 Apr 2026 | Viewed by 92 | Submission Open
Keywords: diet; nutrition; complementary therapy; vitamins; minerals; micro-nutrients; survival; cancer
(This special issue belongs to the Section Clinical Research of Cancer)
Research and Clinical Applications of Gynecologic Cancer Detection Technologies
edited by Porfyrios Korompelis
submission deadline 30 Apr 2026 | Viewed by 92 | Submission Open
Keywords: gynaecological cancer; early diagnosis; artificial intelligence; novel technologies
(This special issue belongs to the Section Methods and Technologies Development)
Innovative Therapeutics for Breast Cancer: Advancing Clinical and Translational Research
edited by and Tamer Saad Kaoud
submission deadline 30 Apr 2026 | Viewed by 86 | Submission Open
Keywords: breast cancer; innovative therapeutics; translational clinical research; targeted therapy; immunotherapy; biomarkers; tumor microenvironment; drug resistance; clinical trials; translational preclinical research
(This special issue belongs to the Section Clinical Research of Cancer)
Tumor Model for the Development of Anti-Cancer Drugs
edited by
submission deadline 30 Apr 2026 | Viewed by 86 | Submission Open
Keywords: tumor models; preclinical cancer models; organoids and spheroids; patient-derived xenografts (PDX); syngeneic models; 3D bioprinting (tumors); tumor-on-chip; drug development; cancer immunotherapy; targeted therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Cellular Plasticity: Tumorigenesis and Therapy (2nd Edition)
edited by and
submission deadline 30 Apr 2026 | Viewed by 82 | Submission Open
Keywords: cell-of-origin; cellular plasticity; clonal evolution; cellular states; metastatic cascade; therapy resistance
(This special issue belongs to the Section Cancer Therapy)
Potential Therapeutic Targets and Non-Invasive Procedures for Improving the Treatment and Follow-Up of HPV-Associated Malignancies (2nd Edition) submission deadline 30 Apr 2026 | Viewed by 78 | Submission Open
Keywords: therapeutic targets in HPV-associated cancers; HPV-targeted therapy; immunotherapy in HPV-associated carcinomas; circulating HPV DNA
(This special issue belongs to the Section Infectious Agents and Cancer)
Role of Myeloid Cells in the Regulation of Cancer Onset and Development
edited by Rita Campanelli
submission deadline 30 Apr 2026 | Viewed by 77 | Submission Open
Keywords: myeloid cells; myeloid-derived suppressor cells; hematological malignancies; solid cancers; inflammation; angiogenesis
(This special issue belongs to the Section Tumor Microenvironment)
Adverse Effects During Cancer Treatment
edited by Yan Gong
submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open
Keywords: cancer; drug-induced adverse effects; cardiotoxicity of cancer treatment; cardiotoxicity of radiation therapy
(This special issue belongs to the Section Cancer Therapy)
Surgical Treatment and Postoperative Outcomes of Gynecological Cancers
edited by Lauren S. Prescott
submission deadline 30 Apr 2026 | Viewed by 50 | Submission Open
Keywords: gynecologic cancers; quality improvement; surgical outcomes; perioperative optimization; surgery; hysterectomy; ovarian cancer; endometrial cancer; cervical cancer
(This special issue belongs to the Section Cancer Therapy)
New Insights in Esophageal Cancer Diagnosis and Treatment
edited by
submission deadline 30 Apr 2026 | Viewed by 48 | Submission Open
Keywords: esophageal cancer; diagnosis; targeted screening; endoscopic treatment
(This special issue belongs to the Section Cancer Therapy)
Cutaneous T-Cell Lymphomas in Special Populations
edited by and Caroline Myers
submission deadline 30 Apr 2026 | Viewed by 25 | Submission Open
Keywords: cutaneous T-cell lymphoma; adult T-cell leukemia/lymphoma; lymphoproliferative disorder; hematopoietic stem cell transplant; secondary malignancy; pediatric lymphoma; skin of color; health care disparities; translational research
Advances in Biliary Tract Cancer: Multidisciplinary Perspectives in Surgery, Endoscopic Management, and Epidemiology
edited by Hiroyuki Kato
submission deadline 30 Apr 2026 | Viewed by 20 | Submission Open
Keywords: biliary tract cancer; cholangiocarcinoma; gallbladder cancer; ampullary cancer; hepatobiliary surgery; ERCP; biliary drainage; epidemiology; immunotherapy; multidisciplinary treatment; translational research
Advances in Virus-Associated Head and Neck Cancer submission deadline 1 May 2026 | 3 articles | Viewed by 9455 | Submission Open
Keywords: onco-virus; virus-associated cancer; head and neck cancers; diagnosis; pathogenesis; epidemiology; prevalence; treatment; HPV; EBV
(This special issue belongs to the Section Infectious Agents and Cancer)
Treatment Response Biomarkers in Hepatocellular Carcinoma: From Basic Science to Clinical Validation
edited by
submission deadline 1 May 2026 | 3 articles | Viewed by 5821 | Submission Open
Keywords: hepatocellular carcinoma; prognostic biomarkers; liver-directed therapy; immune checkpoint inhibitors; combination therapy
(This special issue belongs to the Section Cancer Therapy)
Advances in Medical Imaging for Cancer Detection and Diagnosis
edited by Claudia R. Mello-Thoms and Mark Anastasio
submission deadline 1 May 2026 | 1 articles | Viewed by 5295 | Submission Open
Keywords: photon-counting CT applications and developments; radiomics; AI and ML applications; collaborative CAD/AI; computational pathology; multimodality imaging of cancer; especially in vivo; emerging cancer imaging modalities; cancer imaging; machine learning; artificial intelligence; medical imaging
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Cell Adhesion in Human Cancer
edited by , Makoto Osanai and
submission deadline 1 May 2026 | 2 articles | Viewed by 4827 | Submission Open
Keywords: cell-to-cell adhesion; tight junctions; cytoskeleton; cancer; signal transduction pathways; transcriptional factors; EMT; cell metabolism; mechanical tension; human cells
(This special issue belongs to the Section Molecular Cancer Biology)
Research Advances and Therapeutic Strategies (RATS) in Cardio-Oncology submission deadline 1 May 2026 | 2 articles | Viewed by 3473 | Submission Open
Keywords: cardiotoxicity; artificial intelligence; multi-omics; cardiac toxicities; surveillance; cardioprotective agents; multimodal imaging
(This special issue belongs to the Section Cancer Therapy)
Urologic Cancer: Endoscopic, Laparoscopic, and Robot-Assisted Surgery Management (2nd Edition)
edited by Kouji Izumi
submission deadline 1 May 2026 | 1 articles | Viewed by 2762 | Submission Open
Keywords: prostate cancer; urothelial cancer; kidney cancer; adrenal cancer; transurethral technique; ureteroscopy; ureteral stent
(This special issue belongs to the Section Cancer Therapy)
Protein Kinases and Signal Transduction Pathways in Regulating Tumor Growth
edited by
submission deadline 1 May 2026 | 1 articles | Viewed by 911 | Submission Open
Keywords: protein kinases; protein kinase inhibitors; protein phosphatases; inositol kinases; signal integration; kinase– lipid interaction
(This special issue belongs to the Section Cancer Biomarkers)
Advances of Particle Therapy in Prostate Cancer—2nd Edition
edited by
submission deadline 7 May 2026 | Viewed by 305 | Submission Open
Keywords: prostate cancer; particle therapy; radiation therapy; diagnosis; treatment; SBRT; IMRT
(This special issue belongs to the Section Cancer Therapy)
Rehabilitation Opportunities in Cancer Survivorship
edited by and Alejandro Heredia-Ciuro
submission deadline 8 May 2026 | 3 articles | Viewed by 6396 | Submission Open
Keywords: cancer; rehabilitation; sequelae; disability; impairment
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Artificial Intelligence for Cancer Precision Medicine
edited by Chenyang Shen and
submission deadline 8 May 2026 | Viewed by 37 | Submission Open
Keywords: artificial intelligence; cancer; radiomics
(This special issue belongs to the Section Methods and Technologies Development)
Epigenetics in Cancer and Drug Therapeutics
edited by Bethsebie Sailo and Anup R. Sharma
submission deadline 10 May 2026 | 1 articles | Viewed by 2350 | Submission Open
Keywords: cancer epigenetics; chromatin remodeling complexes; histone modifiers; DNA methylation; molecular target; cancer therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Hepatocellular Carcinoma Progression and Metastasis
edited by
submission deadline 10 May 2026 | 1 articles | Viewed by 2074 | Submission Open
Keywords: hepatocellular carcinoma; tumor progression; metastasis; liver cancer; angiogenesis; epithelial– mesenchymal transition; tumor microenvironment; molecular pathways; biomarkers; targeted therapy; systemic therapy
(This special issue belongs to the Section Cancer Metastasis)
Genetics in Hematological Malignancies
edited by
submission deadline 10 May 2026 | 1 articles | Viewed by 1534 | Submission Open
Keywords: hematological malignancies; genomic alterations; personalized medicine; next-generation sequencing; epigenetics; biomarkers; leukemia; lymphoma; myeloma; genetic profiling
(This special issue belongs to the Section Molecular Cancer Biology)
Artificial Intelligence for Network-Based Oncomarker Discovery and Cancer Prediction
edited by Oleg Blyuss
submission deadline 10 May 2026 | 2 articles | Viewed by 1505 | Submission Open
Keywords: artificial intelligence (AI); network-based biomarkers; graph neural networks (GNNs); multi-omic integration; cancer prediction; oncomarker discovery; prognostic and predictive biomarkers
(This special issue belongs to the Section Cancer Informatics and Big Data)
Targeted Therapy of Pediatric Cancer (2nd Edition) submission deadline 10 May 2026 | 1 articles | Viewed by 1107 | Submission Open
Keywords: leukemia; lymphoma; pediatric solid malignancies; targeted therapy; biomarker discovery; actionable mutations; drug vulnerabilities; combination therapy; immunotherapeutic approaches; preclinical studies
(This special issue belongs to the Section Pediatric Oncology)
Oncoproteins in Cancers: Transcriptional Regulation, Signaling and Targeted Therapy submission deadline 11 May 2026 | Viewed by 210 | Submission Open
Keywords: oncoproteins; targeted therapy; oncogenic signaling pathways; tumor microenvironment; oxidative stress and cancer; tumorigenesis; cancer chemoprevention
(This special issue belongs to the Section Molecular Cancer Biology)
Molecular and Clinical Challenges in Metastatic and Oligometastatic Genitourinary Cancers
edited by Marlon Perera
submission deadline 11 May 2026 | Viewed by 29 | Submission Open
Keywords: genitourinary cancers; oligometastatic disease; metastasis-directed therapy; precision oncology; molecular profiling; biomarkers; liquid biopsy; tumour microenvironment; imaging and radiomics
(This special issue belongs to the Section Cancer Metastasis)
Systemic Treatment for Breast Cancer submission deadline 12 May 2026 | Viewed by 31 | Submission Open
Keywords: breast cancer; biomarker; treatment; management
(This special issue belongs to the Section Cancer Therapy)
Immune-Related Adverse Events in Cancer Immunotherapy
edited by Kate Young and Anna Olsson-Brown
submission deadline 15 May 2026 | 6 articles | Viewed by 14790 | Submission Open
Keywords: check point inhibitors (CPIs); immunotherapy; irAEs; immune checkpoint inhibitors (ICIs); survivorship; long-term toxicity; steroid refractory; biologics; CAR-T; TILs
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Infectious Agents and Cancer in Children and Adolescents
edited by and Eleni Tsotridou
submission deadline 15 May 2026 | 4 articles | Viewed by 10903 | Submission Open
Keywords: infectious agents; immune system; tumor development; immunological memory; oncolytic viruses
(This special issue belongs to the Section Infectious Agents and Cancer)
Endoscopic Advances in Gastrointestinal Oncology
edited by Eduardo Rodrigues-Pinto
submission deadline 15 May 2026 | 1 articles | Viewed by 5417 | Submission Open
Keywords: endoscopic oncology; endoscopic screening; endoscopic resection; endoscopic palliation; staging
(This special issue belongs to the Section Cancer Therapy)
Recent Advance in Colorectal Cancer Liver Metastases
edited by and Jennifer Kalil
submission deadline 15 May 2026 | 3 articles | Viewed by 5097 | Submission Open
Keywords: colorectal cancer liver metastases; histological growth patterns; chemotherapy optimization; liver regeneration; future liver remnant; liquid biopsy; treatment resistance
(This special issue belongs to the Section Cancer Metastasis)
Surgical Management of Non-Small Cell Lung Cancer
edited by József Furák
submission deadline 15 May 2026 | 4 articles | Viewed by 3641 | Submission Open
Keywords: non-small cell lung cancer; surgery; treatment; segmentectomy
(This special issue belongs to the Section Cancer Therapy)
Breast Cancer Screening: Global Practices and Future Directions
edited by Rudolf Morant
submission deadline 15 May 2026 | 2 articles | Viewed by 1482 | Submission Open
Keywords: mammography screening; organized screening programs; tomosynthesis; 2D mammography; artificial intelligence; personalized screening
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Recent Advances in Trachea, Bronchus and Lung Cancer Management: 2nd Edition
edited by , Dionisios G. Spyratos and
submission deadline 15 May 2026 | 1 articles | Viewed by 1081 | Submission Open
Keywords: trachea; bronchus and lung cancer; non-small cell lung cancer (NSCLC); small cell lung cancer (SCLC); cancer management; clinical suspicion; diagnosis; treatment; prevention
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Integrative Histopathological–Molecular–Computational Analysis of Primary Brain Tumors
edited by
submission deadline 15 May 2026 | Viewed by 570 | Submission Open
Keywords: brain tumor histopathology; neuropathology; molecular pathology; digital pathology; artificial intelligence; bioinformatics; computational pathology; deep learning
(This special issue belongs to the Section Cancer Informatics and Big Data)
Minimally Invasive Gastric Cancer Surgery
edited by , Simone Giacopuzzi and Felix Berlth
submission deadline 15 May 2026 | Viewed by 379 | Submission Open
Keywords: gastric cancer; laparoscopy; robotic surgery; fluorescence; minimally invasive surgery; lymphadenectomy
(This special issue belongs to the Section Cancer Therapy)
Targeted Therapy for Liver Metastases submission deadline 15 May 2026 | Viewed by 301 | Submission Open
Keywords: targeted therapy; liver metastases; biological therapy
(This special issue belongs to the Section Cancer Therapy)
Gene Editing and Delivery for Cancer Therapy (2nd Edition)
edited by and
submission deadline 15 May 2026 | Viewed by 159 | Submission Open
Keywords: gene therapy; gene editing; gene delivery; oncolytic viruses; nanomaterial; peptides; nanostructures; exosomes; translational science
(This special issue belongs to the Section Cancer Therapy)
Molecular and Genetic Diagnosis and Targeted Therapy of Myeloproliferative Neoplasms (2nd Edition)
edited by and
submission deadline 15 May 2026 | Viewed by 148 | Submission Open
Keywords: myeloproliferative neoplasm; chronic myeloid leukemia; polycythemia vera; essential thrombocythemia; primary myelofibrosis; MPN; CML; PMF; PV; ET
(This special issue belongs to the Section Molecular Cancer Biology)
Mass Spectrometry and Cancers submission deadline 15 May 2026 | Viewed by 121 | Submission Open
Keywords: cancer; biomolecular; mass spectrometry
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Advances in Locoregional Therapies for Gastrointestinal Cancer Metastases submission deadline 15 May 2026 | Viewed by 95 | Submission Open
Keywords: gastrointestinal cancer metastases; locoregional therapies; interventional radiology; endoscopy; radiation therapy; invasive operations; cytoreductive surgery (CRS); intraperitoneal chemotherapy (IP); heated intraperitoneal chemotherapy (HIPEC); tumor debulking; stereotactic body radiation therapy (SBRT); selective internal radiation therapy (SIRT)
(This special issue belongs to the Section Methods and Technologies Development)
The Surgical Management of Colorectal Cancer
edited by Gyung-mo Son
submission deadline 20 May 2026 | 10 articles | Viewed by 26237 | Submission Open
Keywords: colorectal cancer; surgical management; minimally invasive surgery; laparoscopic surgery; robotic surgery; single port surgery; emergency surgery; image-guided surgery; enhanced recovery after surgery (ERAS); systemic metastasis in colorectal cancer (involving the liver; lung; peritoneum; etc.)
(This special issue belongs to the Section Cancer Therapy)
New Advances in the Treatment of Pediatric Solid Tumors
edited by and Oz Mordechai
submission deadline 20 May 2026 | 3 articles | Viewed by 8424 | Submission Open
Keywords: pediatric oncology; solid tumors; precision medicine; immunotherapy; artificial intelligence; innovative therapies
(This special issue belongs to the Section Pediatric Oncology)
Improving the Quality of Life in Patients with Gynecological Cancer
edited by Vasilios Pergialiotis
submission deadline 20 May 2026 | 1 articles | Viewed by 4935 | Submission Open
Keywords: gynecologic oncology; minimal invasive surgery; ovarian cancer; ERAS protocol; perioperative care; immunonutrition; cervical cancer
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
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